[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"St. Mary's Research Center, Canada\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":98},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100544006","a-smart-design-to-optimize-the-delivery-of-tempo-for-men-with-prostate-cancer-and-their-caregivers-100544006",false,"NCT06363266","A SMART Design to Optimize the Delivery of TEMPO for Men With Prostate Cancer and Their Caregivers","A SMART Design to Optimize the Delivery of TEMPO - a Tailored, wEb-based Psychosocial and Physical Activity Self-Management PrOgram for Men With Prostate Cancer and Their Caregivers","Patient inclusion criteria: Prostate cancer diagnosis; Treatment for prostate cancer (excluding active surveillance) scheduled to start or received within the past 2 years; Nominate a caregiver willing to participate; Report at least moderate anxiety (ESAS-r Anxiety 3+); Be able to read English or French; Have access to the internet\n\nCaregiver inclusion criteria: Are nominated by patient as primary support person; Are patients' spouse, partner, or other family member; If patient does not report moderate anxiety, caregiver needs to; Be able to read English or French; Have access to the internet\n\nExclusion criteria for patient and caregiver: Hospitalized","ALL","18 Years",{"count":19,"type":20},376,"ESTIMATED","INTERVENTIONAL",[23],"NA","Men with prostate cancer and their family caregivers face many physical and emotional challenges from the cancer itself and its treatment(s), which often lead to high anxiety. The pandemic has highlighted the importance of protecting our physical and mental health, and the complex responsibilities that caregivers have in supporting their loved ones. To improve the health of men with prostate cancer and of their caregivers, the research team developed TEMPO: a self-directed Tailored, wEb-based, psychosocial and physical activity self-Management PrOgram. TEMPO was developed with men with prostate cancer and their caregivers over the past 8 years. It also combines the investigators' research conducted over the past decade on providing the best support to those affected by cancer. Because the cancer care workforce is already overstretched, the research team designed TEMPO to be used without guidance from a health care professional. TEMPO is one-of-a kind in its support of both patients and caregivers, and the integration of coping skills training on a wide range of cancer challenges along with a home-based exercise program. Patients and caregivers who have used TEMPO said they improved their communication, learned new skills to cope with both physical and emotional challenges of cancer, and increased their physical activity. The present project builds on this work to further evaluate the cost and impact of TEMPO on men's and caregivers' health. Men with prostate cancer and their caregivers will be assigned by chance to one of two groups a) TEMPO or b) monitor their anxiety for 12 weeks. After 12 weeks, patients' and caregivers' needing more support will be identified based on an assessment of their anxiety level. For those already using TEMPO and needing more support, non-health care professional guidance might be offered. All those in the monitoring group needing more support will now have access to TEMPO. All participants complete surveys to determine whether TEMPO led to improved health outcomes.",[26,27],"Cancer of the Prostate","Anxiety",[29,30,31,32,33,34,35,36,37],"Behavior Change","Caregivers","Coping","E-Health","Illness Self-Management","Physical Activity","Psychosocial Oncology","Self-Directed Interventions","Web-Based Interventions","RECRUITING","2026-06-08",{"date":41,"type":42},"2026-06-11","ACTUAL",{"date":44,"type":42},"2025-08-01",{"date":46,"type":20},"2028-08-31",{"name":48,"class":49},"St. Mary's Research Center, Canada","OTHER",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100532089","tranexamic-acid-use-on-pain-mobility-and-bleeding-following-total-hip-and-total-knee-arthroplasty-100532089","NCT06208267","Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty","The Impact of Additional Post-operative Doses of Tranexamic Acid on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty: A Randomized Controlled Trial","TXA","Inclusion Criteria:\n\n° All adults undergoing primary TKA and THA at St-Mary's Hospital\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Known hypersensitivity or allergy to TXA\n* Previous history of thromboembolic disease\n* Active malignancy (all current cancers other than local skin cancer)\n* Significant renal disease (hematuria, dialysis, kidney transplant)\n* History of convulsions\n* Known defective colour vision\n* Inability or unwillingness to use MyMobility app\n* Unable to communicate in French or English",true,{"count":61,"type":20},210,[23],"Tranexamic acid (TXA) is an anti-fibrinolytic agent developed in the 1960s that has been safely used to reduce blood loss, transfusion rates and bleeding-associated mortality in trauma, obstetrics and orthopedic surgery, including hip fracture care and arthroplasty.\n\nThe efficacy and safety profile of TXA has been extensively studied in numerous clinical trials and observational studies. Its wide range of applications, combined with its favourable risk-benefit ratio, has led to the incorporation of TXA into clinical guidelines and protocols worldwide.\n\nThis RCT aims to compare the current standard dosing for TXA to additional TXA doses given orally post-operatively for THA and TKA patients. The goal is to compare the following between study groups: visible bleeding on post-operative dressing, mobilization (steps, amount of time moving around), pain (visual analog scale), function (Oxford hip and knee scales) and ROM at four to six weeks.",[65],"Postoperative Bleeding","2026-04-22",{"date":68,"type":42},"2026-04-28",{"date":70,"type":42},"2025-08-20",{"date":72,"type":20},"2027-07",{"name":48,"class":49},1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":74},"100555989","virtual-reality-music-in-geriatric-inpatients-100555989","NCT06519253","Virtual Reality Music in Geriatric Inpatients","Virtual Reality Based Music Intervention in an Acute Geriatric Setting","Inclusion Criteria:\n\n* Age of 60 years or older;\n* Medical stability to participate in the trial as determined by treating physician (defined as stable vital signs, absence of new medical events and deteriorating signs),\n* Admitted to the GAU (5 north) at St. Mary's hospital.\n\nExclusion Criteria:\n\n* Medical instability which limits ability to participate in the study (unstable vital signs, delirium, new medical events, deteriorating signs),\n* Unablility to communicate in English or French,\n* Behavioural issues\u002Fdelirium that limit participation in the study,\n* Those who have very severe dementia (using the Reisberg stage 7 which is defined by very limited communication ability, and dependence for all self-care\n* Those without sufficient auditory acuity to undergo assessment and participate in the intervention, which affects their ability to communicate their consent for this study and to listen to music\n* Ophthalmological conditions which affects their ability to participate in the immersive VR (recent eye surgery, severe macular degeneration, severe glaucoma, epilepsy and seizures, etc.).","60 Years",{"count":84,"type":20},30,[23],"Older adults, especially those in acute care require accessible non-pharmacological interventions, such as music to improve their mental health. Immersive 360 virtual reality (VR), is an innovative technology that has been found to be feasible, safe, and enjoyable by older adults. However, VR based music intervention to improve older adults' mental health has not been studied in acute in-patient settings.",[88,89],"Older Adult","Hospitalization","2024-07-22",{"date":92,"type":42},"2024-07-25",{"date":94,"type":42},"2024-05-22",{"date":96,"type":20},"2025-05-22",{"name":48,"class":49},""]