[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100622635","collagenic-vs-collagen-enriched-graft-in-sinus-elevation-rct-100622635",false,"NCT07386184","Collagenic vs Collagen-enriched Graft in Sinus Elevation: RCT","Histological and Radiological Evaluation of Collagenic Porcine Graft vs Collagen-enriched Bovine-derived Graft in Transcrestal Sinus Elevation. A Randomized Prospective, Controlled Study.","C vs CE","Inclusion Criteria:\n\n* Patient requiring vertical elevation of the maxillary sinus floor.\n* Residual alveolar bone height of edentulous maxilla below the floor of the maxillary sinus \\\u003C5 mm.\n* Males and females between 30-80 years old\n* Patients with healthy periodontal conditions (treated periodontitis, PI\\\u003C25%, BoP\\\u003C25%).\n* Patients willing to sign an informed consent and participate in a clinical study.\n* Generally fit and healthy and able to undergo oral surgical procedures under local anesthesia.\n* Teeth at the surgical site requiring extraction were removed at least 12 weeks prior to sinus floor elevation.\n\nExclusion Criteria:\n\n* Patients who smoke more than 5 cigarettes\u002Fday\n* Pregnancy (confirmed by verbal inquiry)\n* Chronic systemic pathologies (e.g. diabetes) and neoplasms of the oro-facial district.\n* Patients undergoing treatment with antiresorptive agents.\n* Patients receiving systemic corticosteroid therapy.\n* Any site with a history of implant failure.\n* Dental sites with acute infections.\n* Chronic inflammatory diseases of the oral cavity.\n* Autoimmune diseases.\n* Documented hypersensitivity to any of the medications intended for use during the treatment protocol.\n* Substance abusers.\n* Patients with known collagen hypersensitivity.\n* Patients with hypersensitivity to porcine-derived materials.\n* History of malignant tumors of the maxillary sinus.\n* History of head\u002Fneck radiation therapy.","ALL","30 Years","80 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to histologically understand if collagenic or collagen enriched graft in sinus lift of healthy volunteers needing for implants in the posterior maxillae may work. The main question it aims to answer are:\n\nwhich material works better histologically and radiologically? Researchers will compare a collagenic graft to collagen enriched graft to see if the osteointegration of the material is the same.\n\nParticipants will undergo a sinus lift with one of the two materials and after six month will undergo a bone sample collection to allow the implant insertion.\n\ntwelve moths thereafter, a radiograph will be taken to measure the extension of the bone regeneration and implant behavior",[28],"Sinus Lift Augmentation",[30],"Randomized controlled prospective clinical trial","NOT_YET_RECRUITING","2026-03-09",{"date":34,"type":35},"2026-03-10","ACTUAL",{"date":37,"type":22},"2026-03-19",{"date":39,"type":22},"2027-12-01",{"name":41,"class":42},"Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100604945","prosthetic-modality-and-mbl-100604945","NCT07156110","Prosthetic Modality and MBL","The Effect of Prosthetic Modality on Bone Level Changes During One-Year Follow-Up","Inclusion criteria: 1. Male or female ≥18 years old. 2. One or more adjacent missing teeth in the posterior maxilla or mandible (positions 4-7). A natural tooth had to be present at the mesial end; however, free-end situations were allowed. 3. Adequate bone quality )D1-3) and availability for Lance Conical implant (MIS Implants, Israel) placement of diameters 3.75 mm or 4.2 mm, length 10-13 mm, 4. Patients are willing to participate and attend the planned follow-up visits.\n\nSystemic exclusion criteria: 1. Medical conditions requiring prolonged use of steroids and\u002For medications that can interfere with bone metabolism. 2. History of leukocyte dysfunction and deficiencies. 3. History of neoplastic disease requiring the use of radiation or chemotherapy. 4. History of renal failure. 5. Metabolic disorders such as osteoporosis. 6. History of uncontrolled endocrine disorders. 7. Physical handicaps that would interfere with the ability to perform adequate oral hygiene. 8. Use any investigational drug or device within 30 days immediately before implant surgery. 9. Alcoholism or any drug abuse. 10. History of immunodeficiency syndromes. 11. Smokers of 10 cigarettes per day, cigar equivalents, or tobacco chewers. 12. In the investigator's opinion, conditions or circumstances would prevent completion of study participation or interfere with the analysis of the study results, such as history of non-compliance or unreliability.\n\nLocal exclusion criteria\n\n1. Any bone augmentation performed on the implant site with a healing period of less than 3 months.\n2. Local inflammation (including untreated periodontitis).\n3. Mucosa disease such as erosive lichen planus\n4. History of local irradiation therapy.\n5. Presence of osseous lesions\n6. History of implant failure\n7. Postextraction sites with less than 6 weeks of healing\n8. Sever bruxism or cjenching habits\n9. Persistent intraoral infection.\n10. Bone type 4.\n\nExclusion criteria at surgery\n\n1. Lack of primary stability less than 35 Ncm.\n2. Need for augmentation procedures during implant surgery.\n3. Inability to place the implant according to the prosthetic requirements.",true,"18 Years",{"count":53,"type":22},60,[25],"The present study will test the effect of different prosthetic modalities on conical and internal hex connection implants, assessing the radiographic MBL changes after one year.\n\nConsecutive patients fulfilling inclusion\u002Fexclusion criteria will enter the study. Once the implant is inserted, patients will be divided into three groups according to the time if their inclusion in the study.\n\nStudy groups (20 patients per group):\n\n1. Group 1: Placing Lance Conical implant with a healing abutment. Three months later, after an impression, a screw-retained restoration will be seated using a Ti-Base abutment.\n2. Group 2: Placing Lance+ (Internal Hex connection) implant with a healing abutment. Three months later, after an impression, a screw-retained restoration will be seated using a Ti-Base abutment.\n3. Group 3: Placing Lance Conical implant together with Connect Abutment (tightened to 30 Ncm) with a Connect healing cap (\"one time one abutment\"). Screw retained restoration after 3 months.\n\nConsecutive inclusion of patients - 1st- group 1, 2nd - group 2, 3rd - group 3 and vice versa.\n\nPrimary outcome variable: bone level changes 12 months post-loading",[57],"Bone Loss",[59,60,61],"Marginal bone level changes","prosthetic modalities","soft tissue adaptation","RECRUITING","2025-09-03",{"date":65,"type":35},"2025-09-04",{"date":67,"type":22},"2025-09-01",{"date":69,"type":22},"2026-12-31",{"name":41,"class":42},1,""]