[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Syracuse University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":234},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,46,71,91,122,147,181,208],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100565934","acceptance-and-commitment-therapy-for-hiv-hazardous-drinkers-100565934",false,"NCT06648629","Acceptance and Commitment Therapy for HIV+ Hazardous Drinkers","Acceptance and Commitment Therapy for HIV+ Hazardous Drinkers: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Living with HIV\n* Drink at unhealthy levels based on self-reported answers to the AUDIT-C, referencing drinking over the previous 3 months \\[score of ≥4 (men) or ≥3 (women) will be used to identify eligible participants\\]\n* on HIV treatment and are\n* 18 years or older.\n* Read at an 8th grade level\n* Can provide a physical address\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Anyone with a score = 12 on the AUDIT-C will be excluded.\n* Anyone with a score ≥20 on the PHQ-9, indicative of severe depression, will be excluded.\n* Anyone with a score of ≥15 on the GAD-7, indicative of severe anxiety, will be excluded.\n\nReferrals for mental health treatment will be given to all participants who screen out.","ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","INTERVENTIONAL",[23],"NA","Alcohol consumption is a critical factor in HIV treatment that significantly contributes to poor treatment-related outcomes. Randomized clinical trials (RCTs) of alcohol interventions for people with HIV (PWH) have had limited success, perhaps due to an increasingly recognized co-morbitity of co-occurring hazardous alcohol use and other mental health-related problems among PWH. This has necessitated a shift in the literature towards trans-diagnostic approaches that target core psychological processes that underlie multiple mental health-related problems. One trans-diagnostic mechanism that is relevant to alcohol and other substance use is experiential avoidance (EA)- i.e., repeated, and maladaptive, use of substances and\u002For other behaviors to escape or avoid unwanted thoughts, feelings, and\u002For urges. Acceptance and commitment therapy (ACT) targets EA and is an empirically supported treatment for multiple psychological and behavioral health-related outcomes; however there have not been any full-scale RCTs of ACT for alcohol use among any population, including PWH. The investigators recently adapted a telephone-delivered ACT intervention originally developed for smoking cessation, into an intervention for PWH who drink at unhealthy levels (NIH\u002FNIAAA; R34AA026246). This six-session, telephone-delivered ACT intervention for alcohol use showed high feasibility and acceptability in a pilot RCT conducted by our team. The overall objective of this application is therefore to determine if ACT can significantly reduce alcohol use and comorbid symptoms of depression, anxiety, and stress among adult PWH who drink at unhealthy levels. The specific aims are: To determine the relative efficacy of ACT, compared to BI, for reducing alcohol use among PWH (Aim 1) and to determine if ACT has an effect on trans-diagnostic processes that in turn affect alcohol use and other psychological and functional outcomes (Aim 2). The investigators will accomplish these aims by: conducting a remote, RCT in which the investigators randomly assign 300 PWH who drink at unhealthy levels to either the ACT intervention the investigators developed (n = 150), or a BI intervention (n = 150) previously shown to reduce alcohol use among PWH. The investigators will assess alcohol-related outcomes-via self-report and a biomarker- at baseline, post-treatment (7 weeks post-baseline), and again 3-, 6-, and 12-months post-randomization. The investigators will also measure EA to determine if it mediates treatment effects for alcohol use and other psychological and functional outcomes, measured at all timepoints.",[26,27],"HIV-1-infection","Alcohol Drinking",[29,30,31,32],"HIV","Alcohol","ACT","Treatment","RECRUITING","2026-02-02",{"date":36,"type":37},"2026-02-04","ACTUAL",{"date":39,"type":37},"2025-01-22",{"date":41,"type":20},"2028-08",{"name":43,"class":44},"Syracuse University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100510701","phase-1-intensive-speech-motor-chaining-treatment-for-residual-speech-sound-disorders-100510701","NCT05929859","Intensive Speech Motor Chaining Treatment for Residual Speech Sound Disorders","iChain","Inclusion Criteria:\n\n* Must speak American English as a dominant language.\n* Must have began learning English by at least the age of 3 years.\n* Must be between 9;0 to 17;11 years of age.\n* Must have reported difficulty with \u002Fɹ\u002F and\u002For \u002Fs\u002F production\n* Must pass pure tone hearing screening at 25 dB at 1000, 2000, and 4000 Hz.\n* Must receive a scaled score of at least 5 on the Listening Comprehension and Story Retelling subtests of the Test of Integrated Language and Literacy Skills (TILLS)\n* Must receive a percentile score of 5 or below on the Goldman-Fristoe Test of Articulation-3 (GFTA-3) Sounds in Words subtest.\n* Must have 1 scorable response with 5+ consecutive correct \u002Fpataka\u002F with \\> 3.4 syllables per second in the MRR-Tri task of the Maximum Performance Tasks OR must demonstrate no childhood apraxia of speech (CAS-only) features in BOTH articulatory and rate\u002Fprosody domains of the ProCAD.\n* Must score \\\u003C40% accurate on \u002Fɹ\u002F and\u002For \u002Fs\u002F probes assessing these sounds at the word level.\n* Must express a desire to modify their speech.\n\nExclusion Criteria:\n\n* Must have no known history of autism spectrum disorder, Down Syndrome, cerebral palsy, intellectual disability, permanent hearing loss, or brain injury.\n* Must not have current cleft palate or voice disorder.","9 Years","17 Years",{"count":56,"type":20},84,[58,59],"PHASE1","PHASE2","The goal of this randomized-controlled trial is to compare distributed treatment schedules and intensive treatment schedules in 84 school-age children with residual speech sound disorders. The main question it aims to answer is:\n\n* How does intensive and distributed treatment affect speech sound learning in residual speech sound disorder?\n\nSome participants will be treated with a traditional Distributed schedule of 2 sessions per weeks for 8 weeks (16 hours total), whereas others will be treated with an Intensive schedule and will complete 16 hours of treatment in 4 weeks.",[62],"Speech Sound Disorder","2026-01-12",{"date":65,"type":37},"2026-01-13",{"date":67,"type":37},"2023-10-26",{"date":69,"type":20},"2028-02-29",{"name":43,"class":44},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":45},"100515208","ai-assisted-treatment-for-residual-speech-sound-disorders-100515208","NCT05988515","AI-Assisted Treatment for Residual Speech Sound Disorders","Inclusion Criteria:\n\n* Must speak a rhotic dialect of American English as a dominant language.\n* Must have begun learning English by at least the age of 3 years.\n* Must be between 9;0 to 17;11 years of age.\n* Must have reported difficulty with \u002Fɹ\u002F production.\n* Must have reported hearing within normal limits.\n* Must receive a Scaled Score of 5 or above on both the Listening Comprehension and Story Retelling subtests from the Test of Integrated Language \\& Literacy Skills (TILLS).\n* Must receive a percentile score of 8 or below on the Goldman-Fristoe Test of Articulation-3 (GFTA-3) Sounds in Words subtest.\n* Must have 1 scorable response with 5+ consecutive correct \u002Fpataka\u002F with \\> 3.4 syllables per second in the MRR-Tri task of the Maximum Performance Tasks OR must demonstrate no childhood apraxia of speech (CAS-only) features in BOTH articulatory and rate\u002Fprosody domains of the ProCAD.\n* Must score \\\u003C40% accurate based on word-level items from our \u002Fɹ\u002F probe list.\n* Must score \\>=15% accuracy on \u002Fɹ\u002F on 45 syllables following Dynamic Assessment.\n* Must express interest in changing their \u002Fɹ\u002F production.\n* Must have oral structure and function that are appropriate for \u002Fɹ\u002F production.\n* Must have access to broadband internet with videoconferencing capabilities\n\nExclusion Criteria:\n\n* Must have no known history of autism spectrum disorder, Down Syndrome, cerebral palsy, intellectual disability, permanent hearing loss, epilepsy\u002Fantiepileptic medication, or brain injury\u002Fneurosurgery\u002Fstroke.\n* Must not have diagnosis of attention deficit disorder, attention deficit hyperactivity disorder, Tourette's, or Obsessive-compulsive disorder.\n* Must have no orthodontic appliances that block the roof of the mouth (e.g., palate expanders).\n* Must not have current cleft palate, fluency disorder, or voice disorder.\n* Must not demonstrate childhood apraxia of speech (CAS-only) features in BOTH articulatory and rate\u002Fprosody domains of the ProCAD.",true,{"count":79,"type":20},26,[23],"The goal of this randomized-controlled trial is to determine how artificial intelligence-assisted home practice may enhance speech learning of the \"r\" sound in school-age children with residual speech sound disorders. All child participants will receive 1 speech lesson per week, via telepractice, for 5 weeks with a human speech-language clinician. Some participants will receive 3 speech sessions per week with an Artificial Intelligence (AI)-clinician during the same 5 weeks as the human clinician sessions (CONCURRENT treatment order group), whereas others will receive 3 speech sessions per week with an AI-clinician after the human clinician sessions end (SEQUENTIAL treatment order group.",[62],"2026-01-07",{"date":85,"type":37},"2026-01-08",{"date":87,"type":37},"2024-09-05",{"date":89,"type":20},"2027-12-31",{"name":43,"class":44},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":77,"sex":16,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":102,"briefSummary":103,"conditions":104,"keywords":109,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":45},"100609511","effects-of-hiit-vs-tre-on-type-2-diabetes-risk-100609511","NCT07215533","Effects of HIIT vs. TRE on Type 2 Diabetes Risk","Differential Effects of HIIT vs. TRE on Type 2 Diabetes Risk in Youth and Younger Adults","Inclusion Criteria:\n\n* Adolescents (age 14-17 years old with sex- and race-specific BMI percentile ≥85th) and young adults with overweight and obesity (age 18 to 30 years old with BMI ≥25 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Chronic medical conditions: heart disease, arrhythmias, diabetes, thyroid disease, bleeding disorder, history of pulmonary disease, hypertension, hepatorenal disease, musculoskeletal disorder, neuromuscular\u002Fneurological disease, autoimmune disease, cancer, peptic ulcers, anemia, or chronic infection (HIV).\n* Have taken any heart, pulmonary, thyroid, anti-hyperlipidemic, hypoglycemic, anti- hypertensive, endocrinologic (e.g., thyroid, insulin, etc.), emotional\u002Fpsychotropic (e.g., Prednisone, Ritalin, Adderall), neuromuscular\u002Fneurological, or androgenic medications (anabolic steroids).\n* Have a pacemaker.","14 Years","30 Years",{"count":101,"type":20},40,[23],"The primary aim of this randomized controlled trial is to examine the effects of a 4-week high-intensity interval training (HIIT) and time-restricted eating (TRE) intervention on cardiometabolic biomarkers in adolescents and young adults.",[105,106,107,108],"Obesity and Type 2 Diabetes","Metabolic Diseases","High-intensity Interval Training","Time-restricted Eating",[107,108,110,111,112,113],"Obesity","Type 2 Diabetes","Youth","Young Adults","2025-10-08",{"date":116,"type":37},"2025-10-10",{"date":118,"type":37},"2024-03-15",{"date":120,"type":20},"2025-12-30",{"name":43,"class":44},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":21,"phases":134,"briefSummary":135,"conditions":136,"keywords":137,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":45},"100609430","treatment-for-s-production-errors-in-children-with-speech-sound-errors-100609430","NCT07214480","Treatment for \u002Fs\u002F Production Errors in Children With Speech Sound Errors","An Alternative Service Delivery Model and Target Selection Approach for the Treatment of \u002Fs\u002F Errors","SPLITS-S","Inclusion Criteria:\n\n1. Age: Participants must be between the ages of 7;0 and 11;11.\n2. \u002Fs\u002F Errors: Participants must experience difficulty on \u002Fs\u002F.\n3. English Language Status: Participants must speak English as a dominant language and must have begun learning English before age 3\n4. Hearing Status: Participants must have no reported hearing loss.\n5. Neurodevelopmental Status: Participants must have no reported neurodevelopmental diagnosis. A reported diagnosis of ADHD\u002FADD is admissible if participants meet all other inclusionary criteria.\n6. Technology Access: Participants must have access to a Windows or Apple computer with the ability to join a Zoom session. Additionally, participants must have wired broadband internet connection at home.\n7. Location: Participants must reside in the United States or Canada.\n8. Orthodontic Appliances: Participants must have no orthodontic retainers or appliances that would prevent them from touching the roof of their mouth with their tongue.\n9. Prescreener Recordings: Participants must accurately produce at least 3 items on the \u002Fs\u002F prescreener probe list. Additionally, participants must accurately produce no more than 36 items on the \u002Fs\u002F prescreener probe list.\n10. Dynamic Assessment Probes: Participants must accurately produce at least 5 out of 45 \u002Fs\u002F syllables correctly and must accurately produce no more than 60% of 75 \u002Fs\u002F words correctly. Additionally, participants must produce at least 75% of \u002Fs\u002F errors as dental or lateral distortion errors.\n11. Oral Mechanism Examination: Participants must demonstrate adequate range of motion of the tongue during a brief oral mechanism examination.\n12. Goldman Fristoe Test of Articulation - 3rd Edition (GFTA-3): Participants must score below the 7th percentile on the GFTA-3 and must not demonstrate errors on more than two sounds other than \u002Fs\u002F and \u002Fz\u002F on the GFTA-3.\n13. Test of Integrated Language and Literacy Skills (TILLS): Must receive a scaled score of at least 5 on the Listening Comprehension and Story Retelling subtests of the Test of Integrated Language and Literacy Skills (TILLS).\n14. Linguisystems Articulation Test (LAT) Inconsistency Screener: Participants must produce less than three inconsistencies on the LAT Inconsistency Screener.\n15. Syllable Repetition Task (SRT): Participants must produce less than four additions on the SRT.\n16. Recording: Consent\u002Fassent to recording of assessment and treatment sessions.\n17. General consent\u002Fassent: Consent\u002Fassent provided for study procedures.\n\nExclusion Criteria:\n\n* 1\\. Age: Participants less than 7;0 or greater than 11;11. 2. \u002Fs\u002F Errors: Participants who do not experience difficulty on \u002Fs\u002F. 3. English Language Status: Participants who do not speak English as a dominant language and\u002For who began learning English prior to age 3 4. Hearing Status: Participants who have reported hearing loss, per parent report.\n\n  5\\. Neurodevelopmental Status: Participants who have a reported neurodevelopmental diagnosis. A reported diagnosis of ADHD\u002FADD is admissible if participants meet all other inclusionary criteria.\n\n  6\\. Technology Access: Participants who do not have access to a Windows or Apple computer with the ability to join a Zoom session. Additionally, participants who do not have wired broadband internet connection at home.\n\n  7\\. Location: Participants who do not reside in the United States or Canada. 8. Orthodontic Appliances: Participants who have orthodontic retainers or appliances that would prevent them from touching the roof of their mouth with their tongue.\n\n  9\\. Prescreener Recordings: Participants who accurately produce less than 3 items on the \u002Fs\u002F prescreener probe list. Additionally, participants who accurately produce more than 36 items on the \u002Fs\u002F prescreener probe list.\n\n  10\\. Dynamic Assessment Probes: Participants who accurately produce less than 5 out of 45 \u002Fs\u002F syllables correctly and\u002For who accurately produce more than 60% of 75 \u002Fs\u002F words correctly. Additionally, participants who produce less than 75% of \u002Fs\u002F errors as dental or lateral distortion errors.\n\n  11\\. Oral Mechanism Examination: Participants who do not demonstrate adequate range of motion of the tongue during a brief oral mechanism examination.\n\n  12\\. Goldman Fristoe Test of Articulation - 3rd Edition (GFTA-3): Participants who score above the 7th percentile on the GFTA-3 and\u002For who demonstrate errors on more than two sounds other than \u002Fs\u002F and \u002Fz\u002F on the GFTA-3.\n\n  13\\. Test of Integrated Language and Literacy Skills (TILLS): Participants who receive a scaled score below 5 on the Listening Comprehension and Story Retelling subtests.\n\n  14\\. Linguisystems Articulation Test (LAT) Inconsistency Screener: Participants who produce greater than three inconsistencies on the LAT Inconsistency Screener.\n\n  15\\. Syllable Repetition Task (SRT): Participants who produce greater than four additions on the SRT.\n\n  16\\. Recording: No consent\u002Fassent provided to recording of assessment and treatment sessions.\n\n  17\\. General consent\u002Fassent: No consent\u002Fassent provided for study procedures.","7 Years","11 Years",{"count":133,"type":20},24,[23],"We want to learn about a new way to help people make the \u002Fs\u002F sound, like in the word \"snake.\" We will be studying a way to teach the \u002Fs\u002F sound that uses very short speech sessions. This study will also collect recordings from people as they say words with the \u002Fs\u002F sound. We will listen to these recordings and check if the words are said clearly.\n\nIn the first visit, we'll do a speech lesson on how to make a clear\n\n\u002Fs\u002F sound. We will also have the participant say some words while we record them talking. If they are a good fit for the study, we will invite them to do a second visit. In the second visit, they will name some pictures, answer some questions, repeat words and sentences, and do some mouth movements. After the second visit, if they are a good fit for the study, we will invite them to do the speech lessons. The speech lessons will each take 10 minutes, and they will have lessons 4 times a week for 8 weeks. They will do these lessons on video chat. They will be randomized to either start right away or after 8 weeks. We'll also ask them to participate in 3 other visits to track progress by having them repeat words with \u002Fs\u002F.",[62],[138],"articulation disorder","2025-10-07",{"date":141,"type":37},"2025-10-09",{"date":143,"type":37},"2025-06-09",{"date":145,"type":20},"2027-01",{"name":43,"class":44},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":21,"phases":156,"briefSummary":157,"conditions":158,"keywords":162,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":180},"100604604","brain-stimulation-effects-on-post-stroke-fatigue-and-aphasia-100604604","NCT07151677","Brain Stimulation Effects on Post-Stroke Fatigue and Aphasia","Pre-Frontal tDCS as a Novel Intervention to Reduce Effects of Post-Stroke Fatigue While Improving Language and Attention in Aphasia","Inclusion Criteria:\n\n1. 18 years or older.\n2. No diagnosis of neurological disorder (other than stroke).\n3. No diagnosis of psychiatric disorder, with the exception of anxiety and\u002For depression if it is managed through medication and\u002For behavioral intervention.\n4. No seizure within the past 6 months.\n5. Not pregnant.\n6. Does not currently have cardiac pacemaker\n7. In chronic phase of recovery, defined as at least 6 months post-stroke.\n8. Not undergoing speech and language therapy targeting auditory comprehension or attention for the duration of the study.\n9. No metal implants in the scalp or bone in the pre-frontal area of the head.\n10. No unhealed skull fractures.\n11. Onset of aphasia related to single, left hemisphere, ischemic stroke.\n12. Damaged brain tissue from stroke does not overlap with left hemisphere dorsolateral prefrontal cortex.\n13. Mild to moderate aphasia (as measured by WAB-R \\*\\*or QAB).\n14. Self-report of post-stroke fatigue (as measured on SF-CAT)\n15. No significant challenges with vision or hearing (with use of corrective aids if needed; eyeglasses, hearing aids).\n16. Willing to allow audio-recording of study sessions.\n\nExclusion Criteria:\n\n1. Younger than 18 years old.\n2. Diagnosis or history of neurological disorder other than stroke.\n3. Diagnosis or history of psychiatric disorder with the exception of anxiety and\u002For depression if it is managed through medication and\u002For behavioral intervention.\n4. History of seizures within the past 6 months.\n5. Pregnant.\n6. Currently has cardiac pacemaker\n7. \\\u003C6 months post-stroke (however, if this is only exclusionary criterion met, participant can be re-evaluated at the 6-month mark if still interested in the study)\n8. Currently undergoing speech and language therapy targeting auditory comprehension or attention.\n9. Metal implants in the scalp or bone in the pre-frontal area of the head.\n10. Currently has an unhealed skull fracture.\n11. Onset of aphasia related to etiology other than ischemic left hemisphere stroke.\n12. Damaged brain tissue significantly overlaps with left hemisphere dorsolateral prefrontal cortex.\n13. No aphasia or severe aphasia (as measured by WAB-R \\*\\*or QAB).\n14. Does not report experience of post-stroke fatigue (as measured on SF-CAT)\n15. Significant challenges with vision and\u002For hearing (even with use of corrective aids).\n16. Unwilling to allow audio-recording of study sessions.",{"count":155,"type":20},60,[23],"The goal of this clinical trial is to determine if electrical brain stimulation applied to the front parts of the brain can help people who have had a stroke improve their fatigue, language, and attention. The main question it aims to answer is:\n\n* Does transcranial direct current stimulation (tDCS) administered to the pre-frontal areas of the brain improve post-stroke fatigue and aphasia?\n* What kinds of participant characteristics are associated with better improvement of post-stroke fatigue and aphasia?\n\nResearchers will compare active electrical stimulation to sham stimulation to see if the active stimulation does a better job at reducing fatigue and language deficits after stroke. Participants will be asked to complete fatigue, language, and cognitive testing before and after receiving 10 sessions of tDCS plus speech and language therapy.",[159,160,161],"Aphasia Following Cerebral Infarction","Stroke Ischemic","Fatigue Symptom",[163,164,165,166,167,168,169,170,171],"aphasia","fatigue","post-stroke fatigue","tDCS","brain stimulation","language treatment","language therapy","speech therapy","speech-language therapy","2025-08-25",{"date":174,"type":37},"2025-09-03",{"date":176,"type":37},"2025-08-04",{"date":178,"type":20},"2029-11",{"name":43,"class":44},2,{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":21,"phases":190,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":45},"100503722","hiit-effects-on-cardiometabolic-health-100503722","NCT05838950","HIIT Effects on Cardiometabolic Health","Detraining Effect of Short-term HIIT on Cardiometabolic Risk in Young Adults With Obesity","Inclusion Criteria:\n\n* Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg\u002Fm2).\n\nExclusion Criteria:\n\n* Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and\u002For other signs of hypothalamic dysfunction such as fatigue, weakness and\u002For lack of interest in activities.\n* Taking weight loss medication(s)\n* Currently enrolled (or within previous 6 months) in a weight loss program;\n* An underlying disease\u002Fmedications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism.\n* Presence of cardiac pacemaker.\n* Current or anticipated participation in another research that would interfere with any of the outcomes.\n* Current or anticipated pregnancy.","25 Years",{"count":155,"type":20},[23],"The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.",[110,193,194,107],"Cardiovascular Diseases","Metabolic Disease",[196,197,198,110,199],"HIIT","Detraining effects","Cardiometabolic disease","Young adults","2025-07-17",{"date":202,"type":37},"2025-07-23",{"date":204,"type":37},"2023-09-29",{"date":206,"type":20},"2025-12-10",{"name":43,"class":44},{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":16,"minAge":216,"maxAge":54,"enrollmentInfo":217,"targetDuration":4,"studyType":21,"phases":219,"briefSummary":220,"conditions":221,"keywords":222,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":45},"100597687","evaluating-the-effectiveness-of-hybrid-and-traditional-speech-therapy-for--and-s-sound-production-100597687","NCT07061730","Evaluating the Effectiveness of Hybrid and Traditional Speech Therapy for \u002Fɹ\u002F and \u002Fs\u002F Sound Production","Genesis: Clinical Trial of Better Speech's Artificial Intelligence Helper for Speech Therapy","GENESIS","Inclusion Criteria:\n\n\\- Response to be filled out by the Parent after sign up.\n\n* Does the child speak American English as one of their primary languages: Yes\n* At what age did the child first begin to learn English? Age 4 or younger\n* Child's current age: \\> 5 years or \\\u003C 17 years 8 months\n* Does the child have any known history of any of the following: autism spectrum disorder, Down Syndrome, cerebral palsy, intellectual disability, permanent hearing loss, epilepsy\u002Fantiepileptic medication, or brain injury\u002Fneurosurgery\u002Fstroke: NO\n* Does the child have a diagnosis of ADD\u002FADHD, Tourette's Syndrome, or OCD? NO\n* Does the child currently have orthodontic appliances that block the roof of the mouth (e.g., palate expanders)? NO\n* Does the child currently have a cleft palate, fluency disorder (e.g., stuttering), or voice disorder? NO\n* Is one of your goals for your child to work on saying the \"r\" or \"s\" sounds? YES\n\nExclusion Criteria:\n\n* EXCLUSIONARY Response to be filled out by the Parent after sign up.\n* Does the child speak American English as one of their primary languages: No\n* At what age did the child first begin to learn English? Age 4 or older\n* Child's current age: \\\u003C5 years or \\> 17 years 8 months\n* Does the child have any known history of any of the following: autism spectrum disorder, Down Syndrome, cerebral palsy, intellectual disability, permanent hearing loss, epilepsy\u002Fantiepileptic medication, or brain injury\u002Fneurosurgery\u002Fstroke: YES\n* Does the child have a diagnosis of ADD\u002FADHD, Tourette's Syndrome, or OCD? YES\n* Does the child currently have orthodontic appliances that block the roof of the mouth (e.g., palate expanders)? YES\n* Does the child currently have a cleft palate, fluency disorder (e.g., stuttering), or voice disorder? YES\n* Is one of your goals for your child to work on saying the \"r\" or \"s\" sounds? NO","5 Years",{"count":218,"type":20},120,[23],"The purpose of this research study is to evaluate the effectiveness of a hybrid Artificial Intelligence-assisted speech therapy model, which combines the use of an AI speech therapist (Jessica) with traditional speech therapy sessions led by a Speech-Language Pathologist (SLP). This study aims to determine whether the hybrid model improves articulation in children more effectively than traditional SLP-only therapy. Over the course of 8 weeks, participants will receive weekly therapy sessions, and those in the hybrid therapy group will also practice with Jessica between sessions. The study will also gather feedback from parents and speech therapists to assess their experiences and satisfaction with treatment.",[62],[223,224,225,32],"Artificial Intelligence","Articulation","Speech Language Pathology","2025-07-08",{"date":228,"type":37},"2025-07-11",{"date":230,"type":37},"2025-05-01",{"date":232,"type":20},"2026-02",{"name":43,"class":44},""]