[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Swissmed Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":111},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100625423","compliance-guided-abdominal-wall-closure-strategy-in-large-ventral-hernia-repair-100625423",false,"NCT07422441","Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair","Impact of a Compliance-Guided Intraoperative Abdominal Wall Closure Decision Strategy on Early Postoperative Respiratory Failure After Large Ventral Hernia Repair Following Preoperative Botulinum Toxin A","CLOSE-STAT","Inclusion Criteria:\n\n* Age 18 years or older\n* Elective repair of a large ventral abdominal wall hernia (including incisional hernia)\n* Preoperative botulinum toxin A preparation performed as part of the local prehabilitation pathway\n* Preoperative abdominal CT available\n* General anesthesia with mechanical ventilation and feasibility of standardized intraoperative respiratory mechanics measurements\n\nExclusion Criteria:\n\n* Severe preoperative respiratory failure judged to preclude standardized intraoperative respiratory mechanics assessment\n* Inability to obtain reliable static respiratory system compliance measurements at predefined timepoints\n* Hemodynamic instability preventing protocolized measurements (as judged by the anesthesiologist)","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed. During closure, pressure inside the abdomen may increase and lung mechanics can worsen. This study will evaluate a structured intraoperative decision approach that uses standard anesthesia measurements of static respiratory system compliance at predefined timepoints to support the choice of abdominal wall closure technique. The main goal is to assess the rate of early postoperative respiratory failure within 72 hours after surgery.",[27,28,29,30],"Hernia, Ventral","Hernia Incisional","Postoperative Complications","Respiratory Insufficiency",[32,33,34,35,36,37,38],"adbominal wall closure","static compliance","respiratory system compliance","intraoperative monitoring","intra-abdominal pressure","complex hernia repair","botulinum toxin a","NOT_YET_RECRUITING","2026-02-12",{"date":42,"type":43},"2026-02-20","ACTUAL",{"date":42,"type":21},{"date":46,"type":21},"2026-11-01",{"name":48,"class":49},"Swissmed Hospital","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":81,"completionDateStruct":82,"leadSponsor":84,"locationsCount":4},"100624264","patient-reported-outcomes-in-women-with-postpartum-abdominal-wall-insufficiency-ppawis-100624264","NCT07407374","Patient-Reported Outcomes in Women With Postpartum Abdominal Wall Insufficiency (PPAWIS)","A Prospective Observational Cohort Study of Quality of Life, Body Image, and Sexual Function in Women With Postpartum Abdominal Wall Insufficiency Syndrome (PPAWIS) Using Patient-Reported Outcome Measures","EMPOWER","Inclusion Criteria:\n\n* Female, age 18-65 years\n* Postpartum status: at least 6 months after last delivery\n* Clinical diagnosis of postpartum abdominal wall insufficiency syndrome (PPAWIS), defined by abdominal wall dysfunction symptoms and\u002For significant quality-of-life impact, with supportive findings on physical examination and\u002For imaging (e.g., diastasis recti and\u002For related abdominal wall insufficiency features)\n* Receiving routine clinical care for PPAWIS at the study site (surgical)\n* Able and willing to provide informed consent and complete patient-reported outcome questionnaires at baseline and follow-up\n\nExclusion Criteria:\n\n* Current pregnancy\n* Planned pregnancy during the follow-up period (up to 12 months), if expected to interfere with outcome assessment\n* Inability to complete questionnaires due to cognitive impairment or insufficient language proficiency in the validated questionnaire language version\n* Severe uncontrolled psychiatric condition that, in the investigator's opinion, would prevent informed consent or reliable questionnaire completion\n* Participation in another interventional study that could materially affect patient-reported outcomes related to abdominal wall function during the follow-up period","FEMALE","65 Years",{"count":61,"type":21},30,"OBSERVATIONAL","Postpartum abdominal wall insufficiency syndrome (PPAWIS) is a multidimensional condition that may affect physical function, quality of life, body image, and sexual health in women after childbirth. Anatomical findings alone do not fully explain symptom burden or patient experience.\n\nThis prospective observational cohort study will collect validated patient-reported outcome measures (PROMs) from women with PPAWIS receiving routine care. PROMs will be assessed at baseline and during follow-up to describe symptom burden and changes over time. The study aims to improve understanding of the patient-centered impact of PPAWIS and to support development of standardized assessment pathways in clinical practice.",[65,66,67,68],"Diastasis Recti and Weakness of the Linea Alba","Abdominal Wall Defect","Postpartum Complication","Abdominal Wall Anomaly",[70,71,72,73,74,75,76,77,78],"PROMs","postpartum abdominal wall insufficiency","PPAWIS","patient-reported outcomes","sexual function","women's health","core stability","quality of life","abdominal wall reconstruction","2026-02-05",{"date":40,"type":43},{"date":42,"type":21},{"date":83,"type":21},"2027-01-01",{"name":48,"class":49},{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100615222","safety-and-efficacy-of-the-3dmax-mid-anatomical-mesh-bd-usa-in-laparoscopic-endoscopic-inguinal-hernia-repair---multicenter-prospective-observational-study-100615222","NCT07289802","Safety and Efficacy of the 3DMax™ MID Anatomical Mesh (BD, USA) in Laparoscopic-endoscopic Inguinal Hernia Repair - Multicenter, Prospective Observational Study","Safety and Efficacy of the 3DMax MID Anatomical Mesh (BD, USA) in Laparoendoscopic Inguinal Hernia Repair: A Multicenter Prospective Observational Cohort Study","3DMS","Inclusion Criteria:\n\n* Age 18 years or older\n* Primary unilateral or bilateral inguinal hernia\n* Scheduled for elective laparoendoscopic inguinal hernia repair (TAPP or TEP)\n* Considered suitable for general anesthesia and laparoendoscopic approach by the treating surgeon\n* 3DMax MID Anatomical Mesh planned for use as part of routine clinical care\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Age below 18 years\n* Emergency surgery (e.g. incarcerated or strangulated hernia requiring urgent intervention)\n* Contaminated or potentially contaminated surgical field\n* Recurrent inguinal hernia in the same groin (previous repair with mesh or suture)\n* Concomitant procedures or clinical situations in which the surgeon decides that a different mesh concept or technique is required\n* Inability or unwillingness to comply with follow-up schedule (e.g. lack of telephone contact, severe cognitive impairment)",{"count":94,"type":21},300,"This is a multicenter, prospective, observational cohort study evaluating the safety and efficacy of the 3DMax MID Anatomical Mesh (BD, USA) in laparoendoscopic inguinal hernia repair. Adult patients undergoing elective transabdominal preperitoneal (TAPP) or totally extraperitoneal (TEP) repair will be enrolled and followed according to routine clinical practice.\n\nThe primary objective is to assess the inguinal hernia recurrence rate within 12 months after surgery. Secondary objectives include evaluation of postoperative pain, groin discomfort and foreign body sensation, as well as early and late postoperative complications.\n\nAll participating patients will receive the 3DMax MID Anatomical Mesh as part of standard care. No additional experimental procedures are planned. Clinical data will be collected at baseline and during predefined follow-up contacts (early postoperative period, 1 month, 3 months and 12 months) using standardized forms and patient interviews.",[97],"Hernia, Inguinal",[99,100,101,102],"Hernia","Mesh","Inguinal Hernia","Recurrence","2025-12-04",{"date":105,"type":43},"2025-12-17",{"date":107,"type":21},"2026-01-01",{"date":109,"type":21},"2027-04-01",{"name":48,"class":49},""]