[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Suez Canal University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":639},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,50,74,87,113,137,170,197,225,249,286,308,329,347,367,391,416,438,463,495,518,538,563,592,612],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100053808","pro-stress-trial-proactive-low-dose-norepinephrine-to-reduce-intraoperative-fluid-administration-in-patients-at-high-risk-for-postoperative-pulmonary-complications-undergoing-laparoscopic-abdominal-surgery-100053808",false,"NCT07627360","PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery","Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial","PRO STRESS","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for elective laparoscopic major abdominal surgery under general anesthesia with an expected duration greater than 2 hours.\n* Patients with ARISCAT score ≥ 45 indicating high risk for postoperative pulmonary complications.\n\nExclusion Criteria:\n\n* Known hypersensitivity to norepinephrine.\n* Severe left ventricular dysfunction with ejection fraction \\\u003C 35%.\n* Significant cardiac arrhythmia.\n* Uncontrolled hypertension defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg.\n* End-stage renal disease.\n* Requirement for vasopressor support before induction of anesthesia.\n* Emergency surgery.","ALL","18 Years",{"count":21,"type":22},130,"ESTIMATED","INTERVENTIONAL",[25],"NA","Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications. This randomized double-blind controlled trial evaluates whether proactive administration of fixed low-dose norepinephrine reduces intraoperative crystalloid administration while maintaining hemodynamic stability in high-risk patients undergoing laparoscopic abdominal surgery. One hundred and thirty patients will be randomized to receive either norepinephrine infusion (0.03 µg\u002Fkg\u002Fmin) or placebo from induction until skin closure within a protocolized hemodynamic strategy guided by mean arterial pressure and pulse pressure variation.",[28,29,30],"Intraoperative Hypotension","Postoperative Pulmonary Complications (PPCs)","Fluid Over-load",[32,33,34,35,36],"Norepinephrine","Fluid Therapy","Pulmonary Complications","Abdominal Surgery","Vasopressor","NOT_YET_RECRUITING","2026-07-10",{"date":40,"type":41},"2026-07-13","ACTUAL",{"date":43,"type":22},"2026-07-15",{"date":45,"type":22},"2026-11",{"name":47,"class":48},"Suez Canal University","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100644440","extracorporeal-shock-wave-therapy-to-kegels-exercise-in-management-of-female-stress-urinary-100644440","NCT07663968","Extracorporeal Shock Wave Therapy to Kegel's Exercise in Management of Female Stress Urinary","Additive Role of Low-intensity Extracorporeal Shock Wave Therapy to Kegel's Exercise in Management of Female Stress Urinary Incontinence : A Prospective Randomized Study","Inclusion Criteria:\n\n* Married Females\n* Diagnosed with stress urinary incontinence, confirmed by clinical evaluation.\n* Ability and willingness to perform KE and attend follow-up visits.\n* Accepting informed consent.\n\nExclusion Criteria:\n\n* Mixed urinary incontinence.\n* Active urinary tract infection (symptomatic or laboratory) confirmed).\n* Known coagulopathy or ongoing anticoagulant therapy.\n* Neurological disorders (e.g., multiple sclerosis, stroke, spinal cord injury) or use of medications affecting bladder control.\n* Pregnancy or recent childbirth (within 6 months)\n* History of pelvic malignancy affecting urinary continence.\n* History of recent surgical intervention or indicated for surgery for urinary incontinence.","FEMALE","25 Years","60 Years",{"count":61,"type":22},84,[25],"Stress urinary incontinence (SUI) is a common pelvic floor disorder among women, especially those with a history of childbirth, aging, or pelvic surgery. Stress urinary incontinence is defined as the complaint of involuntary leakage on effort or exertion, or on sneezing or coughing.\n\nThe condition significantly affects quality of life, emotional well-being, and daily functioning.",[65],"Female Stress Urinary Incontinence","2026-06-18",{"date":68,"type":41},"2026-06-23",{"date":70,"type":22},"2026-07-01",{"date":72,"type":22},"2027-10-30",{"name":47,"class":48},{"id":75,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":23,"phases":77,"briefSummary":26,"conditions":78,"keywords":79,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":86,"locationsCount":49},"100639434",{"count":21,"type":22},[25],[28,29,30],[32,33,34,35,36],"2026-05-31",{"date":82,"type":41},"2026-06-04",{"date":84,"type":22},"2026-05-23",{"date":45,"type":22},{"name":47,"class":48},{"id":88,"slug":89,"hasResults":12,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":49},"100638195","regenerative-endodontics-in-mature-necrotic-teeth-100638195","NCT07584928","Regenerative Endodontics in Mature Necrotic Teeth","Assessment of Clinical Success and Postoperative Pain of Mature Necrotic Teeth With Chronic Apical Periodontitis After Single Visit Regenerative Endodontics Using Different Irrigation Protocols: a Randomized Controlled Clinical Trial","Inclusion Criteria: -adult patients in the age range 18-40 years with necrotic mature anterior teeth with chronic apical periodontitis as evidenced by apical radiolucency.\n\n* patients with good general health, without known systemic diseases or allergic reactions to any of the material used affecting healing outcome, with no sex predilection\n\nExclusion Criteria:\n\n* medically compromised patients, systemic conditions e.g. uncontrolled diabetes or those on immunosuppressive drugs.\n* pregnant females\n* patients with generalized chronic periodontitis, mobility, and deep pockets\n* non-restorable teeth or teeth with open apices\n* teeth where post is needed to be restored or with previous root canal therapy\n* teeth with developmental anomalies, external and internal resorption","40 Years",{"count":96,"type":22},60,[25],"The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential \\& postoperative pain after using different irrigation protocols. The main question it aims to answer are:\n\nDoes nanochitosan can demonstrate clinically successful outcome, minimize postoperative pain \\& flare ups? What is the regenerative potential of mature necrotic teeth with chronic apical periodontitis? Is regeneration an alternative treatment modality for mature necrotic teeth with apical periodontitis? Researcher will compare the regenerative potential \\& postoperative pain after using 2.5% NaOCl+ 17% EDTA, 1% nanochitosan \\& 1% nanochitosan+17% EDTA to see if 1% nanochitosan alone or when used with 17% EDTA can enhance regeneration.\n\nParticipants' root canals will be:\n\nDivided into 3 groups \\&irrigated thoroughly by the different irrigation protocols (2.5% NaOCl+ 17% EDTA, 1% nanochitosan \\& 1% nanochitosan+ 17% EDTA) Regenerative procedures will be done Clinical sensibility test \\& radiographic changes will be evaluated at 6\\&12 months follow up periods Detection of inflammatory mediators from GCF at 6 months follow up periods to be compared with its preoperative levels as a predictor for success or failure Assessment of postoperative pain using Numerical Rating Scale at 6, 12, 24 hours then daily for 7 days",[100],"Necrotic Teeth With Chronic Apical Periodontitis",[102,103,104,105],"Regeneration","Mature necrotic teeth","Nanochitosan","Inflammatory mediators",{"date":107,"type":41},"2026-06-03",{"date":109,"type":22},"2026-08-01",{"date":111,"type":22},"2027-12-01",{"name":47,"class":48},{"id":114,"slug":115,"hasResults":12,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":12,"sex":18,"minAge":120,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100639179","tens-in-nocturnal-enuresis-100639179","NCT07594353","TENS in Nocturnal Enuresis","Maintenance Parasacral Electrical Nerve Stimulation Versus Observation After Initial Response in Children With Primary Nocturnal Enuresis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of primary monosymptomatic nocturnal enuresis (PMNE) based on International Children's Continence Society (ICCS) criteria.\n* Persistent symptoms after at least 8 weeks of standardized urotherapy, including counseling on timed voiding, evening fluid management, and bowel optimization.\n* Baseline severity of ≥3 wet nights per week on a 14-night diary.\n* Ability of the child and caregiver to complete diaries and comply with home treatment and follow-up.\n\nExclusion Criteria:\n\n* Non-monosymptomatic enuresis, daytime urgency, daytime incontinence, dysfunctional voiding, or significant post-void residual.\n* Neurogenic bladder, spinal dysraphism, cerebral palsy, epilepsy uncontrolled on treatment, or other neurologic diseases affecting lower urinary tract function.\n* Congenital or acquired urinary tract abnormalities.\n* Active urinary tract infection.\n* Untreated or refractory constipation at enrollment.\n* Implanted electrical devices, significant dermatologic lesions at electrode sites, or other contraindications to electrical stimulation.\n* Cognitive, behavioral, or social circumstances preventing adherence.","5 Years","16 Years",{"count":123,"type":22},50,[25],"Paracascral transcutaneous electrical nerve stimulation (PTENS) is a credible therapeutic option for nocturnal enuresis. The investigators shall investigate whether maintenance PTENS after initial response improves durability of remission compared with observation alone.",[127],"Nocturnal Enuresis in Children",[129],"TENS","2026-05-22",{"date":132,"type":41},"2026-05-27",{"date":70,"type":22},{"date":135,"type":22},"2027-02-28",{"name":47,"class":48},{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":144,"sex":18,"minAge":145,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":154,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":49},"100640017","autologous-demineralized-dentin-graft-with-or-without-melatonin-for-immediate-implant-osseointegration-100640017","NCT07610876","Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration","Effect of Autologous Demineralized Dentin Graft With or Without Melatonin Gel on the Osseo Integration of Immediately Placed Implants: A Randomized Clinical Study","Inclusion Criteria:\n\n* Age above 20 years\n* Non-restorable maxillary premolar teeth\n* Candidates for immediate implant placement\n* Intact socket walls\n* Jumping gap \\>2 mm\n* Non-smokers or light smokers\n* No acute infection\n* Adequate bone for primary stability\n\nExclusion Criteria:\n\n* Heavy smokers\n* Bruxism or clenching\n* Uncontrolled systemic disease\n* Chemotherapy\u002Fradiotherapy\n* Immunocompromised patients",true,"20 Years",{"count":147,"type":22},16,[25],"This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar region. Sixteen patients requiring extraction and immediate implant placement will be randomly allocated into two groups. Clinical and radiographic outcomes including implant stability, peri-implant probing depth, modified bleeding index, marginal bone loss, buccal bone thickness, and bone density will be evaluated over a 9-month follow-up period.",[151,152,153],"Dental Implants","Immediate Implant Placement","Osseointegration",[155,156,157,158,153,159,160],"Melatonin","Dentin graft","Immediate implant","ADDG","CBCT","Dental implant stability","RECRUITING","2026-05-20",{"date":164,"type":41},"2026-05-28",{"date":166,"type":41},"2025-08-11",{"date":168,"type":22},"2026-11-10",{"name":47,"class":48},{"id":171,"slug":172,"hasResults":12,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":12,"sex":18,"minAge":94,"maxAge":59,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":179,"briefSummary":180,"conditions":181,"keywords":184,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":196,"locationsCount":4},"100638907","injectable-alloplastic-bone-graft-for-socket-preservation-clinical-radiographic-and-histological-evaluation-100638907","NCT07595445","Injectable Alloplastic Bone Graft for Socket Preservation: Clinical, Radiographic, and Histological Evaluation","Clinical, Radiographic, and Histological Evaluation of Injectable Alloplastic Bone Graft in Extraction Socket Preservation","Inclusion Criteria:\n\n* Patient aged between 40 and 60 years.\n* General good health.\n* Presence of a hopeless mandibular posterior tooth that requires extraction.\n* Volunteer subjects have to voluntarily sign an informed consent.\n* Patient Indicated for implant.\n\nExclusion Criteria:\n\n* Patient with systemic disease affection bone metabolism.\n* Large periapical radiographic changes related to the tooth to be Extracted, in the form of abscess, granuloma, or cyst.\n* Teeth need trans-alveolar extraction.\n* Patients with contraindication to surgical treatment.\n* Patients suffering from a psychological disorder.\n* Patients with uncontrolled medical conditions.",{"count":178,"type":22},20,[25],"This study will evaluate the clinical efficacy of injectable alloplastic bone grafts in terms of radiography and histology in order to preserve tooth sockets following extraction. Methodology: Twenty new extraction sockets from twenty surgically extracted non-restorable mandibular molar teeth will be used in this clinical investigation.",[182,183],"Tooth Extraction","Socket Preservation",[185,183,186,187,188,189],"Injectable Alloplastic Bone Graft","Bone Regeneration","Clinical Evaluation","Radiographic Evaluation","Histological Evaluation","2026-05-14",{"date":192,"type":41},"2026-05-19",{"date":194,"type":22},"2026-08",{"date":45,"type":22},{"name":47,"class":48},{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":12,"sex":18,"minAge":204,"maxAge":205,"enrollmentInfo":206,"targetDuration":4,"studyType":23,"phases":208,"briefSummary":209,"conditions":210,"keywords":214,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":49},"100638031","the-objective-of-this-research-is-to-compare-the-clinical-effectiveness-of-the-conventional-lingual-arch-space-maintainers-with-three-dimensional-printed-space-maintainers-100638031","NCT07591324","the Objective of This Research is to Compare the Clinical Effectiveness of the Conventional Lingual Arch Space Maintainers With Three-dimensional Printed Space Maintainers.","Comparative Evaluation of the Conventional and Three-Dimensional Printed Lower Lingual Arch Space Maintainers A Randomized Clinical Trial","Inclusion Criteria:\n\n* Apparently, healthy cooperative children have recently prematurely loss of more than one mandibular primary molar in any of the quadrants, full erupted mandibular first permanent molars in both sides, and whose lower permanent incisors have erupted\n* The permanent successors of the lost primary molars were not expected to erupt within 6 months\n* Angle's class 1 occlusion with normal primary molar relation\n* Caries-free and periodontally healthy abutment teeth\n* Absence of parafunctional habits or abnormal occlusion conditions such as crossbite, open bite, or deep bite.\n* Children's age ranges from 7 to 9 years-old\n* Radiographically, presence of permanent successors, more than one millimeter of bone covering the successor tooth germ, and\u002For only about one-third of the root of the permanent tooth has been formed.\n* Parents and children were accepting the new treatment modality.\n\nExclusion Criteria:\n\n* children exhibited poor oral hygiene, para-functional oral habits, severe crowding, space loss, and abnormal occlusion\n* Extraction of primary molars exceeding three months.\n* Radiographically, absence of permanent successor.\n* uncooperative children","7 Years","9 Years",{"count":207,"type":22},44,[25],"the objective of this research is to compare the clinical effectiveness of the conventional lingual arch space maintainers with three-dimensional printed space maintainers.",[211,212,213],"Gingival Health","Space Maintenance","Pain and Anxiety",[215,216],"lingual arch spacemaintainer","3D printed spacemaintainer","2026-05-12",{"date":219,"type":41},"2026-05-15",{"date":221,"type":41},"2025-01-22",{"date":223,"type":22},"2026-09-01",{"name":47,"class":48},{"id":226,"slug":227,"hasResults":12,"nctId":228,"briefTitle":229,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":144,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":231,"targetDuration":4,"studyType":23,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":4},"100640801","comparative-assessment-of-primary-stability-by-osseodensification-using-densah-burs-conventional-drilling-methods-100640801","NCT07586475","Comparative Assessment of Primary Stability by Osseodensification Using Densah Burs Conventional Drilling Methods.","Inclusion Criteria:\n\n* Male and female patients\n* Patients requiring dental implant placement in areas with varying bone quality\n* Patients without systemic diseases that interfere with bone healing or implant success (e.g., uncontrolled diabetes mellitus or osteoporosis)\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting bone metabolism\n* Presence of large periapical radiographic lesions related to the tooth to be extracted (abscess, granuloma, or cyst)\n* Teeth requiring transalveolar extraction\n* Patients with contraindications to surgical treatment\n* Patients with psychological disorders\n* Patients with uncontrolled medical conditions",{"count":178,"type":22},[25],"This clinical study evaluates and compares the primary stability of dental implants placed using osseodensification with Densah burs versus conventional drilling methods. The goal is to determine whether osseodensification improves implant stability and bone density, especially in areas with low bone quality",[235],"Patient With Low Denisty Bone",[237,238,239,240,241],"dental impant","primary stability","ossseodensfication","densah burs","conventional osteotomy","2026-05-07",{"date":190,"type":41},{"date":245,"type":22},"2026-12",{"date":247,"type":22},"2027-12",{"name":47,"class":48},{"id":250,"slug":251,"hasResults":12,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":256,"targetDuration":4,"studyType":23,"phases":258,"briefSummary":259,"conditions":260,"keywords":263,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":49},"100634983","metagenomic-analysis-and-postoperative-pain-in-infected-root-canals-using-different-irrigation-protocols-100634983","NCT07546773","Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols","Metagenomic Analysis and Post-operative Pain Assessment of Infected Root Canals Using Different Irrigation Protocols: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 18-60 years\n* Requiring root canal treatment for teeth with necrotic pulp\n* Presence of periapical radiolucency confirmed radiographically\n* Good general health with no systemic diseases affecting healing outcomes\n* Willing to provide informed written consent\n* Available for follow-up appointments\n\nExclusion Criteria:\n\n* Patients with open apices\n* Severe periodontal disease\n* Currently taking antibiotics\n* Allergy to study materials (lidocaine, sodium hypochlorite, methylene blue, latex)\n* Pregnant or breastfeeding women\n* Compromised immunity or systemic conditions (e.g., uncontrolled diabetes, HIV, immunosuppressive therapy)\n* Previous root canal treatment on the study tooth\n* Tooth not restorable\n* Presence of vertical root fracture",{"count":257,"type":22},40,[25],"Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure irrigation (PulpSucker device), and mechanical activation (Easy Clean device), have shown promise in enhancing bacterial reduction within the root canal system. However, their impact on postoperative pain has not been fully explored.\n\nThis randomized controlled clinical trial aims to compare bacterial reduction and postoperative pain levels in infected root canals using four different irrigation protocols. The study will use metagenomic analysis to evaluate changes in bacterial community composition and the Visual Analogue Scale (VAS) to assess patient-reported pain levels at multiple time points postoperatively.",[261,262],"Dental Pulp Necrosis","Pulpitis",[264,265,266,267,268,269,270,271,272,273,274,275,276,277],"Root canal treatment","Irrigation protocol","Ultrasonic activation","Laser activation","Negative pressure irrigation","Mechanical activation","Metagenomic analysis","Postoperative pain","Visual analogue scale","Bacterial reduction","Endodontics","PulpSucker","Easy clean device","Next generation sequencing","2026-04-28",{"date":280,"type":41},"2026-05-04",{"date":282,"type":22},"2026-04-30",{"date":284,"type":22},"2028-01-15",{"name":47,"class":48},{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":293,"targetDuration":4,"studyType":23,"phases":294,"briefSummary":295,"conditions":296,"keywords":298,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":307,"locationsCount":49},"100595652","evaluation-of-tenting-the-schneiderian-membrane-of-the-maxillary-sinus-using-titanium-mesh-100595652","NCT07035236","Evaluation of Tenting the Schneiderian Membrane of the Maxillary Sinus Using Titanium Mesh.","Clinical, Radiographic and Histologic Evaluation of Tenting the Schneiderian Membrane Using Titanium Mesh for Maxillary Sinus Lift Procedure: A Randomized Controlled Study","Inclusion Criteria:\n\n* Adult male\u002Ffemale patients with age interval 18:60 years old.\n* Patients with one or more teeth requiring implant supported dental restoration in atrophic maxilla.\n* Alveolar bone height less than 5 mm at the defective site.\n* Good oral hygiene.\n* Patient's consensual agreement to be enrolled in the study.\n\nExclusion Criteria:\n\n* Medically compromised patients with conditions contraindicating surgery (eg. uncontrolled diabetics, bisphosphonate intake, radio or chemotherapy).\n* Patients with active infection at or related to the site of surgery (eg. acute sinusitis).\n* Heavy smokers.\n* Patients not indicated for an implant supported restoration at the time of enrollement (eg. active\u002Funtreated periodontal disease). (Patients developing any medical condition that interferes with the outcomes after enrolment in the study will be excluded).",{"count":178,"type":22},[25],"Twenty posterior maxillary edentulous sites requiring open sinus augmentation for staged dental implant placement will be studied. Group I (study group) the maxillary sinus membrane will be elevated using titanium mesh fixed by bone screws. Group II (control group) will have stainless steel screws\u002Fpins placed bucco-palatally to maintain the elevated membrane and stabilize the formed blood clot. Platelet rich fibrin (PRF) will be placed at the site of elevated membrane in both groups.",[297],"Maxillary Sinus Floor Augmentation",[299,300],"Tenting","Schneiderian membrane","2026-04-23",{"date":303,"type":41},"2026-04-24",{"date":305,"type":41},"2025-07-15",{"date":245,"type":22},{"name":47,"class":48},{"id":309,"slug":310,"hasResults":12,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":314,"eligibilityCriteria":315,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":316,"enrollmentInfo":317,"targetDuration":4,"studyType":318,"phases":4,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":327,"locationsCount":328},"100306978","bispectral-electroencephalography-eeg-in-first-time-hemodialysis-100306978","NCT03276273","Bispectral-Electroencephalography (EEG) in First Time Hemodialysis","The Utility of Using the Bispectral Index (BIS) for Detecting Dialysis Disequilibrium Syndrome (DDS)","BIS7","Inclusion Criteria:\n\n* First Time renal Dialysis\n\nExclusion Criteria:\n\n* subjects' consumption of sedatives\u002Fhypnotics psychotropic drugs, or concomitant neurological disorders affecting mental state such as hepatic encephalopathy, stroke, stupor or dementia and renal transplant patients.","90 Years",{"count":178,"type":22},"OBSERVATIONAL","The severity of minimal dialysis disequilibrium syndrome (DDS) is currently detected and graded clinically using clinical criteria. Bispectral Index (BIS), an electroencephalographic (EEG) derived parameter is widely used in anesthesia and Critical Care setting to detect effects of anesthetic\u002Fhypnotic drugs. The aim of our study was to assess the discriminative power of BIS monitoring to accurately detect DDS.",[321],"Renal Failure Acute Chronic","2026-04-22",{"date":278,"type":41},{"date":325,"type":41},"2017-05-01",{"date":111,"type":22},{"name":47,"class":48},2,{"id":330,"slug":331,"hasResults":12,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":318,"phases":4,"briefSummary":338,"conditions":339,"keywords":4,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":341,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":49},"100304523","bispectral-index-bis-for-classification-of-procalcitonin-pct-sepsis-grades-in-critically-ill-patients-with-sepsis-100304523","NCT03244293","Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis","Sensitivity and Specificity of Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis, Severe Sepsis and Septic Shock and Multiple Organ Failure (MOF)","BIS6","Inclusion Criteria: patients with sepsis\n\n* patients with sepsis\n\nExclusion Criteria:\n\n* Patients who received drugs that would interfere with BIS monitoring",{"count":178,"type":22},"To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.",[340],"Sepsis, Severe",{"date":301,"type":41},{"date":343,"type":41},"2014-01-01",{"date":345,"type":22},"2030-12-01",{"name":47,"class":48},{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":353,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":355,"enrollmentInfo":356,"targetDuration":4,"studyType":318,"phases":4,"briefSummary":358,"conditions":359,"keywords":4,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":361,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":49},"100253506","piers-and-bis-sfitpigf-adrenomedullin-100253506","NCT02578810","PIERS and BIS, sFIT:PIGF, Adrenomedullin","Sensitivity and Specificity of Bispectral Index (BIS) EEG Parameter, sFIT (Soluble FMS Tyrosine Kinase): PIGF (Placental Growth Factor) Ratio, Adrenomedullin for Grading Preeclampsia Integrated Estimate Risk Score (PIERS)","BIS2","Inclusion Criteria\n\n1. Pregnancy at any stage (3 trimesters)\n2. Eclampsia (Frank eclampsia) will be the crux of the study\n3. Pre-eclampsia that is suspected will end up with Frank Eclampsia\n\nExclusion criteria:\n\n1. Any neurological conditions that can alter the electroencephalography like epilepsy\n2. Any medical conditions that can alter the electroencephalography like hypoglycemia","50 Years",{"count":357,"type":22},48,"Pre-eclampsia, more than being proteinuric gestational hypertension alone, is a state of exaggerated systemic inflammation and remains a leading direct cause of maternal morbidity and mortality worldwide.1 Standardization of antenatal and postnatal assessment and surveillance of pre-eclampsia with protocols that recognize the systemic inflammatory model of preeclampsia have been associated with reduced maternal morbidity.",[360],"Eclampsia",{"date":301,"type":41},{"date":363,"type":4},"2016-10",{"date":365,"type":22},"2030-12",{"name":47,"class":48},{"id":368,"slug":369,"hasResults":12,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":18,"minAge":145,"maxAge":374,"enrollmentInfo":375,"targetDuration":4,"studyType":23,"phases":376,"briefSummary":377,"conditions":378,"keywords":380,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":388,"leadSponsor":390,"locationsCount":328},"100596097","intraoperative-fluid-management-guided-by-internal-jugular-vein-on-postoperative-complications-in-abdominal-surgeries-100596097","NCT07041021","Intraoperative Fluid Management Guided by Internal Jugular Vein on Postoperative Complications in Abdominal Surgeries","Effect of Intraoperative Fluid Management Guided by Respiratory Variations of Internal Jugular Vein on Postoperative Complications in Abdominal Surgeries: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients' American Society of Anesthesiologists physical status (ASA) is I and II.\n2. The target age group is 20 to 70 years old.\n3. Patients scheduled for abdominal surgery under general anesthesia with normal renal function.\n\nExclusion Criteria:\n\n1. Refusal of the procedure or participation in the study.\n2. Coagulopathy.\n3. Pre-existing cardiac, renal, and respiratory diseases. 4-Internal jugular vein thrombosis","70 Years",{"count":61,"type":22},[25],"This study investigates the role of respiratory variation in the internal jugular vein as a tool for intraoperative fluid management during abdominal surgeries under general anesthesia.\n\nThe purpose of this clinical trial is to reduce postoperative complications and improve patient outcomes through proper intraoperative fluid management.\n\nThe main question it aims to answer is: Can intraoperative fluid management guided by the respiratory variation of the internal jugular vein during abdominal surgeries reduce postoperative complications? Research Hypothesis (Alternative Hypothesis): We hypothesize that fluid management guided by the respiratory variation of the internal jugular vein during abdominal surgeries can reduce postoperative complications.\n\nThe patients will be divided into two groups and randomized to receive either intraoperative fluid therapy guided by the respiratory variation of the internal jugular vein or standard fluid therapy. Postoperative complications, length of hospital stay, total amount of fluid administered intraoperatively, use of vasopressors in both groups, and incidence of hypotensive episodes will be recorded.",[379],"Postoperative Complications",[379,381,382,383],"Abdominal surgeries","Internal Jugular Vein","Intraoperative fluid therapy","2026-04-05",{"date":386,"type":41},"2026-04-07",{"date":305,"type":41},{"date":389,"type":22},"2026-05",{"name":47,"class":48},{"id":392,"slug":393,"hasResults":12,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":12,"sex":18,"minAge":398,"maxAge":4,"enrollmentInfo":399,"targetDuration":4,"studyType":23,"phases":401,"briefSummary":403,"conditions":404,"keywords":407,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":415,"locationsCount":49},"100599110","phase-3-intranasal-dexmedetomidine-on-blood-pressure-in-elderly-hypertensive-patients-undergoing-cataract-surgery-100599110","NCT07080229","Intranasal Dexmedetomidine on Blood Pressure in Elderly Hypertensive Patients Undergoing Cataract Surgery","The Effect of Intranasal Dexmedetomidine Compared to Placebo on Blood Pressure in Elderly Hypertensive Patients Undergoing Cataract Surgery: A Double-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients aged ≥65 years.\n2. Patients who will have stage 2 hypertension as per ACC\u002FAHA guidelines (Systolic BP \\> 140 and Diastolic BP\\> 90 mmHg)\n3. Elective cataract surgery under local anesthesia.\n4. American Society of Anesthesiologists (ASA) physical status II or III.\n\nExclusion Criteria:\n\n1. Allergy or contraindication to dexmedetomidine.\n2. Significant baseline bradycardia (\\\u003C50 bpm) or arrhythmias.\n3. Use of sedative or anxiolytic medications.\n4. History of severe hepatic, renal, or cerebrovascular diseases.","65 Years",{"count":400,"type":22},126,[402],"PHASE3","Cataract surgery in elderly patients with controlled hypertension carries a risk of hemodynamic instability, particularly fluctuations in mean arterial blood pressure (MAP). Dexmedetomidine, a selective α2-adrenergic agonist, offers hemodynamic stabilization and sedation when administered intranasally and provides a simple and non-invasive premedication option.\n\nThis study evaluates the effects of intranasal dexmedetomidine on perioperative mean arterial blood pressure in patients undergoing cataract surgeries.\n\nResearch Question:\n\nDoes intranasal dexmedetomidine premedication control blood pressure in elderly hypertensive patients undergoing cataract surgery?\n\nResearch Hypothesis:\n\nIntranasal dexmedetomidine significantly reduces MAP and improves secondary outcomes compared to placebo.\n\nPrimary Objective: To evaluate the efficacy of intranasal Dexmedetomidine as a premedication to control hypertension in elderly patients scheduled for cataract surgery.\n\nSecondary Objectives: 1. To assess surgery cancellation rates. 2. To evaluate satisfaction levels among patients, anesthesiologists, and surgeons using the Modified Observer's assessment of alertness\u002Fsedation scale (MOAA\u002FS). 3- To evaluate the effect of intranasal dexmedetomidine on HR multiple readings starting from preoperative hold area till 2 hours postoperatively.\n\nThis randomized, double-blinded clinical trial will include 126 elderly hypertensive patients (≥65 years) undergoing cataract surgery under local anesthesia. Inclusion Criteria will consist of patients aged ≥65 years, ASA II or III, stage 2 hypertension as per ACC \u002F AHA guidelines (SBP\\>140 and DBP\\> 90 mmHg), undergoing elective cataract surgery under local anesthesia. Exclusion Criteria will include allergy or contraindication to dexmedetomidine, significant baseline bradycardia (\\\u003C50 bpm) or arrhythmia, use of sedative or anxiolytic medications, history of severe hepatic, renal, or cerebrovascular disease. Participants will be randomly assigned to receive either intranasal dexmedetomidine (1 mcg\u002Fkg ideal body weight) or a placebo (normal saline) 30 minutes before surgery. MAP, HR, and SpO₂ will be recorded at multiple perioperative intervals, and surgical cancellation rates, satisfaction levels will be noted, surgical duration, and hospital stay will be documented.",[405,406],"Cataract","Hypertension",[405,406,408,409],"Intranasal Dexmedetomidine","Elderly","2026-04-01",{"date":386,"type":41},{"date":413,"type":41},"2025-07-16",{"date":389,"type":22},{"name":47,"class":48},{"id":417,"slug":418,"hasResults":12,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":144,"sex":18,"minAge":94,"maxAge":59,"enrollmentInfo":423,"targetDuration":4,"studyType":23,"phases":424,"briefSummary":425,"conditions":426,"keywords":429,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":4},"100621667","clinical-and-radiographic-evaluation-of-delayed-dental-implant-placement-after-socket-preservation-using-injectable-bone-graft-100621667","NCT07373600","Clinical and Radiographic Evaluation of Delayed Dental Implant Placement After Socket Preservation Using Injectable Bone Graft","Clinical and Radiographic Evaluation of Delayed Implant Placement Following Socket Preservation With Injectable Alloplastic Bone Graft. A Randomized Controlled Study.","* Patient aged between 40 and 60 years\n* General good health.\n* Volunteer subjects have to voluntarily sign an informed consent.\n* Patient Indicated for single implant placement in lower posterior area.\n\nInclusion criteria for patients in group I\n\n· Patient with a previously extracted lower posterior tooth and the socket was preserved with injectable bone graft .\n\nExclusion criteria:\n\n* Patient with systemic disease affection bone metabolism .\n* Patients with contraindication to surgical treatment.\n* Patients with uncontrolled medical conditions.",{"count":178,"type":22},[25],"This clinical study aims to evaluate the clinical and radiographic outcomes of delayed dental implant placement following socket preservation using an injectable alloplastic bone graft material.\n\nThe study will include patients who require tooth extraction and are candidates for implant placement.\n\nAfter tooth extraction, the socket will be preserved using the bone graft material, and dental implants will be placed after a healing period.\n\nClinical and radiographic assessments will be performed to evaluate bone quality, bone height, and implant stability.\n\nThe goal of this study is to determine the effectiveness of injectable alloplastic bone grafts in maintaining the alveolar ridge and improving the success of delayed implant placement.",[427,428],"Alveolar Ridge Preservation","Dental Implant Placement",[428,427],"2026-01-20",{"date":432,"type":41},"2026-01-28",{"date":434,"type":22},"2026-01",{"date":436,"type":22},"2027-11",{"name":47,"class":48},{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":355,"enrollmentInfo":445,"targetDuration":4,"studyType":23,"phases":446,"briefSummary":447,"conditions":448,"keywords":450,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":49},"100613231","inter-flex-three-dimensional-plate-in-management-of-mandibular-fracture-rct-100613231","NCT07263893","Inter Flex Three Dimensional Plate in Management of Mandibular Fracture RCT","Evaluation of the Efficacy of Custom-Made Inter-flex Three-Dimensional Plate in Treatment of Mandibular Fracture A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Patients who are suffering from recent, uninfected, and minimally displaced or unfavorable mandibular fractures\n2. Adult patients with no gender predilection that agreed to present for follow-up visits for minimum postoperative period of immediate,3 months,6 months.\n3. A fracture that demands open reduction and internal fixation\n4. Patients under ASA-1 category\n\nExclusion Criteria:\n\n1. Comminuted, infected mandibular fracture.\n2. Pediatric patients below 4 years old and geriatric patients with completely edentulous mouth.\n3. Patient with osteoporosis\n4. Medical compromised patient (Poorly controlled DM or HTN, COPD, morbid obesity (BMI ≥40), Recent (\\\u003C3 months) MI, ongoing cardiac ischemia or severe valve dysfunction, severe reduction of ejection fraction, shock, sepsis, undergoing regularly scheduled dialysis, history (\\>3 months)\n5. Fractures in completely edentulous patients",{"count":178,"type":22},[25],"The goal of this clinical trial is to learn if The use of a 3D-designed Inter-flex plate will achieve safe and desirable anatomical \\& functional restoration with reduced operative time in mandibular fracture,\n\n* Improvement of occlusal and inter-cuspal relation in addition to stabilized intra-fragmentary mobility,\n* Offer greatest resistance to displacement\n* shows most favorable biomechanical behavior",[449],"Mandibular Fracture Treatment",[451,452,453,454,455],"INTER-FLEX 3D PLATE","mandibular fractures","radiographic assesment","time of surgery","healing",{"date":457,"type":41},"2026-01-22",{"date":459,"type":22},"2026-01-01",{"date":461,"type":22},"2026-12-03",{"name":47,"class":48},{"id":464,"slug":465,"hasResults":12,"nctId":466,"briefTitle":467,"officialTitle":468,"acronym":4,"eligibilityCriteria":469,"healthyVolunteers":144,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":470,"targetDuration":4,"studyType":23,"phases":471,"briefSummary":472,"conditions":473,"keywords":477,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":49},"100614510","accuracy-of-virtual-surgical-planning-versus-traditional-technique-in-zygomaticomaxillary-fracture-reduction-100614510","NCT07280533","Accuracy of Virtual Surgical Planning Versus Traditional Technique in Zygomaticomaxillary Fracture Reduction","Accuracy of Virtual Surgical Planning in Reduction of Zygomatico-Maxillary Fractures A Randomized Clinical Controlled Study","Inclusion Criteria:\n\n* Adults (≥18 years) with clinically and radiographically confirmed ZMC fracture.\n* Fit for general anesthesia and able to undergo CT imaging.\n* Willing to sign informed consent.\n\nExclusion Criteria:\n\n* Systemic diseases impairing bone healing (osteoporosis, cancer, long-term steroid use).\n* Noncompliance or inability to attend follow-up visits.\n* ASA class IV-VI.\n* Previous facial deformities or fractures.",{"count":178,"type":22},[25],"This randomized clinical trial aims to evaluate the accuracy and outcomes of virtual surgical planning (VSP) compared to the traditional surgical technique in the reduction of zygomaticomaxillary complex (ZMC) fractures. Twenty patients with ZMC fractures will be randomly assigned into two equal groups: one treated using virtual planning and prebent titanium miniplates, and the other treated conventionally without virtual planning. Clinical evaluation will include facial symmetry, eye movement, and postoperative complications, while radiographic assessment will be performed using CT scans three months after surgery to measure bone formation and alignment accuracy. The study seeks to determine whether virtual surgical planning improves anatomical restoration, esthetics, and functional outcomes compared to traditional methods.",[474,475,476],"Facial Bone Fracture","Maxillofacial Injury","Zygomaticomaxillary Complex Fracture",[478,479,480,481,482,483,484,485,486],"Zygomaticomaxillary complex fracture","ZMC fracture","Virtual surgical planning","3D printing","Prebent titanium miniplates","Facial symmetry","Computer-assisted surgery","CT evaluation","Traditional surgical method","2025-12-09",{"date":489,"type":41},"2025-12-12",{"date":491,"type":22},"2025-12-25",{"date":493,"type":22},"2026-11-01",{"name":47,"class":48},{"id":496,"slug":497,"hasResults":12,"nctId":498,"briefTitle":499,"officialTitle":500,"acronym":159,"eligibilityCriteria":501,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":502,"enrollmentInfo":503,"targetDuration":4,"studyType":23,"phases":505,"briefSummary":506,"conditions":507,"keywords":509,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":512,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":516,"locationsCount":517},"100613973","root-torque-control-in-cases-treated-with-direct-printed-aligners-100613973","NCT07273552","Root Torque Control in Cases Treated With Direct Printed Aligners","Efficacy of Root Torque Control in Adult Non-extraction Spacing Cases Treated With Directly 3D Printed Clear Aligners: a Cone Beam Computed Tomography Study","Inclusion Criteria:\n\n1. Age: 18- 45 years old.\n2. Non- extraction treatment.\n3. Angle Class I or Class II dental malocclusion with generalized or localized anterior spacing.\n4. Normal probing depth.\n\nExclusion Criteria:\n\n1. Active periodontal disease.\n2. Crowding cases.\n3. Systemic diseases or medications that alter bone metabolism or tooth movement.","45 Years",{"count":504,"type":22},14,[25],"This study aims to three-dimensionally evaluate the efficiency of direct 3D printed aligners in achieving the planned root torque by using CBCT and to assess the associated bone thickness changes and root resorption.",[508],"Effect of Direct Printed Aligners on Root Torque",[510],"Direct printed aligners torque","2025-11-27",{"date":487,"type":41},{"date":514,"type":41},"2025-06-01",{"date":70,"type":22},{"name":47,"class":48},3,{"id":519,"slug":520,"hasResults":12,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":524,"eligibilityCriteria":525,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":502,"enrollmentInfo":526,"targetDuration":4,"studyType":23,"phases":528,"briefSummary":529,"conditions":530,"keywords":532,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":534,"startDateStruct":535,"completionDateStruct":536,"leadSponsor":537,"locationsCount":517},"100613964","crown-movement-in-cases-treated-with-direct-printed-aligners-100613964","NCT07273435","Crown Movement in Cases Treated With Direct Printed Aligners","Comparison of Predicted and Achieved Crown Movements in Adult Spacing Cases Treated With 3D Direct-printed Aligners: A Prospective Clinical Trial","DPA","Inclusion Criteria:\n\n* Age: 18- 45 years old.\n* Non- extraction treatment.\n* Angle Class I or Class II dental malocclusion with generalized or localized anterior spacing.\n* Normal probing depth.\n\nExclusion Criteria:\n\n* Active periodontal disease.\n* Crowding cases.\n* Systemic diseases or medications that alter bone metabolism or tooth movement.",{"count":527,"type":22},23,[25],"This study aims to evaluate the efficiency of direct 3D printed aligners in achieving the crown movement of upper and lower incisors in patients with spacing during space closure and to compare them with the predicted tooth movements",[531],"Effect of Direct Printed Aligners on Crown Movement",[533],"Direct printed aligners crown movement",{"date":487,"type":41},{"date":514,"type":41},{"date":70,"type":22},{"name":47,"class":48},{"id":539,"slug":540,"hasResults":12,"nctId":541,"briefTitle":542,"officialTitle":543,"acronym":4,"eligibilityCriteria":544,"healthyVolunteers":144,"sex":18,"minAge":545,"maxAge":355,"enrollmentInfo":546,"targetDuration":4,"studyType":23,"phases":547,"briefSummary":548,"conditions":549,"keywords":552,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":562,"locationsCount":49},"100607365","zinc-incorporated-bovine-derived--hydroxyappatite-xenograft-in-immediately-placed-implant-100607365","NCT07187609","Zinc Incorporated Bovine Derived- Hydroxyappatite Xenograft in Immediately Placed Implant","Clinical and Radiographic Evaluation of Zinc Incorporated Bovine Derived- Hydroxyappatite Xenograft in Immediately Placed Implant: A Randomized Clinical Study","Inclusion Criteria:\n\n* Adult(male or female) patients between the ages of 21 -50 years who requiring the replacement of one or more non-restorable teeth in the mandible which will be indicated for extraction.\n* Adequate bone dimensions at the implant site with ridge width of at least 6 mm, the availability of at least 3mm of sound subapical bone, the presence of an intact labial bone plate, and no evidance of periapical infection on cone beam computed tomography or clinically\n* The peri-implant gaps larger than 1.5 mm will be included.\n* All patients will be physically healthy with no medical history of any systemic disease.\n\nExclusion Criteria:\n\n* Smokers.\n* Patients with para functional habits such as bruxism and clenching\n* Poorly controlled systemic diseases which preclude local anesthesia or surgical procedures\n* Patients undergoing chemotherapy or radiotherapy and immuno-compromised patients.\n* Pregnant \u002Flactating women.\n* Patients that are allergic to zinc\n* Patients on antibiotic therapy in the pervious 6 months","21 Years",{"count":147,"type":22},[25],"The aim of this study is to evaluate Clinical and radiographic effect of zinc incorporated bovine derived hydroxyapatite xenograft and bovine hydroxyapatite xenograft alone for immediately placed implant",[550,551],"Implant","Zinc Status",[553,550,554],"bone grafts","zinc in corporated bovine drived hydroxyappatite","2025-09-18",{"date":557,"type":41},"2025-09-23",{"date":559,"type":41},"2025-08-13",{"date":561,"type":22},"2026-11-08",{"name":47,"class":48},{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":569,"eligibilityCriteria":570,"healthyVolunteers":12,"sex":18,"minAge":145,"maxAge":398,"enrollmentInfo":571,"targetDuration":4,"studyType":23,"phases":572,"briefSummary":573,"conditions":574,"keywords":578,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":591,"locationsCount":4},"100602617","efficacy-of-bioactive-glass-vs-xenograft-in-maxillary-sinus-augmentation-100602617","NCT07125846","Efficacy of Bioactive Glass vs. Xenograft in Maxillary Sinus Augmentation","Clinical, Radiographic and Histologic Assessment of the Efficacy of Bioactive Glass as a Novel Grafting Material in Maxillary Sinus Floor Augmentation: A Randomized Controlled Study","BIOXENO","Inclusion Criteria:\n\n* Patients requiring maxillary sinus floor augmentation for dental implant placement.\n* Residual alveolar bone height ≤ 4 mm in posterior maxilla (SA4 classification).\n* Age between 20 to 65 years.\n* Good general health and able to attend scheduled follow-up visits.\n* Signed written informed consent.\n\nExclusion Criteria:\n\n* Presence of systemic conditions that could affect bone healing (e.g., uncontrolled diabetes, osteoporosis).\n\nHistory of radiotherapy in the head and neck region.\n\n* Heavy smoking (more than 10 cigarettes\u002Fday).\n* Active sinus pathology or previous sinus surgery.\n* Pregnant or breastfeeding women.\n* Use of medications affecting bone metabolism (e.g., bisphosphonates or corticosteroids).\n* Poor oral hygiene or untreated periodontal disease.",{"count":178,"type":22},[25],"This randomized controlled study aims to evaluate the clinical, radiographic, and histologic efficacy of using bioactive glass bone graft (UNIGRAFT by Biomed Inc., USA) compared to a conventional xenograft in maxillary sinus augmentation procedures. A total of 20 patients classified as SA4 according to the Misch classification will be enrolled and randomly allocated into two groups. Outcomes will be assessed using Cone Beam Computed Tomography (CBCT) for vertical bone gain and, where applicable, histologic analysis. The study is conducted at the Faculty of Dentistry, Suez Canal University.",[575,576,577],"Alveolar Bone Loss","Maxillary Sinus Disease","Tooth Loss",[579,580,581,582,583,584],"Maxillary Sinus Augmentation","Bioactive Glass","Xenograft","Sinus Lift","Bone Grafting","Dental Implant","2025-08-14",{"date":587,"type":41},"2025-08-15",{"date":589,"type":22},"2025-10-15",{"date":410,"type":22},{"name":47,"class":48},{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":598,"eligibilityCriteria":599,"healthyVolunteers":144,"sex":18,"minAge":145,"maxAge":59,"enrollmentInfo":600,"targetDuration":4,"studyType":23,"phases":601,"briefSummary":602,"conditions":603,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":607,"completionDateStruct":609,"leadSponsor":611,"locationsCount":49},"100598006","effect-of-vitamin-d-on-crestal-bone-loss-around-immediate-implant-after-mandibular-premolars-and-molars-extraction-100598006","NCT07065877","Effect of Vitamin D on Crestal Bone Loss Around Immediate Implant After Mandibular Premolars and Molars Extraction","Clinical and Radiographic Assessment Of Immediate Implant With Topical Vitamin D and Xenograft Mixture: A Randomized Controlled Study","vitD","Inclusion Criteria:\n\n* The American Society of Anesthesiologist (ASA) I , II\n* Both Genders. 3- Patients having unrestorable tooth on the posterior mandibular region\n* Age\\>20\n* The patient who have complete their facial growth and teeth eruption\n* No bone disease or lesion in propose implant site\n\nExclusion Criteria:\n\n* Poor oral hygiene patients and\u002For patients\n* Patients with active acute infection.\n* Patients with bad oral habits.\n* Pregnant or lactating women.\n* Heavy smokers.\n* Alcohol and drug addicts.\n* Diabetes disease",{"count":178,"type":22},[25],"What is the difference between grafting the jumping gap upon using xenograft mixed with topical vitamin D clinically regarding crestal bone level and implant stability, radiographically regarding crestal bone level after implant insertion in the posterior region of mandible?",[604],"Crestal Bone Loss","2025-07-11",{"date":305,"type":41},{"date":608,"type":22},"2025-07-20",{"date":610,"type":22},"2027-01-01",{"name":47,"class":48},{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":4,"eligibilityCriteria":618,"healthyVolunteers":12,"sex":18,"minAge":619,"maxAge":4,"enrollmentInfo":620,"targetDuration":4,"studyType":23,"phases":622,"briefSummary":623,"conditions":624,"keywords":628,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":634,"completionDateStruct":636,"leadSponsor":638,"locationsCount":49},"100578384","comparing-efficacy-between-two-protocols-of-intravenous-insulin-infusion-for-diabetic-adults-in-icu-100578384","NCT06810596","Comparing Efficacy Between Two Protocols of Intravenous Insulin Infusion for Diabetic Adults in ICU","Comparing Glycemic Control Efficacy Between The National Health System and Suez Canal University Protocols of Intravenous Insulin Infusion for Diabetic Adults in ICU","Inclusion Criteria:\n\n* Patients who admitted to the hospital with a potentially life-threatening condition (Critically ill patients) with HbA1C \\>6.0.\n\nExclusion Criteria:\n\n* DKA patients.\n* Pregnant or breast-feeding patients.\n* Hyperosmolar Non-Ketotic Coma.","19 Years",{"count":621,"type":22},100,[25],"The goal of clinical trial is to improve the adequacy of blood sugar control in diabetic critically ill adult patients who admitted to the intensive care unit(ICU) in Suez Canal University (SCU) hospitals by comparing glycemic control efficacy between the NHS in the UK and suggested SCU Protocols of Intravenous Insulin Infusion.\n\nThe main questions it aims to answer are:\n\nIs SCU protocol of Intravenous Insulin Infusion more effective than NHS protocol in achieving blood glucose control targets in critically ill adult patients?\n\nResearchers will compare glycemic control efficacy between the NHS in UK and suggested SCU Protocols of Intravenous Insulin Infusion for critically ill Adults in ICU to determine the best protocol in achieving good blood glucose control in diabetic critically ill adult patients in SCU Hospitals.",[625,626,627],"Glycemic Control","Critical Care","Diabetes Mellitus",[625,629,630],"Insulin Infusion Protocol","Critically ill","2025-01-31",{"date":633,"type":41},"2025-02-05",{"date":635,"type":41},"2024-12-15",{"date":637,"type":22},"2025-04-15",{"name":47,"class":48},""]