[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sierra Varona SL\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":300},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,46,77,104,127,148,171,198,226,248,274],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100638932","effects-of-a-combined-repetitive-transcranial-magnetic-stimulation-and-physical-therapy-protocol-on-motor-function-balance-and-quality-of-life-in-chronic-post-stroke-hemiplegia-a-case-series-100638932",false,"NCT07597746","\"Effects of a Combined Repetitive Transcranial Magnetic Stimulation and Physical Therapy Protocol on Motor Function, Balance, and Quality of Life in Chronic Post-Stroke Hemiplegia: A Case Series\"","Inclusion Criteria:\n\n* Diagnosis of first-ever unilateral ischemic or hemorrhagic stroke confirmed by neuroimaging (CT or MRI)\n* Chronic post-stroke hemiplegia (≥ 6 months since stroke onset)\n* Moderate to severe motor impairment of the affected lower limb (FMA-LE score between 10 and 28 points)\n* Age between 18 and 75 years\n* Medically stable and able to participate in a rehabilitation program\n* Ability to understand study procedures and provide written informed consent\n* No contraindications to repetitive transcranial magnetic stimulation (rTMS), according to current safety guidelines.\n\nExclusion Criteria:\n\n* History of epilepsy or seizures\n* Presence of pacemakers, cochlear implants, intracranial metallic implants, or other contraindications to rTMS\n* Severe cognitive impairment or communication deficits preventing participation\n* Progressive neurological disorders or unstable medical conditions\n* Participation in other experimental neurorehabilitation interventions during the study period\n* Any condition judged by investigators to compromise safety or data valid","ALL","18 Years","75 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","Chronic post-stroke hemiplegia frequently results in persistent motor deficits, impaired balance, and reduced quality of life. Conventional physical therapy is fundamental for functional recovery; however, motor improvement often plateaus during the chronic phase. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has shown potential to enhance motor recovery by modulating cortical excitability and promoting neuroplasticity.\n\nThis case series aims to investigate the effects of a combined protocol of repetitive transcranial magnetic stimulation and conventional physical therapy on motor function, balance, and quality of life in individuals with chronic post-stroke hemiplegia. Participants will undergo rTMS applied to the motor cortex in conjunction with a structured physical therapy program. Clinical outcomes will be assessed before and after the intervention to explore feasibility, safety, and potential functional benefits of the combined approach.",[26,27],"Chronic Stroke","Balance",[29,30,31,32,33],"repetitive transcraneal magnetic stimulation","chronic stroke","motor recovery","balance","physical therapy","NOT_YET_RECRUITING","2026-05-13",{"date":37,"type":38},"2026-05-19","ACTUAL",{"date":40,"type":20},"2026-06-05",{"date":42,"type":20},"2026-08-30",{"name":44,"class":45},"Sierra Varona SL","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":16,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100622719","recovery-techniques-on-pain-force-and-muscle-oxygenation-in-athletes-a-crossover-trial-100622719","NCT07387276","\"Recovery Techniques on Pain, Force and Muscle Oxygenation in Athletes: A Crossover Trial\"","\"Effects of Multiple Muscle Recovery Techniques on Pain, Force, Temperature, and Muscle Oxygenation in Professional Athletes: A Randomized Crossover Trial\"","Inclusion Criteria:\n\nProfessional or Semi-professional athletes (specifically basketball players or endurance athletes) with a minimum of 2 years of competitive experience.\n\nAged between 18 and 35 years.\n\nHealthy individuals with no current musculoskeletal injuries in the lower limbs.\n\nRegular training frequency of at least 4-5 sessions per week.\n\nSigned informed consent to participate in the study and follow the 6-week crossover protocol.\n\nCommitment to maintain similar nutritional and sleep habits throughout the duration of the study.\n\nExclusion Criteria:\n\nPresence of any acute or chronic injury in the gastrocnemius or Achilles tendon in the last 6 months.\n\nContraindications for specific therapies:\n\nFor Shockwave Therapy: Blood clotting disorders or use of anticoagulants.\n\nFor TECAR\u002FDiathermy: Metal implants in the lower limbs or pacemakers.\n\nFor Cupping: Acute skin infections or dermatological hypersensitivity.\n\nConsumption of performance-enhancing drugs, anti-inflammatory medication (NSAIDs), or stimulants that could affect muscle oxygenation (SmO2) or pain perception.\n\nRecent surgery in the lower extremities (within the last year).\n\nInability to complete the standardized fatigue protocol or attend all 6 intervention sessions.",true,"MALE","35 Years",{"count":19,"type":20},[23],"The goal of this clinical trial is to evaluate the impact of various passive post-exercise recovery techniques on professional athletes. The main questions it aims to answer are:\n\nDo passive recovery modalities significantly improve muscle oxygenation and tissue temperature immediately following high-intensity effort?\n\nWhich specific technique is most effective in reducing perceived pain, measured by the pressure pain threshold, and restoring muscle strength?\n\nResearchers will compare six different therapeutic interventions-Transfer of Energy Capacitive and Resistive therapy, manual massage, intermittent negative pressure therapy, extracorporeal shockwave therapy, percussion therapy, and pneumatic pressotherapy-to determine which provides a superior immediate physiological and functional recovery effect.\n\nParticipants will:\n\nPerform a high-intensity physical effort designed to induce peripheral fatigue.\n\nBe randomly assigned to receive one of the six recovery protocols.\n\nUndergo objective measurements immediately after the intervention, including near-infrared spectroscopy to assess muscle oxygen saturation, tissue thermography, algometry, and dynamometry.",[60,61,62],"Muscle Soreness","Delayed Onset Muscle Soreness","Athletic Injuries",[64,65,66,67,68],"muscle recovery","SmO2","tecartherapy","shockwave therapy","massage","2026-04-23",{"date":71,"type":38},"2026-04-24",{"date":73,"type":20},"2026-06-01",{"date":75,"type":20},"2026-08-16",{"name":44,"class":45},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100629158","focused-shockwave-therapy-for-plantar-fasciopathy-100629158","NCT07471035","Focused Shockwave Therapy for Plantar Fasciopathy","Focused ESWT vs. Wait-list Management for Plantar Fasciopathy: A Randomized Controlled Trial Evaluating Pain, Function, and Ultrasonographic Plantar Fascia Thickness","Inclusion Criteria:\n\n* Male or female aged between 18 and 70 years. Diagnosis of chronic plantar fasciopathy with symptoms persisting for more than 6 months.\n\nPresence of plantar fascia (PF) thickness \\> 4.0 mm, confirmed by high-resolution ultrasound.\n\nClinical history of localized pain at the medial calcaneal tubercle, specifically upon first steps in the morning or after prolonged rest.\n\nFailure of previous conservative treatments (e.g., stretching, orthotics, or medication).\n\nAbility to follow the High-Load Strength Training (HLST) exercise protocol.\n\nExclusion Criteria:\n\n* Previous treatment with shockwave therapy or corticosteroid injections in the affected foot within the last 6 months.\n\nPrevious surgery for plantar heel pain.\n\nPresence of systemic inflammatory diseases (e.g., rheumatoid arthritis, ankylosing spondylitis).\n\nPregnancy.\n\nCoagulopathies or use of anticoagulant medication.\n\nLocal infection or presence of skin lesions at the application site.\n\nKnown or suspected malignancy in the treatment area.\n\nPresence of neurological conditions or peripheral neuropathy (e.g., tarsal tunnel syndrome).","70 Years",{"count":19,"type":20},[23],"This study investigates whether focused Extracorporeal Shockwave Therapy (fESWT) helps people with chronic heel pain, commonly known as plantar fasciitis. Many patients suffer from this condition for more than six months without relief.\n\nThe study compares two groups: one receiving fESWT treatment plus a specific exercise program, and a \"wait-list\" group that only performs the exercises at first. The shockwave treatment uses precise sound waves targeted at the painful area to stimulate the body's natural healing process.\n\nResearchers will measure if the treatment reduces pain and improves the patient's ability to walk and perform daily activities. Additionally, ultrasound will be used to see if the thickness of the plantar fascia (the tissue under the foot) decreases and returns to a healthier state. The goal is to confirm if fESWT provides a faster and more effective recovery than exercise alone.",[89,90,91],"Plantar Fascitis","Chronic Plantar Fasciitis","Fasciitis",[93,94,95],"FOCUSED SHOCK WAVE THERAPY","fESWT","PLANTAR FASCIA THICKNESS","2026-03-17",{"date":98,"type":38},"2026-03-20",{"date":100,"type":20},"2026-04-15",{"date":102,"type":20},"2027-06-30",{"name":44,"class":45},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":53,"sex":54,"minAge":16,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100621633","inspiratory-muscle-activation-and-post-exercise-recovery-in-professional-football-players-100621633","NCT07373158","Inspiratory Muscle Activation and Post-Exercise Recovery in Professional Football Players","Acute Modulation of Post-Exercise Recovery Through Inspiratory Muscle Activation in Professional Male Football Players: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Male professional football player.\n* Currently under an active professional contract and participating in regular competition.\n* Aged between 18 and 40 years.\n* No participation in inspiratory muscle training (IMT) programs in the past 12 months.\n* Signed informed consent provided by the participant.\n\nExclusion Criteria:\n\n* Musculoskeletal injuries or surgical interventions within the past 6 months.\n* Use of medications affecting cardiac or respiratory function (e.g., beta-blockers, beta-adrenergic inhibitors).\n* Presence of any acute and\u002For chronic disease (cardiorespiratory, neurological, metabolic, oncological, etc.).\n* Use of tobacco, recreational drugs, or stimulant substances.\n* Metallic implants in the cervical region.\n* Presence of a pacemaker.\n* Current participation in other inspiratory muscle training programs.","40 Years",{"count":113,"type":20},30,[23],"Respiratory muscles play a fundamental role in sports performance. Fatigue of these muscles induces changes in maximal inspiratory pressure and autonomic nervous system activity, thereby compromising the athlete's recovery process. The primary aim of this study is to evaluate the specific effects of different inspiratory muscle activation modalities on post-exercise recovery in professional male football players. The study seeks to determine which of the three modalities-bilateral phrenic nerve electrical stimulation, a threshold loading device protocol, or inactivity-provides greater benefits for recovery. The effectiveness of these interventions will be assessed using two key outcome variables: maximal inspiratory pressure (MIP) and heart rate variability (HRV).\n\nThis study is designed as a randomized clinical trial (RCT) in which participants will be allocated into three intervention groups: a bilateral phrenic nerve electrical stimulation group (EG1), in which involuntary diaphragmatic contractions will be induced using an electrotherapy device with current applied to the phrenic nerves; a threshold device group (EG2), in which participants will perform breathing against submaximal inspiratory loads equivalent to 40% of their MIP; and a control group (CG), which will remain seated for a period equivalent to the duration of the other interventions. Group allocation will be ensured through randomization using Microsoft Excel.\n\nRegarding statistical analysis, data normality will be assessed using the Shapiro-Wilk test. Comparisons of quantitative variables will be performed using Student's t test when normality assumptions are met, or the Mann-Whitney U test otherwise. A p value \\\u003C 0.05 will be considered statistically significant.",[117,118],"Sports Physical Therapy","Injury;Sports","2026-01-22",{"date":121,"type":38},"2026-01-28",{"date":123,"type":20},"2026-01-20",{"date":125,"type":20},"2026-04-01",{"name":44,"class":45},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":55,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":4},"100596528","acute-effects-of-inspiratory-muscle-load-on-diaphragmatic-recovery-in-athletes-100596528","NCT07046637","Acute Effects of Inspiratory Muscle Load on Diaphragmatic Recovery in Athletes","Short-Term Effects of Inspiratory Muscle Warm-Up and Fatigue on Diaphragmatic Function in Professional Basketball Players: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Male and female professional basketball players aged between 18 and 35 years.\n* Holding a valid federation license at the autonomous or higher competitive level.\n* A minimum of 3 consecutive seasons of competition in official FEB, FIBA, or equivalent regional leagues.\n* Regular training frequency of ≥4 sessions per week over the past 6 months.\n* No previous experience with inspiratory muscle training.\n* Ability to understand study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* History of chronic respiratory, neuromuscular, or cardiovascular disease.\n* Musculoskeletal injury limiting inspiratory effort or physical participation (current or within the past three months).\n* Previous thoracic or abdominal surgery.\n* Current smokers.\n* Use of pharmacological treatments that could affect respiratory or muscular function.\n* Participation in another interventional study within the past 4 weeks.\n* Inability to understand or follow study instructions.\n* Tympanic membrane perforation or middle\u002Finner ear pathology.\n* Pregnancy or postpartum period within the last 6 months.",{"count":135,"type":20},38,[23],"This randomized controlled trial investigates the acute effects of inspiratory muscle warm-up and fatigue on diaphragmatic function in professional basketball players. Using ultrasound imaging and maximal inspiratory pressure (PIM) assessment, the study evaluates changes in diaphragmatic thickness and respiratory strength before and after specific inspiratory muscle loading protocols. Findings aim to clarify the short-term impact of these interventions on diaphragmatic recovery capacity, with potential implications for respiratory training, performance enhancement, and injury prevention strategies in elite athletic populations.",[117,62,139],"Healthy","2025-07-01",{"date":142,"type":38},"2025-07-03",{"date":144,"type":20},"2025-07-10",{"date":146,"type":20},"2025-08-12",{"name":44,"class":45},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":53,"sex":15,"minAge":155,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":21,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":4},"100584895","effects-of-inspiratory-muscle-fatigue-and-warm-up-on-respiratory-variables-handgrip-strength-and-walking-capacity-in-sedentary-older-adults-100584895","NCT06895304","Effects of Inspiratory Muscle Fatigue and Warm-up on Respiratory Variables, Handgrip Strength, and Walking Capacity in Sedentary Older Adults","Effects of Inspiratory Muscle Fatigue and Warm-up on Respiratory Variables, Handgrip Strength, and Walking Capacity in Sedentary Older Adults: A Randomized Clinical Trial.","Inclusion Criteria:\n\n* Being over 60 years old.\n* Physical independence in terms of gait and transfers\n* Engaging in less than 150 minutes of physical activity per week.\n\nExclusion Criteria:\n\n* Having any pathology that prevents the performance of physical activity.\n* Subjects with impaired cognitive abilities.\n* Subjects with tympanic perforation or middle-inner ear pathology.\n* Subjects with chronic respiratory, cardiac, renal, or metabolic pathology..\n* Subjects who have undergone lower limb surgery within the past 12 months.","65 Years","99 Years",{"count":158,"type":20},33,[23],"Respiratory muscle training represents an effective method increasingly utilized in both sports and healthcare domains, employing various devices, among which threshold devices are prominent. The aim of this study is to determine the relationship between inspiratory muscle fatigue or warm-up and muscular strength in upper and lower limbs, in sedentary older adults, as well as the association between such fatigue and other variables, including maximal inspiratory pressure, diaphragmatic ultrasonography, functionality and handgrip strength.\n\nAccording to our hypothesis, the execution of a protocol inducing inspiratory muscle fatigue or activation in sedentary older adults could influence muscular strength, respiratory function and exercise capacity.\n\nIn this study, subjects will be divided into three groups: the fatigue group , the activation group and the control group.\n\nMeasurements of variables, such as maximal inspiratory pressure, diaphragmatic strength (ultrasound image) and functional capacity, will be conducted.",[162,139],"Sedentary","2025-03-19",{"date":165,"type":38},"2025-03-26",{"date":167,"type":20},"2025-03-31",{"date":169,"type":20},"2025-04-10",{"name":44,"class":45},{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":53,"sex":54,"minAge":16,"maxAge":55,"enrollmentInfo":178,"targetDuration":4,"studyType":21,"phases":180,"briefSummary":181,"conditions":182,"keywords":185,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":197},"100581823","evaluating-combined-electromagnetic-stimulation-for-enhanced-physical-and-psychological-recovery-in-athletes-with-doms-100581823","NCT06855316","Evaluating Combined Electromagnetic Stimulation for Enhanced Physical and Psychological Recovery in Athletes with DOMS","Evaluating Combined Electromagnetic Stimulation for Enhanced Physical and Psychological Recovery in Athletes with DOMS: a Randomized Controlled Study","Inclusion Criteria:\n\n1. be male,\n2. aged between 18 and 35 years\n3. engage in regular exercise at least three times per week for a minimum of one year\n4. have no hypersensitivity to the areas designated for peripheral stimulation\n5. be free from chronic conditions incompatible with exercise performance\n6. have no recent musculoskeletal injuries to the lower limbs within the past six months,\n7. be non-smokers\n8. possess the cognitive capacity to understand the study's objectives and procedures.\n\nExclusion Criteria:\n\n\\-",{"count":179,"type":20},48,[23],"This randomized controlled trial explores the impact of a combined transcranial and peripheral electromagnetic stimulation over the potential correlation between psychological well-being and recovery outcomes of young athletes experiencing Delayed Onset Muscle Soreness.",[183,184],"Recovery, Psychological","Transcranial Magnetic Stimulation",[186,187,188],"transcraneal magnetic stimulation","delay onset muscle soreness","psychological profile","2025-02-26",{"date":191,"type":38},"2025-03-03",{"date":193,"type":20},"2025-02-24",{"date":195,"type":20},"2025-03-07",{"name":44,"class":45},1,{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":15,"minAge":155,"maxAge":205,"enrollmentInfo":206,"targetDuration":4,"studyType":21,"phases":208,"briefSummary":209,"conditions":210,"keywords":214,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":197},"100568823","acute-effects-of-intermittent-hypoxia-hyperoxia-in-older-adults-100568823","NCT06686238","Acute Effects of Intermittent Hypoxia-Hyperoxia in Older Adults","Acute Effects of a Hypoxia-hyperoxia Exposure Session on Sedentary Older Adults on Heart Rate Variability, Blood Pressure, and Oxygen Saturation, a Randomized Double-blind Placebo-controlled Clinical Trial","Inclusion Criteria:\n\n* Being over 60 years old.\n* Having no previous experience in hypoxic training.\n* Engaging in less than 150 minutes of physical activity per week.\n\nExclusion Criteria:\n\n* Having any pathology that prevents the subject from being independent in terms of walking and functionality.\n* Subjects with impaired cognitive abilities.\n* Subjects with pulmonary hypertension, decompensated heart or respiratory disease.\n* To have or have had cancer","90 Years",{"count":207,"type":20},16,[23],"The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with reduced oxygen fraction, controlled through a specific software, using a facial mask and a hypoxic generation device. The objective of this study is to determine if there is a relationship between intermittent hypoxia-hyperoxia exposure and cardiorespiratory condition, blood pressure, and arterial oxygen saturation.\n\nAccording to our hypothesis, acute IHHE in elderly adults may influence cardiorespiratory condition, blood pressure, and arterial oxygen saturation.\n\nThe study will be conducted as a randomized clinical trial. The subjects will be divided into two groups: the experimental group will undergo an IHHE session, breathing air with an oxygen concentration (FiO2) ranging from 10-14% for 1-5 minutes, with 1-3 minutes of rest in hyperoxia (FiO2 30-40%) for a total of 4-8 cycles, based on their acute response to hypoxia. The placebo group will undergo a 5-cycle protocol with an FiO2 of 21%.",[211,212,213,162],"Older Adults","Cardiovascular Health","Blood Pressure",[215,216,217],"hypoxic exposure","older adults","heart rate variability","2024-11-25",{"date":220,"type":38},"2024-11-27",{"date":222,"type":20},"2024-12-05",{"date":224,"type":20},"2024-12-26",{"name":44,"class":45},{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":15,"minAge":155,"maxAge":205,"enrollmentInfo":233,"targetDuration":4,"studyType":21,"phases":234,"briefSummary":235,"conditions":236,"keywords":239,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":242,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":4},"100568829","effects-of-intermittent-hypoxia-hyperoxia-in-older-adults-100568829","NCT06686316","Effects of Intermittent Hypoxia-Hyperoxia in Older Adults","Effects of a 6-week Hypoxia-hyperoxia Exposure Protocol on Sedentary Older Adults on Heart Rate Variability, Blood Pressure, Respiratory Muscle Strength, Pulmonary Function, Inflammatory Biomarkers and Arterial Oxygen Saturation, a Randomized Double-blind Placebo-controlled Clinical Trial","Inclusion Criteria:\n\n* Being over 65 years old.\n* Having no previous experience in hypoxic training.\n* Engaging in less than 150 minutes of physical activity per week.\n\nExclusion Criteria:\n\n* Having any pathology that prevents the subject from being independent in terms of walking and functionality.\n* Subjects with impaired cognitive abilities.\n* Subjects with pulmonary hypertension, decompensated heart or respiratory disease.\n* To have or have had cancer",{"count":207,"type":20},[23],"The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with reduced oxygen fraction, controlled through a specific software, using a facial mask and a hypoxic generation device. The objective of this study is to determine if there is a relationship between intermittent hypoxia-hyperoxia exposure and cardiorespiratory condition, blood pressure, and arterial oxygen saturation.\n\nAccording to our hypothesis, acute IHHE in elderly adults may influence cardiorespiratory condition, inflammatory biomarkers, blood pressure, and arterial oxygen saturation.\n\nThe study will be conducted as a randomized clinical trial. The subjects will be divided into two groups: the experimental group will undergo an IHHE session, breathing air with an oxygen concentration (FiO2) ranging from 10-14% for 1-5 minutes, with 1-3 minutes of rest in hyperoxia (FiO2 30-40%) for a total of 4-8 cycles, based on their acute response to hypoxia. The sham group will undergo a 5-cycle protocol with an FiO2 of 21%.\n\nBoth groups will follow a 6-week protocol with three weekly sessions (Monday, Wednesday, and Friday).",[237,238,211],"Sedentary Behavior","Frailty",[240,241,217],"hypoxic training","elderly",{"date":220,"type":38},{"date":244,"type":20},"2024-12-10",{"date":246,"type":20},"2025-02-05",{"name":44,"class":45},{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":21,"phases":257,"briefSummary":258,"conditions":259,"keywords":261,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":4},"100565833","effects-of-an-early-physioterapy-program-on-the-emotional-well-being-in-acute-hospitalized-patients-100565833","NCT06647316","Effects of an Early Physioterapy Program on the Emotional Well-being in Acute Hospitalized Patients","The Effect of a Physioterapy Program on the Emotional Well-being of Patiens Admitted to an Acute Hospitalization Unit","Inclusion Criteria:\n\n-Volunteer Adults (18 years of age or older) that must provide written informed consent to participate in the study.\n\nHospitalization Requirements\n\n* Participants must have been hospitalized in one of the hospital medical service departments for a minimum of 96 hours prior to enrollment.Eligibility for Physiotherapy:\n* Participants must be deemed eligible for physiotherapy treatment during their hospital stay, as determined by the medical team.\n* Cognitive Function: Participants must have a Mini-Mental State Examination (MMSE) score of 24 points or higher, indicating sufficient cognitive function.\n* Participants must have received a minimum of 4 physiotherapy sessions during their hospital stay.\n* A primary caregiver must be identified and available to participate in the study, although the caregiver does not need to be a family member.\n\nExclusion Criteria:\n\n* Language Impairment: Patients with a language disorder that affects their ability to communicate effectively, thereby preventing them from providing informed consent or fully participating in the study.\n* Language Barriers: Patients who encounter substantial linguistic barriers that cannot be overcome with the provision of interpretation or translation services, thus limiting their ability to comprehend or fully engage in the study.\n* Patients Undergoing Specific Physiotherapeutic Treatments: Patients currently enrolled in physiotherapy programs standardized by the hospital's rehabilitation service for the following conditions: movement recovery, knee prosthesis, hip prosthesis, cardiac surgery, thoracic surgery, and bariatric surgery.",{"count":256,"type":20},101,[23],"Hospitalization due to acute illness often leads to a decline in physical function and quality of life, which significantly impacts the emotional well-being of patients, their families, and primary caregivers. Emotional well-being is a critical aspect of overall health, enabling individuals to cope with and adapt to health challenges. Addressing this dimension within the hospital setting is vital to improving patient outcomes, particularly from a biopsychosocial perspective that considers physical, psychological, and social factors.\n\nThis study aims to evaluate the effectiveness of physiotherapy interventions in enhancing the emotional well-being of hospitalized patients. While early physiotherapy is well-documented for its benefits in preventing complications and improving physical recovery, there is limited research demonstrating its impact on emotional well-being. Furthermore, data on the effects of prolonged hospitalization on the biopsychosocial health of patients is lacking.\n\nConducted at the Hospital Universitario de la Princesa (Madrid, Spain), a high-complexity hospital, this project will assess the role of physiotherapy not only in physical recovery but also in fostering emotional support. The intervention is designed to provide both therapeutic and emotional benefits, incorporating moments of relaxation and leisure into the treatment sessions. The study aligns with the growing global trend towards person-centered care and the humanization of healthcare.\n\nThis approach emphasizes a more holistic and personalized patient experience, where physiotherapy contributes to the overall health and well-being of the patient, addressing their physical and emotional needs.",[260],"Acute Illness",[262,263,264,265],"Well-being","Physiotherapy","Biopsychosocial Health Impact","Hospitalization","2024-10-16",{"date":268,"type":38},"2024-10-17",{"date":270,"type":20},"2024-10-14",{"date":272,"type":20},"2025-08-15",{"name":44,"class":45},{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":155,"enrollmentInfo":281,"targetDuration":4,"studyType":21,"phases":283,"briefSummary":284,"conditions":285,"keywords":288,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":4},"100560760","enhancing-pelvic-floor-function-with-transcranial-magnetic-and-tibial-nerve-stimulation-for-neurogenic-bladder-in-ms-100560760","NCT06581341","Enhancing Pelvic Floor Function With Transcranial Magnetic and Tibial Nerve Stimulation for Neurogenic Bladder in MS","Improvement of Pelvic Floor Function Using Repetitive Transcranial Magnetic Stimulation and Posterior Tibial Nerve Stimulation in Treating Neurogenic Overactive Bladder in Patients With Multiple Sclerosis","Inclusion Criteria:\n\n* Volunteer Adults (Age 18-65)\n* Diagnosis of Multiple Sclerosis\n* Expanded Disability Status Scale (EDSS) 0-7\n* Diagnosis of overactive bladder disfunction secondary to multiple sclerosis\n\nExclusion Criteria:\n\n* Active urinary tract infection at the time of selection.\n* Individuals with a history of urological conditions other than overactive bladder secondary to multiple sclerosis.\n* Contraindications for electrical stimulation:\n* Presence of metal in the skull\n* Intracardiac lines\n* History of increased intracranial pressure\n* Significant heart disease\n* Pacemaker or implantable desfibrillator usage\n* Use of implanted medication pumps\n* Treatment with tricyclic antidepressants or neuroleptics\n* Personal or family history of epilepsy\n* Pregnant or breastfeeding women",{"count":282,"type":20},60,[23],"Multiple Sclerosis (MS) is a chronic, autoimmune, inflammatory, and degenerative neurological disorder that affects the central nervous system. Symptoms vary widely depending on the areas impacted and may include fatigue, vision issues, speech difficulties, tremors, limb weakness, loss of sensation, vertigo, coordination problems, and bladder and bowel dysfunction. Among these, lower urinary tract symptoms are particularly common and significantly impact the quality of life for MS patients.\n\nNeurogenic overactive bladder (NOAB) is a prevalent urinary issue in individuals with MS. Treatment options for NOAB include behavioral therapy, β-3 agonists, anticholinergic agents, posterior tibial nerve neuromodulation (PTNM), botulinum toxin injections, sacral root neurostimulation, and surgical interventions.\n\nRepetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that may improve bladder function by modulating neural activity through an electromagnetic coil placed on the scalp. In contrast, posterior tibial nerve neuromodulation (PTNM) involves electrical stimulation of the spinal cord roots, primarily the S3 segment, to enhance bladder function.\n\nDespite promising evidence, rTMS and PTNM are not yet widely recommended in global guidelines due to the limited number of studies, many of which are case reports. The growing prevalence of overactive bladder underscores the need for effective, non-invasive treatments to improve management and optimize current protocols.\n\nThis study aims to evaluate and compare the efficacy of rTMS and tibial nerve stimulation in managing neurogenic overactive bladder in MS patients at Hospital Universitario de la Princesa. The primary objective is to determine whether rTMS is superior, equivalent, or inferior to tibial nerve stimulation in treating NOAB.\n\nThe study's hypothesis is that the efficacy of transcranial magnetic stimulation will differ from that of tibial nerve stimulation in managing NOAB in MS patients at Hospital Universitario de la Princesa, with a focus on assessing whether rTMS offers superior, equivalent, or inferior outcomes compared to tibial nerve stimulation. This investigation seeks to provide valuable insights into the effectiveness of these treatment modalities.",[286,287],"Neurogenic Overactive Bladder","Multiple Sclerosis",[289,286,290,291],"Múltiple Sclerosis","Posterior Tibial Nerve Meuromodulation","Repetitive Transcranial Magnetic Stimulation.","2024-08-27",{"date":294,"type":38},"2024-09-03",{"date":296,"type":20},"2024-10-01",{"date":298,"type":20},"2025-09-22",{"name":44,"class":45},""]