[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Shanghai Minwei Biotechnology Co., Ltd\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":87},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100643720","phase-1-study-to-evaluate-the-safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-mwx205-100643720",false,"NCT07634510","Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MWX205","A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered MWX205 Injection in Adult Participants With Dyslipidemia","Inclusion Criteria:\n\n1. Adult participants with dyslipidemia will be enrolled in this study.\n2. The absence of clinically significant illness and surgery within 4 weeks prior to study drug administration.\n3. Participants must have fasting triglycerides greater than or equal to 150 mg\u002FdL (1.7 mmol\u002FL) and less than 500 mg\u002FdL (5.7 mmol\u002FL), and LDL-C greater than or equal to 70 mg\u002FdL (1.8 mmol\u002FL) at pre-screening and confirmation within 7 days before randomization.\n4. Have a body mass index within the range 18.5 to 40.0 kg\u002Fm2 (inclusive), with no plans to significantly alter diet or BMI over the course of study.\n5. Females of childbearing potential and males who are not surgically sterile (\\> 90 days since vasectomy with no viable sperm) will agree to use contraception from Screening until 6 months after the administration, OR females of non-reproductive potential\n\nExclusion Criteria:\n\n1. Positive pregnancy test or lactating female participant.\n2. Systolic BP lower than 90 or over 140 mmHg, diastolic BP lower than 40 or over 90 mmHg, HR less than 40 or over 100 bpm at screening.\n3. QTcF over 450 ms at screening.\n4. Consume more than 7 units for women or 14 units for men of alcohol per week within 8 weeks prior to screening (1 unit = 285 mL of beer 3.5%, 75 mL of wine 13.5%, or 25 mL of distilled alcohol 40%).\n5. Participants with established coronary artery disease, peripheral arterial disease, prior stroke, or other clinically significant atherosclerotic cardiovascular disease (such as stent placement or heart bypass, unstable angina or last known ejection fraction of \\\u003C50%).\n6. History of intolerance to SC injection or relevant abdominal scarring (surgical, burns, etc.), or any skin conditions, including infections or open wounds, or dermatitis at the injection site that could interfere with the evaluation of injection reaction.\n7. Have taken any prescription medications that are specifically indicated for lowering serum TGs (e.g., fibric acid derivatives, niacin, and omega-3 fatty acids \\[\\>1 g\u002Fday\\]) or medications that interfere with absorption of dietary cholesterol or fats (e.g., bile acid sequestrants, orlistat) within 2 months prior to screening.\n8. Have received treatment with any liver-targeted siRNA therapy or ASO (Antisense Oligonucleotide) within12 months prior to screening.\n9. Use of ANGPTL3 or PCSK9-inhibiting monoclonal antibodies within 90 days prior to screening.\n10. Use of systemic glucocorticoid therapy for more than 14 consecutive days in the past year, or any glucocorticoid therapy (excluding topical, intra-ocular, intra-articular, intranasal, or inhaled preparations) within 1 month before screening.","ALL","18 Years","60 Years",{"count":20,"type":21},37,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","This study is being done to test a new injection called MWX205 in people with high cholesterol or fat levels in the blood (dyslipidemia).\n\nResearchers will check if a single dose of MWX205 is safe and how the body reacts to it. They will also measure how quickly the drug enters the bloodstream and how long it stays in the body, and compare it with a placebo (inactive treatment).\n\nThe study will help decide the right dose and understand how this medicine could be used in future treatments.\n\nThe main questions this study aims to answer are:\n\n1. Is MWX205 safe after a single dose?\n2. How does the body process MWX205?\n3. Does MWX205 show any effect on the body related to cholesterol levels?",[27],"Dyslipidemias","NOT_YET_RECRUITING","2026-06-08",{"date":31,"type":32},"2026-06-10","ACTUAL",{"date":34,"type":21},"2026-06-22",{"date":36,"type":21},"2027-11-08",{"name":38,"class":39},"Shanghai Minwei Biotechnology Co., Ltd","INDUSTRY",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":63},"100588197","phase-1-a-study-to-evaluate-mwn109-tablets-in-healthy-adult-participants-100588197","NCT06938269","A Study to Evaluate MWN109 Tablets in Healthy Adult Participants","A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MWN109 Tablets in Healthy Adult Participants","Inclusion Criteria:\n\n1. Males or females aged 18 to 60 years (inclusive) at the time of signing the informed consent (Caucasians should be no less than 80% since the implementation of Protocol Clarification Letter #2, dated 02 Sep 2025).\n2. \\[Part A: SAD\\] Body mass index (BMI) of 19.0 to 40.0 kg\u002Fm2 (inclusive) with body weight \\> 65.0 kg and \\\u003C130.0 kg. \\[Part B: MAD\\] BMI of 27.0 to 45.0 kg\u002Fm2 (inclusive) with body weight \\> 65.0 kg and \\\u003C130.0 kg.\n3. Stable body weight within 3 months before screening (defined as self-reported change \\\u003C 5%).\n4. Resting heart rate (supine) ≥ 45 bpm and ≤ 90 bpm with a single 12-lead ECG at Screening. If the heart rate is \\> 90 or \\\u003C 45 bpm, it is to be repeated 2 more times (separated by at least 2 min) and the average of the 3 heart rate values is to be used to determine the participant's eligibility.\n5. Females of childbearing potential and males who are not surgically sterile (\\>180 days since vasectomy with no viable sperm) will agree to use contraception from Screening until 4 months after the last administration, OR females of non-reproductive potential as defined below:\n\n   * Postmenopausal as defined as:\n\n     * No menses for at least 12 months; OR\n     * No menses for at least 12 months AND with a follicle-stimulating hormone level \\> 40 IU\u002FL or according to the definition of \"postmenopausal range\" for the laboratory involved; OR\n   * History of hysterectomy; OR\n   * History of bilateral oophorectomy\n6. Male participants must agree to refrain from sperm donation and females should refrain from ova donation from Screening until 4 months after the last administration.\n7. Willing to maintain current general diet and physical activity regimen, except for the physical activity in the 72 h before each blood sample collection for the clinical laboratory analysis, which should not be strenuous, and willing to be restrained from alcohol and smoking during the study period.\n8. Able to comprehend and willing to sign an informed consent form (ICF) and to abide by all study requirements and restrictions.\n\nExclusion Criteria:\n\n1. Significant history or clinical manifestation of any cardiovascular, metabolic, allergic, endocrine, renal, hepatic, gastrointestinal, hematological, pulmonary, respiratory, dermatological, neurological, gynecological, psychiatric disorders, as determined by the Principal Investigator (or delegate).\n2. Screening blood pressure in supine outside the ranges 90-159 mmHg systolic, 50-95 mmHg diastolic. If abnormal blood pressure is observed, the blood pressure is to be repeated 2 more times, and the average of the 3 blood pressure values is to be used to determine the participant eligibility.\n3. History of insulinoma, or has an event of blood glucose \\\u003C 2.8 mmol\u002FL within 1 year prior to Screening, or with ≥ 3 times of hypoglycemia symptoms within 3 months prior to Screening.\n4. History of febrile illness within 7 days prior to the first dose of IP or participants with evidence of active infection.\n5. Any of the following:\n\n   1. QTcF \\> 450 msec confirmed by repeat measurement;\n   2. QRS duration \\> 120 msec confirmed by repeat measurement;\n   3. PR interval \\> 220 msec confirmed by repeat measurement. Notes: Regarding a), b) and c), ECG is to be repeated 2 more times when out-of-range and the average of the values is to be used to determine the participant eligibility;\n   4. Findings which would make QTc measurements difficult or QTc data uninterpretable;\n   5. History of additional risk factors for torsades de pointes (e.g., heart failure, hypokalemia, family history of long QT syndrome).\n6. Known history or family history of thyroid C-cell tumor\u002Fcarcinoma, multiple endocrine neoplasia syndrome type 2 (MEN2), thyroid dysfunction or thyroid hormone abnormality.\n7. History of diabetes mellitus or clinical evidence of diabetes (e.g., hemoglobin A1c ≥ 6.5%, fasting plasma glucose ≥ 126 mg\u002FdL \\[7.0 mmol\u002FL\\]) at Screening, non-fasting plasma glucose ≥ 200 mg\u002FdL (11.1 mmol\u002FL) at Screening, or use of any hypoglycemic drugs during Screening or within 3 months prior to Screening.\n8. History of acute or chronic pancreatitis, symptomatic gallbladder disease, pancreatic injury and other high-risk factors that may lead to pancreatitis.\n9. With any of following laboratory abnormality at screening and confirmed by a single repeat at the discretion of the Principal Investigator (or delegate):\n\n   a) Elevation in serum amylase or lipase (\\> 1.5 × upper limit of normal \\[ULN\\]). b) Have serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \\> 1.5 × ULN or total bilirubin \\>1.5 × ULN.\n\n   c) Have serum triglycerides (TG) ≥ 5.65 mmol\u002FL (500 mg\u002FdL) at Screening. d) Estimated glomerular filtration rate (eGFR) \\\u003C 80 mL\u002Fmin\u002F1.73m2 by Cockcroft-Gault equation as below: (140 - age) × mass (kg)\u002F72 × creatinine (mg\u002FdL); multiply by 0.85 if female.\n10. Untreated or uncontrolled hypothyroidism\u002Fhyperthyroidism defined as thyroid-stimulating hormone \\> 6 mIU\u002FL or \\\u003C 0.4 mIU\u002FL.\n11. History of clinically significant (in the opinion of the Principal Investigator or delegate) abnormal gastric emptying (e.g., gastric outlet obstruction, gastroparesis), chronic gastrointestinal diseases (e.g., having active ulcer within 6 months prior to Screening, active gastritis or esophagitis, or gastroesophageal reflux disease, irritable bowel disease or severe inflammatory bowel disease).\n12. Presence of clinically significant acute gastrointestinal symptoms (e.g., nausea, vomiting, heartburn or diarrhoea) or malabsorptive states (celiac disease, lactose intolerance or chronic pancreatitis), as judged by the Principal Investigator (or delegate).\n13. Any history or plan of gastrointestinal surgery excluding appendectomy.\n14. Positive hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCV-Ab), or human immunodeficiency virus (HIV-1 and HIV-2) antibodies.\n15. Any history of severe psychiatric disorder such as major depressive disorder, bipolar disorder, and schizophrenia, or history of suicidal ideation, behavior or attempts or other psychiatric disorder.\n16. History of alcoholism or drug\u002Fchemical abuse within 1 year prior to D-1.\n17. Alcohol consumption of \\> 21 units per week for males and \\> 14 units per week for females, on average. One unit of alcohol equals 1\u002F2 pint (285 mL) of beer, 1 glass (125 mL) of wine, or 1\u002F6 gill (25 mL) of spirits.\n18. Positive alcohol breath test result or positive urine drug screen (confirmed by repeat) during the Screening period.\n19. Daily use of more than 10 cigarettes\u002Fday (on average), or 2 cigars\u002Fday (on average), or equivalent use of any nicotine-containing product within 6 weeks prior to Screening.\n20. Participant is unwilling to refrain from strenuous exercise (e.g., heavy lifting, weight training, and aerobics) for 72 h prior to each blood collection for clinical laboratory tests.\n21. Females of pregnant or lactating, or those with a positive pregnancy test at Screening.\n22. Intolerance to venipuncture for blood sampling or history of fainting at blood drawing or sight of blood, unless deemed acceptable by the Principal Investigator (or delegate).\n23. Long-term use of drugs directly affecting the gastrointestinal motility (including but not limited to mosapride, cisapride) or gastrointestinal surgery within 12 weeks prior to Screening and are inappropriate for participation in this clinical study as assessed by the Principal Investigator (or delegate).\n24. History of severe Types I-IV hypersensitivity reactions, anaphylaxis, cytokine release syndrome, atopic individuals, or allergic reactions to multiple drugs. If the Principal Investigator (or delegate) is considering enrolling a participant with multiple drug allergies, agreement with the Medical Monitor should be sought.\n25. History of or suspected allergy or hypersensitivity to the IP or its components.\n26. Use or intend to use any prescription medications\u002Fproducts other than hormone replacement therapy, oral, implantable, transdermal, injectable, or intrauterine contraceptives within 14 days prior to dosing, unless deemed acceptable by the Principal Investigator (or delegate)and agreement with the Sponsor.\n27. Use or intend to use slow-release medications\u002Fproducts considered to still be active within 14 days prior to D-1, unless deemed acceptable by the Principal Investigator (or delegate).\n28. Use of any nonprescription medications\u002Fproducts including vitamins, minerals, and phytotherapeutic\u002Fherbal\u002Fplant-derived preparations within 7 days prior to D-1 or during the study, unless deemed acceptable by the Principal Investigator (or delegate) and agreement with Sponsor, with the exception of paracetamol\u002Facetaminophen (maximum 2 g per day for up to 3 days) and topically applied medications which is permitted up to 48 h prior to dosing.\n29. Participants with a history of infectious diseases (which may affect the ability of the participant to participate in the study at the discretion of the Principal Investigator or delegate), severe trauma, or major surgical operation within 4 weeks prior to Screening.\n30. Have been vaccinated within 4 weeks prior to Screening or plan to have vaccination during the study.\n31. Donation of blood or massive blood loss (\\> 450 mL) OR receipt of blood products within 12 weeks prior to Screening, plasma from 2 weeks prior to Screening, and platelets from 6 weeks prior to Screening.\n32. Participation in a clinical study involving administration of an investigational agent\u002Fdevice or vaccine (new chemical entity) within 30 days or 5 half-lives, or having received a biological product within 12 weeks prior to Screening.\n33. Poor peripheral venous access.\n34. Are investigative site personnel directly affiliated with this study and their immediate families. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.\n35. The presence of clinically significant physical examination, vital sign, drug, or ECG findings at Screening or baseline or laboratory findings at Screening that, in the opinion of the Principal Investigator (or delegate) or Medical Monitor, may interfere with any aspect of study conduct or interpretation of results.\n36. Are deemed unsuitable by the Principal Investigator (or delegate) for any other reason.",true,{"count":49,"type":21},60,[24],"This is a Phase 1, randomized, double-blind, placebo-controlled, single-and-multiple ascending dose study in which the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of orally administered MWN109 tablets will be assessed in healthy adult participants.",[53],"Overweight or Obesity","RECRUITING","2025-11-17",{"date":57,"type":32},"2025-11-20",{"date":59,"type":32},"2025-06-18",{"date":61,"type":21},"2026-05",{"name":38,"class":39},2,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":47,"sex":16,"minAge":17,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":74,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},"100582172","phase-1-a-study-to-evaluate-mwn109-injection-in-healthy-subjects-100582172","NCT06859853","A Study to Evaluate MWN109 Injection in Healthy Subjects","A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MWN109 Injection in Healthy Subjects","Inclusion Criteria:\n\n1. Males or females, of any race, aged 18 to 50 years (inclusive) at Screening.\n2. \\[Part A: SAD\\] BMI of 19.0 to 40.0 kg\u002Fm2 (inclusive). \\[Part B: MAD\\] BMI of 27.0 to 45.0 kg\u002Fm2 (inclusive) with a minimum body weight of 50.0 kg for females and 55.0 kg for males.\n3. History of stable body weight for 3 months (defined as change \\\u003C 5%).\n4. Resting heart rate (supine) ≥ 45 bpm and ≤ 90 bpm with a single 12-lead ECG at Screening.\n5. Females of childbearing potential and males will agree to use contraception as detailed further in the protocol.\n6. Male participants must agree to refrain from sperm donation and females should refrain from ova donation from D-1 until 4 months after the last administration.\n7. Able to comprehend and willing to sign an ICF and to abide by all study requirements and restrictions.\n\nExclusion Criteria:\n\n1. Significant history or clinical manifestation of any cardiovascular, metabolic, allergic, endocrine, renal, hepatic, gastrointestinal, hematological, pulmonary, respiratory, dermatological, neurological, gynecological, psychiatric, disorders as determined by the investigator (or designee).\n2. History of pheochromocytoma or has uncontrolled blood pressure, as defined as systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 100 mmHg.\n3. History of insulinoma or has an event of blood glucose \\\u003C 2.8 mmol\u002FL within 1 year prior to Screening, or with ≥ 3 times of hypoglycemia symptoms within 3 months prior to Screening.\n4. History of febrile illness within 7 days prior to the first dose of IP or participants with evidence of active infection.\n5. Any of the following:\n\n   1. QTcF \\> 450 msec regardless of gender , confirmed by repeat measurement.\n   2. QRS duration \\> 110 msec confirmed by repeat measurement.\n   3. PR interval \\> 220 msec confirmed by repeat measurement.\n   4. Findings which would make QTc measurements difficult or QTc data uninterpretable.\n   5. History of additional risk factors for torsades de pointes (e.g., heart failure, hypokalemia, family history of long QT syndrome).\n6. Known history or family history of thyroid C-cell tumor\u002Fcarcinoma, multiple endocrine neoplasia syndrome type 2 (MEN2), thyroid dysfunction or thyroid hormone abnormality.\n7. History of diabetes mellitus Type I or II or clinical evidence of diabetes (e.g., hemoglobin A1c ≥ 6.5%, fasting blood glucose ≥ 126 mg\u002FdL \\[7.0 mmol\u002FL\\]) at Screening, non-fasting glucose ≥ 200 mg\u002FdL (11.1 mmol\u002FL) at Screening, or use of any hypoglycemic drugs during Screening or within 3 months prior to Screening\n8. History of acute or chronic pancreatitis, symptomatic gallbladder disease, pancreatic injury and other high-risk factors that may lead to pancreatitis.\n9. With any of following laboratory abnormality:\n\n   1. Elevation in serum amylase or lipase (\\> 1.5 × upper limit of normal \\[ULN\\]).\n   2. Have serum AST or ALT \\> 2 × ULN or total bilirubin \\>1.5 × ULN.\n   3. Have serum TG ≥ 5.65 mmol\u002FL (500 mg\u002FdL) at screening\n   4. Estimated glomerular filtration rate (eGFR) \\\u003C 90 mL\u002Fmin\u002F1.73m2.\n10. History of clinically significant abnormal gastric emptying (e.g., gastric outlet obstruction, gastroparesis), severe chronic gastrointestinal diseases (e.g., having active ulcer within 6 months prior to Screening, active gastritis or esophagitis, or uncontrolled gastroesophageal reflux disease, irritable bowel disease or severe inflammatory bowel disease).\n11. Long-term use of drugs directly affecting the gastrointestinal motility (including but not limited to mosapride, cisapride) or gastrointestinal surgery within 12 weeks prior to Screening and are inappropriate for participation in this clinical study as assessed by the Investigator.\n12. Positive hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCV-Ab), or human immunodeficiency virus (HIV-1 and HIV-2) antibodies and p24 antigen.\n13. Any history of severe psychiatric disorder such as major depressive disorder, bipolar disorder, and schizophrenia, or history of suicidal ideation, behavior or attempts or other psychiatric disorder (within 2 years of Screening).\n14. Any suicidal ideation as identified by endorsement of (answered yes to) any of the items numbered 1-5 on the Columbia Suicide Severity Rating Scale (C-SSRS), if applicable.\n15. History of alcoholism or drug\u002Fchemical abuse within 1 year prior to D-1.\n16. Alcohol consumption of \\> 21 units per week for males and \\> 14 units per week for females, on average. One unit of alcohol equals ½ pint (285 mL) of beer or lager, 1 glass (125 mL) of wine, or 1\u002F6 gill (25 mL) of spirits.\n17. Positive alcohol breath test result or positive urine drug screen (confirmed by repeat) during the Screening period.\n18. Daily use of more than 10 cigarettes\u002Fday (on average), or 2 cigars\u002Fday (on average), or equivalent use of any tobacco product within 6 weeks prior to Screening.\n19. Females of pregnant or lactating, or those with a positive pregnancy test at Screening.\n20. Intolerance to venipuncture for blood sampling or history of fainting at blood drawing or sight of blood, unless deemed acceptable by the Investigator (or designee).\n21. History of severe Types I-IV hypersensitivity reactions, anaphylaxis, cytokine release syndrome, atopic individuals, or allergic reactions to multiple drugs. If the Investigator is considering enrolling a participant with drug allergies, agreement with the Medical Monitor should be sought.\n22. History of or suspected allergy or hypersensitivity to the investigational product or its components\n23. Use or intend to use any prescription medications\u002Fproducts other than hormone replacement therapy, oral, implantable, transdermal, injectable, or intrauterine contraceptives within 14 days prior to dosing, unless deemed acceptable by the Investigator (or designee).\n24. Use or intend to use slow-release medications\u002Fproducts considered to still be active within 14 days prior to D-1, unless deemed acceptable by the Investigator (or designee).\n25. Use or intend to use any nonprescription medications\u002Fproducts including vitamins, minerals, and phytotherapeutic\u002Fherbal\u002Fplant-derived preparations within 7 days prior to D-1, unless deemed acceptable by the Investigator (or designee).\n26. Participants with a history of infectious diseases (which may affect the ability of the participant to participate in the study at the discretion of the Investigator), severe trauma, or major surgical operation within 4 weeks prior to Screening.\n27. Have been vaccinated within 4 weeks prior to Screening or plan to have vaccination during the study.\n28. Donation of blood or massive blood loss (\\> 450 mL) OR receipt of blood products within 12 weeks prior to Screening.\n29. Participation in a clinical study involving administration of an investigational agent\u002Fdevice or vaccine (new chemical entity) or having received a biological product within 12 weeks prior to Screening.\n30. Poor peripheral venous access.\n31. Are investigative site personnel directly affiliated with this study and their immediate families. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.\n32. The presence of clinically significant physical examination, vital sign, drug, or ECG findings at Screening or baseline or laboratory findings at Screening that, in the opinion of the Investigator or Medical Monitor, may interfere with any aspect of study conduct or interpretation of results.\n33. Any skin condition and\u002For tattoo that may interfere with the evaluation of safety at the injection site.\n34. Are deemed unsuitable by the Investigator (or designee) for any other reason.","50 Years",{"count":73,"type":21},72,[24],"This study is a Phase1, randomized, double-blinded, and placebo-controlled study. In each cohort, enrolled participants will be randomized to receive either placebo or MWN109.",[77],"Overweight or Obese","2025-04-11",{"date":80,"type":32},"2025-04-15",{"date":82,"type":32},"2025-03-17",{"date":84,"type":21},"2025-11-25",{"name":38,"class":39},1,""]