[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Shanghai Eye Disease Prevention and Treatment Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":373},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,43,71,93,119,139,164,194,218,244,266,291,315,329,351],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100592629","virtual-far-sight-reading-device-for-myopia-intervention-among-pre-myopic-children-100592629",false,"NCT06995911","Virtual Far-sight Reading Device for Myopia Intervention Among Pre-myopic Children","A Randomized Controlled Clinical Trial on the Efficacy and Safety of the Virtual Far-sight Reading Device for Myopia Intervention in Pre-myopic Children","Inclusion Criteria:\n\n* Age: 6-12 years (inclusive), gender unrestricted.\n\n  * Worse eye cycloplegic spherical equivalent refraction (SER): -0.5 D \\\u003C SER ≤ +0.75 D; Cylinder ≤ -1.5 D in both eyes; Interocular anisometropia ≤ 1.5 D ③ Visual acuity: Best-corrected visual acuity (BCVA) ≤ 0.1 logMAR in both eyes. ④ Family history: At least one parent with myopia.\n\n    * Intraocular pressure (IOP): 10-21 mmHg in both eyes; Interocular IOP difference ≤ 5 mmHg\n\n      ⑥ Compliance: Commitment to daily home use of the Far-Image Light Field Desk per protocol, immediate notification to investigators if unable to comply, and completion of scheduled follow-ups.\n\n      ⑦ Informed consent: Signed assent form (minor) and written informed consent from legal guardian.\n\nExclusion Criteria:\n\n* Ocular comorbidities affecting vision\u002Frefractive development: Marfan syndrome; Lens pathologies (e.g., cataracts); Glaucoma; retinal detachment; retinopathy of prematurity\n\n  * Systemic diseases: Immune\u002FCNS disorders; Down syndrome; Severe cardiopulmonary\u002Fhepatic\u002Frenal dysfunction; Uncontrolled asthma\n\n    * Ocular abnormalities: Manifest strabismus; Binocular vision dysfunction; Pathological ocular changes or active ocular inflammation ④ Recent myopia interventions (within 3 months prior to screening): Orthokeratology; multifocal contact lenses; Functional spectacles, red-light therapy\n\n      ⑤ Medications affecting efficacy evaluation (within 3 months): Anticholinergics (e.g., atropine, pirenzepine); Cholinergics (e.g., pilocarpine)\n\n      ⑥ Participation in other clinical trials within 3 months.\n\n      ⑦ Contraindications\u002Fallergies to cycloplegics or study-related medications.\n\n      ⑧ Chronic psychiatric disorders or cognitive impairment.\n\n      ⑨ Other conditions deemed unsuitable by investigators.","ALL","6 Years","12 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial wants to find out if the Virtual Far-sight Reading Device can help prevent or slow down myopia progression in children and teenagers with pre-myopia. We also want to know what makes this treatment work better for some participants and check for any eye or body-related side effects over time.\n\nMain questions:\n\nCan using the Virtual Far-sight Reading Device reduce the risk of myopia? Is the device safe to use every day for up to 6 months?\n\nWhat we'll do:\n\nResearchers will compare two groups of children:\n\nGroup A: Uses the device for reading\u002Fwriting (at least 1 hour daily) Group B: Does regular reading\u002Fwriting without the device After 90 days, the groups will switch to see if the results stay the same.\n\nParticipants will:\n\n* Have free eye checkups 3 times over 6 months\n* Use the device during homework time (if in the desk group)\n* Report any eye discomfort or problems",[27,28],"Myopia","Pre-myopia",[27,28],"RECRUITING","2026-05-21",{"date":33,"type":34},"2026-05-26","ACTUAL",{"date":36,"type":34},"2025-06-01",{"date":38,"type":21},"2026-05-31",{"name":40,"class":41},"Shanghai Eye Disease Prevention and Treatment Center","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100616945","led-red-light-in-modulating-choroidal-microcirculation-to-retard-retinal-atrophy-in-pathological-myopia-100616945","NCT07312214","LED Red Light in Modulating Choroidal Microcirculation to Retard Retinal Atrophy in Pathological Myopia","A Randomized Controlled Trial of LED Red Light in Modulating Choroidal Microcirculation to Retard Retinal Atrophy in Pathological Myopia","Inclusion Criteria:\n\n* Age range: 18 to 55 years old;\n* Baseline visual acuity: Best Corrected Visual Acuity (BCVA) ≥ 0.1 (LogMAR ≤ 1.0);\n* Meeting the diagnostic criteria for high myopia: Spherical Equivalent (SE) ≤ -6.00 D and Axial Length (AL) ≥ 26.0 mm;\n* Meeting one of the following pathological fundus changes:\n\n  (i) Fundus manifestations corresponding to Category 2 (diffuse chorioretinal atrophy), Category 3 (patchy chorioretinal atrophy), or Category 4 (macular atrophy associated with choroidal neovascularization) of the META-PM classification criteria\\*; (ii) Category 1 of the META-PM classification criteria\\* complicated with macular schisis; (iii) BCVA \\\u003C 0.6;\n\nExclusion Criteria:\n\n* Concurrent with other ophthalmic diseases that may affect visual acuity or outcome assessment, including active myopic choroidal neovascularization (CNV) requiring anti-VEGF therapy, macular hole, vitreous hemorrhage, diabetic retinopathy, retinal detachment, retinal vein occlusion, optic neuritis, uveitis, severe cataract, and glaucoma;\n* Systemic contraindications: Photosensitive epilepsy, autoimmune diseases (e.g., systemic lupus erythematosus), or pregnant\u002Flactating women; Patients who have undergone intraocular surgery, laser treatment, or ophthalmic medication therapy within 3 months prior to enrollment;\n* Patients unable to comply with regular follow-up (e.g., due to remote residence) or with cognitive impairment;\n* Opaque refractive media that hinder fundus examination.","18 Years","55 Years",{"count":53,"type":21},158,[24],"The goal of this clinical trial is to learn if LED repeated low-level red light (RLRL) therapy works to treat pathologic myopia in adults. It will also learn about the safety of LED-RLRL. The main questions it aims to answer are:\n\nDoes LED-RLRL modulate choroidal microcirculation to retard retinal atrophy in pathological myopia? What medical problems do participants have when receiving LED-RLRL therapy? Researchers will compare with a sham device (identical in appearance but delivering \\\u003C10% of the original device's energy output) to see if LED-RLRL works to treat pathologic myopia.\n\nParticipants will:\n\nTake LED-RLRL or sham LED-RLRL twice daily, 3 minutes per session, 5 days per week, for a total duration of 12 months.\n\nVisit the clinic once every 3 months for checkups and tests. Keep a diary of their symptoms and their visual perception.",[57],"Pathologic Myopia",[59,60,61,62],"repeated low-level red light","LED","myopia","treatment","2026-05-12",{"date":65,"type":34},"2026-05-15",{"date":67,"type":34},"2025-12-31",{"date":69,"type":21},"2028-12-30",{"name":40,"class":41},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":42},"100634128","efficacy-of-multi-type-photolithography-flat-microstructure-lenses-for-childhood-myopia-control-100634128","NCT07535658","Efficacy of Multi-Type Photolithography Flat Microstructure Lenses for Childhood Myopia Control","Comparative Efficacy and Safety of Multi-Type Photolithography Flat Microstructure Spectacle Lenses Versus Spectacle Lenses With Aspherical Lenslets for Myopia Control in Chinese Children: A 12-Month Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age: 6 years ≤ age ≤ 8 years (calculated based on the informed consent date);\n2. The spherical equivalent (SE) of both eyes is 0D to +1.00D (inclusive of boundary values) after cycloplegia;\n3. Astigmatism: Cylindrical power of both eyes ≤ 1.00D;\n4. Anisometropia: Difference in spherical equivalent between both eyes ≤ 1.00D;\n5. Corrected visual acuity: Best corrected visual acuity (BCVA) of both eyes ≥ 1.0 (decimal notation, 5m);\n6. General health status: No systemic syndromes that affect ocular development; no long-term use of growth hormone, corticosteroids, or antiepileptic drugs;\n7. Previous intervention: No use of any myopia control methods within the past 3 months, including but not limited to: multifocal glasses, atropine eye drops, red light therapy, acupuncture, etc.\n8. Compliance with spectacle wear: Parents ensure that the child wears glasses for ≥8 hours per day;\n9. Follow-up capability: Ability to attend scheduled follow-ups for 12 months (4 visits in total);\n10. Informed consent from guardian: Legal guardian signs the informed consent form; children also sign the assent form.\n\nExclusion Criteria:\n\n1. History or presence of glaucoma, corneal disease, or other ocular organic disease, or acute or chronic ocular inflammation;\n2. Combined with systemic major diseases, mental diseases, or systemic collagen metabolism diseases;\n3. Used any myopia intervention drugs or devices in the past 3 months;\n4. Those who have participated in other similar clinical studies in the past 3 months;\n5. Diagnosis of amblyopia, constant strabismus, and other congenital eye diseases;\n6. Those who are allergic to the lens material or products related to the study;\n7. Allergy to mydriatic agents and related ophthalmic medications;\n8. Allergic to photochromic materials or related dyes; taking photosensitizing drugs; suffering from photo-induced skin or neurological disorders;\n9. Unable to understand the study content or unable to cooperate with the follow-up;\n10. Other reasons why the research doctor believes the patient is not suitable for the study.","8 Years",{"count":80,"type":21},255,[24],"The goal of this clinical trial is to learn if photolithographic flat microstructure lenses work to prevent myopia in children. It will also learn about the safety of different designs of photolithographic flat microstructure lenses. The main questions it aims to answer are:\n\nAre photolithography flat microstructure lenses effective and safe in preventing myopia in children? Does the depth of tinted lenses affect visual quality? Researchers will compare photolithography flat microstructure lenses to a spectacle lenses with aspherical lenslets to see if photolithography flat microstructure lenses works to prevent myopia in children.\n\nParticipants will:\n\nWear photolithography flat microstructure lenses or Spectacle Lenses with Aspherical Lenslets more than 8H per day for 1 year.\n\nVisit the clinic once every 3 months for checkups and tests.",[27],"NOT_YET_RECRUITING","2026-04-14",{"date":87,"type":34},"2026-04-17",{"date":89,"type":21},"2026-04-15",{"date":91,"type":21},"2027-12-31",{"name":40,"class":41},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":101,"sex":16,"minAge":102,"maxAge":50,"enrollmentInfo":103,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},"100498469","china-axial-length-study-100498469","NCT05770661","China Axial Length Study","Axial Length Study of Children and Adolescents in Ten Provinces of China","CALS","Inclusion Criteria:\n\n* Aged 3 to 18 years\n* Have been lived in the research areas for at least one year, and will not move to other places in the following two years\n* Parents or guardians sign an informed consent form, and children over 6 years old need oral consent to participate\n\nExclusion Criteria:\n\n* Mental diseases, unable to cooperate to complete the eye assessment\n* Ophthalmic diseases, inability to cooperate to complete the inspection",true,"3 Years",{"count":104,"type":21},30000,"OBSERVATIONAL","The primary objective of this multi-center, observational study is to establish the reference ranges of axial length in Chinese children and adolescents.\n\n30,000 children aged 3-18 years were examined with cycloplegia to collect their ocular parameters and were all followed up for three years with annual visits.",[108,27,109],"Axial Length","Child Development","2025-12-11",{"date":112,"type":34},"2025-12-18",{"date":114,"type":34},"2023-03-10",{"date":116,"type":21},"2026-12-31",{"name":40,"class":41},2,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":102,"maxAge":17,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":136,"leadSponsor":138,"locationsCount":42},"100606545","early-onset-myopia-intervention-project-100606545","NCT07176949","Early-Onset Myopia Intervention Project","Project on Myopia Surveillance and Intervention Services for Preschool Children in Shanghai","EOM","Inclusion Criteria:\n\n* Age 3-6 years, gender unrestricted;\n* Bilateral cycloplegic spherical equivalent (SE) ≤ +0.75 D, astigmatism ≤-2.5 D, anisometropia ≤2.5 D;\n* Best corrected visual acuity: ≥0.5 for ages 3-5, ≥0.7 for age 6;\n* Accept regular follow-up, written informed consent from guardians, verbal informed consent from children;\n* Possess normal thinking and language communication skills, and can actively cooperate to wear spectacles as required.\n\nExclusion Criteria:\n\n* Existence of strabismus or amblyopia or other binocular vision abnormalities, accommodation dysfunction, cataract and history of eye surgery;\n* Any ocular or systemic disease that may affect vision and refractive development (e.g., Keratoconus, Marfan syndrome, retinopathy of prematurity, etc.);\n* Current or previous use of other treatments for myopia intervention, such as pharmacological (atropine) and optical (orthokeratology lenses or DIMS spectacle lenses) approaches, interrupt use for at least 4 weeks;\n* Allergy or contraindication to cycloplegic drugs;\n* Epilepsy or other mental disorders unable to expressing consent;\n* Other conditions deemed unsuitable for participation by the researcher.",{"count":128,"type":21},508,[24],"The prevalence of myopia among children has been increasing year by year, which has become a globle public health issue. Studies have shown that defocusing lenses and atroping eyedrops can control the progression of myopia, but there is little evidence of its efficacy in myopia intervention of young pre-schoolers who will face a greater risk of progression to high myopia later in life. Therefore, this study aims to evaluate the effectiveness and safety of spectacle lenses with highly aspherical lenslets (Essilor's Stellest) , as well as 0.01% and 0.05% low concentration atropine eyedrops in myopia intervention among young children aged 3-6.",[27,28],"2025-09-10",{"date":134,"type":34},"2025-09-16",{"date":36,"type":34},{"date":137,"type":21},"2028-05-31",{"name":40,"class":41},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":42},"100602225","efficacy-and-safety-of-spectacle-lenses-with-halt-max-technology-on-high-myopia-control-in-children-and-adolescents-100602225","NCT07120737","Efficacy and Safety of Spectacle Lenses With H.A.L.T. MAX Technology on High Myopia Control in Children and Adolescents","Efficacy and Safety of Spectacle Lenses With Maximized Highly Aspherical Lenslets Target Technology (H.A.L.T. MAX) on High Myopia Control in Children and Adolescents: a Randomized Controlled Research","Inclusion Criteria:\n\n* Voluntary, willing to follow the protocol, able to read and understand the information form and give free and informed consent (for parents\u002Fguardian of children subjects) and assent (for subjects aged 7-14 years old);\n* 7-14 years old，regardless of sex;\n* Spherical equivalent refraction (SE) after cyclopegia ≤ -5.00 D and ≥ -9.00D;\n* Anisometropia and Astigmatism ≤2.50D;\n* Best corrected distance visual acuity of at least 0.8 in both eyes;\n* Willing to wear only the spectacles provided by the investigator for all days (\\>10 hours) during the study without additional interventions;\n* Accept randomization;\n* Able to sign the informed consent form with the accompaniment and understanding of parents or guardians.\n\nExclusion Criteria:\n\n* Allergic or intolerant to cycloplegic drugs；\n* Exclude children on high dose atropine (1%) or red light therapy；\n* Any previous history of myopia control treatment in the previous 30 days, like low dose atropine, defocus spectacles, or thokeratology and acupuncture；\n* History or presence of an ocular disease, strabismus or amblyopia or other binocular vision abnormalities, accommodation dysfunction, and cataract.；\n* History of eye surgery；\n* Ocular or systemic diseases that may be associated with myopia, such as Marfan syndrome, retinopathy of newborns, diabetes, etc；\n* Anatomic or skin factors affecting the wearing of spectacles；\n* Other conditions unsuitable for inclusion (patients with excessive expectations for the effect of the defocus spectacle lenses or desires to try other myopia interventions).","7 Years","14 Years",{"count":149,"type":21},224,[24],"Children aged 7-14 years with high myopia were randomly assigned to a control group or an intervention group at a 1:1 ratio. The intervention group wore H.A.L.T. MAX lenses for at least 10 hours per day for 2 years, and the control group wore ordinary single-vision (SV) spectacles for at least 10 hours per day. At the 1-year follow-up examination (6-month visit), control subjects whose equivalent spherical diopter change (SER) was ≥0.75 D were switched to H.A.L.T. MAX lenses until the end of year 2. After entering year 2, all remaining control (SV) subjects will be replaced with H.A.L.T. MAX defofocus frames for at least 10 hours per day until the end of year 2. And continue to wear it for at least 10 hours per day. To evaluate the efficacy, safety and compliance of H.A.L.T. MAX lenses in delaying myopia progression in children with high myopia, and to provide a scientific basis for the formulation and practice of public health programs for delaying myopia progression and the risk of blindness and visual impairment caused by high myopia.",[27,153],"High Myopia",[61,155],"high myopia","2025-08-11",{"date":158,"type":34},"2025-08-13",{"date":160,"type":21},"2025-09-01",{"date":162,"type":21},"2028-12-01",{"name":40,"class":41},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":101,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":171,"targetDuration":102,"studyType":105,"phases":4,"briefSummary":173,"conditions":174,"keywords":178,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":42},"100581406","real-world-study-of-myopia-prevention-and-control-in-children-100581406","NCT06849895","Real-World Study of Myopia Prevention and Control in Children","Real-World Study of Myopia Prevention and Control in Children: a Prospective Cohort Study","Inclusion Criteria:\n\n1. All students from the enrolled schools;\n2. Participants must be able to cooperate with and complete all required ophthalmic examinations;\n3. Written informed consent must be obtained from their parents or legal guardians.\n\nExclusion Criteria:\n\n1. Ocular abnormalities (e.g., strabismus, amblyopia, or other significant eye diseases);\n2. Systemic diseases that may affect ocular health;\n3. Current participation in other myopia intervention programs.",{"count":172,"type":21},15000,"This prospective, school-based cohort study aims to enroll approximately 15,000 primary school students from multiple districts in Shanghai, China and to observe the outcomes on myopia prevention and control in children with varying refractive status (including sufficient hyperopia reserve, relative insufficiency in hyperopia reserve, pre-myopia and myopia) who are exposed to a school-based categorized and integrated interventions strategy in real-world settings.\n\nThe primary objective of this study is to observe the change in the incidence and prevalence of myopia as well as the the progression of myopia among primary school students population under a school-based interventions, including increasing outdoor activities and wearing special designed optical lenses. The second objective is to identify factors influencing the outcomes and assess the compliance of different intervention methods. Additionally, a cost-effectiveness analysis will be conducted to assess the implementation process, providing technical solutions and operational models for wider application.",[27,175,176,177],"Refractive Errors","Children","Cohort",[61,179,180,181,182,183,184,185],"premyopia","outdoor activities","myopia prevention","myopia control","children","compliance","defocus optical lenses","2025-02-23",{"date":188,"type":34},"2025-02-27",{"date":190,"type":21},"2025-02-28",{"date":192,"type":21},"2028-02-28",{"name":40,"class":41},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":101,"sex":16,"minAge":78,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":42},"100571192","minimum-power-and-frequency-of-repeated-low-level-red-light-to-effectively-control-myopia-progression-100571192","NCT06717048","Minimum Power and Frequency of Repeated Low-level Red-light to Effectively Control Myopia Progression","An Exploratory Study on the Minimum Power and Frequency of Repeated Low-level Red-light to Effectively Control Myopia Progression","Inclusion Criteria:\n\n1. Age: 8-10 years old\n2. Low myopia: cycloplegic spherical equivalent refractions (SERs) range from -0.50 (inclusive) to -3.00 diopters (D) and astigmatism less than -2.5 D in either eye.\n3. signed informed consent and was able to participate in the study\n\nExclusion Criteria:\n\n1. Secondary myopia, such as a history of retinopathy of prematurity or other neonatal diseases; syndromic myopia with a known genetic disorder or connective tissue disease, such as Stickler syndrome or Marfan syndrome\n2. Strabismus or other binocular vision abnormalities\n3. Cloudy refractive media: cloudy cornea, cataract or intraocular lens surgery\n4. Eye diseases that affect retinal function: macular degeneration, diabetic retinopathy, retinal detachment, glaucoma or ocular hypertension, endophthalmitis, uveitis, optic neuropathy, etc.\n5. History of refractive surgery, internal eye surgery, laser therapy, vitreous injection, etc.\n6. diabetes, hypertension and other systemic disorders\n7. History of use of retinal toxic drugs, such as hydroxychloroquine, etc.\n8. Use of orthokeratology, atropine, multifocal frame glasses and other myopia control methods; children who are currently receiving atropine, orthokeratology, multifocal frame glasses and other myopia control treatment, can be enrolled after 2 weeks of treatment.\n9. Other reasons considered unsuitable for inclusion by the study physician, including but not limited to other ocular and systemic disease abnormalities","10 Years",{"count":203,"type":21},108,[24],"To explore the minimum power and frequency of Repeated Low-level Red-light (RLRL) to control myopia progression in low-myopic children aged 8-10 years, and the rebound effect of low-myopic children after discontinuation of RLRL with different combinations of power and frequency.",[27,207,208,209],"Refractive Error - Myopia","Choroidal Thickness","Retina","2024-11-29",{"date":212,"type":34},"2024-12-04",{"date":214,"type":21},"2024-12-09",{"date":216,"type":21},"2025-06-09",{"name":40,"class":41},{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":147,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":227,"briefSummary":228,"conditions":229,"keywords":232,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":4},"100561784","visual-training-for-improving-intermittent-exotropia-visual-function-100561784","NCT06594666","Visual Training for Improving Intermittent Exotropia Visual Function","Clinical Study on the Effectiveness and Safety of Visual Training for Improving Intermittent Exotropia Visual Function","Inclusion Criteria:\n\nAged 6 to 14 years. Intermittent exotropia meeting all of the following criteria: Exodeviation at least 10Δ at distance measured by the prism and alternate cover test, near deviation does not exceed distance deviation by more than 10Δby prism and alternate cover test, mean distance Newcastle Control Score (NCS)≥2 points (mean of 3 assessments during the examination).\n\nRefractive error between -5.00 D \\\u003C spherical equivalents (SEs) ≤ -1.00 D, astigmatism ≤1.50D, anisometropia ≤1.5D, best visual acuity in each eye of 1.0.\n\nNot receiving any other form of strabismus or myopia treatment within 3 months. Willing to follow the research plan and participate in the entire research process.\n\nParticipants and guardians agree to be randomly assigned and sign an informed consent form.\n\nExclusion Criteria:\n\nVertical strabismus; Diagnosed with other eye diseases or visual abnormalities such as strabismus, amblyopia, etc; Existence of cognitive or learning disabilities that may affect the effectiveness of training; patients with neurological disorders; Unable to cooperate with eye examination and follow-up work.",{"count":226,"type":21},78,[24],"The goal of this clinical tral is to investigate that if VR\u002FAR visual training can improve the visual function in children with intermittent exotropia.\n\nThe main question it aims to answer is :\n\nDoes the VR\u002FAR visual training can enhance stereoscopic vision function in children with intermittent exotropia.\n\nResearchers will compare intervention group to control group to see if VR\u002FAR visual training could enhance stereoscopic vision function in children with intermittent exotropia.\n\nParticipants will:\n\nThe intervention group will receive 20 minutes of VR\u002FAR visual training once a day for a period of one year.\n\nFollow up check ups at the hospital every 3 months. Keep a diary of the values of stereoscopic vision function and Newcastle Control Score.",[230,231],"Intermittent Exotropia","Visual Functions",[233,234,235],"visual training","visual function","intermittent exotropia","2024-09-10",{"date":238,"type":34},"2024-09-19",{"date":240,"type":21},"2024-09-15",{"date":242,"type":21},"2026-02-28",{"name":40,"class":41},{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":101,"sex":16,"minAge":17,"maxAge":201,"enrollmentInfo":251,"targetDuration":4,"studyType":22,"phases":253,"briefSummary":254,"conditions":255,"keywords":258,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":262,"completionDateStruct":263,"leadSponsor":265,"locationsCount":4},"100561092","brain-visual-perception-training-for-prevention-and-control-of-premyopia-100561092","NCT06585657","Brain Visual Perception Training for Prevention and Control of Premyopia","Clinical Study on Brain Visual Perception Training for Prevention and Control of Myopia in Children with Premyopia","Inclusion Criteria:\n\nChildren aged 6-10 years with premyopia, defined as a cycloplegic spherical equivalent refraction (SER) of the more myopic eye in the range of -0.50 to 0.75 (inclusive) diopters (D) and having at least 1parent with an SER in either eye of -3.00D or less.\n\nExclusion Criteria:\n\nChildren have astigmatism of 1.50D or more, anisometropia of 1.50 D or more, strabismus and other ocular abnormalities, any systemic diseases, or a history of any myopia interventions.",{"count":252,"type":21},156,[24],"The goal of this clinical trial is to investigate whether brain visual perception training can effectively prevent myopia in children with pre myopia. It will also learn about the safety of brain visual perception training.\n\nThe main questions it aims to answer are: Does brain visual perception training slow down the growth of axial length? What medical issues may participants encounter when using the brain visual perception training system? Researchers will compare participants who receive brain visual perception training with a control group to see if the training group can delay the onset of pre myopia in children Participants will: The training group will receive 20 minutes of brain visual perception training once a day for a period of one year. Follow up check ups at the hospital every 3 months. Keep a diary of the values of axial length and refractive diopter.",[256,257],"Visual Function","Myopia Progressing",[259,179],"brain visual perception training","2024-09-09",{"date":238,"type":34},{"date":240,"type":21},{"date":264,"type":21},"2026-03-31",{"name":40,"class":41},{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":273,"enrollmentInfo":274,"targetDuration":4,"studyType":22,"phases":276,"briefSummary":277,"conditions":278,"keywords":279,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":42},"100556726","dual-focus-soft-contact-lenses-for-controlling-rapid-progressive-myopia-in-young-adults-100556726","NCT06528860","Dual-focus Soft Contact Lenses for Controlling Rapid Progressive Myopia in Young Adults","The Effectiveness and Acceptability of Dual-focus Soft Contact Lenses for Controlling Rapid Progressive Myopia in Young Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18-25 years;\n* Myopia progression \\\u003C= -0.50D in either eye in the past year (evaluated by -manifest refraction);\n* The subject eye: cycloplegic spherical equivalent ranges from -2.00D to -6.0D and cylinder power doesn't exceed -1.50D;\n* The subject eye's best corrected visual acuity \\\u003C= logMAR 0.1;\n* Anisometropia does not exceed 1.50D.\n\nExclusion Criteria:\n\n* Current use of MC interventions or prior use of MC interventions within the past 6 months;\n* Disease or anatomical factors that affect the wearing of contact lenses;\n* History of myopia correction surgery;\n* Suffering from ocular or systemic diseases that may be related to myopia, such as Marfan syndrome, retinopathy of prematurity, diabetes, etc.;\n* pregnant female;\n* Other conditions deemed unsuitable by the investigators.","25 Years",{"count":275,"type":21},144,[24],"This study aims to evaluate the effectiveness and acceptability of dual-focus soft contact lenses in controlling rapid myopia progression in adults through a randomized controlled trial. By applying myopia control measures to the adult population, we hope to provide scientific evidence for the effective control of adult myopia progression and offer insights into the understanding of myopia progression during early adulthood.",[27],[27,280,281,282],"Dual-focus contact lenses","Young adults","Adult myopia progression","2024-07-26",{"date":285,"type":34},"2024-07-30",{"date":287,"type":21},"2024-08-31",{"date":289,"type":21},"2027-09-30",{"name":40,"class":41},{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":16,"minAge":297,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":301,"conditions":302,"keywords":304,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":4},"100554900","a-comparative-study-of-the-results-of-dynamic-and-opd-static-measurement-of-pupil-diameter-before-and-after-cataract-surgery-by-pupil-detectors-100554900","NCT06505096","A Comparative Study of the Results of Dynamic and OPD Static Measurement of Pupil Diameter Before and After Cataract Surgery by Pupil Detectors","Inclusion Criteria:\n\n(1) diagnosed with cataract; (2) treated with lens ultrasonic emulsification combined with monofocal IOL implantation in our hospital; (3) agreed to participate and cooperate with this study.\n\nExclusion Criteria:\n\n(1) acute eye disease symptoms, such as eye redness, eye pain, increased ocular secretions, etc.; (2) other eye diseases that seriously affect visual function in both eyes, such as amblyopia, high myopia, glaucoma, diabetic retinopathy, severe age-related macular degeneration and retinal detachment, etc.; (3) intra-operative or post-operative complications in cataract surgery; combined with other ophthalmic surgeries; and any other ophthalmic surgery for both eyes in the follow-up period; the presence of any other ophthalmic surgery in both eyes in the follow-up period. (4) Inability to understand the informed consent form and inability to communicate.","50 Years","90 Years",{"count":300,"type":21},60,"Age-related cataract remains the leading cause of blindness in developing countries. And, with the aging of the population in these countries, the number of cataract patients will continue to grow. With accurate biological measurements and the implantation of a suitable IOL, most cataract patients can achieve good distance vision after surgery. Studies have shown differences in pupil diameter and sensitivity in patients with different refractive states, with correlations to accommodation status as well as refractive error. The pupil is an important factor to be evaluated during the selection of an artificial lens (Intraocular lens, IOL), especially a functional IOL.\n\nAmong the various instruments used for preoperative cataract biological measurements, the light source is mostly a fixed parameter, and the static pupil diameter measurement by fixed illumination light source detection as an evaluation method is relatively rough. In this study, we are going to simulate different illumination states in daily life and set up two kinds of measurement instruments, namely, OPD and binocular pupil detector, so as to obtain more realistic research results and to explore the following: 1. The static and dynamic measurement of pupil diameter by people of different refractive states in different periods of preoperative and postoperative period. 2. Whether there is a difference between the static and dynamic pupil measurement results, 2. the change of pupil size under the stimulation of different light sources, and to compare the difference between the two detection methods, to provide objective pupil indexes for the more scientific selection of functional IOLs, to provide a basis for the selection of more accurate pupil measurement methods, to accurately screen the population of the use of functional IOLs, and to improve the patient's satisfaction after the operation.\n\nPurpose of the study To simulate the difference between the preoperative and postoperative pupil diameters of cataract patients measured by static and dynamic methods under daily illumination, to select a more accurate pupil measurement method, and to make corrections for the evaluation of preoperative biometric indexes.",[303],"Cataract",[305,306],"cataract","pupil size","2024-07-16",{"date":309,"type":34},"2024-07-17",{"date":311,"type":21},"2024-08-01",{"date":313,"type":21},"2026-01-01",{"name":40,"class":41},{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":16,"minAge":297,"maxAge":298,"enrollmentInfo":321,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":322,"conditions":323,"keywords":324,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":325,"startDateStruct":326,"completionDateStruct":327,"leadSponsor":328,"locationsCount":4},"100554926","a-dynamic-study-of-pupil-diameter-after-artificial-lens-implantation-in-patients-with-high-myopia-100554926","NCT06505434","A Dynamic Study of Pupil Diameter After Artificial Lens Implantation in Patients With High Myopia","Inclusion Criteria:\n\n(1) a diagnosis of myopia: equivalent spherical lens extent (SE) SE ≤ -0.0 D when the eye is relaxed in accommodation; (2) a diagnosis of cataract; (3) surgical treatment with sequential lens ultrasonoemulsification combined with monofocal IOL implantation in both eyes at our hospital; and (4) consent to participate and cooperate in this study.\n\nExclusion Criteria:\n\n(1) Symptoms of acute eye diseases, such as eye redness, eye pain, and increased eye discharge; (2) Other binocular eye diseases that seriously affect visual function, such as amblyopia, glaucoma, diabetic retinopathy, severe age-related macular degeneration and retinal detachment; (3) Intra-operative or post-operative complications from cataract surgery; combined with other ophthalmologic surgeries; and any other ophthalmologic surgeries in both eyes during the follow-up period; (4) History of injuries; (5) Inability to understand the informed consent; and (6) Inability to communicate. ) history of trauma; (5) inability to understand the informed consent form and inability to communicate.",{"count":300,"type":21},"Age-related cataract remains the leading cause of blindness in developing countries. And, with the aging of the population in these countries, the number of cataract patients will continue to grow. With accurate biological measurements and the implantation of appropriate IOLs, most cataract patients can achieve good distance vision after surgery. However, it should not be overlooked that the current global prevalence of myopia is over 28.3% and is expected to reach 49.8% by 2050, while the rate of high myopia will increase from the current 4.0% to 9.8%. The prevalence of cataracts is significantly higher in the highly myopic population than in the orthoptic population.\n\nThe pupil is an important factor to be evaluated during the selection of an artificial lens (Intraocular lens, IOL), especially a functional IOL. It has been shown that the diameter and sensitivity of the pupil in patients with high myopia are also significantly different from those in the orthopneic population, and that there is a correlation with the adjustment status and refractive error. The purpose of this study is to investigate the following: 1. Whether the change of refractive status before and after IOL implantation in highly myopic cataract patients will lead to the change of pupil physiological characteristics, and whether the modification of preoperative measurement parameters can expand the population of myopic patients who can be reasonably applied to the functional IOL and obtain a high degree of satisfaction from patients. 2. Pupil diameter under a single fixed light source is a rough assessment for the screening of the population for functional IOLs, and this study was conducted in a single fixed light source. In this study, we measured the maximum value of pupil diameter, minimum value of pupil diameter, and rate of change of pupil diameter under bright vision and dark vision, and analyzed the correlation between the above three parameters and visual quality to further optimize the objective index of pupil diameter for the screening of functional IOL applicants.\n\nObjectives of the study\n\n1. To observe the dynamic changes of pupil diameter and its visual quality before and after lens extraction combined with IOL implantation in myopic patients, and to analyze the correlation between the changes of pupil diameter and visual quality;\n2. To explore the patterns of refractive error and pupil biometric changes in myopic patients before and after IOL implantation, and to make corrections for the evaluation of preoperative biometric indexes for reference.",[303],[305,155],{"date":309,"type":34},{"date":311,"type":21},{"date":313,"type":21},{"name":40,"class":41},{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":101,"sex":16,"minAge":50,"maxAge":336,"enrollmentInfo":337,"targetDuration":4,"studyType":22,"phases":339,"briefSummary":340,"conditions":341,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":42},"100320718","shanghai-eye-study-for-adults-100320718","NCT03455478","Shanghai Eye Study for Adults","SESA","Inclusion Criteria:\n\n* shanghai residents aged ≥18 years old\n\nExclusion Criteria:\n\n* cognitive and\u002For mobility disorders; non-shanghai residents; younger than 18 years old.","100 Years",{"count":338,"type":21},1000000,[24],"Blindness and visual impairment severely impact the visual health and life quality of people, particularly the 2.566 million senior citizens aged at 65 and above in Shanghai. The main reason is uncorrected refractive error, of which, 62.1% can be solved through refractive correction. For this reason, the uncorrected refractive errors of 154,000 senior citizens in Shanghai can be taken as a priority among the public health issues to prevent blindness. Now, with the aim to reduce the prevalence rate of blindness and visual impairment, it is planned to establish a public health service mechanism in terms of refractive error screening and correction for the elderly by relying on Shanghai's three-level (city-district-community) eye diseases prevention network, using proper refractive correction technology, and moving related services forward to communities in order to screen, identity, and correct blindness and visual impairment caused by refractive errors as early as possible.",[342],"Blindness,Visual Impairment, Refractive Error, Cataract, High Myopia, Aging","2022-05-17",{"date":345,"type":34},"2022-05-24",{"date":347,"type":34},"2016-01-01",{"date":349,"type":21},"2026-11-30",{"name":40,"class":41},{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":355,"acronym":356,"eligibilityCriteria":357,"healthyVolunteers":101,"sex":16,"minAge":358,"maxAge":50,"enrollmentInfo":359,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":361,"conditions":362,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":42},"100330877","shanghai-children-and-adolescent-diabetes-eye-study-100330877","NCT03587948","Shanghai Children and Adolescent Diabetes Eye Study","SCADE","Inclusion Criteria:\n\n* (1) provision of a written informed consent by a guardian;\n* (2) age over 5 years and less than 18 years;\n* (3) diagnosis of type 1 or type 2 diabetes based on the WHO diagnostic criteria for cases.\n\nExclusion Criteria:\n\n* (1) eyelid diseases - eyelid entropion, eyelid ectropion, eyelid, ptosis, and palpebral dyskinesia;\n* (2) conjunctival diseases - pterygium and conjunctivitis;\n* (3) history of ocular surface chemical injury or use of eye drops with moisturizing artificial tears;\n* (4) history of eye surgery within 6 months or history of retinal laser photocoagulation;\n* (5) systemic diseases - Sjogren syndrome, Parkinson's disease, rheumatoid arthritis, Grave 's disease, systemic lupus erythematosus, and others.","5 Years",{"count":360,"type":21},600,"To compare the prevalence of eye disease between children and adolescents with diabetes mellitus and healthy people, and to analyze the related factors of eye diseases in diabetic patients.",[363,364],"Diabetes Mellitus","Eye Diseases","2018-07-03",{"date":367,"type":34},"2018-07-16",{"date":369,"type":34},"2018-01-01",{"date":371,"type":21},"2028-01-01",{"name":40,"class":41},""]