[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Simon Fraser University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":148},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,73,99,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100487944","postural-sway-and-counterpressure-maneuvers-for-pediatric-syncope-100487944",false,"NCT05633693","Postural Sway and Counterpressure Maneuvers for Pediatric Syncope","Impact of Postural Sway on Cardiovascular Control in Pediatric Patients With Syncope","Inclusion Criteria:\n\nWe are looking for English speaking pediatric patients aged 6-18 years with a diagnosis of recurrent fainting (at least two episodes of fainting with loss of consciousness or near loss of consciousness in the last year) of a vasovagal origin or associated with the postural orthostatic tachycardia syndrome (POTS) (as determined by a paediatric cardiologist) to take part in this study.\n\nExclusion Criteria:\n\nThose with a diagnosis of recurrent fainting accompanied by any of the following will not be eligible to take part:\n\nKnown history of:\n\n* Suspected or confirmed cardiac arrhythmia (e.g., Wolff-Parkinson-White, Long QT)\n* Traumatic head injury\n* New presentation of a seizure disorder OR epilepsy recurrence\n* Overdose or intoxication\n* Structural heart disease\n* Cardiovascular disease including hypertension, diabetes, or renal disease\n* Hypoglycemia\n* Physical and\u002For psychological disability that impact their ability to complete the tests\n\nFemale participants of childbearing age will be excluded if they are pregnant, or think they might be. Participants who are taking any cardiovascular acting medications, including treatment for cardiovascular disease, or medications for orthostatic syncope (e.g. fludrocortisone, slow-release sodium chloride, β-blockers, midodrine) will be excluded from the study.\n\nIn order to reduce the likelihood of transmission of COVID-19, participants will only be eligible to participate in the study if they have received full immunisation against COVID-19 according to current Health Canada guidelines. Accordingly, participants will be asked to provide evidence of their vaccination status in order to take part in the study.","ALL","6 Years","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular responses to maneuvers of exaggerated sway, leg crossing, crouching, and gluteal muscle tensing in children who faint (N=20), as well as their height, weight, muscularity, and pubertal (Tanner) stage. Autonomic cardiovascular control will be measured using a Valsalva manoeuvre (expiration against a closed airway for 20 seconds) and a supine-stand test. The primary outcomes are noninvasive measures of cardiovascular responses to the maneuvers (blood pressure, cerebral blood flow, and stroke volume (volume of blood pumped per heartbeat). Comparisons will be made across levels of sex, diagnosis, Tanner stage, muscularity, height, and degree of autonomic control.",[27,28,29],"Syncope, Vasovagal","Postural Orthostatic Tachycardia Syndrome","Orthostatic Intolerance","RECRUITING","2026-04-22",{"date":33,"type":34},"2026-04-23","ACTUAL",{"date":36,"type":34},"2023-04-17",{"date":38,"type":21},"2027-06",{"name":40,"class":41},"Simon Fraser University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":67,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100488110","phase-2-no-ad-use-of-nitric-oxide-no-donors-for-the-prevention-of-autonomic-dysreflexia-ad-during-bowel-care-following-sci-100488110","NCT05635851","NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI","NO AD","Inclusion Criteria:\n\n* participants must have had a traumatic spinal cord injury at least one year ago\n* regular bowel care routine\n* can communicate in English\n\nExclusion Criteria:\n\n* cauda equina or conus lesions\n* currently use ventilator\n* colostomy, or do not perform regular bowel care\n* skin breakdown (pressure sores)\n* cannot communicate in English\n* under 19 years old\n* possibly or certainly pregnant\n* medical\u002Fpsychiatric condition or substance abuse that is likely to affect ability to complete study\n* currently using medications containing PDE-5 inhibitors\n* currently using medications containing GTN\n* allergy to GTN","19 Years","80 Years",{"count":53,"type":21},26,[55],"PHASE2","This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.",[58,59],"Spinal Cord Injuries","Autonomic Dysreflexia",[61,62,63,64,65],"spinal cord injury","autonomic dysreflexia","blood pressure","bowel care management","defecation","NOT_YET_RECRUITING",{"date":33,"type":34},{"date":69,"type":21},"2026-12",{"date":71,"type":21},"2028-02",{"name":40,"class":41},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":16,"minAge":50,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":42},"100487006","the-effect-of-water-carbonation-on-orthostatic-tolerance-100487006","NCT05621460","The Effect of Water Carbonation on Orthostatic Tolerance","Inclusion Criteria:\n\n* healthy, English-speaking\n\nExclusion Criteria:\n\n* pregnancy or suspected pregnancy, history of cardiovascular disease, history of neurological disease, history of recurrent fainting (≥ 2 episodes of fainting with loss of consciousness in the prior 6 months)",true,"50 Years",{"count":82,"type":21},25,[24],"The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers. Orthostatic tolerance refers to the ability to maintain an adequate blood pressure when standing. In some individuals blood pressure can fall when standing, predisposing to dizzy spells or fainting episodes. Drinking water can boost blood pressure and making fainting episodes less likely. However, it is not clear whether the carbonation of the water has any further impact on the blood pressure response. This is important because it may be that carbonated water expands the stomach (gastric distension), provoking an increase in sympathetic activity. The increase in sympathetic nervous system activity boosts blood pressure. Resolving this question would have important implications for patients with syncope. This study will test whether carbonated water will have any further impact on blood pressure than the already known effect of non-carbonated water.",[86,87,88],"Orthostatic Hypotension","Syncope","Vasovagal Syncope",[90,91,92],"Tilt table","Osmopressor reflex","Gastropressor reflex",{"date":33,"type":34},{"date":95,"type":34},"2023-09-01",{"date":97,"type":21},"2027-04",{"name":40,"class":41},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":79,"sex":16,"minAge":18,"maxAge":80,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":119,"locationsCount":42},"100541912","impact-of-blood-phobia-on-fainting-susceptibility-100541912","NCT06336031","Impact of Blood Phobia on Fainting Susceptibility","Inclusion Criteria:\n\n* male and female\n* 18 to 50 years old\n* those without a suspected BII fear and those with a suspected fear\n* english speaking\n\nExclusion Criteria:\n\n* diagnosis of any cardiovacular or neurological disorder\n* menopausal\n* taking medication for a cardiovascular condition\n* if they are pregnant",{"count":106,"type":21},20,[24],"The primary purpose of this study is to characterize cardiovascular autonomic function to emotional stimuli (blood-injection-injury phobia \\[needle phobia\\]) during an orthostatic (upright) challenge in individuals with and without known needle phobia. It is well established that emotional stress can produce hypotensive (low blood pressure) reactions. Interestingly, these hypotensive reactions to venipuncture (even with minimal blood drawn), insulin injections, finger sticks for blood sugar monitoring, dental care, and vaccinations can affect up to a quarter of adults and appear to be uniquely associated with blood-injection-injury phobia rather than other phobias. These hypotensive reactions can ultimately lead to a vasovagal syncope (fainting) response, and lead to increased avoidance of medical and dental procedures as a result of this phobia. Ultimately, this has severe implications on public health and places additional strain on the Canadian healthcare system. Currently, there is limited understanding surrounding the initiation of this response. Additionally, a comprehensive profile of cardiovascular autonomic function during exposure to provoking stimuli during orthostatic stress has not been captured in the literature. We will test individuals with and without blood-injection-injury phobia using our standard approach while exposing them to emotional stimuli.",[27,110],"Blood, Injection, Injury Type Phobia",[112],"tilt table","2025-05-12",{"date":115,"type":34},"2025-05-15",{"date":117,"type":34},"2024-03-30",{"date":69,"type":21},{"name":40,"class":41},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":79,"sex":127,"minAge":18,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":145,"leadSponsor":147,"locationsCount":42},"100557457","running-online-injury-prevention-feasibility-study-100557457","NCT06538363","Running Online Injury Prevention Feasibility Study","ROIPF","Inclusion Criteria:\n\n* Cis-gender female (someone who was born female and currently identifies as a woman) runners\n* Over the age of 18\n* Have not been injured in the last 3 months (\\*\\*For the purpose of this study, an injury is defined as \"musculoskeletal (originating from the bones, muscles, joints) that has restricted the ability to run in any way (distance, speed, duration) for at least 7 days or for 3 consecutive training sessions\"\\*\\*)\n* Have run on average 3 times\u002Fweek for the last 6 months\n* Own a GPS-enabled smart watch with an optical wrist heart rate sensor\n* Fit shoe size between 6.5 and 8.5 US women's sizing\n* Able to attend one of the in-person orientation sessions\n* Able to understand written and spoken English\n\nExclusion Criteria:\n\n* Any current pain with running","FEMALE",{"count":129,"type":21},60,[24],"The main purpose of this study is to test the feasibility of a larger scale interventional study. The investigators want to understand whether data can be reliably collected data various different streams while participants follow a standard 12-week half-marathon training program, and whether participants follow training recommendations.",[133],"Musculoskeletal Injury",[135,136,137,138,139,140],"Running","Wearable sensors","Biomechanics","Training","Education","Female athlete","2024-08-01",{"date":143,"type":34},"2024-08-05",{"date":141,"type":21},{"date":146,"type":21},"2025-01-01",{"name":40,"class":41},""]