[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sunkaky Medical Cooperation\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":79},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100598036","adipose-stem-cell-mitochondria-supplementation-to-oocytes-ascent-100598036",false,"NCT07066267","Adipose Stem Cell Mitochondria Supplementation to Oocytes (ASCENT)","Clinical Application of Autologous Adipose Stem Mitochondria Transplantation to Oocytes for Improving Embryo Quality in Patients With Recurrent Pregnancy Failure","Inclusion Criteria:\n\n* Having at least three previous failed IVF trial\n* Specifically consented for to collect biopsies for Preimplantation generic testing for aneuploidy (PGTA) analysis\n* Specifically consented for to have single blastocyst transfer (recommended)\n* No major uterine or ovarian abnormalities\n* Specifically consented for to have all embryos frozen\n* Specifically consented for to collect adipose tissues from subcutaneous liposuction\n* BMI level level \\\u003C26kg\u002Fm2\n\nExclusion Criteria:\n\n* Ovarian endometriosis with Chocolate cysts (American Fertility Society (AFS)) classification type 3 and 4\n* Any medical contraindication oocyte retrieval or subsequent procedures Ovarian hyperstimulation syndrome Bleeding disorders Sex hormone allergies Severe emotional defect on injections\n* Severe sperm abnormalities\n* \\\u003C5 million\u002FmL motile sperm\n* Uterine structural anomalies\n* Polycystic ovaries\n* Premature ovarian failure","FEMALE","29 Years","39 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to investigate the potential of autologous adipose stem cell (ASC) mitochondrial transfer (ASCENT) to oocytes along with intracytoplasmic sperm injection (ICSI)as a means of enhancing embryo development and improving the success rate of in patients with a history of multiple IVF failures. Embryo quality plays a crucial role in determining the success of assisted reproductive technologies and directly contributes to repeated pregnancy failures. Several factors, including age, physiological conditions, genetics, and environmental influences, can significantly impact embryo quality. Oocytes, the largest cells in the human body, are heavily reliant on mitochondria. Mitochondria's role in providing energy for oocytes is crucial, and insufficient energy production has been linked to poor oocyte and embryo quality. Some human studies have shown that increasing oocyte mitochondrial mass can improve embryo quality in patients who have experienced repeated IVF failures.",[27,28,29,30,31],"Female Infertility","Oocyte Competence","Mitochondria","Recurent Implantation Failures","Advanced Age",[33,34,35,36,37],"mitochondria","mitochondria transplantation","Adipose stem cell","oocyte","Female infertility","RECRUITING","2025-07-14",{"date":41,"type":42},"2025-07-17","ACTUAL",{"date":44,"type":42},"2025-04-25",{"date":46,"type":21},"2026-12-31",{"name":48,"class":49},"Sunkaky Medical Cooperation","INDUSTRY",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":78,"locationsCount":50},"100564473","investigate-the-efficacy-of-using-nmn-to-improve-embryo-development-capacity-100564473","NCT06629636","Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity.","Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity and IVF Success Rate in Patients Who Have Experienced IVF Failures.","Inclusion Criteria:\n\n* Agree to participate in the study\n* 32-42 years old\n* Having at least one previous embryo implantation failure\n* History of low Embryo quality at day3 or day5 (according to Veeck's and Gardner's Criteria)\n* No major uterine or ovarian abnormalities\n* BMI level 18-25kg\u002Fm2\n\nExclusion Criteria:\n\n* Ovarian endometriosis with Chocolate cysts (AFS type 3 and 4)\n* Patients who have taken different supplements such as coenzyme Q10, vitamin E, carnitine,niacin, nicotinamide, or other vitamin B3-related etc. within the previous month\n* Any medical contraindication of oocyte retrieval or subsequent procedures\n* Couples where the husband presents with severe sperm abnormalities\n* Couples where the husband presents \\<5 million\u002FmL motile sperm\n* Uterine structural anomalies\n* Polycystic ovaries\n* Premature ovarian failure\n* Individuals who need regular medication to treat chronic diseases such as diabetes, hypertension, gout, hyperuricemia, etc.\n* Individuals who need drug treatment for any mental illness such as epilepsy and depression.\n* Individuals who suffer from infectious diseases such as hepatitis B, active tuberculosis, AIDS, etc.\n* Cancer patients or receiving chemo\u002Fradiotherapy treatment within the past 3 years.","32 Years","42 Years",{"count":61,"type":21},60,[24],"The objective of this study is to investigate the efficacy of NMN supplementation in enhancing embryo developmental capacity and improving IVF success rates in patients experiencing IVF failures.",[65,27],"Repeated IVF Failure",[67,68,27,69,70,71],"IVF failure","NMN","Japan","Oocyte Mitochondria","Anti aging","2024-10-03",{"date":74,"type":42},"2024-10-08",{"date":76,"type":42},"2024-08-20",{"date":46,"type":21},{"name":48,"class":49},""]