[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"StudySetGo\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100642255","the-effect-of-a-daily-magnesium-and-melatonin-supplement-on-sleep-quality-in-people-with-nighttime-leg-cramps-100642255",false,"NCT07651514","The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg Cramps","An Investigation Into the Effect of a Daily Magnesium and Melatonin Based Multi-Ingredient Dietary Supplement on Sleep Quality in Individuals With Self-Reported Nighttime Leg Cramps.","MISIT","Inclusion Criteria:\n\n* Adults aged 40-75 years\n* Self-reported poor sleep quality (PSQI \\>5) at screening\n* Self-reported nocturnal leg cramp averaging ≥4 episodes per fortnight at screening\n* Capacity to understand and provide electronic informed consent\n* Willing to wear an Oura Ring wearable device continuously throughout the study period\n* Access to a smartphone\u002Ftablet with iOS 15 or higher and Android 9 or higher and willing to install and use the Oura and Trialflare applications\n* Be a resident of and permanently living in Florida with no planned travel across more than one time zone for at least 1 night during the study period\n\nExclusion Criteria:\n\n* Current or recent (within 4 weeks of randomisation) use of melatonin, magnesium, or other supplements specifically taken for sleep or leg cramps or listed as an ingredient of the intervention supplement.\n* Current use of any prescription medication\n* Diagnosed sleep disorder (e.g. obstructive sleep apnoea, restless legs syndrome, insomnia disorder)\n* Known or suspected secondary cause of nocturnal leg cramps (e.g. peripheral vascular disease, neurological condition, renal impairment, thyroid disorder)\n* Any current or prior diagnosis of:\n* Cancer or malignancy of any kind (prior malignancy is not exclusionary if the participant is in confirmed remission and has completed all treatment)\n* Cardiovascular disease (e.g. hypertension, coronary artery disease, heart failure, arrhythmia, stroke, peripheral vascular disease)\n* Autoimmune disorder (e.g. rheumatoid arthritis, lupus, multiple sclerosis)\n* Gastrointestinal disorder (e.g. IBS, malabsorption syndromes)\n* Neurological disorder (e.g. epilepsy, Parkinson's disease, dementia)\n* Hepatic or renal impairment\n* Diabetes mellitus (type 1 or type 2)\n* Severe psychiatric disorder (e.g. schizophrenia, bipolar disorder)\n* Myasthenia Gravis\n* Known hypersensitivity or allergy to any ingredient in the active or placebo product\n* Rotating shift work or irregular sleep patterns\n* Current participation in another interventional clinical trial\n* Inability to comply with study procedures or remote visit schedule\n* Breastfeeding, pregnant, or planning to become pregnant during the study period",true,"ALL","40 Years","75 Years",{"count":22,"type":23},50,"ESTIMATED","INTERVENTIONAL",[26],"NA","Participants are being invited to take part in a research study. Before deciding whether to take part, it is important for participants to understand why the research is being done and what it will involve.\n\nPurpose: This study will investigate whether a multi-ingredient nutritional supplement containing magnesium and melatonin can improve sleep quality in adults who experience disrupted sleep due to nighttime leg cramps.\n\nWhat participation involves: Participation lasts 8 weeks. Participants will be randomly assigned to take either the nutritional supplement or a placebo (inactive look-alike) every night before bed for 6 weeks. Participants will wear an Oura Ring wearable device on one finger continuously for 8 weeks throughout the study and complete short questionnaires using a smartphone app. The Oura Ring and study supplement will be sent to the participant's home address. Participants will never need to travel to a research centre; all contact with the research team will be by video call, phone, messaging, or email.\n\nHow long: Total involvement will be 8 weeks, made up of a 2-week baseline period and a 6-week supplementation period. Each day, participants will complete a short app-based questionnaire (approximately 1 minute). At the end of weeks 2, 4, 6, and 8, participants will complete additional app-based questionnaires (approximately 10 minutes).",[29,30],"Poor Sleep Quality","Leg Cramps, Nocturnal","RECRUITING","2026-06-10",{"date":34,"type":35},"2026-06-16","ACTUAL",{"date":32,"type":23},{"date":38,"type":23},"2026-09-10",{"name":40,"class":41},"StudySetGo","NETWORK",""]