[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Swiss Paraplegic Research, Nottwil\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":304},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,41,73,101,123,146,179,206,230,252,279],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100628060","cardiac-morphology-and-function-in-individuals-with-autonomic-dysreflexia-100628060",false,"NCT07456722","Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia","Assessment of Cardiac Morphology and Function in Individuals With and Without Autonomic Dysreflexia Due to Spinal Cord Injury or Disease","HEART_REMOD_AD","Inclusion Criteria:\n\n* adults aged 18 years or older\n* long-term (\\>10 years), motor-complete SCI\u002FD (AIS A and B)\n* Group A (24 individuals): high-level (\\>Th6) SCI\u002FD and autonomic dysreflexia\n* Group B (24 individuals): low-level (\\\u003CTh10) SCI\u002FD without autonomic dysreflexia\n* signed informed consent\n\nExclusion Criteria:\n\n* congenital heart defects\n* valvular disease(s)\n* cardiomyopathy\n* medium to severe arrhythmia\n* myocardial infarction\n* comorbidities causing morphologic heart changes including primary hypertension, aortic stenosis\n* comorbidities causing arterial hypertension\n* use of anti-hypertensive treatment\n* smokers\n* individuals after sacral deafferentation surgery\n* pregnancy\n* active implanted medical devices\n* claustrophobia\n* inability to comply with the measurement procedures","ALL","18 Years",{"count":20,"type":21},48,"ESTIMATED","OBSERVATIONAL","This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI\u002FD) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history. The primary objective is to compare cardiac changes between 24 individuals with high-level SCI\u002FD (above Th6) who have AD and 24 individuals with low-level SCI\u002FD (below Th10) who do not have AD. A secondary objective examines how factors such as age, sex, injury duration, and physical activity are associated with cardiac remodeling.\n\nAll 48 participants will undergo cardiac MRI as well as blood measurement of B-type natriuretic peptid to assess cardiac morphology and function. The findings could shed light on a potentially underestimated cardiovascular risk factor in the SCI\u002FD population.",[25,26,27],"Autonomic Dysreflexia","Spinal Cord Injuries and Disorders (SCI\u002FD)","Cardiac Remodeling","NOT_YET_RECRUITING","2026-03-09",{"date":31,"type":32},"2026-03-11","ACTUAL",{"date":34,"type":21},"2026-05-01",{"date":36,"type":21},"2028-10-31",{"name":38,"class":39},"Swiss Paraplegic Research, Nottwil","NETWORK",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":40},"100605656","virtual-walking-to-reduce-chronic-neuropathic-pain-in-subjects-with-sci-100605656","NCT07165353","Virtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI","Virtual Walking With Habitual Feedback to Reduce Chronic Neuropathic Pain in Individuals With Spinal Cord Injury","Inclusion Criteria:\n\n* Sufficient knowledge of German language to understand the instructions, assessments and to fill in questionnaires.\n* Age ≥ 18y, ≤ 75y\n* Chronic traumatic or non-traumatic SCI (\\>6 month after SCI) with an SCI severity grade AIS A, B, C or D\n* At or below level spinal cord injury neuropathic pain on trunk or lower extremities diagnosed by a neurologist following the ISCIP classification (Bryce et al., 2012) of at least 4\u002F10 intensity on a NRS (Langford et al., 2023)\n* Ability to draw with a pen\n\nExclusion Criteria:\n\n* \\- Serious psychiatric disorders, which are accompanied by imminent or current acute harm to oneself or others, or which require inpatient psychiatric treatment for other reasons, or other indications of a foreseeable, seriously harmful effect of participation in the study based on the clinical impression from the psychological screening interview\n* Participants with a walking ability more than 5 minutes without walking aids\n* Pregnancy (anamnestic) in women of child-bearing age (18-49 years)\n* Known epilepsy\n* neurological disorders (multiple sclerosis, ALS, Guillan-Barré Syndrome, congenital disorders, polyneuropathy)","75 Years",{"count":50,"type":21},40,"INTERVENTIONAL",[53],"NA","About 70% of people with a spinal cord injury in Switzerland have chronic pain that lasts more than 3 to 6 months. This pain can be caused by muscle or joint problems, or by nerve damage (neuropathic pain). Neuropathic pain is often hard to treat, and current treatments may cause side effects or not work well.\n\nThis study will test whether virtual walking from different visual perspectives can reduce chronic neuropathic pain and improve quality of life after spinal cord injury. We will also compare which perspective works best.\n\nTo better understand how the training works, we will use two tests-quantitative sensory testing (QST) and contact heat-evoked potentials (CHEPs)-to measure changes in the pain and nerve systems.",[56,57],"Spinal Cord Injuries (SCI)","Neuropathic Pain Due to Spinal Cord Injury",[59,60,61,62,63],"neuropathic pain","virtual walking","virtual reality","spinal cord injury pain","spinal cord injury","RECRUITING","2026-01-19",{"date":67,"type":32},"2026-01-21",{"date":69,"type":32},"2026-01-20",{"date":71,"type":21},"2027-11-30",{"name":38,"class":39},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":51,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":40},"100585677","the-effects-of-eccentric-compared-to-standard-strength-training-in-primary-spinal-cord-injury-rehabilitation-100585677","NCT06905470","The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation","The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation - a Matched-Pair Randomized Controlled Trial","KREHA3","Inclusion Criteria:\n\n* 18 years or older.\n* informed consent as confirmed per signature.\n* traumatic or disease-related SCI.\n* participating in the routine strength training program during primary SCI rehabilitation at the study center (generally this is initiated around one month after SCI onset).\n* wheelchair dependency during activities of daily living, defined by a score of 0-2 in the SCIM subsection regarding \"Mobility in the house\".\n* passed sports medical assessment and having sufficient biceps\u002Ftriceps function to perform arm-crank training, as determined by an experienced sports medicine physician\n\nExclusion Criteria:\n\n* inflammatory or neurodegenerative diseases (including multiple sclerosis or Guillain-Barré syndrome).\n* comorbidities or other health issues that may interfere with study participation, inability or contraindications to undergo the investigated intervention.\n* MRI contraindications (magnetic metal parts or electronic implants such as pacemakers in the body).\n* pregnancy (anamnestic).",{"count":82,"type":21},20,[53],"The goal of this clinical trial is to assess the effects of eccentric arm-crank (KREHA) training compared to standard clinical routine strength (STAN) training in individuals undergoing primary spinal cord injury (SCI) rehabilitation.\n\nThe main questions this trail aims to answer are:\n\n* what are the effects of the training on upper body strength, aerobic performance, muscle volume, functional independence, and health-related quality of life?\n* is the KREHA training feasible to implement into the rehabilitation routine?\n\nParticipants will:\n\n* perform either 20 KREHA sessions or 20 STAN sessions within 12 weeks\n* perform a test battery to collect data on training effects before (pretest) and after (posttest) the study intervention",[86],"Spinal Cord Injury",[88,89,90,91,92],"eccentric training","strength training","upper body","aerobic performance","muscle volume","2025-12-01",{"date":95,"type":32},"2025-12-02",{"date":97,"type":21},"2026-03-01",{"date":99,"type":21},"2028-03-01",{"name":38,"class":39},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":40},"100288664","depolarising-electrical-skin-stimulation-in-neuropathic-and-postoperative-pain-100288664","NCT03037684","Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain","Selective Activation of Unmyelinated Skin Nerve Fibres Using Slow Depolarising Transcutaneous Electrical Stimulation in Patients With Neuropathic Pain or Chronic Postoperative Pain","Inclusion Criteria:\n\n* Group (1) patients with neuropathic pain\n* Group (2) patients with chronic postoperative pain\n\nExclusion Criteria (both Groups):\n\n* severe psychiatric disorder requiring hospitalisation in the past\n* any neurological disease other than the pain diagnosis","65 Years",{"count":110,"type":21},75,"The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.",[113],"Neuropathy;Peripheral",[59,115],"chronic postoperative pain",{"date":117,"type":32},"2025-12-08",{"date":119,"type":32},"2017-03-27",{"date":121,"type":21},"2025-12-31",{"name":38,"class":39},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":48,"enrollmentInfo":129,"targetDuration":4,"studyType":51,"phases":130,"briefSummary":131,"conditions":132,"keywords":133,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":40},"100333433","investigation-into-optimal-fes-training-characteristics-after-spinal-cord-injury-100333433","NCT03621254","Investigation Into Optimal FES Training Characteristics After Spinal Cord Injury","Inclusion Criteria:\n\n* Greater than 6-weeks post-trauma after SCI.\n* Traumatic and atraumatic spinal cord injuries between C7 and T10\n* Participants diagnosed with \"motor complete' spinal cord injury American Spinal Injury Association Impairment Scale A and B.\n* Age between 18-75 years old.\n* Both male and female.\n* Have at least 90º bilateral knee flexion.\n* Able to perform FES muscle contractions (not FES intolerant).\n* Able to follow verbal instructions.\n\nExclusion Criteria:\n\n* A recent history of trauma to the lower limb.\n* Severe or infected pressure sore on weight-bearing skin areas.\n* Illness caused by acute urinary tract infection.\n* Uncontrolled spasticity or pain.\n* History of cardiovascular \u002F cardiorespiratory disease contraindicating exercise.\n* Uncontrolled orthostatic hypotension.\n* Unhealed decubiti at electrode placement area.\n* Recurrent and uncontrolled autonomic dysreflexia.\n* Active heterotopic ossification.\n* Other peripheral or central neurologic injury.",{"count":82,"type":21},[53],"The aim of this study is to investigate two different modalities of functional electrical stimulation (FES) leg exercise in patients with spinal cord injury (SCI). The primary outcomes being compared are 1. FES-induced leg aerobic fitness, and 2. FES-induced leg strength. There will be two FES-leg training groups, and sub-acute patients with SCI will be randomised between the groups - high-short \\[HI-SHORT\\] and low-long \\[LO-LONG\\]. Both groups (n=10 per group) will exercise on the Hasomed RehaStim™ exercise ergometer for 6-8 weeks, three-four times per week (24 therapy sessions). \\[HI-SHORT\\] will perform 10 x 2-min of high-intensity interval training with a recovery of 1-2 min between exercise bouts. \\[LO-LONG\\] will perform 20+ min of continuous exercise at a low-moderate exercise intensity. Exercise intensity for \\[HI-SHORT\\] and \\[LO-LONG\\] will be titrated by neuromuscular stimulation characteristics. The primary outcomes will be assessed before training commences and after 6-8 weeks of training has been completed.",[86],[134,135,136,137],"Functional Electrical Stimulation","Exercise Training","Aerobic Fitness","Muscle Strength","2025-11-20",{"date":140,"type":32},"2025-11-26",{"date":142,"type":32},"2019-01-07",{"date":144,"type":21},"2026-12",{"name":38,"class":39},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":51,"phases":156,"briefSummary":157,"conditions":158,"keywords":162,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":40},"100611832","shoulder-health-after-rehabilitation-and-performance-training-100611832","NCT07245706","Shoulder Health After Rehabilitation and Performance Training","Ensuring Shoulder Health as a Key Factor for Long Term Health and Functioning of Manual Wheelchair Users","SHARP","Inclusion Criteria:\n\n* Persons with a paraplegia below T2\n* Manual wheelchair user\n* Age 18 - 70 years\n* At discharge from initial rehabilitation\n\nExclusion Criteria:\n\n* Trauma or surgery of the shoulder with medical indication for immobilization of more than four weeks\n* Constant use of power assistance for the wheelchair\n* Any surgical implants that exclude the participant for MRI assessments of the shoulder\n* Inability to follow the study instructions, e.g., mental health problems, language problems, dementia, claustrophobia (for MRI) etc.\n* Persons with congenital conditions leading to SCI, SCI in the context of palliative care, neurodegenerative disorders, and Guillain-Barré syndrome\n* Pregnancy","70 Years",{"count":50,"type":21},[53],"The goal of this study is to investigate the impact of a home-based shoulder strength training on the overall shoulder health in manual wheelchair users, and if the timepoint of such a training makes a difference. The study is focusing on persons with a spinal cord injury in the thoracic or lumbar region of the spine, that have only recently been injured and will soon be discharged from primary rehabilitation.\n\nThe shoulder training will take place either 3 or 12 months after discharge from primary rehabilitation and will be carried out twice a week for 12 weeks.\n\nThere are six measurements occurring every three months, which leads to an overall duration of 15 months. The measurements consist of:\n\n* Questionnaires about independence in daily life, participation, quality of life and physical activity\n* Assessment of shoulder strength, range of motion and function\n* Measurement of the daily wheelchair use during one week via sensors that are fixed to the wheelchair and wrist\n* one further questionnaire at the end of the measurement week about the occurrence of shoulder pain\n\nAdditionally, on four of the six measurement timepoints, a magnet resonance image (MRI) of the shoulder will be taken to assess the shoulder status (pathology, muscle volume and quality).\n\nThough all these measurements the researchers can additionally assess the load of daily life on the shoulders, and how well this matches the preparation during the primary rehabilitation.",[86,159,160,161],"Nervous System Diseases","Musculoskeletal Diseases","Injury",[163,164,165,166,167,168,169,170],"Shoulder","Wheelchair","Training","Activity of Daily Life","Load","Capacity","Functioning","Monitoring","2025-11-17",{"date":173,"type":32},"2025-11-24",{"date":175,"type":21},"2025-12",{"date":177,"type":21},"2029-12",{"name":38,"class":39},{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":187,"targetDuration":4,"studyType":51,"phases":189,"briefSummary":190,"conditions":191,"keywords":192,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":40},"100582977","the-effect-of-probiotic-and-prebiotic-supplementation-on-gastrointestinal-health-in-individuals-with-chronic-spinal-cord-injury-100582977","NCT06870331","The Effect of Probiotic and Prebiotic Supplementation on Gastrointestinal Health in Individuals With Chronic Spinal Cord Injury","The Effect of Probiotic and Prebiotic Supplementation on Gastrointestinal Health in Individuals With Chronic Spinal Cord Injury: A Randomized Controlled Crossover Trial","PRO-GIDSCI","Inclusion Criteria (at screening):\n\n* Age: ≥ 18 years\n* Sex: male and female.\n* Chronic SCI (\\>1 year post-injury)\n* Individuals with para- and tetraplegia (American Spinal Cord Injury (ASIA) Impairment Scale (AIS) score A-D)\n* Having significant gastrointestinal complaints, indicated with \"yes\" at screening and by a GIQLI questionnaire score below 110 at baseline\n* Signed written informed consent\n\nExclusion Criteria (at screening):\n\n* Antibiotic use within the last four weeks before starting the study\n* Major dietary changes within the last four weeks before starting the study, such as initiating a vegan or ketogenic diet\n* Presence of clinically relevant medical conditions, including Crohn's disease, diagnosed eating or gastrointestinal disorders, assessed on an individual basis\n* Intake of significant concomitant medication, including immunomodulating therapy, mesalazines, or steroids, assessed on an individual basis\n* Concurrent participation in other clinical trials investigating or potentially affecting GI health\n* Insufficient German language skills to follow the study procedures\n* Pregnancy (anamnestic)",{"count":188,"type":21},50,[53],"The goal of this clinical trial is to evaluate the effect of probiotic and prebiotic supplementation in individuals with chronic spinal cord injury experiencing gastrointestinal complaints.\n\nThe main questions this trail aims to answer are:\n\n* what are the effects of the supplementation on gastrointestinal symptoms?\n* what are the effects of the supplementation on gut microbiome composition?\n* what are the effects of the supplementation on inflammatory serum markers?\n* what are the effects of the supplementation on gastrointestinal transit time?\n\nParticipants will:\n\n* take either the probiotic or prebiotic supplement daily for eight weeks, followed by a four-week \"wash-out period\" (= no intake of either supplement) and a subsequent eight-week intake of the other supplement.\n* visit the study center for four appointments, during which various measurements will be performed.",[86],[193,194,195,196,197],"probiotic","prebiotic","gastrointestinal health","microbiome","dietary supplement","2025-10-02",{"date":200,"type":32},"2025-10-03",{"date":202,"type":32},"2025-08-11",{"date":204,"type":21},"2027-06",{"name":38,"class":39},{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":213,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":214,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":216,"conditions":217,"keywords":218,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":40},"100569028","a-comprehensive-assessment-of-altered-embodiment-in-individuals-with-spinal-cord-injury-100569028","NCT06688916","A Comprehensive Assessment of Altered Embodiment in Individuals With Spinal Cord Injury","SCI_Embodiment","Inclusion Criteria for all participants:\n\n* Age between 18 and 60\n* Normal or corrected-to-normal visual acuity\n* German or Italian native speaker\n\nAdditional Inclusion Criteria only for individuals with SCI:\n\n* Diagnosis of traumatic spinal cord injury\n* Lesion level below T1 (first thoracic vertebra)\n* Time since injury \\>= 12 months\n* Residual sensation on the upper leg (sensory capability of 1 or higher on at least one leg in the dermatomes L2 and L3 for both light touch and pin prick).\n\nExclusion Criteria for all participants:\n\n* Pregnancy or breastfeeding\n* Diagnosis of other psychiatric or neurological disorders (e.g. epilepsy, tumor in the central nervous system)\n* Confirmed diagnosis of alcohol and\u002For drug abuse with active consumption within the last 6 months\n* Confirmed diagnosis of traumatic brain injury, intended as visible changes in the brain diagnosed by a radiologist\n* Stroke\n* Inability to perform study procedures (e.g. inability to consent)\n\nAdditional Exclusion Criteria for both HC and SCI undergoing the fMRI procedure:\n\n* Active medical devices (e.g. cardiac pacemaker)\n* Inability to perform study procedures (e.g. claustrophobia)",true,{"count":215,"type":21},80,"Spinal cord injury (SCI) occurs when trauma or other factors damage the spinal cord, disrupting the flow of sensory information from the body to the brain. This interruption can interfere with embodiment-the body awareness and physical sensations processed by the brain-sometimes leading to a phenomenon called disembodiment.\n\nFor people with SCI, disembodiment may appear as unusual body sensations, like feeling that a limb is in a different position than it actually is. Such changes in body awareness can impact daily life, mental health, and rehabilitation outcomes.\n\nDespite its importance, the study of embodiment in SCI remains limited. This project aims to explore how SCI alters embodiment, focusing on its specific characteristics, the effects on daily life, and the underlying brain activity as measured by functional magnetic resonance imaging (fMRI). Both people with and without SCI will participate.\n\nProcedure: Participants will complete a single examination lasting 2 to 2.5 hours, including approximately 55 minutes in the MRI scanner (with preparation and follow-up).",[56],[63,219,220,221,222],"embodiment","bodily sensations","magnetic resonance imaging","daily life",{"date":224,"type":32},"2025-10-08",{"date":226,"type":32},"2025-06-04",{"date":228,"type":21},"2026-05",{"name":38,"class":39},{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":234,"acronym":235,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":237,"minAge":18,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":240,"conditions":241,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":40},"100584648","urine-incontinence-occurrence-and-sexual-hormones-in-women-with-chronic-spinal-cord-injurydisease---a-pilot-study-100584648","NCT06892080","Urine Incontinence Occurrence and Sexual Hormones in Women With Chronic Spinal Cord Injury\u002FDisease - a Pilot Study","SexHormInkont","Inclusion Criteria:\n\n* women\n* age ≥ 18 years\n* chronic neurogenic bladder dysfunction due to acquired spinal cord injury\n* regular menstrual cycle (26-30 days\u002Fcycle)\n* written consent given\n* UI group only: UI at least once per month\n\nExclusion Criteria:\n\n* Detrusor overactivity in storage phase above 15cmH20\n* Oligomenorrhea or amenorrhea (infrequent or absent menstrual periods)\n* Hormonal intake\u002Fcontraception\n* Intake of androgens\n* Intake of drugs which interfere with female sex hormones significantly\n* Individuals who underwent sex reassignment surgery\n* Pregnant or breastfeeding women\n* Women who are trying to conceive\n* Gynaecological carcinoma\n* Endometriosis\n* Ovariectomy\n* Current pelvic floor physiotherapy\n* Reconstructive surgery of bladder\n* Local irritation of the bladder, such as bladder tumour, bladder stones, acute urinary tract infection at study start\n* Inability to follow study procedures (cognitive or language barriers)","FEMALE",{"count":239,"type":21},24,"There is a knowledge gap about the influence of the menstrual cycle on bladder function in women with spinal cord injury. So far, studies regarding urinary incontinence have primarily focused on women after menopause. It has become clear that a lack of the sex hormone estrogen, which occurs after menopause, can lead to urinary incontinence. During the course of the menstrual cycle, women also experience fluctuations in their sex hormones, particularly estrogen. The estrogen level is highest before ovulation and decreases afterwards. The investigators aim to explore whether this drop in hormone levels could lead to more frequent urinary incontinence during this phase. In order to offer the patients optimal treatment for urinary incontinence, it is important to understand the potential causes behind it. Participants will document their menstrual cycles and episodes of urinary incontinences over three menstrual cycles using a diary, and urine tests. This research project is a pilot study and is being conducted by Swiss Paraplegic Research at the Swiss Paraplegic Centre. The investigators are recruiting 12 participants who experience incontinence at least once a month and 12 participants who experience incontinence less frequently or not at all.",[86,242,243],"Urinary Incontinence","Menstrual Cycle","2025-07-30",{"date":246,"type":32},"2025-08-03",{"date":248,"type":32},"2025-07-01",{"date":250,"type":21},"2027-06-30",{"name":38,"class":39},{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":51,"phases":261,"briefSummary":263,"conditions":264,"keywords":267,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":40},"100564777","phase-4-decolonization-efficacy-of-polyhexanide-vs-mupirocin-100564777","NCT06633588","Decolonization Efficacy of Polyhexanide vs. Mupirocin","Surgical Prophylaxis: Assessing Decolonization Efficacy of Polyhexanide Versus Mupirocin and Chlorhexidine in Decolonizing Staphylococcus Aureus Preoperatively in Elective Spine Surgery (SPADE): A Pilot Randomized Controlled Trial","SPADE","Inclusion Criteria:\n\n* Age over 18 years\n* Scheduled for elective spinal surgery\n* Colonized with Staphylococcus aureus\n* Informed consent provided\n\nExclusion Criteria:\n\n* Emergency spine surgery\n* Methicillin-resistant Staphylococcus aureus (MRSA) or mupirocin-resistant S. aureus\n* Known allergies to products used in the trial\n* Pregnant or breastfeeding women\n* Recent antibiotic therapy (within 14 days)\n* Known non-compliance, substance abuse, or psychological disorders\n* Participation in another antimicrobial trial within the last 30 days",{"count":239,"type":21},[262],"PHASE4","This pilot randomized controlled trial evaluates the feasibility, tolerability, and preliminary efficacy of a decolonization regimen using polyhexanide in reducing Staphylococcus aureus colonization in the preoperative phase of elective spine surgery, compared to the standard mupirocin and chlorhexidine regimen. The trial involves 24 participants randomized into two groups: one receiving polyhexanide and the other receiving mupirocin and chlorhexidine. The primary outcome is the randomization rate, with secondary outcomes including other feasibility outcomes, tolerability, and efficacy measures such as the reduction in S. aureus colony-forming units (CFUs) and changes in the nasal and skin microbiome composition.",[265,266],"Staphylococcus Aureus","Colonization, Asymptomatic",[268,269,270],"Staphylococcus aureus colonization","Spinal surgery","decolonization","2025-05-21",{"date":273,"type":32},"2025-05-28",{"date":275,"type":32},"2025-05-01",{"date":277,"type":21},"2027-04-30",{"name":38,"class":39},{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":51,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":40},"100575718","robot-assisted-vs-conventional-occupational-therapy-of-the-upper-limb-in-individuals-with-cervical-spinal-cord-injury-100575718","NCT06775925","Robot-assisted Vs. Conventional Occupational Therapy of the Upper Limb in Individuals with Cervical Spinal Cord Injury","Robot-assisted Vs. Conventional Occupational Therapy of the Upper Limb in Individuals with Cervical Spinal Cord Injury: the Armeo X-over Trial","Armeo X-over","Inclusion Criteria:\n\n* Informed Consent signed by the subject\n* Intermediate (\\>16 days and ≤81 days post-injury) traumatic or non-traumatic cSCI during primary rehabilitation at the Swiss Paraplegic Centre (SPC)\n* Neurological level of injury: C1-T1\n* American Spinal Injury Association Impairment Scale (AIS): A-D\n* Impairment of upper limb function (GRASSP-QtG score unilateral \\\u003C 25 at baseline t0)\n* Ability to sit for 60 minutes and perform training with ArmeoSpring\n* Stratification parameters available\n\nExclusion Criteria:\n\n* Inability to follow the procedures of the investigation\n* Severe concomitant neurological disease\n* Concomitant neurodegenerative or progressive diseases\n* Impairment of upper limb function due to peripheral nerve lesions\n* Severe concurrent medical disease or any other issue that in the opinion of the investigator would confound the results\n* Orthopedic limitations of the upper limb\n* Device specific contraindications\n* Participation in other interventional trials",{"count":50,"type":21},[53],"The goal of this clinical trial is to learn the effects of robot-assisted therapy using the ArmeoSpring on upper limb function compared to conventional occupational therpay in individuals with cervical spinal cord injury (cSCI). The main questions it aims to answer are:\n\n\\- Which of the two forms of therapy, robot-assisted therapy or conventional occupational therapy, is more effective in terms of improving arm and hand function?\n\nThe study is designed as a cross-over trial, which means that each participant will receive both therapy forms consecutively, whereas the order is assigned randomly (either robot-assisted therapy first and then occupational therapy, or vice versa).\n\nIn addition to their clinical routine therapy , participants will:\n\n* complete a baseline assessment\n* practice one therapy form (either robot-assisted or occupational therapy) with one arm for 6 weeks (3 x 30 min per week)\n* complete a intermediate assessment\n* practice the other therapy form (either occupational or robot-assisted therapy) with one arm for 6 weeks (3 x 30 min per week)\n* complete a post assessment\n* complete a follow-up assessment (if the post assessment was completed prior to 150 days post-injury)",[291],"Cervical Spinal Cord Injury",[293,294,295],"upper limb function","robot-assisted therapy","occupational therapy","2025-03-05",{"date":298,"type":32},"2025-03-10",{"date":300,"type":32},"2025-02-01",{"date":302,"type":21},"2027-12",{"name":38,"class":39},""]