[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sys2Diag\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":119},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,72,95],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100631944","emotions-from-salivary-biomarkers-in-an-architectural-context-100631944",false,"NCT07507266","Emotions From Salivary Biomarkers in an Architectural Context","Evaluation of Emotions From Salivary Molecular Biomarkers in an Architectural Context","Archi'Motion","Inclusion Criteria:\n\n* Subject over 18 years old\n* Subject agreeing to follow the study procedures\n* Subject capable of understanding the purpose, nature, and methodology of the study\n* Subject affiliated with a French social security scheme or beneficiary of such a scheme.\n\nExclusion Criteria:\n\n* Subject not affiliated with a French Social Security scheme or not a beneficiary of such a scheme\n* Subject deprived of liberty, protected adult, vulnerable person, or minor\n* Subject with proven or suspected chronic infectious disease that could pose a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)\n* Subject with a deficiency (vision, anosmia) preventing proper interaction with the architectural work\n* Subject presenting signs of active oral inflammation, advanced periodontitis, or severe gingivitis\n* Subject suffering from Gougerot-Sjögren syndrome (dry syndrome) or mouth cancer\n* Pregnant or breastfeeding women.",true,"ALL","18 Years",{"count":21,"type":22},60,"ESTIMATED","OBSERVATIONAL","Architecture influences our well-being. People's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment. Neuroarchitecture is a discipline that combines neuroscience and architecture to design spaces adapted to the psychological and physiological needs of users. Several studies related to neuroarchitecture have been conducted according to different architectural parameters such as style, natural environment, lighting, color, and sunlight pattern. Recent studies show that emotional states can be evaluated by physiological responses. This physiological regulation comes from the action of enzymes and hormones that represent the activity of the autonomic nervous system. Measuring specific biomarkers through non-invasive biological tests in saliva provides physiological data on an individual's emotional state in response to stimuli, particularly visual or tactile.",[26],"Emotions",[28,29,30],"Biomarkers","Architecture","Stimuli","NOT_YET_RECRUITING","2026-04-09",{"date":34,"type":35},"2026-04-14","ACTUAL",{"date":37,"type":22},"2026-06-09",{"date":39,"type":22},"2028-06-14",{"name":41,"class":42},"Sys2Diag","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":17,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100631943","pilot-study-on-the-correlation-between-accelerations-experienced-100631943","NCT07507253","Pilot Study on the Correlation Between Accelerations Experienced","Pilot Study on the Correlation Between Accelerations Experienced During Matches by Professional Rugby Players and a Profile of Salivary Biomarkers Identified in the Literature as Related to Concussion.","BIOIMPACT","Inclusion Criteria:\n\n* Male subject\n* Subject aged between 19 and 20 years\n* Subject willing to follow the study procedures\n* Subject capable of understanding the purpose, nature, and methodology of the study\n* Subject affiliated with a French social security scheme or a beneficiary of such a scheme\n* Subject who has signed the non-opposition to participation in the research\n* Subject who has signed the informed consent for salivary micro-RNA analysis\n* Subject selected in the French under-20 rugby team (U20).\n\nExclusion Criteria:\n\n* Subject not affiliated with a French Social Security scheme or not a beneficiary of such a scheme\n* Subject deprived of liberty, protected adults, vulnerable persons, or minors\n* Subject with proven or suspected chronic infectious disease that may pose a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)\n* Subject suffering from Gougerot-Sjögren syndrome (dry syndrome)\n* Refusal to sign the non-opposition\n* Refusal to sign the informed consent for salivary micro-RNA analysis.\n\nSpecific Non-Inclusion Criteria:\n\n* Subject who has suffered a recent stroke or epileptic event (within the last two months)\n* Subject suffering from neurological diseases.","MALE","19 Years","20 Years",{"count":56,"type":22},66,"Concussion, or mild traumatic brain injury, accounts for 85% of brain injuries and is common in both professional and amateur sports. It results from kinetic impacts causing a temporary disruption of brain function, often without visible abnormalities on imaging, making diagnosis difficult.\n\nThe majority of concussions remain undetected, without specific management. To facilitate detection, the development of reliable salivary BMs is essential, as they offer a non-invasive, rapid, and simple method for early identification of biological changes related to concussions.",[59],"Sport Related Concussion",[61,28,62,63],"Concussion","Sport","Instrumented mouthguards","RECRUITING","2026-04-03",{"date":32,"type":35},{"date":68,"type":35},"2025-01-22",{"date":70,"type":22},"2028-01-21",{"name":41,"class":42},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":17,"sex":52,"minAge":19,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":43},"100527560","salivary-biomarkers-for-concussion-100527560","NCT06149351","Salivary Biomarkers for Concussion","Determination of the Physiological Profile and Evaluation of the Effect of Intense Physical Exertion Among Professional Athletes","SportCo","Inclusion Criteria:\n\n* Male participants aged between 18 and 50 years old.\n* Participants willing to comply with the study procedures.\n* Participants capable of understanding the purpose, nature, and methodology of the study.\n* Participants affiliated to a French social security system or beneficiaries of such a system.\n* Participants who have signed the non-opposition form to participate in the research.\n\nNon-inclusion Criteria:\n\n* Participant not affiliated to a French social security system or not a beneficiary of such a system.\n* Participants deprived of liberty, protected adults, vulnerable individuals, or minors.\n* Participants with a proven or suspected chronic infectious disease that may introduce a risk of contamination during sample handling (laboratories not equipped to handle this type of sample).\n* Refusal to sign the non-opposition form to participate in the research.\n\nNon-inclusion specific criteria\n\n* Subject who has had a recent stroke or epilepsy event (within the past two months).\n* Subject suffering from neurological diseases.","50 Years",{"count":82,"type":22},80,"Concussion (CC) (also called mild head trauma), which accounts for 85% of all head injuries, is very common in professional and amateur athletes. CC is an injury to the brain resulting from the direct or indirect impact of external mechanical forces, momentarily disrupting its function on a cellular level. Unlike more serious head injury (moderate and severe), which can be diagnosed using neuroimaging techniques (CT, MRI, etc.), patients suffering from CC do not necessarily show visible signs of structural abnormalities. As a result, diagnosis of CC is offen difficult.\n\nRecently, several salivary biomarkers (proteins and nucleic acids) of sport related concussion have been identified in professional athletes. However, their reference values have not been determined with sufficient robustness to enable their employment in concussion diagnostic tests.",[59],[86],"Concussion, Biomarkers, Sport","2026-03-12",{"date":89,"type":35},"2026-03-16",{"date":91,"type":35},"2023-12-12",{"date":93,"type":22},"2027-12-12",{"name":41,"class":42},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":43},"100617547","evaluation-of-emotion-related-salivary-molecular-biomarkers-100617547","NCT07320040","Evaluation of Emotion-related Salivary Molecular Biomarkers","Evaluation of Emotion-related Salivary Molecular Biomarkers Following Olfactory Stimuli","EMJOY","Inclusion Criteria:\n\n* Subject willing to follow study procedures\n* Subject able to understand the purpose, nature and methodology of the study\n* Subject has signed informed consent form\n* Subjects between 18 and 60 years of age.\n\nExclusion Criteria:\n\n* Subjects deprived of liberty, protected adults, vulnerable persons or minors\n* Subjects with a proven or suspected chronic infectious disease that could entail a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)\n* Rejection to sign the consent form.\n\nNon specific inclusion criteria:\n\n* Pregnant or breastfeeding women\n* Subjects presenting anosmia during the last 15 days\n* Subjects presenting symptoms and signs of active oral inflammation, advanced periodontitis or severe gingivitis.","60 Years",{"count":105,"type":22},240,"Recent studies show that emotional states can be discriminated by physiological responses. This physiological regulation results from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers, using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state in response to stimuli, particularly olfactory stimuli.",[108],"Emotion",[28,30,110],"Related","2026-01-27",{"date":113,"type":35},"2026-01-29",{"date":115,"type":35},"2022-11-14",{"date":117,"type":22},"2027-06-14",{"name":41,"class":42},""]