[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Shenzhen Kangning Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":75},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100543628","teem-gifts-a-gamified-mhealth-to-reduce-post-discharge-suicide-risk-100543628",false,"NCT06358339","TEEM-GIFTS: A Gamified mHealth to Reduce Post-Discharge Suicide Risk","The Tailored Evidence-based Enhancements in Mental Health-Gamified and Individualized Follow-Up Treatment for Suicide (TEEM-GIFTS) : Implementing a Gamified mHealth Intervention to Reduce Post-Discharge Suicide Risk in Patients With Mental Disorders Using Multiphase Optimization Strategy (MOST)","Inclusion Criteria:\n\nFor patients\n\n* Being 18 years and above;\n* Being diagnosed with mental disorders;\n* Having received inpatient care for three days or more;\n* Living in Shenzhen and having no plan to leave Shenzhen in the following 12 months after discharge;\n* Being able to use apps or WeChat (WeChat mini program) on smart phones.\n\nFor lay health care supporters (LHSs)\n\n* Being 18 years and above;\n* Being without any diagnosis of mental disorder;\n* Being the lay health care supporter in the family;\n* Living in Shenzhen and having no plan to leave Shenzhen in the following 12 months after discharge;\n* Being able to use apps or WeChat (WeChat mini program) on smart phones.\n\nFor the clinic and community mental health service providers\n\n* Being 18 years and above;\n* Having practiced in mental health service at least for 12 months.\n\nExclusion criteria For patients\n\n* Refusing to provide written consent or be unable to provide written consent due to any cognitive problems.\n* Being discharged by the patient's or LHSs' demand against medical advice.\n* With no ID, no stable residence nor any source of income.\n\nFor For lay health care supporters (LHSs)\n\n* Refusing to provide written consent.\n\nFor the clinic and community mental health service providers\n\n* Refusing to provide written consent.","ALL","18 Years",{"count":19,"type":20},640,"ESTIMATED","INTERVENTIONAL",[23],"NA","Patients with mental disorders are at significantly higher risk of suicide after discharge compared to the general population and patients with other diseases. Currently, there is a lack of post-discharge community suicide risk management services in China. The research team's preliminary research suggests that mHealth interventions are well-accepted and feasible for reducing the suicide risk in patients with mental disorders. Furthermore, the inclusion of gamification elements can enhance treatment adherence and user engagement. However, determining the appropriate combination of gamification elements and evaluating the implementation effectiveness of gamified mHealth interventions for suicide risk are challenges in transforming these into regular community mental health services. This study will leverage gamification theory and community-based participatory research to design a gamified mHealth intervention model aimed at reducing suicide risk among discharged patients with mental disorders, and to develop a corresponding management strategy. Using the multi-phase optimization strategy (MOST), the study will identify the optimal combination of gamification elements to reduce suicide risk and increase the outpatient follow-up rate. Through an implementation science framework, the investigators will evaluate the process, outcomes, cost, and feasibility of this management strategy with the goal of reducing suicide risk among these patients. The findings from this study will provide a scientific basis for innovative suicide risk management models for discharged patients with mental disorders in China, thereby paving the way for the application of implementation science in mental health.",[26],"Suicide",[28,29,30,31,32],"Psychiatric patients","Post-discharge suicide","Gamification","Multiphase optimization strategy","Implementation science","RECRUITING","2026-04-21",{"date":36,"type":37},"2026-04-24","ACTUAL",{"date":39,"type":37},"2025-05-01",{"date":41,"type":20},"2027-12-31",{"name":43,"class":44},"Shenzhen Kangning Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":45},"100512031","effect-of-orexin-system-on-nicotine-addiction-and-its-neural-mechanism-100512031","NCT05947162","Effect of Orexin System on Nicotine Addiction and Its Neural Mechanism","Effect of Orexin System on Nicotine Addiction Among Smokers and Its Neural Mechanism","Inclusion Criteria:\n\n1. Nicotine addicts who meet the DSM-V diagnostic criteria for substance dependence, that is, smoking ≥ 10 cigarettes per day and smoking age ≥ 2 years;\n2. Communicate normally with the researcher and cooperate with the researchers;\n\nExclusion Criteria:\n\n1. Psychotic symptoms or a family history of mental disorders;\n2. A history of dependence or behavior (gambling, online games) addiction other than alcohol, drugs, etc.;\n3. Use benzodiazepines or received antipsychotic drugs within 2 weeks;\n4. Epilepsy, craniocerebral injury history, coma history, brain organic or serious physical disease;\n5. Body mass index (BMI) \\> 30 ;\n6. Can not tolerate magnetic resonance examinations.",true,"60 Years",{"count":56,"type":20},150,[23],"The goal of this clinical trial is to reveal the role and mechanism of orexin in nicotine addicts, compared to healthy control. The main questions it aims to answer are:\n\n* Whether nicotine addiction-related behaviors, including nicotine withdrawal symptoms, cue-induced increased psychological craving, and relapse behavior are related to plasma orexin levels ?\n* What is the neural mechanism of the orexin system in the fMRI brain network?\n\nParticipants will be asked to do as followed:\n\n1. Day 1: Fill in the scale, test the concentration of exhaled CO, collect 5ml of blood from the vein, and take about 60 minutes.\n2. Day 1-3: Test and record the amount of smoking for 3 days, about 5 minutes.\n3. Day 4-5: Collect fMRI data, for about 60 minutes, perform extinction training, for about 30 minutes\n4. Day 6: Fill in the scale, test the concentration of CO in exhaled breath, collect 5ml of venous blood, test after subsidence and ignition test, and collect fMRI data, for about 60 minutes.\n5. Follow-up (2 weeks\u002F4 weeks): Complete the follow-up on smoking craving and relapse by phone within 2 weeks, about 5 minutes, and complete the scale and collect fMRI data in the 4th week, about 60 minutes.",[60],"Tobacco Use Disorder",[62,63,64,65],"nicotine","orexin","craving","withdrawal","NOT_YET_RECRUITING","2023-10-12",{"date":69,"type":37},"2023-10-13",{"date":71,"type":20},"2023-11-01",{"date":73,"type":20},"2027-07-31",{"name":43,"class":44},""]