[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Southcentral Foundation\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100557467","jumpstarting-advance-care-planning-with-anai-people-100557467",false,"NCT06538493","Jumpstarting Advance Care Planning With ANAI People","Jumpstarting Culturally-informed Advance Care Planning With ANAI People in Primary Care","JUMP","Inclusion Criteria:\n\nAge 40 or older with a qualifying serious illness condition (e.g., COPD) OR Age 65 or older (regardless of diagnosis) AND Alaska Native and\u002For American Indian AND Empaneled to a primary care provider AND 2 or more to primary care in last 12 months AND No advance directives documented in electronic health record\n\nExclusion Criteria:\n\nUnable to provide informed consent AND\u002FOR Not able to complete 30-minute study visit by phone, video call, or in person","ALL","40 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"NA","The older Alaska Native\u002FAmerican Indian (ANAI) population is increasing at twice the rate of the general population with a higher burden of serious illness. Older ANAI adults with serious illness are half as likely to have advance directives (AD), indicating a need for improved access to and utilization of advance care planning (ACP) to ensure that medical care aligns with the values, goals, and preferences of ANAI patients and their families throughout the illness trajectory. The major goals of this cluster randomized trial (CRT) are to (1) evaluate the comparative effectiveness of usual care and JUMPSTART- ANAI, a culturally tailored ACP communication intervention, for prompting patient-driven ACP conversations between ANAI adults and primary care providers and to (1) identify key factors to successfully implement the intervention in health systems serving ANAI adults with serious illness.",[27],"Advance Care Planning","RECRUITING","2026-06-11",{"date":31,"type":32},"2026-06-15","ACTUAL",{"date":34,"type":32},"2025-04-01",{"date":36,"type":21},"2027-05-31",{"name":38,"class":39},"Southcentral Foundation","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":40},"100558831","metabolism-informed-care-to-aid-alaska-native-people-to-quit-smoking-quit-100558831","NCT06556238","Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT)","Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT): Pilot Intervention and Assessment of Barriers and Facilitators of Implementation","QUIT","Inclusion Criteria:\n\n(Patients)\n\n* Alaska Native or American Indian person by self-report\n* eligible for or already receiving services at Southcentral Foundation (SCF)\n* age 18 years or older\n* daily smoking in the past 30-days\n* if other nicotine or tobacco products are used, cigarettes are main product used\n* planning to schedule an appointment with the Quit Tobacco Program to seek smoking cessation treatment in the next 30 days\n* willing to make a quit attempt within 30 days of enrollment in the Quit Tobacco Program\n* willing to have a blood test to inform their treatment\n* willing to try a pharmacologic treatment\n* willing to provide a saliva sample\n* has phone service\n* has access to broadband internet on mobile phone at home, work, or other location\n* has an Android or iPhone mobile phone compatible with the Smokerlyzer app\n\n(Staff)\n\n\\- Staff participants of qualitative interviews to assess acceptability and feasibility of the intervention must be a health care professional at Southcentral Foundation (SCF), involved in the care of one of the participants of the study, that is their care team staff; including but not limited to: primary care providers, tobacco treatment specialists\u002Fhealth educators, pharmacists, nurse case managers, behavioral health consultants, certified medical assistants, and lab technicians.\n\nExclusion Criteria:\n\n(Patients)\n\n* Participated in the prior study phase\n* participated in a cessation program during the past 3 months\n* their provider has not approved varenicline in their referral to the Quit Tobacco Program\n* has history of serious hypersensitivity or skin reactions to varenicline\n* has bleeding disorder or is currently receiving cancer treatment\n* questionable capacity or impaired decision-making capacity","18 Years",{"count":51,"type":21},50,[24],"The purpose of this study is to refine and pilot an intervention using the Nicotine Metabolite Ratio (NMR) to inform the selection of pharmacologic treatment to increase smoking abstinence among Alaska Native and American Indian people. This is a single-arm pilot trial to assess and improve acceptability and feasibility.",[55],"Smoking Cessation","2026-04-21",{"date":58,"type":32},"2026-04-24",{"date":60,"type":32},"2025-11-17",{"date":62,"type":21},"2026-06",{"name":38,"class":39},""]