[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"TC Erciyes University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":664},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,52,0,25,[9,51,82,111,137,168,189,213,239,265,295,321,343,364,393,414,440,461,491,510,543,572,596,621,647],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100644621","interscalene-block-versus-infraspinatus-teres-minor-interfascial-plane-block-for-shoulder-arthroscopy-100644621",false,"NCT07670780","Interscalene Block Versus Infraspinatus-Teres Minor Interfascial Plane Block for Shoulder Arthroscopy","Comparison of the Effects of Interscalene Block and Infraspinatus-Teres Minor Interfascial Plane Block on Postoperative Analgesia and Diaphragmatic Function in Patients Undergoing Shoulder Arthroscopy.","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* ASA physical status I-II\n* Scheduled for elective shoulder arthroscopy\n* No known allergy to study medications\n* No psychiatric disorder\n* No opioid dependence\n* Ability to use patient-controlled analgesia (PCA) and complete VAS assessments\n* No contraindication to peripheral nerve blocks\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Refusal to participate\n* Uncontrolled hypertension\n* Chronic pain or ongoing analgesic treatment\n* Significant cardiac disease (coronary artery disease, arrhythmia, heart failure)\n* Diabetes mellitus","ALL","18 Years","65 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective randomized controlled study aims to compare the effects of interscalene block, infraspinatus-teres minor interfascial plane block, and a control group on postoperative analgesia and diaphragmatic function in patients undergoing shoulder arthroscopy. A total of 120 patients will be enrolled and allocated into three groups. Postoperative pain scores, opioid consumption, rescue analgesic requirements, and diaphragmatic function will be evaluated and compared among the groups. The study seeks to determine whether the infraspinatus-teres minor interfascial plane block can provide effective postoperative analgesia with less impact on diaphragmatic function compared with interscalene block.",[28,29,30],"Postoperative Pain","Shoulder Arthroscopic Surgeries","Diaphragmatic Dysfunction",[32,33,34,35,36,37,38],"ınterscalene block","Shoulder Arthroscopy","Regional Anesthesia","Postoperative Analgesia","Diaphragmatic Function","Ultrasound-Guided Block","Infraspinatus-Teres Minor Interfascial Plane Block","NOT_YET_RECRUITING","2026-06-29",{"date":42,"type":43},"2026-07-01","ACTUAL",{"date":45,"type":22},"2026-06-22",{"date":47,"type":22},"2028-08-28",{"name":49,"class":50},"TC Erciyes University","OTHER",{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":12,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},"100639100","comparison-of-sacral-esp-block-and-caudal-block-in-pediatric-hypospadias-surgery-100639100","NCT07619651","Comparison of Sacral ESP Block and Caudal Block in Pediatric Hypospadias Surgery","Prospective Comparison of Sacral Erector Spinae Plane Block and Caudal Epidural Block for Postoperative Analgesia in Pediatric Hypospadias Surgery","Inclusion Criteria:\n\n1. Male patients aged between 6 months to 7 years\n2. Scheduled for hypospadias repair surgery\n3. ASA physical status I-II\n4. No known allergy to local anesthetic agents\n5. No contraindications to peripheral nerve blocks\n6. Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n1. Known congenital coagulopathy\n2. Known allergy to local anesthetic agents\n3. Severe systemic disease (ASA III-IV)\n4. Severe organ failure\n5. Neurological disorders","MALE","6 Months","7 Years",{"count":62,"type":22},60,[25],"Hypospadias surgery in pediatric patients requires effective postoperative analgesia to ensure patient comfort and reduce perioperative stress. Caudal epidural block is widely used for analgesia in pediatric urological procedures; however, alternative regional techniques such as the sacral erector spinae plane (ESP) block have recently gained attention.\n\nThis prospective comparative study aims to compare the analgesic efficacy of sacral ESP block and caudal epidural block in pediatric patients undergoing hypospadias surgery. Participants will be allocated to receive either sacral ESP block or caudal epidural block according to the study protocol.\n\nThe primary outcome will be postoperative pain scores within the first 24 hours after surgery. Secondary outcomes will include total analgesic consumption, time to first rescue analgesia, and block-related complications.",[66,28],"Hypospadias",[68,69,70,35,71],"Sacral Erector Spinae Plane Block","Caudal Epidural Block","Hypospadias Surgery","Pediatric Urology","RECRUITING","2026-06-21",{"date":75,"type":43},"2026-06-25",{"date":77,"type":43},"2026-01-05",{"date":79,"type":22},"2026-11-01",{"name":49,"class":50},1,{"id":83,"slug":84,"hasResults":12,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":19,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100641295","developmental-support-program-a-intervention-study-100641295","NCT07656272","Developmental Support Program: A Intervention Study","The Effect of a Developmental Support Program for Parents of Children Aged 1-3 Years in a Family Health Center: An Interventional Study","Inclusion Criteria:\n\n* Parents with children aged 12-36 months\n* Children with a percentile value between the 3rd and 97th percentile\n* Able to speak and understand Turkish\n* No previous participation in a similar program\n* Having internet access and the ability to use a computer\u002Flaptop, tablet, or smartphone\n* At least primary school graduates\n* Able to read and comprehend written information\n* Willing to participate in the study\n\nExclusion Criteria:\n\n* Adolescent parents\n* Parents of children with congenital anomalies, chronic diseases, or a history of prematurity\n* Individuals with a diagnosed mental health disorder",true,"FEMALE","15 Years",{"count":62,"type":22},[25],"This study aims to evaluate the effectiveness of an online video-based developmental support program for parents of children aged 1-3 years receiving care at a Family Health Center. Approximately 60 parents will be randomly assigned to either an intervention group, which will receive a four-week online developmental support program, or a control group, which will continue to receive usual healthcare services. Data will be collected at baseline, two weeks after the intervention, and at one- and three-month follow-up assessments. The study will examine the effects of the online video-based developmental support program on parents' attitudes toward child development, developmental awareness, parenting self-efficacy, and the quality of the home environment that supports child development.",[96],"Development and Health",[98,99,100,101,102],"Developmental Support Program","Self-Efficacy in Parenting Tasks","Mindful Awareness in Parenting","Parents' Attitudes Towards Psychosocial Development","Stimulating Home Environment","2026-06-15",{"date":105,"type":43},"2026-06-18",{"date":107,"type":22},"2026-09-01",{"date":109,"type":22},"2028-06-30",{"name":49,"class":50},{"id":112,"slug":113,"hasResults":12,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":89,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":81},"100637204","ai-supported-case-analysis-among-nursing-students-100637204","NCT07614503","AI-Supported Case Analysis Among Nursing Students","The Effect of AI-Supported Case Analysis on Nursing Students' Learning Experience, Learning Outcomes, Clinical Self-Efficacy, and Cognitive Load","Inclusion Criteria:\n\n* Students who are active fourth-year nursing students during the spring semester of the 2025-2026 academic year,\n* Have previously taken the theoretical course on the nursing process,\n* Own a cell phone with an internet connection,\n* And have previously prepared a patient-specific care plan for an inpatient in at least one internal medicine clinic will be included in the sample.\n\nExclusion Criteria:\n\n* Students who have not taken the course,\n* Students who have never participated in case-based learning sessions,\n* Students who do not agree to participate in the study will not be included in the research.",{"count":119,"type":22},40,[25],"The aim of this study is to determine the effect of AI-supported internal medicine nursing case analysis on students' case management performance, learning outcomes, learning experience, clinical self-efficacy, and cognitive load levels. This study will be conducted using a single-blind randomized controlled trial design for the quantitative research and an individual interview design for the qualitative research. Students will be randomly assigned to either the intervention (artificial intelligence) or control (case analysis) group.",[123,124],"Nursing Students","Artificial Intelligence (AI)",[126,127,128],"nursing student","airtificial intelligence","nursing education","2026-05-22",{"date":131,"type":43},"2026-05-29",{"date":133,"type":22},"2026-05-25",{"date":135,"type":22},"2026-06-30",{"name":49,"class":50},{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":12,"sex":17,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":23,"phases":149,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":4},"100637077","pre-emptive-local-anesthesia-and-sevoflurane-consumption-in-pediatric-dental-anesthesia-100637077","NCT07608900","Pre-emptive Local Anesthesia and Sevoflurane Consumption in Pediatric Dental Anesthesia","Effect of Pre-emptive Local Anesthesia on Sevoflurane Consumption, Agent Uptake, and Carbon Footprint in Pediatric Day-case Dental General Anesthesia: A Prospective Randomized Controlled Trial","PEDSEVOLA","Inclusion Criteria:\n\n* Children aged 4 to 12 years\n* Scheduled for elective day-case dental treatment under general anesthesia\n* ASA physical status I or II\n* Planned sevoflurane-based general anesthesia\n* Planned oral endotracheal intubation\n* Eligibility for standardized low-flow anesthesia with fresh gas flow of 1 L\u002Fmin\n* Eligibility for BIS-guided sevoflurane titration\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* Age younger than 4 years or older than 12 years\n* ASA physical status III or higher\n* Emergency dental procedures\n* Known allergy or contraindication to sevoflurane\n* Known allergy or contraindication to amide local anesthetics, articaine, or epinephrine\n* Known or suspected malignant hyperthermia susceptibility\n* Significant cardiovascular, respiratory, hepatic, renal, or neurological disease requiring non-standard anesthetic management\n* Chronic opioid or sedative use\n* Planned airway management other than oral endotracheal intubation\n* Dental procedures in which withholding pre-emptive local anesthesia is considered clinically inappropriate for safety or hemostasis\n* Refusal of participation by parent or legal guardian","4 Years","12 Years",{"count":148,"type":22},80,[25],"This study will evaluate whether pre-emptive local anesthesia reduces sevoflurane consumption during pediatric day-case dental treatment performed under general anesthesia.\n\nChildren aged 4 to 12 years scheduled for elective dental treatment under general anesthesia will be included. Participants will be assigned to either receive pre-emptive local anesthesia before the dental procedure or receive no pre-emptive local anesthesia. General anesthesia will be standardized using sevoflurane, low fresh gas flow, endotracheal intubation, and bispectral index monitoring.\n\nThe main outcome will be sevoflurane consumption expressed as mL\u002Fkg\u002Fhour. Secondary outcomes will include anesthetic agent uptake, time from sevoflurane discontinuation to extubation, and estimated carbon dioxide-equivalent emissions.\n\nThe aim is to determine whether pre-emptive local anesthesia can reduce volatile anesthetic requirement and improve early recovery while maintaining adequate anesthetic depth in children undergoing dental general anesthesia.",[152],"Sevoflurane Consumption",[154,155,156,157,158,159],"Pediatric dental anesthesia","Sevoflurane","Sevoflurane consumption","Pre-emptive local anesthesia","Agent uptake","Carbon footprint","2026-05-20",{"date":162,"type":43},"2026-05-27",{"date":164,"type":22},"2026-08",{"date":166,"type":22},"2027-09",{"name":49,"class":50},{"id":169,"slug":170,"hasResults":12,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":89,"sex":17,"minAge":18,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":177,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":81},"100639238","phase-4-effect-of-two-different-irrigation-protocols-and-activation-techniques-on-postoperative-pain-in-single-visit-endodontic-retreatment-prospective-randomized-clinical-trial-100639238","NCT07599254","Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* o Patients aged 18-60 years who are classified as medically healthy (ASA I or II),\n\n  * Mature, single-rooted and canal teeth that had root canal treatment at least four years ago,\n  * Teeth with previous root canal obturation 2-4 mm short of the apex,\n  * Teeth that do not need periodontal and prosthetic treatment and whose periapical index score (PAI) is between 2 and 4 ,\n  * Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,\n  * Teeth suitable for rubber dam isolation.\n\nExclusion Criteria:\n\n* o Patients who had taken analgesics, antibiotics, or corticosteroids within two weeks before root canal retreatment,\n\n  * Teeth exhibiting periodontal attachment loss,\n  * Presence of vertical root fractures, external root resorption, or perforations,\n  * Teeth with retained broken instruments,\n  * Non-restorable teeth,\n  * Patients in the pregnancy and breastfeeding period.","60 Years",{"count":176,"type":22},100,[178],"PHASE4","The relationship between different root canal irrigation techniques and pain after root canal treatment",[181],"Apical Periodontitis","2026-05-14",{"date":160,"type":43},{"date":185,"type":43},"2025-01-01",{"date":187,"type":22},"2026-07-15",{"name":49,"class":50},{"id":190,"slug":191,"hasResults":12,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":196,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":198,"conditions":199,"keywords":201,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":212},"100633449","comparison-of-the-analgesic-efficacy-of-adductor-canal-block-and-combined-adductor-canal-block-plus-ipack-block-in-knee-surgery-100633449","NCT07526831","Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Block in Knee Surgery","Comparison of the Analgesic Efficacy of Adductor Canal Block Versus Adductor Canal Block Combined With Local Anesthetic Infiltration Between the Popliteal Artery and the Capsule of the Knee (IPACK) in Patients Undergoing Knee Surgery","Inclusion Criteria:\n\n* ASA (American Society of Anesthesiologists) I- ASA II-ASA III Patients\n\nExclusion Criteria:\n\n* history of allergy to the study medication\n* refusal to participate",{"count":62,"type":22},"OBSERVATIONAL","To evaluate the effectiveness of Adductor Canal Block and combined Adductor Canal plus IPACK block in reducing postoperative pain and analgesic requirements in patients undergoing knee surgery.",[200],"Knee Arthroplasty, Total",[202,203,204],"ultrasound","IPACK block","Adductor Canal Block","2026-05-13",{"date":182,"type":43},{"date":208,"type":22},"2026-04-15",{"date":210,"type":22},"2028-05-01",{"name":49,"class":50},2,{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":89,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":23,"phases":223,"briefSummary":224,"conditions":225,"keywords":229,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":4},"100638465","effects-of-stress-ball-use-and-breathing-exercises-on-pain-and-vital-signs-during-drain-removal-after-total-knee-arthroplasty-100638465","NCT07586436","Effects of Stress Ball Use and Breathing Exercises on Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty","The Effect of Stress Ball Use and Breathing Exercises on Procedural Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty: A Randomized Controlled Trial","TDP","Inclusion Criteria:\n\n* Adults aged 18 years and older undergoing primary total knee arthroplasty\n* Patients with a surgical drain in place and scheduled for drain removal in the postoperative period\n* Able to provide informed consent\n* Able to communicate and understand instructions\n\nExclusion Criteria:\n\n* Patients with chronic pain syndromes or regular opioid use\n* Patients with cognitive impairment, delirium, or communication difficulties\n* Patients with contraindications to drain removal (e.g., active bleeding, hemodynamic instability)\n* Patients with neurological conditions affecting pain perception",{"count":222,"type":22},105,[25],"This randomized controlled trial aims to evaluate the effects of stress ball use and breathing exercises on procedural pain and vital signs during drain removal in patients undergoing total knee arthroplasty. Although drain removal is a short procedure, it is often associated with sudden and intense pain and may trigger physiological stress responses such as increased heart rate, blood pressure, and respiratory rate.\n\nA total of 105 patients will be randomly assigned to three groups: stress ball group, breathing exercise group, and standard care group. The interventions will be applied starting one minute before drain removal, continuing throughout the procedure, and for two minutes afterward.\n\nPain levels will be assessed using the Numeric Rating Scale (NRS), and vital signs (heart rate, blood pressure, respiratory rate, and oxygen saturation) will be measured at predefined time points before, during, and after the procedure. The findings of this study are expected to provide evidence on the effectiveness of simple, non-pharmacological interventions in reducing procedural pain and improving physiological stability during drain removal",[226,227,228],"Total Knee Arthroplasty","Total Knee Arthroplasty Recovery","Pain After Knee Arthroscop",[226,230,231],"pain","Vital Signs","2026-05-08",{"date":182,"type":43},{"date":235,"type":22},"2026-05-05",{"date":237,"type":22},"2026-08-30",{"name":49,"class":50},{"id":240,"slug":241,"hasResults":12,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":12,"sex":17,"minAge":246,"maxAge":18,"enrollmentInfo":247,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":249,"conditions":250,"keywords":253,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":81},"100640603","evaluation-of-preoperative-gastric-ultrasonography-in-pediatric-patients-in-terms-of-patient-safety-100640603","NCT07581691","Evaluation of Preoperative Gastric Ultrasonography in Pediatric Patients in Terms of Patient Safety","Evaluation of Preoperative Gastric Ultrasonography in Pediatric Patients in Terms of Patient Safety in Non-Operating Room Anesthesia Applications","Inclusion Criteria:\n\n* Children between 0-18 years of age and ASA I-II patients will be included in the study.\n\nExclusion Criteria:\n\n* Patients over 18 years of age,\n* ASA-III and above patients,\n* patients with gastrointestinal dysfunction,\n* patients who cannot assume the lateral decubitus position for gastric -ultrasound measurements,\n* those who have had previous lower esophageal or gastric surgery,\n* those who do not comply with institutional fasting guidelines,\n* those with concomitant systemic diseases affecting gastric emptying,\n* those with a high body mass index (BMI) \\> 40 kg\u002Fm2,\n* those with gastroesophageal reflux or aspiration risk factors, and emergency cases with delayed gastric emptying despite appropriate fasting time will not be included in the study.","0 Years",{"count":248,"type":22},200,"Preoperative evaluation of stomach fullness with ultrasound in children who will undergo anesthesia outside the operating room",[251,252],"Nonoperating Room Anesthesia","Gastric Ultrasound",[254,255,256],"nonoperating room anesthesia","pediatric nonoperating room anesthesia","gastric ultrasound","2026-05-06",{"date":259,"type":43},"2026-05-12",{"date":261,"type":43},"2024-11-15",{"date":263,"type":22},"2026-09-30",{"name":49,"class":50},{"id":266,"slug":267,"hasResults":12,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":89,"sex":17,"minAge":272,"maxAge":273,"enrollmentInfo":274,"targetDuration":276,"studyType":197,"phases":4,"briefSummary":277,"conditions":278,"keywords":281,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":81},"100635405","effect-of-preoperative-fasting-duration-on-postoperative-pain-and-emergence-agitation-in-pediatric-patients-undergoing-urogenital-surgery-100635405","NCT07552259","Effect of Preoperative Fasting Duration on Postoperative Pain and Emergence Agitation in Pediatric Patients Undergoing Urogenital Surgery","The Impact of Preoperative Fasting Duration on Postoperative Pain and Emergence Agitation in Children Aged 2-8 Years Undergoing Elective Urogenital Surgery: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age between 2 and 8 years\n* ASA physical status I-II\n* Scheduled for elective urogenital surgery\n\nExclusion Criteria:\n\n* ASA physical status ≥ III\n* Malnutrition\n* Neuropsychiatric disorders\n* Respiratory tract infection\n* Developmental delay\n* Surgery longer than 2 hours","2 Years","8 Years",{"count":275,"type":22},250,"1 Day","This study aims to evaluate the effect of preoperative fasting duration on postoperative pain and emergence agitation in pediatric patients undergoing urogenital surgery.",[28,279,280],"Emergence Delirium","Emergence Agitation",[282,283,284,285,286,28,287],"Preoperative Fasting","Pediatric Anesthesia","FLACC","PAED","Urogenital Surgery","Postoperative Agitation","2026-04-30",{"date":257,"type":43},{"date":291,"type":22},"2026-05-01",{"date":293,"type":22},"2027-07-01",{"name":49,"class":50},{"id":296,"slug":297,"hasResults":12,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":89,"sex":17,"minAge":273,"maxAge":18,"enrollmentInfo":302,"targetDuration":4,"studyType":23,"phases":303,"briefSummary":304,"conditions":305,"keywords":307,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":81},"100635664","mediterranean-diet-and-gut-microbiota-in-children-with-systemic-lupus-erythematosus-100635664","NCT07555626","Mediterranean Diet and Gut Microbiota in Children With Systemic Lupus Erythematosus","Effects of a Mediterranean Diet-Based Nutritional Intervention on Gut Microbiota, Disease Activity, and Nutritional Status in Children With Systemic Lupus Erythematosus","Inclusion Criteria:\n\nFor participants with Systemic Lupus Erythematosus (SLE):\n\n* Diagnosis of SLE according to the SLICC classification criteria.\n* SLE diagnosis established at least 6 months prior to enrollment.\n\nFor healthy controls (household members):\n\n* Living in the same household as participants with SLE.\n* Body mass index (BMI) within the normal range.\n\nExclusion Criteria:\n\nFor participants with SLE:\n\n* Presence of active infection.\n* Renal failure, or history of major trauma or surgery within the past 6 months.\n* Presence of additional chronic diseases other than SLE.\n* Use of antibiotics or probiotics within the past 4 weeks.\n* Following a specific or restrictive diet.\n* Illiteracy or cognitive impairment that may limit understanding of the intervention.\n\nFor healthy controls (household members):\n\n* Presence of active infection\n* Presence of any chronic disease\n* Use of antibiotics or probiotics within the past 4 weeks\n* Following a specific or restrictive diet\n* Illiteracy or cognitive impairment that may limit understanding of study procedures",{"count":62,"type":22},[25],"The goal of this clinical trial is to learn if a Mediterranean diet can improve gut microbiota, disease activity, and nutrition in children with systemic lupus erythematosus (SLE). The study will include children with SLE and healthy family members living in the same home.\n\nThe main questions it aims to answer are:\n\nDoes a Mediterranean diet improve gut microbiota in children with SLE? Does the diet help reduce disease activity? Does the diet improve overall nutrition? Researchers will compare children with SLE to healthy family members to better understand how diet, gut microbiota, and health are related.\n\nParticipants will:\n\nGive stool samples at the beginning and end of the study to analyze gut microbiota.\n\nHave body measurements taken. Record what they eat for 3 days (2 weekdays and 1 weekend day). Answer questions about their diet, physical activity, sleep, and health. Children with SLE in the intervention group will receive nutrition counseling based on the Mediterranean diet for 12 weeks. The counseling will focus on increasing foods rich in polyphenols and reducing processed foods to improve overall diet quality. They will also receive advice on physical activity.\n\nAt the end of the study, some participants will join a group discussion to share their experiences.",[306],"Systemic Lupus Erythematosus (SLE)",[308,309,310,311,312],"Mediterranean Diet","Systemic Lupus Erythematosus","Gut microbiota","Individual nutrition counseling","Child","2026-04-21",{"date":315,"type":43},"2026-04-29",{"date":317,"type":22},"2026-06",{"date":319,"type":22},"2029-02",{"name":49,"class":50},{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":12,"sex":17,"minAge":145,"maxAge":328,"enrollmentInfo":329,"targetDuration":4,"studyType":23,"phases":331,"briefSummary":332,"conditions":333,"keywords":335,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":341,"leadSponsor":342,"locationsCount":81},"100634236","the-effect-of-vrtual-realty-headsets-on-anxety-fear-and-physological-parameters-in-chldren-with-cancer-undergong-intrathecal-chemotherapy-100634236","NCT07537062","The EFFECT of VİRTUAL REALİTY HEADSETS on ANXİETY, FEAR and PHYSİOLOGICAL PARAMETERS in CHİLDREN With CANCER UNDERGOİNG INTRATHECAL CHEMOTHERAPY","THE EFFECT of VİRTUAL REALİTY HEADSETS on ANXİETY, FEAR, and PHYSİOLOGİCAL PARAMETERS in CHİLDREN With CANCER UNDERGOİNG INTRATHECAL CHEMOTHERAPY","Inclusion Criteria:\n\n1. outside the 4-10 age range,\n2. have a chronic or genetic illness,\n3. have an intellectual, visual, or hearing impairment,\n4. cannot adapt to virtual reality glasses,\n5. are uncooperative (both themselves and their parents),\n6. neither they nor their parents are willing to participate in the research and have not given their verbal or written consent will not be included in the study.\n\nExclusion Criteria:\n\n1. outside the 4-10 age range,\n2. have a chronic or genetic illness,\n3. have an intellectual, visual, or hearing impairment,\n4. cannot adapt to virtual reality glasses,\n5. are uncooperative (both themselves and their parents),\n6. neither they nor their parents are willing to participate in the research and have not given their verbal or written consent will not be included in the study.","10 Years",{"count":330,"type":22},20,[25],"This study was planned to determine the effect of virtual reality glasses on anxiety, fear, and physiological parameters in cancer patients aged 4-10 years undergoing intrathecal chemotherapy. The main questions that the study aimed to answer are as follows:\n\n* Could virtual reality glasses affect the fear experienced by children undergoing intrathecal chemotherapy?\n* Could virtual reality glasses affect the anxiety experienced by children undergoing intrathecal chemotherapy?\n* Does virtual reality goggles have an effect on the physiological parameters of children undergoing intrathecal chemotherapy? Researchers will compare the effects of virtual reality glasses on fear, anxiety, and physiological parameters (heart rate, blood pressure, respiratory rate, and oxygen saturation) in children with cancer undergoing intrathecal chemotherapy to a control group that will not receive any intervention.\n\nCancer patients participating in the study will be given virtual reality glasses before intrathecal chemotherapy treatment.",[334],"Pediatric Cancer",[336],"pediatrıc cancer, virtual reality glasses, intrathecal chemotherapy","2026-04-20",{"date":339,"type":43},"2026-04-23",{"date":77,"type":43},{"date":317,"type":22},{"name":49,"class":50},{"id":344,"slug":345,"hasResults":12,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":350,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":352,"conditions":353,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":4},"100633690","mmp-23-and-periapical-healing-outcomes-100633690","NCT07529964","MMP-2\u002F3 and Periapical Healing Outcomes","Association of MMP-2 and MMP-3 Polymorphisms With 12-Month Radiographic Healing After Nonsurgical Root Canal Treatment in Chronic Apical Periodontitis: A Prospective Clinical Study","Inclusion Criteria:\n\n* Single-rooted teeth\n* PAI score ≥ 3\n* Fully developed root apices\n* Periodontal probing depth less than 5 mm\n* Indication for primary nonsurgical root canal treatment\n\nExclusion Criteria:\n\n* Previous endodontic treatment in the selected tooth\n* Diagnosis of symptomatic apical abscess\n* Presence of root fracture or internal\u002Fexternal resorption\n* Use of systemic antibiotics within the previous 4 weeks\n* Analgesic intake within 48 hours before treatment\n* Ongoing immunosuppressive therapy\n* Pregnancy or breastfeeding",{"count":351,"type":22},50,"This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in patients with chronic apical periodontitis. A total of 50 patients will undergo standardized endodontic treatment and will be followed for 12 months. Genotyping will be performed using baseline DNA samples, and periapical healing will be assessed using the Periapical Index (PAI). The relationship between genetic variations and treatment outcomes will be analyzed to determine whether host-related genetic factors influence healing patterns after root canal therapy.",[354,355],"Chronic Apical Periodontitis","Periapical Healing","2026-04-08",{"date":358,"type":43},"2026-04-14",{"date":360,"type":22},"2026-05-15",{"date":362,"type":22},"2027-06-25",{"name":49,"class":50},{"id":365,"slug":366,"hasResults":12,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":370,"eligibilityCriteria":371,"healthyVolunteers":12,"sex":90,"minAge":372,"maxAge":373,"enrollmentInfo":374,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":376,"conditions":377,"keywords":381,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":81},"100631382","predicting-spinal-hypotension-in-cesarean-section-100631382","NCT07499947","Predicting Spinal Hypotension in Cesarean Section","The Value of Waist Circumference, Body Mass Index, and Modified Shock Index in Predicting Spinal Anesthesia-Induced Hypotension During Cesarean Section: A Prospective Observational Study","prediction","Inclusion Criteria:\n\n1. American Society of Anesthesiologists (ASA) Class II\n2. Having regular antenatal visits\n3. Singleton pregnancy at ≥37 weeks of gestation\n4. Pregnant women aged 18-45 -\n\nExclusion Criteria:\n\n1. Those with eclampsia, those with preeclampsia\n2. Undergoing an emergency cesarean section\n3. Those with bleeding diathesis and those receiving anticoagulant therapy\n4. With a history of carotid artery stenosis,\n5. Cardiovascular disease,\n6. Hypertension,\n7. Chronic obstructive pulmonary disease,\n8. Heart rhythm outside of sinus\n9. Patients with a history of cerebrovascular disease\n10. Alcoholism or psychiatric illness\n11. Placenta previa, accreta, and percreta","18 Months","45 Months",{"count":375,"type":22},321,"This prospective observational study investigates the predictive value of anthropometric and hemodynamic indices for spinal anesthesia-induced hypotension (SAIH) during cesarean section. While spinal anesthesia is preferred for its rapid onset, SAIH remains a frequent complication risking maternal and fetal safety. The study enrolled parturients at Erciyes University, excluding those with hypertension or extreme weight\u002Fheight. Preoperative measurements included BMI, waist circumference (WC), body roundness index (BRI), and modified shock index (MSI). Following standardized spinal anesthesia with hyperbaric bupivacaine (Harten's dosage), hemodynamic parameters and sensory block levels were monitored. This research aims to determine whether BRI and WC offer superior predictive utility compared with conventional markers such as BMI and MSI to enhance individualized risk assessment in obstetric anesthesia.",[378,379,380],"Spinal Anesthesia","Cesarean Section","Hypotension",[382,383,384,380],"Bupivacaine","Cesarean","Spinal anesthesia","2026-03-30",{"date":387,"type":43},"2026-03-31",{"date":389,"type":43},"2026-03-16",{"date":391,"type":22},"2026-11-30",{"name":49,"class":50},{"id":394,"slug":395,"hasResults":12,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":89,"sex":17,"minAge":18,"maxAge":174,"enrollmentInfo":400,"targetDuration":4,"studyType":23,"phases":401,"briefSummary":402,"conditions":403,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":4},"100623972","effect-of-cryotherapy-on-anesthetic-success-and-pain-in-irreversible-pulpitis-100623972","NCT07403578","Effect of Cryotherapy on Anesthetic Success and Pain in Irreversible Pulpitis","Effect Of Cryotherapy On Anesthetıc Success And Intraoperatıve Paın In Mandıbular Premolars Wıth Irreversıble Pulpıtıs: A Prospectıve Randomızed Clınıcal Trıal","Inclusion Criteria:\n\n* Systemically healthy patients classified as ASA I or II, aged between 18 and 60 years,\n* Presence of a restorable mandibular premolar tooth diagnosed with symptomatic irreversible pulpitis,\n* History of spontaneous pain or lingering pain elicited by thermal stimuli,\n* Positive response with lingering pain to cold testing (Endo Ice; Coltene, Altstätten, Switzerland),\n* Positive response at low current levels to electric pulp testing (Parkell Inc., USA),\n* Teeth with closed apex and no radiographic evidence of periapical pathology (intact periodontal ligament space and absence of periapical radiolucency),\n* Patients presenting with moderate or severe preoperative pain, as assessed using the visual analogue scale (VAS).\n\nExclusion Criteria:\n\n* Patients who had taken analgesic, anti-inflammatory, or opioid medication within the last 12 hours before treatment,\n* Patients with systemic conditions that may affect pain perception, inflammatory response, or healing,\n* History of antibiotic use within the previous month or requirement for antibiotic prophylaxis,\n* Teeth presenting with clinical or radiographic signs of pulp necrosis or apical periodontitis (Pain on percussion or palpation, presence of sinus tract or swelling, presence of periapical radiolucency),\n* Teeth with root resorption, immature apices, severe coronal destruction preventing proper isolation, or calcified canals,\n* Teeth that had undergone previous endodontic treatment, including pulpotomy or root canal filling,\n* Patients with neurological or psychiatric conditions that could interfere with pain perception or accurate pain reporting,\n* Inability to achieve adequate isolation with a rubberdam.",{"count":176,"type":22},[25],"This prospective randomized clinical trial aimed to evaluate the effects of different anesthesia protocols on anesthetic success and intraoperative pain during root canal treatment of mandibular premolars diagnosed with symptomatic irreversible pulpitis. A total of 100 systemically healthy patients were randomly allocated into four groups: infiltration anesthesia alone, inferior alveolar nerve block (IANB) alone, infiltration anesthesia combined with cryotherapy, and IANB combined with cryotherapy. Cryotherapy was applied intraorally for 5 minutes immediately after anesthetic administration.\n\nThe effectiveness of anesthesia was confirmed using electric pulp testing and cold testing prior to treatment. Root canal therapy was completed in a single visit by a calibrated operator. Intraoperative pain was assessed during access cavity preparation using a visual analogue scale (VAS). Anesthetic success was defined as the presence of no or mild pain, whereas moderate or severe pain indicated anesthetic failure and required supplemental anesthesia.\n\nThe primary objective of the study was to determine whether the adjunctive use of cryotherapy improves anesthetic success and reduces intraoperative pain in mandibular premolars with symptomatic irreversible pulpitis. The null hypothesis was that no significant differences would be observed among the study groups in terms of anesthetic success or intraoperative pain intensity.",[404,405],"Irreversible Pulpitis","Cryotherapy","2026-02-10",{"date":408,"type":43},"2026-02-11",{"date":410,"type":22},"2026-01-30",{"date":412,"type":22},"2026-12-30",{"name":49,"class":50},{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":420,"eligibilityCriteria":421,"healthyVolunteers":12,"sex":90,"minAge":18,"maxAge":422,"enrollmentInfo":423,"targetDuration":4,"studyType":23,"phases":425,"briefSummary":426,"conditions":427,"keywords":429,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":437,"leadSponsor":439,"locationsCount":81},"100621529","effetcs-of-mndfulness-based-stress-reduction-n-women-wth-coronary-artery-dsease-100621529","NCT07371806","EFFETCS OF MİNDFULNESS-BASED STRESS REDUCTION İN WOMEN WİTH CORONARY ARTERY DİSEASE","THE EFFECT OF A MINDFULNESS-BASED STRESS REDUCTION PROGRAM ON QUALITY OF LIFE , ANXIETY AND EMPOWERMENT LEVELS IN WOMEN WITH CORONARY ARTERY DISEASE","MBSR-CADWOMEN","Inclusion Criteria:\n\n* Diagnosed with coronary artery disease (CAD) for at least 1 month.\n* Score of 14 or higher on the Short Form of the State-Trait Anxiety Inventory (STAI-SF) at baseline.\n* At least primary school education.\n* Age between 18 and 50 years.\n* Sexually active.\n* Having an active social network.\n\nExclusion Criteria:\n\n* Individuals with hearing or language impairments that would hinder communication.\n* Women who have entered menopause.\n* Women with psychiatric disorders.\n\nDiscontinuation Criteria:\n\n* Participants who choose to withdraw from the study.\n* Participants who miss two intervention sessions.\n* Participants with incomplete data on study forms.","50 Years",{"count":424,"type":22},70,[25],"Coronary artery disease (CAD) is a common cardiovascular condition characterized by the narrowing or blockage of the coronary arteries that supply oxygen-rich blood to the heart muscle. CAD represents a significant cause of morbidity and mortality, particularly among individuals aged 40 and older, affecting millions of men and women worldwide. Patients with CAD experience not only physical symptoms but also psychological challenges, including stress and anxiety, which can negatively impact quality of life. In recent years, mindfulness-based interventions have emerged as scientifically supported approaches to help individuals with chronic diseases manage stress and enhance emotional regulation skills. While the existing literature includes studies evaluating the effects of mindfulness-based interventions in CAD and other cardiovascular conditions, most investigations address mixed patient populations and do not thoroughly examine sex-specific differences. Notably, women with CAD may experience symptoms and psychological effects differently than men. Therefore, there is a need for tailored, comprehensive intervention models that address the multidimensional needs of female patients, including stress management, anxiety reduction, and empowerment. This study aims to evaluate the effectiveness of mindfulness-based interventions in women with CAD, providing a targeted approach that addresses both clinical and psychosocial outcomes. The findings are expected to offer valuable insights into improving quality of life and enhancing coping strategies for women living with chronic cardiovascular disease.",[428],"Coronary Artery Disease (CAD)",[430,431,432],"Coronary artery disease","Mindfulness-based intervention","Quality of life","2026-01-28",{"date":435,"type":43},"2026-01-29",{"date":208,"type":22},{"date":438,"type":22},"2026-10-15",{"name":49,"class":50},{"id":441,"slug":442,"hasResults":12,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":4,"eligibilityCriteria":446,"healthyVolunteers":12,"sex":90,"minAge":18,"maxAge":447,"enrollmentInfo":448,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":450,"conditions":451,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":456,"completionDateStruct":458,"leadSponsor":460,"locationsCount":4},"100621568","prediction-of-hypotension-and-postdural-puncture-headache-by-carotid-artery-corrected-flow-time-100621568","NCT07372313","Prediction of Hypotension and Postdural Puncture Headache by Carotid Artery Corrected Flow Time","Ability of Preoperative Carotid Artery Corrected Flow Time to Predict Hypotension and Postdural Puncture Headache During Cesarean Section","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) Class II\n* Regular antenatal visits\n* Singleton pregnancy at ≥37 weeks' gestation\n* Pregnant women aged 18-49\n\nExclusion Criteria:\n\n* Patients with eclampsia or preeclampsia\n* Patients who have undergone emergency cesarean section\n* Patients with bleeding diatheses and those receiving anticoagulant therapy\n* Patients with a history of ≥50% carotid artery stenosis\n* Patients with cardiovascular disease\n* Hypertension\n* Patients with chronic obstructive pulmonary disease\n* Patients with a heart rhythm other than sinus rhythm\n* Patients with a history of cerebrovascular disease\n* Patients with alcoholism or psychiatric illness\n* Patients with placenta previa, accreta, or percreta\n* Patients with diabetes","49 Years",{"count":449,"type":22},90,"Anesthesia for cesarean delivery can be provided through general or neuraxial anesthesia (spinal or epidural). Hypotension is a common complication of both methods. Hypotension associated with spinal anesthesia can cause dizziness, nausea, vomiting, restlessness, and confusion in the mother, while also decreasing blood flow to the baby, leading to hypoxia and fetal acidosis. Untreated persistent hypotension poses a life-threatening risk to both mother and baby.\n\nIn recent years, ultrasonography has become widely used to assess volume status. Carotid artery corrected flow time (FTc) is primarily affected by left ventricular preload and is related to myocardial contractility and afterload. Therefore, it can predict intraoperative hypotension.\n\nPostdural puncture headache (PDPH) is a relatively common complication after neuraxial blocks. PDPH is generally defined as an orthostatic headache caused by low cerebrospinal fluid pressure accompanied by neck pain, tinnitus, hearing changes, photophobia, and\u002For nausea. Risk factors include female gender, young age, pregnancy, a previous history of PDPH, low CSF pressure, and low BMI.\n\nThis study will be conducted on pregnant women undergoing elective cesarean sections under spinal anesthesia in the cesarean operating room at Erciyes University Faculty of Medicine Hospital. The correlation between preoperative carotid artery FTc levels in pregnant women and the incidence of intraoperative hypotension and postoperative PDPH will be investigated, as will whether FTc levels are a significant predictor of the likelihood of developing intraoperative hypotension and postoperative PDPH. Carotid artery FTc will be measured 1 hour before surgery, and baseline systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), peripheral oxygen saturation (SPO2), and heart rate will be recorded in the operating room. Values will be recorded at 1, 2, 3, 5, 10, 12, 15, and 30 minutes after spinal anesthesia. Patients will be assessed postoperatively for postdural puncture headache using a numerical rating scale (NRS) on days 2, 3, and 7.\n\nThis study is expected to demonstrate the ability of preoperative FTc to predict hypotension and PDPH, to determine the threshold value for predicting hypotension and PDPH, and to improve or modify the anesthesia method in patients with predicted hypotension and PDPH.",[452,453],"Hypotension in Pregnant Women","Headache in Pregnant Women","2026-01-19",{"date":433,"type":43},{"date":457,"type":22},"2026-02-15",{"date":459,"type":22},"2027-04-15",{"name":49,"class":50},{"id":462,"slug":463,"hasResults":12,"nctId":464,"briefTitle":465,"officialTitle":466,"acronym":4,"eligibilityCriteria":467,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":468,"targetDuration":4,"studyType":23,"phases":470,"briefSummary":471,"conditions":472,"keywords":474,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":490,"locationsCount":81},"100613943","the-effect-of-cold-vapor-on-dyspnea-thirst-nausea-and-physiological-parameters-in-the-pacu-after-laparoscopic-inguinal-hernia-surgery-100613943","NCT07273162","The Effect of Cold Vapor on Dyspnea, Thirst, Nausea, and Physiological Parameters in the PACU After Laparoscopic Inguinal Hernia Surgery","The Effect of Cold Vapor Inhalation on Dyspnea Thirst Nausea and Physiological Parameters in the Recovery Unit After Laparoscopic Inguinal Hernia Surgery","Inclusion Criteria:\n\n* Volunteering to participate in the study\n* Being aged 18 years or older\n* Being able to speak and understand Turkish\n* Having cognitive, affective, and communicative competence\n* Having intact visual and auditory functions\n* Having undergone elective laparoscopic inguinal hernia surgery under general anesthesia\n* Having an ASA score of I or II\n* Having a total Modified Aldrete Score of ≥9 and a consciousness score of 2 (fully awake) in the postoperative period\n* Not having developed vomiting prior to the intervention\n* Having a body temperature within the normal physiological range (36-37.5 °C)\n\nExclusion Criteria:\n\n* Having cold vapor application planned by physician order in the PACU prior to the study\n* Having signs and symptoms of upper or lower airway obstruction\n* Developing agitation and having communication insufficiency\n* Having an allergy to cold vapor application\n* Having a diagnosis of obstructive pulmonary disease (e.g., COPD, asthma) or heart failure\n* Having a known history of any neurological or psychiatric disease\n* Having a postoperative nasogastric catheter inserted\n* Having received preoperative diagnoses associated with nausea, vomiting, or dyspnea",{"count":469,"type":22},66,[25],"Cold vapor application is considered a promising intervention with the potential to alleviate side effects associated with anesthesia and surgery in the postoperative period. This study aims to determine the effect of cold vapor inhalation on dyspnea, thirst, nausea, and physiological parameters following laparoscopic inguinal hernia surgery.\n\nHypotheses (H1);\n\nH1a: Patients administered cold vapor will report lower dyspnea severity compared to the control group.\n\nH1b: Patients administered cold vapor will report lower thirst levels compared to the control group.\n\nH1c: Patients administered cold vapor will report lower nausea severity compared to the control group.\n\nH1d: Patients administered cold vapor will show significant differences in physiological parameters compared to the control group.",[473],"Patients Undergoing Laparoscopic Inguinal Hernia Repair",[475,476,477,478,479,480,481,482,483],"PACU","Laparoscopy","inguinal hernia","cold vapor","dyspnea","thirst","nausea","physiological parameters","surgery","2026-01-15",{"date":486,"type":43},"2026-01-16",{"date":488,"type":22},"2025-12-20",{"date":107,"type":22},{"name":49,"class":50},{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":495,"acronym":4,"eligibilityCriteria":496,"healthyVolunteers":89,"sex":17,"minAge":146,"maxAge":18,"enrollmentInfo":497,"targetDuration":4,"studyType":23,"phases":499,"briefSummary":500,"conditions":501,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":506,"completionDateStruct":507,"leadSponsor":509,"locationsCount":4},"100620287","the-effect-of-a-web-based-education-program-on-eating-habits-metabolic-control-and-self-management-in-adolescents-with-type-1-diabetes-mellitus-and-their-mothers-with-irregular-eating-behavior-100620287","NCT07355660","The Effect of a Web-Based Education Program on Eating Habits, Metabolic Control, and Self-Management in Adolescents With Type 1 Diabetes Mellitus and Their Mothers With Irregular Eating Behavior","Inclusion Criteria:\n\n* T1DM adolescents and their mothers who have internet access at home,\n* have a DEPS-R score of 20 or higher,\n* are between the ages of 12 and 18,\n* have been diagnosed with T1DM at least one year ago,\n* have no other chronic illness other than T1DM, and\n* agree to participate in the study\n\nExclusion Criteria:\n\n* Diabetes diagnosis lasted less than one year.\n* The adolescent has a chronic condition other than T1DM.\n* The adolescent and their mother have cognitive or perceptual disabilities in understanding the website's content.\n* Participants who did not complete the training program.",{"count":498,"type":22},24,[25],"The study was planned as a randomized controlled experimental study to investigate the effects of a web-based educational program given to adolescents with diabetes mellitus and their mothers on eating habits, metabolic control, and self-management.\n\nThe prevalence of Type 1 diabetes is increasing worldwide and is reported to be the third most common chronic disease in childhood (Lowes et al., 2015). It is generally accepted that effective management of diabetes requires education for both the patient and the family regarding management components such as blood glucose monitoring, insulin replacement, diet, exercise, and problem-solving strategies (Couch et al., 2008). Since diabetes management requires lifestyle changes, many health professionals recommend providing education to the whole family (Shiel et al., 2023).\n\nAdolescence is a period of developing autonomy and often means reduced parental involvement; however, an adolescent with Type 1 diabetes is also coping with a serious, life-threatening disease (Polfuss et al., 2015). Increased self-care responsibilities during adolescence create additional complex challenges for the management and treatment of diabetes. Websites providing information about diabetes to adolescents offer problem-solving opportunities and an interactive environment for sharing experiences.\n\nThe study population will consist of adolescents and their mothers followed at the Pediatric Endocrinology Outpatient Clinic of Erciyes University Mustafa Eraslan and Fevzi Mercan Children's Hospital. In the first phase of the study, the Descriptive Characteristics and Eating Disorder Behavior Scale (DESPR) will be administered to adolescents and their mothers to identify adolescents with eating disorder behaviors. The sample was determined as 272 adolescents using the G Power program with a margin of error of d=0.2, a margin of error of 0.05, and a 95% confidence interval. For the second phase of the study, adolescents with a DESPR score of 20 or higher will be divided into three groups: Intervention I (Adolescents Only), Intervention II (Adolescents and Mothers), and Control Group (Clinical Practice Routine). The sample size was calculated using the G Power program with a margin of error of d=0.4, a margin of error of 0.05, and an 85% confidence interval, resulting in a total of 72 individuals, with 24 individuals in each group. The groups into which individuals will be placed will be determined using the block randomization method applied on the www.randomizer.org website.\n\nTraining Implementation:\n\nTraining will be given to two groups: Web-Based Intervention Group I (Adolescents) and Intervention Group II (Adolescents and Mothers). An initial introductory meeting will be held, and training on how to use the web program will be given in a single 40-minute session. Website Preparation: The website will be structured using WordPress, a web-based software development tool that supports most web browsers. Website content will be evaluated using the DISCERN Measurement Tool by a faculty member from the Department of Endocrinology and Metabolic Diseases, three faculty members from the Faculty of Nursing, three Diabetes Education Nurses, and a faculty member from the Department of Nutrition and Dietetics. The researcher will introduce the website to adolescents by explaining its name and how to use it. Individuals in the intervention group will also be given usernames and passwords to access the site. New topics, blog posts, and quizzes related to the topic will be added to the site each week, and a reminder message will be sent to individuals in the intervention group when a new topic is added. The website will include an interface where members can log in to their own pages, enter blood glucose measurements, access training modules, exchange messages, and perform administrative tasks (user lists, monitoring all measurements, and tracking training results). The \"Contact\" page on the website will allow users to send messages to site administrators. Six menus are planned for the website: \"Home\", \"Our Team\", \"Blog\", \"Training\", \"Surveys\", and \"Contact\". Blog Menu: This will be a space where members can chat with each other and share their experiences. The aim is to encourage members to comment on topics determined by the site administrator and share their experiences. After using the website, everyone will be given the opportunity to comment on the materials provided. Educational materials cover topics such as Type 1 diabetes, nutrition for young people with diabetes, carbohydrate counting, acute complications such as hypoglycemia, long-term complications, physical exercise in diabetes, diabetes treatment, insulin, and continuous glucose monitoring.",[502],"Type 1 Diabetes Mellitus","2026-01-14",{"date":505,"type":43},"2026-01-21",{"date":486,"type":22},{"date":508,"type":22},"2026-12-16",{"name":49,"class":50},{"id":511,"slug":512,"hasResults":12,"nctId":513,"briefTitle":514,"officialTitle":515,"acronym":516,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":58,"minAge":518,"maxAge":519,"enrollmentInfo":520,"targetDuration":59,"studyType":197,"phases":4,"briefSummary":521,"conditions":522,"keywords":524,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":81},"100618677","the-effects-of-holmium-laser-enucleation-and-thulium-laser-enucleation-on-continence-urethral-stricture-and-sexual-function-in-benign-prostatic-hyperplasia-100618677","NCT07334730","The Effects of Holmium Laser Enucleation and Thulium Laser Enucleation on Continence, Urethral Stricture, and Sexual Function in Benign Prostatic Hyperplasia","A Prospective Analysis of the Effects of Holmium Laser Enucleation (HoLEP) and Thulium Laser Enucleation (ThuLEP) on Continence, Urethral Stricture, and Sexual Function in Benign Prostatic Hyperplasia","EHTCUS","Inclusion Criteria:\n\n* Diagnosis of benign prostatic hyperplasia (BPH).\n* Indication for surgical treatment of BPH.\n* Male patients aged 40-90 years.\n\nExclusion Criteria:\n\n* Patients with active urinary tract infection (UTI).\n* Patients at high risk who cannot undergo spinal or general anesthesia.\n* Patients with uncontrolled bleeding diathesis.","40 Years","90 Years",{"count":248,"type":22},"This study aims to evaluate the effects of Holmium Laser Enucleation of the Prostate (HoLEP) and Thulium Laser Enucleation of the Prostate (ThuLEP), performed for the treatment of benign prostatic hyperplasia (BPH), on the following parameters: urinary continence, development of urethral or bladder neck stricture, and sexual function, including erectile function, ejaculation, and libido.",[523],"Benign Prostate Obstruction (BPO)",[525,526,527,528,529,530,531,532,533,534],"HOLEP","THULEP","BPO","Urinary Incontinence","Sexual Function","Urethral Stricture","Benign Prostate Obstruction","Benign Prostate Hyperplasia","Holmium","Thulium","2025-12-31",{"date":537,"type":43},"2026-01-12",{"date":539,"type":22},"2026-02-01",{"date":541,"type":22},"2026-10-01",{"name":49,"class":50},{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":551,"targetDuration":552,"studyType":197,"phases":4,"briefSummary":553,"conditions":554,"keywords":556,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":564,"lastUpdatePostDateStruct":565,"startDateStruct":567,"completionDateStruct":569,"leadSponsor":571,"locationsCount":81},"100615693","risk-factors-for-postoperative-fever-and-sepsis-following-retrograde-intrarenal-surgery-100615693","NCT07295925","Risk Factors for Postoperative Fever and Sepsis Following Retrograde Intrarenal Surgery","Prospective Evaluation of Clinical, Laboratory and Operative Predictors of Postoperative Fever and Sepsis After Retrograde Intrarenal Surgery (RIRS)","SARIS","Inclusion Criteria:\n\n* Age 18 years or older.\n* Patients scheduled to undergo retrograde intrarenal surgery (RIRS) for the treatment of renal or ureteral stones.\n* Completion of routine preoperative and postoperative clinical assessments required for RIRS.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Terminal-stage malignancy.\n* Bleeding diathesis or known immunodeficiency.\n* Active infectious condition at the time of surgery.\n* Patients deemed unsuitable for anesthesia or surgery by the Department of Anesthesiology.\n* Pregnancy.\n* Contraindications to RIRS or inability to complete required perioperative evaluations.",{"count":275,"type":22},"3 Days","This prospective clinical study aims to evaluate preoperative, intraoperative, and postoperative characteristics of patients undergoing retrograde intrarenal surgery (RIRS) for urinary stone disease. A total of approximately 250 patients will be assessed to identify clinical, laboratory, and operative factors associated with postoperative fever and sepsis. By systematically collecting and analyzing perioperative data, the study seeks to determine independent predictors that may support improved risk stratification and patient safety in endourological practice.",[555],"Urolithiasis",[557,558,555,559,560,561,562,563],"RIRS","Sepsis","Endourology","Retrograde Intrarenal Surgery","Postoperative Fever","Postoperative Sepsis","Ureteroscopy","2025-12-19",{"date":566,"type":43},"2025-12-22",{"date":568,"type":22},"2026-01",{"date":570,"type":22},"2026-12",{"name":49,"class":50},{"id":573,"slug":574,"hasResults":12,"nctId":575,"briefTitle":576,"officialTitle":576,"acronym":4,"eligibilityCriteria":577,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":578,"targetDuration":4,"studyType":23,"phases":580,"briefSummary":581,"conditions":582,"keywords":585,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":592,"completionDateStruct":594,"leadSponsor":595,"locationsCount":81},"100613789","the-effect-of-aromatherapy-foot-massage-on-neuropathic-pain-in-patients-with-type2-diabetes-100613789","NCT07271160","The Effect of Aromatherapy Foot Massage on Neuropathic Pain in Patients With Type2 Diabetes","Inclusion Criteria:\n\n* Patients with a Douleur neuropathic pain questionnaire score of 4 and above,\n* 18 years and over,\n* No psychiatric illness,\n* Patients who are able to answer all the questions,\n* Turkish-speaking patients.\n\nExclusion Criteria:\n\n* Patients who cannot be contacted,\n* Any limb, vascular problem or wound that prevents the application of foot massage,\n* Thrombophlebitis, occlusive arterial disease, fever, etc. Those who are inconvenient to massage due to illness,\n* Patients who refused to participate in the study.",{"count":579,"type":22},78,[25],"The aim of this clinical trial is to learn about the effect of aromatherapy foot massage on neuropathic pain in patients with Type 2 diabetes. In addition, while determining the effect of aromatherapy foot massage on neuropathic pain; it was also aimed to find the source of the reduction in pain.\n\nThe main questions he aimed to answer are as follows:\n\nDoes aromatherapy foot massage have an effect on neuropathic pain in patients with type 2 diabetes? Does foot massage have an effect on neuropathic pain in patients with type 2 diabetes? The researchers will compare an oil without aromatherapy oil with a placebo group to see if aromatherapy foot massage reduces neuropathic pain.\n\nParticipants:\n\nParticipants will perform the massage treatment three times a week for 4 weeks. Participants will perform foot massage for 10 minutes, 5 minutes on each foot. Participants will be evaluated by calling once a week for 4 weeks.",[583,584],"Type 2 Diabetes Mellitus (T2DM)","Neuropathic Pain",[586,587,588],"neuropathic pain","type 2 diabetes","aromatherapic massage","2025-12-07",{"date":591,"type":43},"2025-12-09",{"date":593,"type":22},"2025-12-01",{"date":360,"type":22},{"name":49,"class":50},{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":602,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":604,"enrollmentInfo":605,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":606,"conditions":607,"keywords":609,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":613,"lastUpdatePostDateStruct":614,"startDateStruct":616,"completionDateStruct":618,"leadSponsor":620,"locationsCount":81},"100580905","real-world-experience-of-oral-agents-on-fatigability-in-multiple-sclerosis-100580905","NCT06843382","Real-world Experience of Oral Agents On Fatigability in Multiple Sclerosis","Real-World Comparative Effects of Teriflunomide and Dimethyl Fumarate on Physical and Cognitive Fatigability in Multiple Sclerosis: The ROOF-MS Multicenter Prospective Cohort Study","ROOF-MS","Inclusion Criteria:\n\n* Relapsing Multiple Sclerosis (RRMS or active SPMS) diagnosis, confirmed according to the 2017 revised McDonald criteria.\n* 18 years or older at the time of enrollment.\n* Newly initiated teriflunomide treatment as part of routine clinical care.\n* Ambulatory status (EDSS ≤ 7.0), capable of completing study assessments.\n* Ability and willingness to provide informed consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Diagnosis of Primary Progressive Multiple Sclerosis (PPMS).\n* Severe comorbidities affecting mobility or cognitive function (e.g., advanced cardiovascular, pulmonary, or neuromuscular disease).\n* Neurological or psychiatric conditions that prevent cognitive testing (e.g., advanced cognitive impairment, untreated severe depression).\n* Severe upper extremity motor dysfunction, limiting 9-Hole Peg Test (9-HPT) or Symbol Digit Modalities Test (SDMT) completion.\n* Pregnancy or breastfeeding at the time of enrollment.\n* Inability to comply with study visits at baseline, 3 months, 6 months, and 12 months.","75 Years",{"count":176,"type":22},"This multicenter, prospective, real-world study evaluates how two commonly used oral disease-modifying therapies-teriflunomide and dimethyl fumarate-affect physical and cognitive fatigability in adults with multiple sclerosis (MS). Fatigability refers to an objective decline in physical or cognitive performance during sustained activity and represents a major barrier to daily functioning for many individuals with MS.\n\nParticipants starting either teriflunomide or dimethyl fumarate as part of routine clinical care will be followed for 12 months at regular visits (baseline, 3, 6, 9, and 12 months). At each visit, standardized assessments will measure walking endurance, gait performance, hand function, and information-processing speed. Patient-reported outcomes about fatigue, mood, quality of life, and daily functioning will also be collected. Brain MRI scans performed as part of usual care will be reviewed to document disease activity.\n\nThe goal of the ROOF-MS study is to understand whether these two therapies differ in their impact on physical and cognitive fatigability, functional outcomes, symptom burden, and real-world treatment adherence. Because this is an observational study, no experimental treatments are given, and all clinical decisions remain the responsibility of the treating physicians.\n\nBy examining fatigability in everyday clinical settings, this study aims to generate evidence that can help patients, families, and health care providers make more informed treatment decisions.",[608],"Multiple Sclerosis",[608,610,611,612],"Teriflunomide","Fatigability","Real-world study","2025-11-18",{"date":615,"type":43},"2025-11-21",{"date":617,"type":22},"2025-11-20",{"date":619,"type":22},"2027-06-15",{"name":49,"class":50},{"id":622,"slug":623,"hasResults":12,"nctId":624,"briefTitle":625,"officialTitle":626,"acronym":627,"eligibilityCriteria":628,"healthyVolunteers":89,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":629,"targetDuration":4,"studyType":23,"phases":630,"briefSummary":631,"conditions":632,"keywords":634,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":640,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":81},"100584347","hot-compress-application-in-open-abdominal-surgery-100584347","NCT06888154","Hot Compress Application in Open Abdominal Surgery","The Effect of Hot Compress Applied on the Intestines on Postoperative Nausea-vomiting and Bowel Function in Abdominal Surgery","HotCompress","Inclusion Criteria:\n\n* Abdominal surgery in the general surgery ward\n* 18 years of age or older\n* Patients with BMI in the normal range (18.50-24.99 kg\u002Fm2)\n* Able to communicate verbally\n* Those who volunteered to participate in the study\n* Patients with no mental confusion, conscious and oriented will be included.\n\nExclusion Criteria:\n\n* Previous gastrointestinal system surgery\n* Complications in the postoperative period\n* History of small bowel resection and ileostomy or colostomy\n* Surgical history of inflammatory bowel diseases, emergency surgery, neoadjuvant therapy, appendectomy,\n* Chronic opioid use,\n* Experiencing chronic constipation (≤ 2 bowel movements per week),\n* Abdominal radiotherapy\n* Patients admitted to intensive care unit and patients with bleeding will not be included in the study.",{"count":148,"type":22},[25],"This study aims to evaluate the effect of hot compress application to the intestines during abdominal surgery on postoperative nausea-vomiting and bowel function.\n\nVolunteers will be randomly assigned to the intervention and control groups. Initially, 30 patients will be included in each group, and the study will be completed based on the effect size determined by power analysis.\n\nHypotheses:\n\nH0: Covering the intestines with saline heated at 36°C during surgery has no effect on postoperative nausea and vomiting.\n\nH1: Covering the intestines with saline heated at 36°C during surgery affects postoperative nausea and vomiting.\n\nH01: Covering the intestines with saline heated at 36°C during surgery has no effect on postoperative bowel function.\n\nH11: Covering the intestines with saline heated at 36°C during surgery affects postoperative bowel function.\n\nInclusion Criteria:\n\nUndergoing abdominal surgery in the general surgery ward, Aged 18 years or older, Having a BMI between 18.50-24.99 kg\u002Fm², Able to communicate verbally, Willing to participate in the study, Conscious and oriented patients.\n\nExclusion Criteria:\n\nHistory of previous gastrointestinal surgery, Postoperative complications, History of small bowel resection, ileostomy, or colostomy, History of emergency surgery, neoadjuvant therapy, appendectomy, or inflammatory bowel disease, Chronic opioid use, Chronic constipation (≤ 2 bowel movements per week), History of abdominal radiotherapy, Admission to the intensive care unit or postoperative bleeding.\n\nApplication:\n\nIntervention Group: Routine preoperative procedures will be performed. During surgery, the intestines will be covered with sterile gauze soaked in saline heated at 36°C to prevent drying and reduce the risk of infection. Routine postoperative procedures will also be applied.\n\nControl Group: Routine preoperative, intraoperative, and postoperative procedures will be applied. During surgery, the intestines will be covered with sterile gauze soaked in unheated saline, following standard practice.\n\nOutcome Measures:\n\nPrimary Outcome: Gastrointestinal function assessment index, including time to first flatulence, first defecation, first normal bowel sounds, and first consumption of liquid\u002Fsemi-solid food.\n\nSecondary Outcome: Gastrointestinal symptoms such as nausea, abdominal bloating, pain, and vomiting.",[633],"Abdominal Surgery by Laparotomy",[635,636,637,638],"abdominal surgery","hot compress","operating room","nursing","2025-10-01",{"date":641,"type":43},"2025-10-06",{"date":643,"type":43},"2025-05-15",{"date":645,"type":22},"2026-02-25",{"name":49,"class":50},{"id":648,"slug":649,"hasResults":12,"nctId":650,"briefTitle":651,"officialTitle":652,"acronym":4,"eligibilityCriteria":653,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":654,"targetDuration":4,"studyType":23,"phases":656,"briefSummary":657,"conditions":658,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":661,"completionDateStruct":662,"leadSponsor":663,"locationsCount":4},"100608989","the-key-to-emotional-balance-100608989","NCT07208721","The Key to Emotional Balance","The Key to Emotional Balance: The Effect of a Positive Psychotherapy-Based Balance Model on Emotion Regulation, Recovery, and Life Purpose in Bipolar Disorder","Inclusion Criteria:\n\n1. Having a diagnosis of bipolar I or bipolar II disorder according to the DSM-5.\n2. Being between 18 and 65 years of age.\n3. Being literate and having the cognitive capacity to participate in written questionnaires.\n4. Being in a stable mood\u002Fremission (neither severely manic nor severely depressed) at the start of the study.\n5. Being on medication or willing and able to comply with treatment.\n6. Voluntarily agreeing to participate in the study and signing the informed consent form.\n\nExclusion Criteria:\n\n1. Being in an episode of acute mania or severe depression.\n2. Having a diagnosis of another serious psychiatric disorder such as schizophrenia, schizoaffective disorder, severe anxiety disorder, or obsessive-compulsive disorder (OCD).\n3. Cognitive impairments, such as dementia, severe cognitive impairment, or mental retardation, that would prevent participation in the recommended therapy.\n4. Individuals with a history of substance abuse within the last 6 months or ongoing active substance use.\n5. Individuals who have attempted suicide within the last 6 months or who currently have suicidal thoughts (patients at high risk of suicide).\n6. Refusal to attend regular therapy sessions or severe resistance to psychotherapy.\n7. Individuals who are not compliant with recommended medication for bipolar disorder.\n8. Serious medical problems or chronic conditions that would prevent recommended psychotherapy (e.g., uncontrolled epilepsy or serious cardiovascular disease).\n9. Inability to speak Turkish sufficiently to understand the questionnaires and therapeutic interventions or difficulty communicating.\n\nExclusion Criteria:\n\n1. Not attending psychoeducation sessions more than three times or not completing any of the pretest and posttest measures of the data collection forms.\n2. Relapse of disease during the study and inability to comply with the program.\n3. Participating in any other program while the study is ongoing.",{"count":655,"type":22},74,[25],"This randomized controlled experimental study aimed to evaluate the effects of the Key to Emotional Balance (KBA) psychoeducational program, based on the Balance Model of Positive Psychotherapy (PPT), on indicators of emotion regulation difficulties, recovery, and purpose in life in adults with bipolar disorder. Intervention and control groups (n=37 each; total n=74) will be formed through simple random assignment. The intervention will consist of eight individual sessions, each lasting 40-50 minutes. Data will be collected using the Difficulty in Emotion Regulation, Recovery Assessment Scale, and the Life Goals Scale in the Context of PPT. Measurements will be conducted as a pretest and posttest.",[651],"2025-09-28",{"date":641,"type":43},{"date":639,"type":22},{"date":107,"type":22},{"name":49,"class":50},""]