[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Slovak Academy of Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":79},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100591874","lifestyle-for-the-brain-health---nutrition-and-exercise-training-intervention-100591874",false,"NCT06986096","Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention","Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention, LIBRA-NET","LIBRA-NET","Inclusion Criteria:\n\n* Non-smokers\n* Signed informed consent\n* Presence of subjective or mild cognitive impairment (SCI\u002FaMCI)\n* Elevated levels of selected biomarkers confirming the presence of a pathological process characteristic of Alzheimer's disease\n* Absence of any psychological, sociological, or geographical factors that could jeopardize participation in the project.\n\nExclusion Criteria:\n\n* Presence of severe cardiovascular, liver, or kidney diseases; advanced or poorly controlled diabetes mellitus (HbA1c \\>7%), treated with insulin or incretin analogs; cancer or any other severe disease as assessed by the responsible physician. A history of cancer treated with chemotherapy or radiotherapy if within less than 5 years post-treatment.\n* Lack of cooperation, inflexible schedule, or problematic transportation.\n* Insufficient functional capacity or presence of comorbidities that prevent participation in the training program (assessment by an internist, cardiologist, neurologist, orthopedic specialist, or other relevant specialists).\n* Presence of a pacemaker or any metal implants (contraindication for MRI examination), or allergy to local anesthetics (contraindication for muscle biopsy).\n* Smoking, alcohol dependence, or addiction to other narcotic substances.\n* Stroke or myocardial infarction within the last year.\n* Long-term treatment for psychiatric disorders - a depressive syndrome is not an exclusion criterion if it is compensated by therapy.\n* Other diseases of the musculoskeletal or nervous system that potentially interfere with the ability to exercise or cognition - such as severe arthritis, Parkinson's disease, significant essential tremor, epilepsy, etc.\n* Concurrent participation in another clinical study.\n* Therapy with cholinesterase inhibitors unless the patient is on a stable dose.","ALL","60 Years","80 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's disease.\n\nThe aim of the study is to assess the impact of a supervised 9-month intervention with aerobic-strength training and nutritional counseling compared to cognitive training and stretching on the brain, cognitive and motor functions, metabolism, physical fitnes and plasma markers of neurodegenertion in older adults at increased risk of developing Alzheimer's disease.",[28,29,30,31,32],"Aging","Alzheimer Disease","Life Style, Healthy","Exercise","Cognitive Impairment","RECRUITING","2025-05-22",{"date":36,"type":37},"2025-05-29","ACTUAL",{"date":39,"type":37},"2024-09-01",{"date":41,"type":22},"2026-12",{"name":43,"class":44},"Slovak Academy of Sciences","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":45},"100591669","digitalization-of-personalised-health-risk-management-100591669","NCT06983431","DIGITALIZATION OF PERSONALISED HEALTH RISK MANAGEMENT","DIGITALIZATION OF PERSONALISED HEALTH RISK MANAGEMENT IN AT-RISK GROUPS TO IMPROVE HEALTH OUTCOMES THROUGH INTEGRATION OF TECHNOLOGICAL AND SOCIAL INNOVATION","DIG4HEALTH","Inclusion Criteria:\n\n* obesity (BMI 27-42 kg\u002Fm²)\n* capacity and willingness to use smartphone\n* capacity and willingness to use wearables\n* readiness to change (validated questionaire)\n\nExclusion Criteria:\n\n* diseases that prevent participation in the program, or insufficiently controlled diseases, or terminal-stage illnesses\n* excessive alcohol consumption or a history of other addictions\n* patients currently participating in a weight-loss program (commercial, medically supervised, or a research study)\n* patients using anti-obesity medications who are in the dosage adjustment phase within the last four weeks\n* patients who are not mentally, physically, or technologically capable of participating\n* patients who are unable to provide informed consent\n* patients not adhering to the study protocol","25 Years","65 Years",{"count":57,"type":22},320,[25],"The principal objective of the project is:\n\n* to bring together academic and business research organisations in a joint partnership integrating technological and social innovation,\n* in order to develop proof-of-concept of a scalable and cost effective personalised digital health program for (pre)obesity patients,\n* by integrating, in an ethical manner, adaptive AI components aimed at personalisation of the program as well as its cost management,\n* with the ultimate objective to support sustained behavioural change leading to adoption and internalisation of healthy lifestyle choices.",[61,62],"Pre-obesity","Obesity",[64,65,66,67,68,69,70],"wearable","behavioural intervention","habitual physical activity","quality of life","body weight and composition","sleep duration \u002F eficiency","heart rate variability","2025-05-17",{"date":73,"type":37},"2025-05-21",{"date":75,"type":37},"2025-05-05",{"date":77,"type":22},"2026-06-30",{"name":43,"class":44},""]