[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Swiss Tropical & Public Health Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":316},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,55,104,147,175,204,232,260,289],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100577588","phase-3-efficacy-and-safety-of-emodepside-in-participants-with-soil-transmitted-helminth-infections-100577588",false,"NCT06800248","Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections","A Phase III Single-center, Randomized, Double-Blinded, Parallel-group, Active Controlled Study to Evaluate the Efficacy and Safety of a Single Dose of Emodepside Compared to Multiple Doses of Mebendazole in Adolescent and Adult Participants With Soil-transmitted Helminthiasis","TREMO-Siargao","Inclusion Criteria:\n\n1. Male or non-pregnant (confirmed by a negative serum pregnancy test) and non-breastfeeding female participants aged 12 years and older.\n2. T. trichiura as a single infection or co-infection with hookworm and\u002For A. lumbricoides, confirmed by presence of T. trichiura eggs assessed by Kato-Katz thick smears from two stool samples (infection intensity defined as number of eggs per gram of stool (EPG): (1) light (1-999 EPG), (2) moderate to heavy (≥1000 EPG).\n3. A minimum infection intensity of 24 eggs per gram of stool at baseline and at least two positive slides out of the four slides assessed at baseline.\n4. Written informed consent signed by the participant and\u002For legally authorized representative(s) according to the participant's age as established per local regulations. In addition, participant's assent is required as applicable by local laws and regulations for adolescents of 12-17 years of age.\n5. Women of childbearing potential must agree to use an effective, culturally appropriate contraceptive measure from at least 28 days prior to first dosage for hormonal contraceptives only and for non-hormonal contraceptive measures from screening Visit 2 until End of Study Visit.\n\nExclusion Criteria:\n\n1. Presence of any systemic illnesses, renal and\u002For hepatic impairment, any other acute or chronic health conditions or congenital disorders which, in the opinion of the Investigator, would make the participant unsuitable for participation in a clinical study or may interfere with the efficacy, safety, and\u002For pharmacokinetic (PK) evaluation of the study drug.\n2. Any of the following:\n\n   1. Platelet \\\u003C75,000\u002Fmm3\n   2. Alanine Aminotransferase (ALT) or Serum Glutamic Pyruvic Transaminase (SGPT) \\>3x upper limit of normal (ULN)\n   3. Total bilirubin \\>2xULN\n   4. Estimated Glomerular Filtration Rate (eGFR) \\\u003C90 ml\u002Fmin\u002F1.73 m2 (adolescents) or estimated creatinine clearance (CrCl) \\\u003C90 ml\u002F min (adults)\n3. Treatment with the following anthelminthic drugs: albendazole, mebendazole, ivermectin, within 28 days before the first dose of study intervention or planned before End of Study Visit.\n4. Use of sensitive CYP3A4 substrates within 14 days before the start of the first study intervention and until at least 14 days after the last administration of study intervention.\n5. Treatment with metronidazole within 2 days before the first dose of study intervention or planned before 24 hours after last administration of study intervention.\n6. Previous assignment to a study intervention for another study planned to be administered during the period the participant is enrolled in this study (from date of informed consent to last follow-up).\n7. Known allergy\u002Fhypersensitivity to mebendazole and\u002For emodepside","ALL","12 Years",{"count":20,"type":21},315,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and\u002For A. lumbricoides.",[27,28,29],"Trichuris Trichiura; Infection","Hookworm Infection","Ascaris Lumbricoides Infection",[31,32,33,34,35,36,37,38,39,40,41],"Trichuris trichiura","Ascaris lumbricoides","STH","Efficacy","Safety","Hookworm","Emodepside","Soil-transmitted helminths","Roundworm","Whipworm","Mebendazole","NOT_YET_RECRUITING","2026-06-10",{"date":45,"type":46},"2026-06-11","ACTUAL",{"date":48,"type":21},"2026-09",{"date":50,"type":21},"2027-08",{"name":52,"class":53},"Swiss Tropical & Public Health Institute","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":63,"minAge":18,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":68,"conditions":69,"keywords":87,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":54},"100636706","improved-child-nutrition-and-development-through-social-transfers-100636706","NCT07569172","Improved Child Nutrition and Development Through Social Transfers","Taabo Enhanced Nutrition and Development Through Economic Rewards","TENDER","Inclusion Criteria:\n\n1. Are enrolled in the Taabo multigenerational birth cohort (MGC)\n2. Completed the postpartum interview of the Taabo MGC\n3. Have a child who is within two weeks of their 12-month birthday,\n4. are breastfeeding at time of recruitment,\n5. live in the Taabo HDSS, Côte d'Ivoire\n6. have no illnesses that contraindicates breastfeeding,\n7. had a healthy singleton infant with a birth weight of at least 2500 grams, and\n8. agree to participate and sign an informed consent; if underage (12-17 years), a legal representative will also have to agree to sign the informed consent\n\nExclusion Criteria:\n\n1. Plans to move permanently outside study area\n2. Has a medical, intellectual or psychological disability\n3. Contraindication for breastfeeding\n4. Children born with \\\u003C 2500 grams","FEMALE",{"count":65,"type":21},1040,[67],"NA","The goal of this clinical trial is to learn if a conditional social transfer works to improve rates of complementary breastfeeding. It will also learn about the impacts of social transfers on maternal and child health and development. The main questions it aims to answer are:\n\n* Does the social transfer increase complementary breastfeeding rates at 24-months postpartum?\n* Does the social transfer increase complementary breastfeeding duration?\n* Does the social transfer impact child health and development?\n* Does the social transfer impact maternal physical and mental health?\n\nResearchers will compare a conditional social transfer to a control group that only receives education about breastfeeding recommendations to see if a conditional social transfers works to increase complementary breastfeeding.\n\nParticipants will:\n\nReceive a pamphlet explaining the current recommendations of breastfeeding Receive instructions that if they meet the recommendation to breastfeed until 24-months postpartum they receive a social transfer or receive no additional information Complete home visits at 12- and 24-months postpartum Complete detailed questionnaire",[70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86],"Breastfeeding","Breastfeeding Education","Breastfeeding Duration","Breastfeeding Continuation","Child Growth","Stress","Infectious Diseases","Anemia","Child Development","Weight Loss","Blood Pressure","Mental Health","Diarrhea","Coughing","Eczema","Allergies","Antibiotic Use",[88,89,90,91,92,93,94,95],"breastfeeding","cash transfer","child health","maternal health","mental health","child growth","child development","education","2026-04-28",{"date":98,"type":46},"2026-05-06",{"date":100,"type":21},"2026-06-01",{"date":102,"type":21},"2028-02-28",{"name":52,"class":53},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":129,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":54},"100506981","prevalence-incidence-and-risk-signature-of-chronic-kidney-disease-in-sub-saharan-africa-100506981","NCT05881447","Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in Sub-Saharan Africa","Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in a Primary Care Setting in Semirural Sub-Saharan Africa","RenalTWO","Inclusion Criteria:\n\nall adult patients (≥18 years) attending the outpatients department of the Bagamoyo district hospital (BDH) or the associated Fukayosi and Yombo dispensary\n\nExclusion Criteria:\n\n* \\\u003C18 years of age\n* not living in the BDH catchment area\n* not of African decent\n* not willing to come back for follow-up visits","18 Years","99 Years",{"count":115,"type":21},1200,"OBSERVATIONAL","Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. The prevalence of CKD is increasing worldwide and is assumed to also dramatically increase in Sub-Saharan Africa (SSA). Key shortcomings of available data on CKD in SSA are as follows: (i) Available data are based on single measurements and, therefore, cannot distinguish between harmless transient deterioration in kidney function and chronic kidney damage; (ii) Accurate information regarding renal protein loss, an important and early marker of kidney disease, is lacking; (iii) Cardiovascular risk factors for CKD, such as obesity, hypertension and diabetes, are often not searched for. Likewise non-classic potential risk factors, such as endemic infectious diseases, socioeconomic status and lifestyle have not been consistently recorded; (iv) Information to interrogate linked interaction over time between risk factors and development of CKD is unavailable. With this project, situated in a region representative of semi-rural SSA, we aim to fill this knowledge gap and (i) establish guideline conform prevalence data of CKD and its major cardiovascular risk factors, as well as (ii) prospectively define the incidence of cardiovascular- and non-classic risk factors of CKD. The data from (i) and (ii) is used to develop predictive models. A prospective cohort of 1200 individuals in a primary care facility will serve as study population. The population is representing a society in transition from rural to more urban lifestyle. In the pilot study, participants will be followed for one years and undergo the clinical and biomedical testing required to capture CKD and its classic and non-classic risk factors over time.",[119,120,121,122,123,124,77,125,126,127,128],"Chronic Kidney Diseases","Type 2 Diabetes Mellitus","Arterial Hypertension","Obesity","Cardiovascular Diseases","HIV Infections","Underweight","Infections","Albuminuria","Dyslipidemias",[130,131,132,77,133,134,135,136,137],"CKD","Risk factors","Cardiovascular disease","Point of care diagnostics","Albumin creatinine ration (ACR)","Estimated glomerular filtration rate (eGFR)","Kidney Disease: Improving Global Outcomes (KDIGO)","HbA1c","RECRUITING","2026-04-23",{"date":141,"type":46},"2026-04-29",{"date":143,"type":46},"2023-06-21",{"date":145,"type":21},"2026-12-31",{"name":52,"class":53},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":155,"sex":63,"minAge":112,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":163,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":173,"locationsCount":174},"100565746","improving-menstrual-and-vaginal-health-for-all-100565746","NCT06646185","Improving Menstrual and VAginal Health for All","IMVAHA: Improving Menstrual and VAginal Health for All","IMVAHA","Inclusion Criteria:\n\n* able to provide informed consent;\n* aged 18-35;\n* residing in the recruitment region and expecting to reside in the same region for at least six months following recruitment (Yaoundé\u002F Gounougou, Cameroon; Loreto\u002FLima\u002FMaynas provinces, Peru; or Basel-Landschaft and Basel-Stadt cantons, Switzerland);\n* are native speakers or are able to read and understand one of the following languages in each respective country (German, French, Italian, English or Spanish in Switzerland; French or English in Cameroon; Spanish in Peru);\n* had menstrual cycles of 21-35 days for at least the last 4 months;\n* had menses which lasted at least 3 days for at least the last 4 months.\n\nExclusion criteria:\n\n* experienced a menstrual abnormality with any of the menstrual cycles in the last 4 months (such as oligomenorrhea or amenorrhea, or bleed more than 7 days a month);\n* are pregnant or actively trying to become pregnant;\n* are breastfeeding;\n* used antibiotics and\u002For vaginal antifungals in the last 30 days prior to recruitment;\n* had a vaginal birth in the last 6 months;\n* vaginal surgery, perineal surgery, uterine surgery, miscarriage or abortion in the last 6 months;\n* history of Toxic Shock Syndrome ;\n* positive to detection of the toxic shock syndrome toxin-1 gen (tst) using Polymerase Chain Reaction (PCR);\n* Intrauterine device in situ;\n* under medication (treatment against infectious or chronic disease) at the time of recruitment or during the 3 weeks prior to recruitment;\n* clinical symptoms of vaginal infection;\n* smoker.",true,"35 Years",{"count":158,"type":21},100,[67],"A three-period crossover trial will study the effects of short-term use of 3 menstrual products (menstrual pad, tampon, menstrual cup) on the bacterial composition of the vaginal microbiome in three countries (Peru, Cameroon, and Switzerland). Each crossover period consists of two menstrual cycles, thus resulting in a 6-month trial. Participants will be randomly assigned to one of 6 exposure sequences (different order of products per sequence); in each sequence, participants will adopt each menstrual product for 2 menstrual cycles. Participants will provide vaginal microbiome samples via self-sample swabs at 3 points during each menstrual cycle. Given the crossover design of the study, there is not a dedicated control group.",[162],"Effects of Menstrual Products on the Vaginal Microbiome",[164,165,166,167],"vaginal microbiome","menstruation","crossover study","menstrual products","2026-04-20",{"date":139,"type":46},{"date":171,"type":46},"2026-04-15",{"date":145,"type":21},{"name":52,"class":53},3,{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":17,"minAge":182,"maxAge":183,"enrollmentInfo":184,"targetDuration":4,"studyType":22,"phases":186,"briefSummary":188,"conditions":189,"keywords":191,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":54},"100630503","phase-4-integrating-point-of-care-testing-poct-for-newborn-screening-and-early-care-for-sickle-cell-disease-in-yopougon-cte-divoire-100630503","NCT07488520","Integrating Point of Care Testing (POCT) For Newborn Screening and Early Care for Sickle Cell Disease in Yopougon, Côte d'Ivoire","STEP","Inclusion Criteria:\n\n1. Children aged 0 - 6 months old identified at selected health facilities within the study area\n2. Babies whose age plus the gestation period reaches 37 weeks or more\n3. Children who did not receive a blood transfusion within the past 90 days\n4. Children whose parents or guardians have consented to participate in the study by signing a consent form\n\nExclusion Criteria:\n\n1. Children already diagnosed with SCD\n2. Children that are participating in another clinical research project\n3. Children that are critically ill and require emergency treatment","0 Months","6 Months",{"count":185,"type":21},120,[187],"PHASE4","The goal of this clinical trial is to learn if a multifaceted intervention composed of Gazelle-Multispectral sickle cell disease (SCD) point of care testing (POCT) and early initiation of comprehensive SCD care in children with SCD disease aged 0 - 6 months can improve their clinical outcomes.\n\nThe main questions it aims to answer are:\n\n* Does the intervention lower the number of SCD-related illnesses?\n* Does the intervention lower the illness incidence defined as seeking health care at any health facility - with or without treatment - for any episode related to a SCD related illness?\n* Does the intervention lower all-cause death rate (at the end of 1, 2, 3 and 3.5 years of follow-up)?\n\nResearchers will compare the multifaceted intervention results with those of historical data (based on erratic SCD testing and treatment) from the region.\n\nParticipants will undergo a SCD screening test using the Gazelle Multispectral platform and if positive they will undergo confirmatory testing with HemoTypeSC™. Participants with SCD will receive early comprehensive clinical interventions i.e. standard administration of antibacterial and antimalarial prophylaxis, vaccinations for pneumococcal and Haemophilus influenzae type b (Hib), hydroxyurea, parental education about the need for regular and, if necessary, urgent medical care.",[190],"Sickle Cell Disease (SCD)",[192,193,194,195],"Sickle cell disease","Newborn Screening","Early Care for Sickle Cell Disease","Point of care testing","2026-03-18",{"date":198,"type":46},"2026-03-23",{"date":200,"type":21},"2026-04",{"date":202,"type":21},"2029-12",{"name":52,"class":53},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":63,"minAge":212,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":22,"phases":215,"briefSummary":216,"conditions":217,"keywords":219,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":54},"100619204","improving-uptake-of-antenatal-care-services-in-rural-cte-divoire-100619204","NCT07341581","Improving Uptake of Antenatal Care Services in Rural Côte d'Ivoire","Supply and Demand-Side Interventions to Improve Uptake of Antenatal Care Services: a Randomized Controlled Trial in Rural Côte d'Ivoire","Taabo ANC","Inclusion criteria for pregnant women:\n\n* Currently pregnant\n* Aged 15 years or older\n* Live in the area served by the Taabo Health \\& Demographic Surveillance System\n* Estimated gestational age of less than 6 completed months of pregnancy\n\nInclusion criteria for male partners:\n\n* Aged 15 and older\n* Married to or currently the main romantic partner of a woman who is enrolled in the study","15 Years",{"count":214,"type":21},1290,[67],"The past two decades have brought significant increases in the availability of maternal health care services in many low- and middle-income countries, with a large increase in the number of health facilities that provide these services. However, many women still do not receive the basic services recommended by the World Health Organization. In many settings, antenatal care is associated with substantial financial cost, which means that obtaining high quality care can involve complex intrahousehold bargaining and decision-making. Women have more access to information about these services, but men generally make the financial decisions. If men are unaware of the magnitude and timing of financial needs, securing adequate financial resources may be difficult.\n\nThe investigators plan to conduct a randomized-controlled experiment of supply- and demand-side solutions to increase uptake of recommended antenatal care services in rural Côte d'Ivoire, where there are currently substantial gaps in service coverage. Despite Côte d'Ivoire's \"free maternity care\" policy, many recommended services - including ultrasounds and laboratory tests - continue to carry costs for patients. On the supply side, the study will evaluate the impact of providing key services (including ultrasounds, laboratory testing, and iron and folic acid supplements) for free to pregnant women (in line with Côte d'Ivoire's policy of free provision). On the demand side, the study will evaluate the impact of providing information about antenatal care recommendations to pregnant women (alone or with their partners), and of providing a financial planning session to pregnant women or their partners, or both together. The study will evaluate the impacts of these interventions on the uptake of recommended antenatal care services.",[218],"Uptake of Antenatal Health Care Services",[91,220,221,222,223],"sub-Saharan Africa","antenatal care","vouchers","financing","2026-01-19",{"date":226,"type":46},"2026-01-22",{"date":228,"type":46},"2026-01-16",{"date":230,"type":21},"2027-02",{"name":52,"class":53},{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":155,"sex":63,"minAge":4,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":22,"phases":242,"briefSummary":243,"conditions":244,"keywords":246,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":4},"100600269","effect-of-culturally-tailored-health-education-on-postnatal-care-use-among-postpartum-women-in-ethiopia-100600269","NCT07095296","Effect of Culturally Tailored Health Education on Postnatal Care Use Among Postpartum Women in Ethiopia","Effect of a Culturally Tailored Health Education Intervention Based on Social Cognitive Theory and the Theory of Planned Behavior on Postnatal Care Utilization Among Postpartum Women in Ethiopia","ECTHE","Cluster-Level Eligibility Criteria:\n\nTo be eligible for inclusion, clusters must meet the following criteria:\n\n* A catchment population size of at least 5,000 people\n* An average of more than 50 antenatal care (ANC) visits per month\n* Location in a peri-urban area to facilitate participant follow-up\n\nIndividual-Level Eligibility Criteria (for mothers):\n\n* Gestational age between 20 and 24 weeks at the time of enrollment\n* Residence within one hour's travel distance from the selected health facility\n\nIndividual-Level Exclusion Criteria:\n\n* Mothers who plan to relocate from the selected cluster area before or shortly after delivery\n* Mothers who do not speak either Afan Oromo or Amharic, as these are the languages used for delivering the intervention.\n* Mothers who have already completed all recommended postnatal care visits during their most recent previous birth",{"count":241,"type":21},864,[67],"This clinical study aims to find out if a redesigned health education program-one that respects local cultural beliefs and is based on well-known behavior change theories-can help improve how well mothers care for their newborns and how often they use postnatal care services. The main hypothesis is that culturally tailored health education provided by trained midwives will lead to: 1. Increased use of postnatal care services by mothers after childbirth, and 2. Improved knowledge among mothers about how to care for their newborns.\n\nIn the study, midwives will first be trained in how to provide this culturally appropriate health education. Then, the trained midwives will deliver four health education sessions-once a month-to pregnant women during their regular antenatal (before birth) visits at health facilities.",[245],"Intervention",[247,248,249,250,251],"PNC","Counseling","Health education","Newborn care","Cluster Randomized Trial","2025-12-01",{"date":254,"type":46},"2025-12-03",{"date":256,"type":21},"2025-12",{"date":258,"type":21},"2026-07",{"name":52,"class":53},{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":63,"minAge":112,"maxAge":268,"enrollmentInfo":269,"targetDuration":4,"studyType":22,"phases":271,"briefSummary":272,"conditions":273,"keywords":277,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":288},"100528202","social-transfers-for-exclusive-breastfeeding-in-brazil-100528202","NCT06157697","Social Transfers for Exclusive Breastfeeding in Brazil","Social Transfers for Exclusive Breastfeeding in São Paulo, Brazil","STEBB","Inclusion Criteria:\n\n* Gave birth in the last 72 hours\n* Exclusively breastfeeding at time of recruitment and intend to continue to exclusively breastfeed\n* Part of or eligible Bolsa Familia or on the Bolsa Familia list (CAD Unico)\n* Lives in São Paulo\n* No illnesses that contraindicates breastfeeding\n* Had a healthy singleton infant of 37 weeks or more gestation with a birth weight of at least 2500 grams\n* Agrees to participate and sign an informed consent; if under age (12-17 years), a legal representative will also have to agree to sign the informed consent\n\nExclusion Criteria:\n\n* Plans to move permanently outside study area\n* Has a medical, intellectual or psychological disability\n* Contraindication for breastfeeding\n* Preterm births\n* Children born with \\\u003C 2500 grams","50 Years",{"count":270,"type":21},400,[67],"The goal of this study is to assess the effectiveness of social transfers on exclusive breastfeeding rates in São Paulo, Brazil. The main research questions are:\n\n1. Are social transfers effective at increasing exclusive breastfeeding rates\n2. Are social transfers effective in prolonging the duration of exclusive breastfeeding\n3. Are social transfers effective in prolonging the duration of complementary breastfeeding\n4. What are the long-term impacts of social transfers for breastfeeding on child health and development\n\nParticipants will be randomly assigned to one of three groups: 1) control, no social transfer 2) non-conditional social transfer at 6-months postpartum, and 3) conditional social transfer at six months postpartum; conditional upon the mothers exclusive breastfeeding status.\n\nAll participants receive education about the benefits of exclusive breastfeeding and current international recommendations.\n\nResearchers will compare the intervention groups to the control group to see if social transfers are effective at increasing exclusive breastfeeding rates at six months postpartum.",[274,70,275,276],"Breast Feeding, Exclusive","Development, Child","Development, Infant",[278,94,279],"exclusive breastfeeding","social transfer","2025-06-18",{"date":282,"type":46},"2025-06-24",{"date":284,"type":46},"2025-03-06",{"date":286,"type":21},"2027-10",{"name":52,"class":53},2,{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":297,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":22,"phases":301,"briefSummary":302,"conditions":303,"keywords":304,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":288},"100454789","digital-support-systems-to-improve-child-health-and-development-in-peru-100454789","NCT05202106","Digital Support Systems to Improve Child Health and Development in Peru","Digital Support Systems to Improve Child Health and Development in Peru - a Randomized Controlled Trial","DigitalECD","Inclusion Criteria:\n\n* children residing in the study area\n\nExclusion Criteria:\n\n* children with disabilities\n* families planning to leave study area\n* families participating in national Cuna Mas program","3 Months","9 Months",{"count":300,"type":21},2400,[67],"About 250 million children under age five are at risk of not reaching their developmental potential due to continued exposure to ill health, malnutrition and lack of appropriate learning environments. A large number of initiatives have been launched in recent years to support early childhood development, with home visiting programs increasingly being recognized as a key strategy for improving child wellbeing. However, the most effective ways to reach families in low income settings remain unclear due to the large expense associated with personal family visits. This project assesses the effectiveness and equity of a newly developed digital platform designed to deliver evidence-based, individualized parenting support through automated services. The Afinidata platform uses state-of-the art machine learning algorithms to allow caregivers to get answers to questions about child health and development, while also identifying and promoting age- and development-appropriate activities for parents to support their children. The goal of this study is to rigorously assess the reach, impact and cost effectiveness of this digital platform in a poor rural population through a randomized controlled trial. The study is designed as mixed-methods evaluation approach with repeated feedback into the Afinidata system. A total of 2400 newborns will be enrolled in a randomized controlled trial in San Marcos, Peru, and followed up for two years. The primary study outcome will be children's healthy development at 24 months of age assessed through the Bayley Scales of Infant and Toddler Development (BSID-III). Secondary outcomes will be systems utilization, program coverage and cost-effectiveness, as well as caregiver satisfaction. If proven effective, this innovative digital platform may increase global access to low-cost parental support -a widely recognized key strategy for improving child well-being.",[78],[94,305,306,307],"stimulation","mobile phones","digital interventions","2025-05-14",{"date":310,"type":46},"2025-05-18",{"date":312,"type":46},"2021-09-01",{"date":314,"type":21},"2026-06-30",{"name":52,"class":53},""]