[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sheikh Zayed Medical College\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":225},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,43,72,101,124,150,176,202],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100614860","bupivacaine-with-or-without-dexmedetomidine-for-postoperative-pain-relief-in-abdominal-surgery-100614860",false,"NCT07285083","Bupivacaine With or Without Dexmedetomidine for Postoperative Pain Relief in Abdominal Surgery","Comparison of Pain Relief by Bupivacaine With Dexmedetomidine and Bupivacaine Alone in Transversus Abdominis Plane Block for Postoperative Analgesia in Patients Undergoing Abdominal Surgeries.","Inclusion Criteria:\n\n1. Age between 21 to 45 years.\n2. Undergoing elective abdominal surgery (exploratory laparotomy, ileostomy reversal, laparoscopic\u002Fopen cholecystectomy, mesh repair of paraumbilical hernias).\n3. The patient must be capable of providing informed consent.\n\nExclusion Criteria:\n\n1. Pregnancy.\n2. Severe allergies to local anesthetics.\n3. Pre-existing chronic pain conditions.\n4. Participation in another clinical trial within the past 30 days.","ALL","21 Years","45 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates the effectiveness of adding dexmedetomidine to bupivacaine for postoperative analgesia in patients undergoing abdominal surgeries. The research compares pain relief in two groups: one receiving a combination of bupivacaine and dexmedetomidine via a transversus abdominis plane (TAP) block, and the other receiving bupivacaine alone. The study aims to evaluate whether dexmedetomidine enhances pain relief, reduces the need for additional pain medication, and impacts sedation and side effects such as hypotension, bradycardia, and nausea. Conducted at Sheikh Zayed Medical College in Rahim Yar Khan, Pakistan, the trial will involve 80 participants and will measure pain using the Visual Analogue Scale (VAS), along with monitoring other vital parameters and complications over 12 hours post-surgery. The primary objective is to determine if the addition of dexmedetomidine provides superior pain control without significantly increasing side effects.",[27],"Pain, Postoperative",[29],"Transversus abdominis plane (TAP) block","RECRUITING","2025-12-18",{"date":33,"type":34},"2025-12-22","ACTUAL",{"date":36,"type":34},"2024-08-01",{"date":38,"type":21},"2025-12",{"name":40,"class":41},"Sheikh Zayed Medical College","OTHER_GOV",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100578321","phase-2-comparison-between-efficacy-of-topical-25podophyllin-and-cryotherapy-on-genital-warts-100578321","NCT06809777","Comparison Between Efficacy of Topical 25%Podophyllin and Cryotherapy on Genital Warts","Comparison Between the Efficacy and Safety of Topical Podophyllin 25% Versus Cryotherapy in the Treatment of Anogenital Warts","Inclusion Criteria:\n\n* Age: 16-60years\n* Gender: Any gender\n* All new clinically diagnosed cases of plane warts\n* Type of warts: plane warts\n* Area: Ano-genital warts\n* Size: Less than 10cm2(cummulative)\n* No. of warts: Upto 20\n* Duration of disease: Any\n\nExclusion Criteria:\n\n* Pregnancy and lactating females\n* Bleeding disorders\n* Immunocompromised patients.\n* Diabetic patients \u002F Peripheral vascular disease.\n* Bleeding warts, moles, birthmarks.\n* Any other inflammatory dermatosis on that area\n* History of any previous treatment in last 2 months.\n* Liver\u002FRenal disease\n* Hypersensitivity to Podophyllin.","16 Years","60 Years",{"count":53,"type":21},96,[55],"PHASE2","Human papilloma virus (HPV), is the major prevalent cause of sexually transmitted disease affecting genitalia, causing Condylomata Accuminata, also known as external genital warts or anogenital warts.¹ Occurring in men and women with a prevalence rate of 0.6-1.2% worldwide. It primarily affects those in the age range of 20-25 years. Human papilloma virus infections subclinically are primarily caused by either type HPV- 6 or HPV- 11.\n\nA vast variety of treatment options are available to treat CA , including immunomodulators ( imiquimod, purified protein derivative and the HPV vaccine), physical ablation ( cryotherapy and electrodessication) and topical cytotoxic drugs ( TCA, phenol, 5- fluorouracil, retinoids, podophyllin and bleomycin)¹ . Although there are multiple effective treatment are present for EGW, no single treatment has been identified as the best ideal way to treat CA.\n\nCryotherapy causes the destruction of keratinocytes infected with HPV by using below zero temperature and leading to thermal cell necrosis.\n\nPodophyllum peltatum and Podophyllum emodi are the main source of Podophyllin, a refined plant- based resin.¹² It works by attaching itself to the infected cell's microtubule disturbing the linking process which stops the mitotic process during the metaphase stage of cell division causing the death of epithelial cell.\n\nStudy will include patients which will be divided into 2 groups A \\& B, 48 in each group. Group A will receive topical 25% podophyllin resin via cotton bud under supervision once weekly for 04 weeks. Group B will receive cryotherapy of 10sec freeze cycle twice weekly for 04 weeks. Patient will be followed at interval of 4 weeks and 8 weeks from start of treatment.\n\nTreatment will be considered efficant when decrease in the number of warts is clinically evident at follow up visits. Efficacy of treatment will be graded as 'excellent' \\>90% clearance, 'good'60-89% clearance, 'satisfactory'30-59% clearance and 'poor'\\\u003C30% clearance.",[58],"Anogenital Human Papilloma Virus Infection",[60,61,62],"Anogenital warts","Topical 25% podophyllin","cryotherapy","NOT_YET_RECRUITING","2025-05-12",{"date":66,"type":34},"2025-05-13",{"date":68,"type":21},"2025-06-29",{"date":70,"type":21},"2025-12-10",{"name":40,"class":41},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":42},"100579569","phase-2-various-procedural-treatment-options-for-androgenetic-alopecia-100579569","NCT06826001","Various Procedural Treatment Options for Androgenetic Alopecia","COMPARISON OF EFFICACY OF TOPICAL FINESTERIDE VERSUS TOPICAL MINOXIDAL IN TREATMENT OF ANDROGENETIC ALOPECIA","Inclusion Criteria:\n\n* Age: 20-50 years\n* Gender: Male\n* ANDROGENETIC ALOPECIA with AGA stage 2-6 Norwood-Hamilton -classification\n* Patients not taking any treatment in last 1 month\n\nExclusion Criteria:\n\n* Abrasion or abnormalities to the scalp\n* Hair transplant\n* Hypersensitivity\n* Recent history of local infections of the head\n* History of relevant significant disease active seborrheic dermatitis\n* Concurrent use of :\n* corticosteroids\n* anabolic steroids or over-the-counter 'hair restorers'\n* use of drugs with anti-androgenic properties within 6 months light or laser treatment of the scalp within the last 3 months.","MALE","20 Years","50 Years",{"count":83,"type":21},190,[55],"Androgenetic alopecia (AGA)is the most common form of alopecia. It predominantly affects males, but there has been a significant surge in female preponderance too, over the last decade Minoxidil belong to the anti-hypertensive class but it also affects the potassium channels present in vascular smooth muscles and hair follicles. This potassium channel activity may stimulate the microcirculation around the hair follicles and induces arteriolar vasodilation, thereby encouraging conditions conducive to hair growth Topical administration of finasteride offers the potential to reduce systemic effects related to its mechanism of action by preferentially inhibiting 5-a reductase in the scalp, as has been suggested in recent years so in this study we are going to compare efficacy of topical minoxidil versus topical finasteride in treatment of androgenetic alopecia",[87],"Androgenetic Alopecia",[89,90,91,92],"androgenetic alopecia","finasteride","minoxidil","hairloss","2025-02-07",{"date":95,"type":34},"2025-02-13",{"date":97,"type":21},"2025-02",{"date":99,"type":21},"2025-07",{"name":40,"class":41},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":108,"maxAge":51,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":122,"leadSponsor":123,"locationsCount":42},"100578860","phase-2-treatment-options-for-chronic-urticaria-100578860","NCT06816784","Treatment Options for Chronic Urticaria","COMPARISON OF OUTCOME OF AUTOLOGOUS SERUM THERAPY VS LEVOCETRIZINE IN THE TREATMENT OF CHRONIC URTICARIA","Inclusion Criteria:\n\n* Age: 13-60 years\n* Gender: Both male and female\n* Patients having urticaria for more than 6 weeks diagnosed clinically\n\nExclusion Criteria:\n\n* Pregnancy and lactating females\n* Patients who are immunosuppressed either due to medication or disease.\n* Patients suffering from chronic diseases i-e chronic liver disease, chronic kidney disease.\n* Patients taking steroids in last 2 weeks.","13 Years",{"count":110,"type":21},72,[55],"chronic urticaria is one of the most common dermatological disease affecting many people, exploring most treatment options for its treatment is need of an hour.\n\nOur study aim to compare the efficacy of Autologous Serum Therapy (AST) with levocetirizine in Chronic Urticaria patients",[114],"Chronic Urticaria",[116,117,118],"chronic urticaria","autologous serum therapy","levocetrizine",{"date":120,"type":34},"2025-02-10",{"date":97,"type":21},{"date":99,"type":21},{"name":40,"class":41},{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":108,"maxAge":81,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":133,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":42},"100575309","phase-2-various-procedural-treatment-options-for-post-acne-atrophic-scars-100575309","NCT06770608","Various Procedural Treatment Options for Post-acne Atrophic Scars","Comparison of Outcome of Microneedling With Autologous Platelet Rich Plasma Verses Microneedling With Topical Insulin in the Treatment of Post-Acne Atrophic Scars","Inclusion Criteria:\n\n* Age: 13-50 years\n* Gender: both male and female\n* Type of acne scar: Atrophic acne scar\n* Patients not taking prior treatment in last 1-2 months\n\nExclusion Criteria:\n\n* Pregnancy and lactating females\n* Bleeding disorders\n* Platelet count less than 100000\n* Hypersensitivity to insulin, PRP\n* Keloidal tendency\n* Active herpes simples, warts and molluscum contagiosum\n* Unrealistic expectations",{"count":132,"type":21},60,[55],"Post acne scars are formed as a result of very inflamed and nodulocystic acne. Most common type of acne scars are atrophic scars and they are further classified on the basis of depth and size of destruction into ice pick, boxcar and rolling scars. Evaulating the most efficacious, safe and affordable treatment option is the need of the hour. This study is going to compare the efficacy of microneedling with autologous platelet rich plasma verses microneedling with topical insulin in the treatment of post-acne atrophic scars as to find out the relatively more effective and safer treatment.",[136],"Post-acne Atrophic Scars",[138,139,140,141],"Microneedling","Autologous platelet rich plasma","Topical insulin","Post-acne atrophic scars","2025-01-07",{"date":144,"type":34},"2025-01-13",{"date":146,"type":21},"2025-01",{"date":148,"type":21},"2025-04",{"name":40,"class":41},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":16,"minAge":157,"maxAge":51,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":164,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":42},"100572921","phase-2-systemic-treatment-options-for-generalized-lichen-planus-100572921","NCT06739551","Systemic Treatment Options for Generalized Lichen Planus","Comparison of Efficacy of Oral Methotrexate and Acitretin for Generalized Lichen Planus","Inclusion Criteria:\n\n* Age: 18-60 years\n* Gender: both male and female\n* Type of Lichen planus: generalized lichen planus\n* Patients not taking prior treatment in last 1 month\n\nExclusion Criteria:\n\n* Pregnancy and lactating females\n* Bleeding disorders\n* Abnormal liver function tests\n* Platelet count less than 100000\n* Hypersensitivity to Methotrexate or Acitretin\n* Unrealistic expectations","18 Years",{"count":159,"type":21},124,[55],"Lichen planus is a chronic inflammatory skin condition with unknown etiology. It requires a long term treatment. Evaulating the most efficacious, safe and affordable treatment option is the need of the hour. This study is going to compare the efficacy of two familiar drugs (acitretin and methotrexate) in the treatment of generalized lichen planus as to find out the relatively more effective and safer treatment.",[163],"Lichen Planus",[163,165,166,167],"Acitretin","Methotrexate","Efficacy","2024-12-17",{"date":170,"type":34},"2024-12-18",{"date":172,"type":21},"2024-12-10",{"date":174,"type":21},"2025-03-20",{"name":40,"class":41},{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":16,"minAge":157,"maxAge":51,"enrollmentInfo":183,"targetDuration":4,"studyType":22,"phases":185,"briefSummary":186,"conditions":187,"keywords":189,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":42},"100568386","phase-2-role-of-oral-voriconazole-in-the-treatment-of-resistant-dermatophyte-infections-100568386","NCT06680544","Role of Oral Voriconazole in the Treatment of Resistant Dermatophyte Infections","Comparing the Efficacy of Oral 200 Milligram Voriconazole Once a Day Vs. Twice a Day in the Treatment of Resisitant Dermatophyte Infections (Tinea Corporis and Tinea Cruris)","Inclusion Criteria:\n\n1. Resistant cases of tinea cruris and tinea corporis: Those cases who received the standard dosage of oral antifungals i.e. oral terbinafine 5mg\u002Fkg per day for 4 weeks or oral itraconazole 5mg per\u002Fkg\u002Fday for 4 weeks but they did not recover from the infection.\n2. Skin area: Groin and trunk\n3. Total diameter of the lesions: 5cm to 80 cm\n\nExclusion Criteria:\n\n1. History of hypersensitivity to azoles\n2. All those individuals having immunocompromised state (malignancy, tuberculosis, AIDS, history of organ transplant and history of immunosuppressive drug treatment etc.)\n3. Patients of diabetes, liver or kidney disease.\n4. Lactating mother\n5. Pregnant female",{"count":184,"type":21},120,[55],"Treatment of dermatophyte infection in our country (Pakistan) is becoming difficult due to the developing resistance to traditional antifungal agents. Assessing the effectiveness ,feasibility and standard dosage of a newer antifungal drug like voriconazole is the need of the hour in resistant cases of dermatophyte infection.",[188],"Dermatophyte Infection",[190,191,192,193],"Tinea","Voriconazole","Dermatomycoses","Antifungal Agents","2024-11-07",{"date":196,"type":34},"2024-11-08",{"date":198,"type":21},"2024-11-15",{"date":200,"type":21},"2025-03-15",{"name":40,"class":41},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":209,"sex":16,"minAge":157,"maxAge":51,"enrollmentInfo":210,"targetDuration":4,"studyType":22,"phases":212,"briefSummary":214,"conditions":215,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":4},"100459550","early-phase-1-efficacy-of-dexmedetomidine-vs-midazolam-for-early-extubation-in-critically-ill-agitated-patients-undergoing-weaning-100459550","NCT05264077","Efficacy of Dexmedetomidine vs Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning","Efficacy of Dexmedetomidine Versus Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning","Inclusion Criteria:\n\n* all patients with age \\\u003C60 irrespective of gendre\n\nExclusion Criteria:\n\n\\- Patients who refuse to give consent, severely altered conscious level (GCS \\\u003C 8\u002F15), traumatic injury causing hypoxemia e.g., severe head \u002F chest \u002F facial trauma or pneumothorax, severe pneumonia, arrhythmia, impaired hearing or blindness, severe hepatic or renal disease, on neuromuscular blocking agents, recent myocardial infarction, use of anti-psychotics, hypersensitivity to any of the drug under study.",true,{"count":211,"type":21},66,[213],"EARLY_PHASE1","Comparison of effect of dexmedetomidine and midazolam in icu patients who put on mechanical ventilation and show agitation on weaning.Selection of better agent minimises the drug related side effects like respiratory depression but also helps in weaning for early extubation,give hemodynamic stability and reduce morbidity and mortality in icu..",[216],"Agitation, Emergence","2024-08-06",{"date":219,"type":34},"2024-08-07",{"date":221,"type":21},"2024-11-01",{"date":223,"type":21},"2025-07-31",{"name":40,"class":41},""]