[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Stefano Zaffagnini\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":214},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,41,63,81,104,127,152,173,194],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100582810","long-term-clinical-and-radiographic-results-of-revision-anterior-cruciate-ligament-reconstruction-using-a-single-bundle-technique-and-external-tenodesis-with-achilles-tendon-allograft-100582810",false,"NCT06868147","Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using a Single-bundle Technique and External Tenodesis With Achilles Tendon Allograft.","Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using Over The Top Single-bundle Technique and Lateral Extra-articular Tenodesis With Achilles Tendon Allograft.","ACL_REVISION","Inclusion Criteria:\n\n1. Age between 18 and 50 years at the time of surgery;\n2. Male and female gender;\n3. Patients who have undergone revision of anterior cruciate ligament reconstruction with a single-bundle \"Over-The-Top\" technique and external tenodesis using Achilles tendon allograft, with or without associated procedures, at least 2 years post-surgery;\n4. A radiograph taken immediately before or after the surgery of the affected knee;\n5. Patients who have provided consent to participate in the study.\n\nExclusion Criteria:\n\n1. Patients no longer accessible;\n2. Patients who deny consent to participate in the study;\n3. Advanced knee osteoarthritis (Outerbridge grade III-IV) at the time of surgery;\n4. Severe obesity (BMI \\> 35);\n5. Lower limb conditions that prevent the patient from maintaining an upright position with full weight-bearing during the assessment;\n6. Infection or hematological or rheumatic conditions at the time of the assessment.","ALL","18 Years","50 Years",{"count":21,"type":22},59,"ESTIMATED","OBSERVATIONAL","Several techniques for revision of anterior cruciate ligament (ACL) reconstruction and different types of grafts have been used over the years. These include single-bundle techniques, double-bundle techniques, and single-bundle techniques with external tenodesis. We also distinguish between the use of autografts and grafts from donors, or allografts.\n\nThe choice of surgical technique and graft type is strongly influenced by the progression of damage characterizing these patients (meniscal, chondral, or ligamentous), the surgical decisions made during the initial surgery (graft used, orientation, and number of bone tunnels), or any complications that occurred.\n\nThe use of a specific type of graft is heavily dependent on its availability: it is likely that the first-choice graft for some surgeons may be unavailable because it has already been used. The use of allografts is now commonly accepted by the scientific community, with the Achilles tendon standing out for its biomechanical properties and size. Unlike autografts, it does not damage the patient's ligamentous tissue, which is thus preserved.\n\nSince osteoarthritis is one of the most debated consequences of anterior cruciate ligament revision, an analysis of the results is essential to provide a clearer understanding of the risks and benefits associated with the different types of procedures.",[26,27],"ACL","LET","RECRUITING","2026-06-30",{"date":31,"type":32},"2026-07-02","ACTUAL",{"date":34,"type":32},"2025-03-19",{"date":36,"type":22},"2027-01",{"name":38,"class":39},"Stefano Zaffagnini","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":48,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":40},"100644524","differences-in-outcomes-and-failure-rates-between-allografts-and-autografts-in-revision-anterior-cruciate-ligament-reconstruction-100644524","NCT07671235","Differences in Outcomes and Failure Rates Between Allografts and Autografts in Revision Anterior Cruciate Ligament Reconstruction","ACLREV_GRAFT","Inclusion Criteria:\n\nAge 18-50 years at the time of surgery Male and female patients Patients undergoing revision anterior cruciate ligament (ACL) reconstruction with possible associated procedures, with at least 2 years of follow-up Written informed consent to participate in the study\n\nExclusion criteria:\n\nPatients lost to follow-up Refusal to provide informed consent Advanced knee osteoarthritis (Outerbridge grade III-IV) at the time of surgery Severe obesity (BMI \\> 35) Lower limb conditions preventing full weight-bearing standing during evaluation Active infection, hematologic disease, or rheumatologic disease at the time of assessment",{"count":49,"type":22},150,"Anterior cruciate ligament (ACL) rupture is one of the most common knee injuries, particularly in young and physically active individuals. Despite advances in reconstruction techniques, graft failure and rerupture remain clinically relevant. Revision ACL surgery is more complex than primary reconstruction and is associated with inferior outcomes, with rerupture rates of approximately 13%, reaching up to 25% when both subjective and objective failure criteria are considered.\n\nThe main goal of ACL reconstruction is to restore anteroposterior and rotational knee stability, prevent secondary meniscal and cartilage damage, and enable return to sport. Surgical outcomes depend on several intraoperative factors, including graft choice and tunnel geometry, which are particularly relevant in revision settings.\n\nDiagnosis of ACL rerupture is primarily clinical, based on instability tests (Lachman, anterior drawer, pivot shift), and supported by instrumental assessment such as the KT-1000 arthrometer, which provides an objective measure of joint laxity.\n\nRevision ACL reconstruction can be performed using different surgical techniques (single-bundle, double-bundle, or combined extra-articular procedures) and graft types (autograft or allograft). Surgical strategy depends on multiple factors such as meniscal and cartilage status, previous surgery characteristics, tunnel positioning\u002Fenlargement, and fixation devices. However, no consensus exists regarding the optimal approach in terms of mid- to long-term outcomes.\n\nA major long-term complication is the development of osteoarthritis, particularly in this typically young and active patient population. Identification of modifiable factors, such as surgical technique and graft type, may help reduce failure risk and joint degeneration.\n\nThis study aims to evaluate clinical and radiographic outcomes over a follow-up period exceeding two years in patients undergoing revision ACL reconstruction with different surgical techniques and graft types. The study also integrates objective knee laxity assessment using KT-1000 and markerless motion analysis based on artificial intelligence. Functional movements are recorded via video and analyzed using Sports2D software, enabling 2D kinematic analysis without markers or sensors, providing quantitative functional data to complement clinical and radiographic evaluation.",[52,53],"ACL Injury","Graft Failure","NOT_YET_RECRUITING","2026-06-22",{"date":57,"type":32},"2026-06-26",{"date":59,"type":22},"2026-07",{"date":61,"type":22},"2027-05",{"name":38,"class":39},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":73,"conditions":74,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":76,"startDateStruct":77,"completionDateStruct":78,"leadSponsor":80,"locationsCount":40},"100644496","biological-evaluation-of-orthopedic-materials-an-in-vitro-study-using-patient-derived-human-samples-100644496","NCT07671521","Biological Evaluation of Orthopedic Materials: An In Vitro Study Using Patient-Derived Human Samples","RAISE","Femoral condyle, tibial plateau and synovial membrane samples\n\nPatients undergoing primary total knee arthroplasty at the Orthopaedic and Trauma Clinic II of the IRCCS Istituto Ortopedico Rizzoli (Bologna, Italy), in whom collection of tibial plateau, femoral condyles and\u002For synovial tissue is planned.\n\nInclusion criteria:\n\nAge 18-80 years, male or female Primary tricompartmental osteoarthritis Body Mass Index (BMI) \\\u003C 35 Kellgren-Lawrence grade III-IV osteoarthritis Written informed consent\n\nExclusion criteria:\n\nPrevious partial knee arthroplasty or cartilage repair\u002Fregenerative procedures Rheumatoid arthritis or chronic corticosteroid\u002Fimmunosuppressive therapy Positive testing for HIV, HBV or HCV infection Concentrated bone marrow (BMC) samples\n\nPatients of both sexes providing written informed consent and presenting with the following characteristics:\n\nInclusion criteria:\n\nAge 18-70 years Medial compartment knee osteoarthritis (Kellgren-Lawrence grade II-III for \\>4 months) Failure of ≥6 months of conservative treatment (NSAIDs\u002Fanalgesics, hyaluronic acid, corticosteroid or PRP injections) Written informed consent\n\nExclusion criteria:\n\nInability to provide informed consent Knee trauma within the previous 6 months Malignancy, rheumatic disease, uncontrolled diabetes, uncontrolled thyroid disorders Alcohol or drug abuse BMI \\> 35 Intra-articular injections within the previous 6 months Knee surgery within the previous 12 months HIV, HBV or HCV positivity Platelet-rich plasma (PRP) samples\n\nPatients of both sexes with degenerative cartilage disease of the knee.\n\nInclusion criteria:\n\nAge 18-65 years Clinical signs and symptoms of knee cartilage degeneration Radiographic or MRI evidence of degeneration (Kellgren-Lawrence grade II-IV) Hemoglobin \\> 11 g\u002FdL Platelet count \\> 150,000\u002Fmm³ No clinically relevant ECG abnormalities Written informed consent\n\nExclusion criteria:\n\nRheumatoid arthritis or chronic corticosteroid\u002Fimmunosuppressive therapy Uncontrolled diabetes Hematological disorders or anticoagulant\u002Fantiplatelet therapy Thyroid metabolic disorders Alcohol, drug or medication abuse NSAID use within 3 days prior to blood draw Cardiovascular disease contraindicating a 150 mL blood draw HIV, HBV or HCV positivity","80 Years",{"count":72,"type":22},50,"The anterior cruciate ligament (ACL) is the primary stabilizer of the knee joint, and ACL injuries are highly prevalent, particularly among physically active and athletic individuals. Although ACL reconstruction is a well-established orthopedic procedure, significant challenges remain regarding biological integration between the graft and bone, which may negatively affect clinical outcomes.\n\nIn recent years, advanced biomaterials and regenerative medicine approaches have gained increasing attention as potential strategies to enhance osteointegration and promote more physiological tissue healing. Before clinical application, these materials must undergo rigorous in vitro biological evaluation in accordance with international standards, particularly ISO 10993-5 for cytotoxicity assessment.\n\nThe study will investigate cytotoxicity, cell viability, inflammatory responses, pro-fibrotic effects, and osteogenic potential using relevant human cell models. The regenerative effects of platelet-rich plasma (PRP), a source of growth factors, will also be evaluated.\n\nThe biomaterials under investigation include a titanium alloy and polylactic acid (PLA), both widely used in orthopedic applications. The main objective is to demonstrate their biocompatibility, absence of cytotoxic, inflammatory, and pro-fibrotic effects, and their ability to support osteogenic processes and tissue integration. The findings will provide essential evidence for subsequent preclinical in vivo studies and future clinical translation.",[75],"Cytotoxicity",{"date":57,"type":32},{"date":59,"type":22},{"date":79,"type":22},"2028-06",{"name":38,"class":39},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":40},"100596746","clinical-and-biomechanical-outcomes-of-anterior-cruciate-ligament-acl-reconstruction-associated-with-lateral-extra-articular-tenodesis-let-100596746","NCT07049484","Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET)","Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET): a Short-term Prospective Arthrometric Study","LETOTT","Inclusion Criteria:\n\n* Patients undergoing isolated ACL reconstruction using gracilis and semitendinosus tendons with the over-the-top technique and LET.\n* Both male and female patients.\n* Patients who have given consent to participate in the study.\n* Age between 18 and 50 years at the time of surgery.\n\nExclusion Criteria:\n\n* Previous surgery on the same limb (meniscectomy, prior ACL reconstruction, displaced fractures).\n* Surgical technique different from Over-the-Top with LET using autologous gracilis and semitendinosus tendons.\n* Other concomitant ligament injuries requiring surgical treatment.\n* Patients undergoing additional procedures at the same time as ACL reconstruction and LET (e.g., concomitant osteotomy, meniscus transplant, cartilage procedure…).\n* Patients who did not provide informed consent.",{"count":90,"type":22},51,"The anterior cruciate ligament (ACL) is one of the main stabilizers of the knee joint, and its injury is among the most common soft tissue injuries of the knee. Several surgical reconstruction techniques are available, utilizing various tissues as a graft for the neo-ligament, including both autografts and allografts.\n\nThe \"Over-the-top single-bundle technique with gracilis and semitendinosus tendons combined with lateral extra-articular tenodesis (LET)\" was developed in 1998 by Prof. Marcacci and Prof. Zaffagnini, and it is still the preferred method for ACL reconstruction at the Second Clinic of the Rizzoli Orthopaedic Institute.\n\nCadaveric biomechanical studies have shown that combining LET with ACL reconstruction improves knee joint stability in both the anteroposterior and rotational planes. However, a recent in vivo study has challenged this hypothesis, showing that in patients undergoing surgery, the addition of LET enhances knee stability only in the anteroposterior direction and only for a limited period of six months. At twelve months postoperatively, joint laxity appeared similar to that of patients who did not undergo the additional procedure. Furthermore, the same study did not assess rotational instability using the pivot-shift test, an essential parameter as it is closely linked to knee stability and the patient's subjective perception of surgical success.\n\nDespite the increasing use of LET in conjunction with ACL reconstruction, few studies have analyzed the short-term postoperative effects of lateral extra-articular tenodesis and its potential benefits during the early stages of rehabilitation and return to sport.\n\nThis study was conceived in response to this clinical question, with the goal of evaluating anteroposterior and rotational laxity in a group of patients who underwent ACL reconstruction combined with LET, in order to analyze clinical outcomes and, most importantly, any changes in stability during the early postoperative period.\n\nThe results aim to improve understanding of knee stability in the initial phase following surgery, providing valuable information for rehabilitation teams to optimize recovery protocols and more effectively guide return-to-sport decisions for patients undergoing both procedures.",[93,94,95],"ACL Reconstruction","Tenodesis","ACL Injuries","2026-04-21",{"date":98,"type":32},"2026-04-22",{"date":100,"type":32},"2026-03-24",{"date":102,"type":22},"2029-06",{"name":38,"class":39},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":40},"100615192","evaluation-of-survival-and-clinical-outcomes-of-patients-treated-with-isolated-all-inside-meniscal-sutures-or-with-meniscal-sutures-associated-with-ligament-reconstruction-100615192","NCT07289412","Evaluation of Survival and Clinical Outcomes of Patients Treated With Isolated All-inside Meniscal Sutures or With Meniscal Sutures Associated With Ligament Reconstruction","Men Repair","Inclusion Criteria:\n\n* Both male and female patients.\n* Patients who underwent meniscal repair surgery using the all-inside technique for isolated meniscal lesions or lesions associated with ligament injuries between 01\u002F01\u002F2017 and 30\u002F06\u002F2025, with a minimum follow-up of two years.\n* Patients aged between 12 and 65 years at the time of surgery.\n* Patients who have provided consent to participate in the study.\n* Patients who underwent preoperative radiological investigations (MRI) of the affected knee showing meniscal lesions requiring surgical treatment, also confirmed during diagnostic arthroscopy.\n\nExclusion Criteria:\n\n* Meniscal lesions resulting from previous meniscal repairs.\n* Patients younger than 12 years or older than 65 years at the time of surgery.\n* Patients who did not provide informed consent.\n* Patients who are no longer contactable.\n* Patients who did not engage in sports activity in the 2 years prior to surgery","12 Years","65 Years",{"count":114,"type":22},300,"Meniscal tears are among the most common injuries of the knee joint. The average annual incidence is between 60 and 70 cases per 100,000 people. Among young athletes, these injuries account for 20-30% of all knee injuries, while in individuals over 50 they are frequently present even without symptoms (up to 60%). Meniscal tears often coexist with other intra-articular injuries: about one third of all cases occur together with an ACL rupture, which significantly increases the likelihood of a meniscal lesion. Possible treatments range from total meniscectomy, partial or selective meniscectomy, to meniscal suturing.\n\nCompared with meniscectomy, meniscal repair preserves meniscal function and reduces the risk of progression to knee osteoarthritis from 51.42% (after meniscectomy) to 21.28% in patients who undergo meniscal repair. The main meniscal suture techniques are classified as inside-out, outside-in, and all-inside.\n\nThe present study aims to analyze the failure rates in patients who underwent meniscal repair using the all-inside technique at a single referral center, evaluating the complication rate, the need for reoperation, and the clinical satisfaction of the operated patients.\n\nThe results obtained aim to improve the understanding of the effectiveness of all-inside meniscal sutures-electively used at our referral center-compared with inside-out techniques.\n\nThe purpose of this study is to collect and analyze the cases of patients surgically treated with all-inside sutures for isolated meniscal tears or tears associated with other ligament injuries. The goal is to evaluate the survival and reoperation rates in patients who underwent all-inside meniscal repair for isolated meniscal injuries or those associated with ligament injuries, aged between 12 and 65 years, operated on at the II Clinic of the Rizzoli Orthopaedic Institute between 01\u002F01\u002F2017 and 30\u002F06\u002F2025, with a minimum follow-up of 2 years.",[117,118],"Suture, Complication","Ligament Laceration","2026-04-15",{"date":121,"type":32},"2026-04-16",{"date":123,"type":32},"2026-02-25",{"date":125,"type":22},"2027-12",{"name":38,"class":39},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":137,"phases":138,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":40},"100600406","study-of-functional-magnetic-resonance-signal-variations-in-patients-undergoing-anterior-cruciate-ligament-reconstruction-with-the-application-of-a-dedicated-neuromotor-training-100600406","NCT07097077","Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Reconstruction With the Application of a Dedicated Neuromotor Training","ACL-fMRI-TNMT","Inclusion Criteria:\n\n* Patients who have undergone anterior cruciate ligament reconstruction surgery at any healthcare facility\n* Able to understand and consent, adults, who have provided informed consent to participate in the study\n* Male or female\n* Age between 18 and 30 years at the time of signing the informed consent\n* Tegner activity level \\> 6\n\nExclusion Criteria:\n\n* History and\u002For evidence of any neurological disorder or functional impairment;\n* Evidence of previous surgeries on the lower limb;\n* Inability to provide informed consent;\n* Inability to perform the tasks required by the procedure;\n* Pregnant or breastfeeding women;\n* Oncology patients;\n* Contraindications to undergoing MRI examinations.","30 Years",{"count":136,"type":22},12,"INTERVENTIONAL",[139],"NA","Lower limb injuries represent the majority of sports-related injuries, with knee injuries being among the most common. In particular, anterior cruciate ligament (ACL) injuries are considered highly devastating and career-threatening for both professional and amateur athletes. Current surgical and rehabilitation treatments often fail to provide fully satisfactory short- and long-term outcomes. A very high risk of re-injury exists, especially in younger patients, with up to 35% experiencing a second ACL injury, alongside a significant long-term risk of early knee osteoarthritis.\n\nMost ACL injuries are non-contact or indirect contact injuries, implicating biomechanical factors and neuromuscular control as key determinants of injury mechanisms. Recent literature shows that patients suffering a non-contact ACL injury have a higher risk of re-injury compared to those with contact injuries, suggesting a significant cognitive component in injury processing, surgery, rehabilitation, and return to sport.\n\nRecent rehabilitation studies have introduced targeted neuromotor training designed to \"rebuild\" biomechanical and neuromuscular patterns to avoid mechanisms leading to re-injury. Movement quality tests are used post-training to confirm the reduction of risky biomechanical patterns, often resulting in a score indicating movement quality.\n\nGiven the brain's involvement in such injuries, pioneering studies have used functional magnetic resonance imaging (fMRI) to investigate changes in cortical brain areas following ACL injury and reconstruction. Evidence shows adaptations in both central and peripheral nervous systems, with altered sensorimotor cortex activation in patients during simple motor tasks, differing from healthy subjects. Prefrontal cortex alterations correlate with severe quadriceps muscle activation asymmetries, linking these brain patterns to post-injury return-to-sport outcomes.\n\nHowever, no studies have yet evaluated the interaction between cortical activation (neural compensations) measured by fMRI and outcomes from targeted neuromotor training during ACL rehabilitation. Understanding brain activation implications is crucial for developing large-scale rehabilitation protocols to reduce the risk of a second, potentially more devastating, knee injury.\n\nThis study aims to reveal whether a neuromotor training protocol can positively influence cognitive brain areas related to human movement, particularly by reducing risky injury patterns. It will be the first to test whether dedicated neuromuscular training effectively reduces neural compensations and cortical activation related to non-automated movement, favoring automation areas important for a safe return to sport.\n\nPatients will directly benefit from participating in the innovative neuromotor training program, with functional MRI scans conducted before training begins (post-surgery) and after training completion. Indirectly, the study will assess whether neuromotor training can adapt patient neuromotor patterns to reduce re-injury risk, ultimately benefiting future patients undergoing ACL reconstruction.",[142,52,143,144],"fMRI","Rehabilitation Exercise","Neuromuscular Control",{"date":146,"type":32},"2026-02-27",{"date":148,"type":32},"2026-02-07",{"date":150,"type":22},"2027-07",{"name":38,"class":39},{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":163,"conditions":164,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":40},"100319659","acl-reconstruction-clinical-outcome-100319659","NCT03441659","ACL Reconstruction: Clinical Outcome","Anterior Cruciate Ligament Reconstruction: Clinical Outcome at Middle and Long Term Follow-Up","RIC-ACL","Inclusion Criteria:\n\n1. Patients who have provided informed written written consent;\n2. Patients aged between 18 and 60;\n3. Patients undergoing reconstructive surgical treatment of the anterior cruciate ligament (ACL)\n\nExclusion Criteria:\n\n1. Patients unable to understand and to want;\n2. Patients who have not signed informed consent;","60 Years",{"count":162,"type":22},1000,"The study is intended to include all patients who will undergo surgical reconstruction of the anterior cruciate ligament (ACL). The patients will be monitored and evaluated preoperatively and also at 6 months and 1, 2 and 5 years after the intervention through a clinical visit or telephone interview. Such assessments will include the administration of questionnaires to determine the patient's functional symptoms and the objective examination of the knee during a medical examination to quantify its stability.",[52],"2026-01-29",{"date":167,"type":32},"2026-02-02",{"date":169,"type":32},"2020-12-17",{"date":171,"type":22},"2030-12",{"name":38,"class":39},{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":112,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":40},"100606335","clinical-instrumental-evaluation-and-assessment-of-return-to-sports-activity-in-patients-surgically-treated-for-isolated-stener-like-lesions-of-the-medial-collateral-ligament-mcl-or-in-the-context-of-multiligament-injuries-and-articular-fractures-100606335","NCT07174219","Clinical-instrumental Evaluation and Assessment of Return to Sports Activity in Patients Surgically Treated for Isolated \"Stener-like\" Lesions of the Medial Collateral Ligament (MCL) or in the Context of Multiligament Injuries and Articular Fractures","STENER_MCL","Inclusion Criteria:\n\n* Patients of both male and female sex.\n* Patients who underwent surgical re-insertion of the distal insertion of the medial collateral ligament starting from 01\u002F01\u002F2020 and all patients scheduled for this type of surgical intervention until 12\u002F31\u002F2027;\n* Patients aged between 12 and 65 years at the time of surgery;\n* Patients who underwent isolated distal medial collateral ligament re-insertion surgery, as well as those who underwent the same procedure combined with other interventions on the same knee (e.g., multiligament injuries, reduction and osteosynthesis of bone fractures);\n* Patients who have given consent to participate in the study;\n* Patients who have undergone preoperative radiological investigations of the affected knee confirming the diagnosis of distal medial collateral ligament injury (MRI in the case of ligament injuries; X-ray and\u002For CT scan in the case of articular fractures).\n\nExclusion Criteria:\n\n* Previous fractures of the same limb treated surgically.\n* Patient age under 12 years at the time of surgery or patients over 65 years of age.\n* Patients who have not provided informed consent.\n* Patients who are no longer contactable.\n* Patients who have not engaged in sports activity in the 2 years prior to the surgical intervention.",{"count":181,"type":22},43,"The knee is a complex joint stabilized by four main ligaments: the anterior and posterior cruciate ligaments and the medial and lateral collateral ligaments. Multiligamentous knee injuries involve at least two ligaments and usually result from high-energy trauma, causing significant functional limitations.\n\nOne specific injury is the \"Stener-like\" lesion of the medial collateral ligament (MCL), characterized by an avulsion at its distal tibial insertion with interposition of tendons from the pes anserinus, which prevents natural healing. This lesion often occurs with other ligament or bone injuries and requires surgical treatment.\n\nDiagnosis is clinical, supported by MRI to confirm the distal lesion and tendon interposition. Despite its importance, literature on this injury is scarce, with only a few studies and case reports, often limited by small sample sizes and lack of standardized follow-up assessments.\n\nDue to the rarity and complexity of these injuries, there is a need for a comprehensive clinical study with standardized evaluations to improve understanding and develop standardized surgical treatments for isolated and associated Stener-like MCL lesions.",[184,185],"Ligament Injury","Knee Injuries","2025-09-15",{"date":188,"type":32},"2025-09-16",{"date":190,"type":32},"2025-09-10",{"date":192,"type":22},"2030-08",{"name":38,"class":39},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":40},"100596114","outcomes-and-complication-rates-of-anterior-cruciate-ligament-reconstruction-using-the-over-the-top-technique-combined-with-lateral-extra-articular-tenodesis-in-patients-over-50-years-old-compared-with-a-control-group-of-patients-under-30-100596114","NCT07041242","Outcomes and Complication Rates of Anterior Cruciate Ligament Reconstruction Using the \"Over-the-top\" Technique Combined With Lateral Extra-articular Tenodesis in Patients Over 50 Years Old, Compared With a Control Group of Patients Under 30","ACL_50_YO","Inclusion Criteria:\n\n* Patients operated on between 2007 and 2023 who were over 50 years old at the time of surgery (study group) and patients under 30 years old at the time of surgery (control group).\n* Patients who underwent ACL reconstruction using the gracilis and semitendinosus tendons with the over-the-top + LET technique.\n* Patients of both male and female sex.\n* Patients who have provided consent to participate in the study.\n\nExclusion Criteria:\n\n* Previous surgery on the same limb (meniscectomy, prior ACL reconstruction, surgically treated fractures, osteotomies, meniscal transplants).\n* Concomitant surgery on the same limb (osteotomies, meniscal transplants).\n* Surgical technique different from the over-the-top with LET using autologous gracilis and semitendinosus tendons.\n* Other concomitant ligament injuries requiring surgical treatment.\n* Patients younger than 18 years at the time of surgery (minors) or patients aged between 30 and 50 years at the time of surgery.\n* Patients who have not provided informed consent.\n* Patients with a follow-up period shorter than 2 years.",{"count":202,"type":22},164,"The anterior cruciate ligament (ACL) is one of the main stabilizers of the knee, and its injury is among the most common soft tissue injuries of the knee. Surgical reconstruction of the ACL can be performed using various techniques and different types of tissue grafts, including both autografts and allografts.\n\nAlthough ACL reconstruction is a widely performed surgical procedure in young and physically active individuals-typically patients under 30 years of age-to promote return to sports and prevent early onset of osteoarthritic degeneration, the surgical approach has historically been less common in patients over the age of 50. This is largely due to the lower functional demands typically observed in older patients.\n\nHowever, with increasing life expectancy and a corresponding rise in functional demands among older individuals, the surgical approach to ACL reconstruction has been progressively reconsidered in the over-50 population. Several recent studies have aimed to evaluate the outcomes of ACL reconstruction in older adults, showing promising results in terms of both recurrence rates and complication rates.\n\nAt the II Clinic of the Rizzoli Orthopaedic Institute, under the direction of Professor Zaffagnini, the preferred technique for ACL reconstruction is the \"single-bundle over-the-top technique using gracilis and semitendinosus tendons, combined with a lateral extra-articular tenodesis (LET).\" LET is an additional surgical step performed alongside ACL reconstruction, which has shown excellent results, especially in young patients at high risk of reinjury. Specifically, clinical data have shown that adding LET to ACL reconstruction can reduce the failure rate by approximately 30%, significantly improve knee stability, and enable a faster return to sports-all without increasing the rate of complications compared to the standard isolated ACL reconstruction technique.\n\nGiven these encouraging results in terms of safety and reduced failure rates, the combined ACL + LET procedure has historically been used at the Rizzoli Orthopaedic Institute for all patients, including those over 50 years of age.\n\nThe consistent use of this technique allows for the creation of a homogeneous patient cohort, all treated with the same surgical approach. This also enables the formation of two comparable patient groups-one over 50 and one under 30-both treated with the same technique, allowing for a meaningful comparison of primary and secondary endpoints.\n\nWhile several studies have aimed to compare ACL reconstruction outcomes in older populations with those in younger cohorts, to date, there are no studies in the literature that specifically assess the outcomes and complication rates of ACL reconstruction using the over-the-top technique combined with LET in patients over 50, and compare them with those of younger patients undergoing the same surgical procedure.\n\nGiven the growing demand for ACL reconstruction in older patients, we believe it is important to evaluate outcomes in patients over 50 and compare them with a younger cohort, to determine whether the over-the-top + LET technique may be a valid therapeutic option not only for young patients but also for older adults.\n\nOf particular interest is the assessment of the reduced risk of failure and complication rate of the ACL + LET technique performed in over-50 patients, to determine whether the excellent clinical outcomes observed in younger individuals are also confirmed in an older population.",[26,27,205],"Hamstring Muscles","2025-07-14",{"date":208,"type":32},"2025-07-17",{"date":210,"type":32},"2025-07-13",{"date":212,"type":22},"2027-06",{"name":38,"class":39},""]