[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Taipei Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":658},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,34,0,25,[9,41,71,101,123,152,180,209,240,265,286,312,334,361,380,401,425,450,479,504,523,551,577,600,630],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100642107","the-potential-application-of-plasma-activated-water-in-fibromyalgia-patients-100642107",false,"NCT07659236","The Potential Application of Plasma-Activated Water in Fibromyalgia Patients","Inclusion Criteria:\n\n1. Currently experiencing widespread bodily pain for a duration of at least three months and diagnosed by a clinical specialist as a fibromyalgia patient.\n2. Aged between 20 and 75 years.\n3. Clear understanding and the ability to communicate with the researchers in Mandarin or Taiwanese dialect through spoken or written language.\n4. Willingness to participate in this research after receiving an explanation and the ability to cooperate with the research procedures.\n\nExclusion Criteria:\n\n1. Malignant tumors.\n2. Currently experiencing an acute infection.\n3. Concurrent central nervous system disorders such as stroke or Parkinson's disease.\n4. Concurrent endocrine system disorders such as hypothyroidism.\n5. Significant autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, lupus, and others.\n6. Currently pregnant.","ALL","20 Years","75 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Fibromyalgia is a chronic syndrome characterized by widespread pain that is commonly observed in pain, rheumatology, or rehabilitation clinics. Previous studies have suggested a fibromyalgia prevalence rate of approximately 2%. Currently, evidence shows that fibromyalgia might be partially associated with increased oxidative stress, caused by mitochondrial abnormalities, genetic abnormalities, and excessive metal intake. Some research teams have experimented with dietary adjustments to control oxidative stress, but the relationship between diet and oxidative stress has not been conclusively confirmed.\n\nPlasma-activated water is a method of storing the high-energy benefits of water and effectively utilizing its energy. It also improves solubility and conductivity at room temperature. It involves activating nano gold particles with a specific wavelength light source to create surface plasmon resonance, resulting in thermoelectrons. These thermoelectrons then disrupt or reduce the hydrogen bonding capacity between water molecules in the tetrahedral chemical structure network, leading to the formation of smaller water molecules known as plasma-activated water.\n\nStudies on animals have shown that plasma-activated water possesses free radical-scavenging and antioxidant properties. It can reduce liver oxidative stress damage induced by sleep deprivation and is non-toxic. Recent studies have shown that plasma-activated water can treat cancer, chronic diseases, and degenerative conditions in animal models. In a lung cancer animal model, combining plasma-activated water with cisplatin chemotherapy increased the mice's survival time. In an animal model with chronic kidney disease, drinking plasma-activated water reduced fibronectin expression and slowed kidney fibrosis. Plasma-activated water reduced oxidative stress in an animal model of chronic sleep deprivation-induced liver damage, thereby enhancing the antioxidant and anti-inflammatory capabilities of the liver cells. In an animal model with Alzheimer's disease, it reduced amyloid-β protein expression and improved memory. In a rat model with Parkinson's disease, plasma-activated water suppressed inflammation and protected nerve cells.\n\nSince plasma-activated water has demonstrated antioxidant effects in mouse and rat animal models and previous clinical trials have shown that drinking plasma-activated water does not have toxic reactions and does not significantly affect drug metabolism in the human body, this study aims to assess the safety and potential symptom improvement effects of long-term consumption of plasma-activated water in fibromyalgia patients.",[27],"Safety and Potential Symptom Improvement Effects of Long Term Consumption of Plasma Activated Water in Fibromyalgia Patients","RECRUITING","2026-06-16",{"date":31,"type":32},"2026-06-22","ACTUAL",{"date":34,"type":32},"2024-07-01",{"date":36,"type":21},"2026-07-31",{"name":38,"class":39},"Taipei Medical University","OTHER",1,{"id":42,"slug":43,"hasResults":12,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":12,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":40},"100641904","effect-of-a-theory-based-multicomponent-ehealth-intervention-program-100641904","NCT07644143","Effect of A Theory-based Multicomponent eHealth Intervention Program","Effect Of A Theory-Based Multicomponent Ehealth Intervention On Weight Self - Stigma, Bodyweight And Quality Of Life Among Overweight And Obese Adults: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 to 55 years\n* Body mass index (BMI) ≥23 kg\u002Fm²\n* Weight self-stigma, defined as a Weight Self-Stigma Questionnaire (WSSQ) score \\>36\n* Owns or has regular access to a smartphone\n* Resides in Phan Dinh Phung municipality, Thai Nguyen Province, Vietnam\n* Able to read and write in Vietnamese\n\nExclusion Criteria:\n\n* Type 1 or type 2 diabetes\n* Uncontrolled hypertension, defined as blood pressure ≥160\u002F100 mmHg\n* Cardiovascular event, such as stroke or myocardial infarction, within the past year\n* Weight loss of ≥5% of initial body weight in the past 3 months or ≥10% in the past 2 years\n* Participation in a weight-loss program within the past 3 months\n* Cognitive impairment, including a diagnosis of dementia\n* Psychiatric condition, including major depression or generalized anxiety disorder\n* Current use of weight-loss medication\n* History of bariatric surgery\n* Unable to perform physical activity\n* Engages in ≥150 minutes of structured physical activity per week or \\>75 minutes of high-intensity exercise per week\n* Pregnant or planning pregnancy within the next 6 months","18 Years","55 Years",{"count":51,"type":21},60,[24],"This study is a two-arm pilot randomized controlled trial designed to evaluate the feasibility and preliminary effects of an Acceptance and Commitment Therapy (ACT) theory-based mobile application integrated with a smartphone pedometer plus health education on weight self-stigma and lifestyle behaviors among overweight or obese adults.\n\nA total of 60 participants will be recruited and randomized 1:1 to the intervention (ACT-based app + pedometer + health education) or control condition. Outcomes will be assessed at baseline (T0), immediately after intervention (T1), and at 1 month after intervention (T2) and 3 months after intervention (T3) following intervention initiation. The primary outcomes are body weight (weight loss) and weight self-stigma measured; secondary outcomes include eating behavior, physical activity level, and quality of life.\n\nAnalyses will include per-protocol evaluation using linear mixed-effects models to test group, time, and group-by-time effects on primary and secondary outcomes, with intention-to-treat analyses conducted as sensitivity analyses using multiple imputation for missing weight and weight self-stigma data.\n\nFindings will inform the design of a future definitive trial and contribute evidence on eHealth approaches to reducing weight-related stigma and supporting healthier lifestyles.",[55],"Overweight , Obesity",[57,58,59,60,61],"eHealth","Weight Self-Stigma","Obesity","Overweight","Quality of Life","NOT_YET_RECRUITING","2026-06-11",{"date":65,"type":32},"2026-06-12",{"date":67,"type":21},"2026-07-01",{"date":69,"type":21},"2026-12-15",{"name":38,"class":39},{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":40},"100643704","precision-icu-care-evaluating-an-ai-driven-nursing-decision-support-system-for-delirium-prevention-100643704","NCT07631494","Precision ICU Care: Evaluating an AI-Driven Nursing Decision Support System for Delirium Prevention","Efficacy of an Intelligent Computational Nursing Decision Support System in Precision Critical Care for Delirium Prevention: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18 years\n* High risk of developing delirium are defined as PRE-DELIRIC (PREdiction of DELIRium in ICu patients) with a score of ≥40%\n* Sedation assessment form (Richmond Agitation-Sedation). Scale, RASS) is assessed as between +1 and -1\n* Patient is clearly aware and able to communicate with Chinese and Taiwanese customers.\n\nExclusion Criteria:\n\n* Those who have developed delirium before joining the study (assessed by the Intensive Care Delirium Screening Checklist (ICDSC) \\>4 points)\n* Expected to stay in the ICU for less than 24 hours\n* APACHE II score \\> 25 (meaning \\> 50% mortality)\n* Delirium cannot be evaluated, such as those with severe acute brain injury, audio-visual impairment, speech problems, psychotic disorders, aphasia, or in the entire ICU During this period, patient remained comatose.",true,{"count":80,"type":21},188,[24],"Delirium affects up to 83% of mechanically ventilated patients in the Intensive Care Unit (ICU), often leading to longer hospital stays and long-term memory or cognitive problems. While standard care protocols (such as the ABCDEF bundle) exist, they are often difficult to implement fully due to their complexity and the heavy workload on nursing staff.\n\nTo address these challenges, this study introduces a 'Precision Nursing' approach by integrating Artificial Intelligence (AI) and Virtual Reality (VR). We will implement an AI-driven system to assist nurses in making personalized care decisions more efficiently. Additionally, interactive VR technology will be used to stimulate patients' cognitive function and encourage early mobility. Our goal is to reduce the clinical burden on healthcare providers while significantly improving recovery outcomes for ICU patients.",[84,85],"Delirium in the Intensive Care Unit","Sleep Quality",[87,88,89,90,91,92],"Artificial Intelligence","delirium","intensive care unit","Virtual Reality","sleep","machine learning","2026-06-01",{"date":95,"type":32},"2026-06-08",{"date":97,"type":21},"2026-06",{"date":99,"type":21},"2028-06",{"name":38,"class":39},{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":78,"sex":16,"minAge":48,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},"100637083","pi-ysp-0111-formulation-on-human-gut-microbiota-and-body-composition-100637083","NCT07618000","PI-YSP-0111 Formulation on Human Gut Microbiota and Body Composition","Evaluation of the Effects of the PI-YSP-0111 Formulation on Human Gut Microbiota and Body Composition","Inclusion Criteria:\n\n1. Healthy males or females aged 18 to 65 years.\n2. BMI between 23.0 and 40.0 kg\u002Fm².\n3. Waist circumference: ≥ 90 cm for males and ≥ 80 cm for females.\n4. Participants are willing to maintain their usual dietary habits, daily routines, and physical activity levels during the study period, and have no plans to relocate.\n5. Participants have fully understood the study procedures and have signed the informed consent form.\n\nExclusion Criteria:\n\n1. Presence of gastrointestinal diseases, such as inflammatory bowel disease, irritable bowel syndrome, gastroesophageal reflux disease, Crohn's disease, or a history of bariatric surgery.\n2. Recent history of acute gastroenteritis, constipation or diarrhea; psychiatric disorders (e.g., depression or schizophrenia); cardiovascular diseases (e.g., hypertension); known allergy or hypersensitivity to the investigational product; extreme dietary habits; significant body weight change (\\>4.5 kg) within the past three months; recent use of antibiotics or antifungal agents; or use of medications affecting gastrointestinal function (such as probiotics, laxatives, or nonsteroidal anti-inflammatory drugs \\[NSAIDs\\]).\n3. Exposure to unapproved medications, alcohol abuse, or substance abuse.\n4. Female-specific conditions, including significant gastrointestinal symptoms during menstruation, irregular menstrual cycles, pregnancy, planned pregnancy, or breastfeeding (participants who become pregnant during the study period will also be excluded).\n5. Short-term use of corticosteroids, nonsteroidal anti-inflammatory drugs, immunosuppressive agents, interferons, or immunomodulatory agents within the past one month.\n6. Use of any weight-loss medications (including oral agents, injections, or traditional Chinese medicine) within the past three months.\n7. Participation in any other interventional clinical study within the past one month.\n8. History of cancer or current malignancy within the past two years, except for non-melanoma skin cancer.\n9. Occurrence of major trauma or any surgical procedures within the past one month.\n10. History of diabetic ketoacidosis.","65 Years",{"count":110,"type":21},140,[24],"The expected outcome of this study is that continuous 8-week supplementation with the PI-YSP-0111 prebiotic formulation will exert beneficial effects on gut microbiota modulation and liver health.",[114],"Heathly Volunteers","2026-05-26",{"date":93,"type":32},{"date":118,"type":32},"2026-04-08",{"date":120,"type":21},"2027-04-07",{"name":38,"class":39},2,{"id":124,"slug":125,"hasResults":12,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":12,"sex":16,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":140,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":40},"100639450","developing-precision-microbiota-based-cocktail-modification-therapy-to-delay-the-progression-of-parkinsons-disease-pd---use-preclinical-human-trials-to-confirm-the-impact-of-the-optimal-probiotic-y7-tryptophan-and-branched-chain-amino-acid-cocktail-formula-on-early-stage-pd-patients-100639450","NCT07619560","Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal \"Probiotic Y7, Tryptophan and Branched-chain Amino Acid\" Cocktail Formula on Early Stage PD Patients","Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease - Use Preclinical Human Trials to Confirm the Impact of the Optimal \"Probiotic Y7, Tryptophan and Branched-chain Amino Acid\" Cocktail Formula on Early Stage Parkinson's Disease Patient","Inclusion Criteria:\n\nSubject Inclusion Criteria:\n\n1. Age between 30-85 years old.\n2. Diagnosed with early-stage Parkinson's disease (Hoehn and Yahr scale stage 1-3).\n3. Brain MRI confirms striatal degeneration in the basal ganglia region, with no history of stroke.\n4. Responds to Parkinson's disease-related medications (e.g., Levodopa).\n5. Free of any major or acute illnesses.\n6. Able to comply with the 12 weeks intervention and required assessments for the study.\n\nExclusion Criteria:\n\n1. Unable to complete interviews or has mobility issues.\n2. Presence of major or acute illness before or during the study.\n3. Co-existing intestinal co-infections, such as CDI, E. coli, Salmonella, Shigella, Campylobacter, plague, or cytomegalovirus.\n4. Allergic to the intervention product.\n5. Pregnant or breastfeeding women.","30 Years","85 Years",{"count":133,"type":21},120,[24],"Preclinical human trials will be utilized to validate the research direction, followed by clinical trials to assess the impact of a cocktail formula product containing the optimal probiotic Y7 combined metabolites on motor, cognitive, and non-motor functions in early Parkinson's disease patients. The study aims to recruit 120 patients (stage 1-3) and employ a two-arm, randomized controlled trial (RCT) design, dividing subjects into intervention and control groups for a 12 weeks trial period. Commercial development will be contingent upon the clinical trial outcomes, evaluating whether the product offers clinical benefits such as delaying Parkinson's disease progression in motor, cognitive, and non-motor functions. Additionally, a personalized and precise prognosis prediction model for Parkinson's disease will be established. This model will gather comprehensive clinical data, including motor function assessments (functional tests, UPDRS), biochemical markers, questionnaire responses, and genotype data (TPM array), as well as metabolite and microbial data. Through integrated analysis of this biological information using machine learning techniques, a personalized and accurate prognosis prediction model for Parkinson's disease will be developed. This model will predict the disease status of PD patients 12 weeks later, accounting for factors such as cocktail therapy. The results will empower PD patients to understand their individual disease progression and treatment prognosis, enabling them to prepare accordingly. Moreover, this model will aid researchers in identifying patient profiles more likely to benefit from treatment, thereby enhancing the evaluation of the efficacy and applicability of cocktail therapy.",[137,138,139],"Parkinson Disease (PD)","Gut Microbiota","Probiotic",[141,142,143],"Parkinson's Disease","Probiotics","Gut microbiota","2026-05-24",{"date":146,"type":32},"2026-06-02",{"date":148,"type":32},"2025-05-20",{"date":150,"type":21},"2027-08-31",{"name":38,"class":39},{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":12,"sex":16,"minAge":158,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":161,"briefSummary":162,"conditions":163,"keywords":165,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":40},"100640319","ai-chatbot-enabled-epro-symptom-monitoring-and-self-management-for-early-cardiovascular-kidney-metabolic-syndrome-100640319","NCT07577284","AI Chatbot-Enabled ePRO Symptom Monitoring and Self-Management for Early Cardiovascular-Kidney-Metabolic Syndrome","Inclusion Criteria:\n\n* Adults ≥40 years\n* Classified as having stage CKM syndrome (stage 1-2)\n* Receiving outpatient care\n* Able to communicate in Mandarin\u002FTaiwanese, and\n* Having access to a smartphone\u002Ftablet\n\nExclusion Criteria:\n\n* End-stage kidney disease requiring dialysis or are listed for kidney transplantation\n* Have terminal illness (\\\u003C6 months life expectancy)\n* Have significant cognitive impairment\n* Currently enrolled in another interventional study targeting cardiovascular-kidney-metabolic syndrome or multimorbidity","40 Years",{"count":160,"type":21},72,[24],"This randomized clinical trial aims to evaluate whether an AI chatbot-enabled, nurse-led electronic patient-reported outcome (ePRO) intervention can improve symptom management and self-care in adults with early-stage cardiovascular-kidney-metabolic (CKM) syndrome. The study will also assess the safety and feasibility of the intervention. Researchers will investigate whether the program reduces symptom burden, improves patient activation and health literacy, and lowers healthcare utilization such as emergency department visits and hospitalizations compared with usual ePRO monitoring alone. A total of 72 participants will be randomly assigned to either an intervention group, which receives weekly AI chatbot-supported symptom monitoring combined with nurse-led feedback and self-management support, or a control group receiving ePRO monitoring without feedback. Participants will complete PROMIS-29 assessments weekly and attend study evaluations at baseline, 3 months, and 6 months, while clinical outcomes and healthcare use are tracked through electronic medical records.",[164],"Cardiovascular Kidney Metabolic Syndrome",[166,167,168,169,170,171],"artificial intelligence","Chatbot","electronic patient-reported outcomes","patient activation","randomized controlled trial","cardiovascular kidney metabolic syndrome","2026-05-05",{"date":174,"type":32},"2026-05-11",{"date":176,"type":21},"2026-05-30",{"date":178,"type":21},"2029-07-31",{"name":38,"class":39},{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":12,"sex":16,"minAge":108,"maxAge":4,"enrollmentInfo":187,"targetDuration":4,"studyType":22,"phases":189,"briefSummary":190,"conditions":191,"keywords":196,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":40},"100640906","feasibility-and-effects-of-inspiratory-muscle-training-combined-with-blood-flow-restriction-for-frail-older-adults-100640906","NCT07573995","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Community-dwelling adults aged 65 years and older who are classified as at least \"vulnerable\" using the Clinical Frailty Scale (score ≥4).\n* Participants must have no cognitive impairment and be able to follow commands, as assessed by the Mini-Mental State Examination (MMSE).\n\nExclusion Criteria:\n\n* (1) are unable to participate in exercise (e.g., due to severe musculoskeletal disorders)\n* (2) have high-risk factors for exercise, such as uncontrolled hypertension (\\>150 mmHg systolic blood pressure (SBP) \u002F \\>90 mmHg diastolic blood pressure (DBP), coagulation disorders, and deep venous thrombosis\n* (3) have hematological disorders or are using hematology related-medications\n* (4) have significant comorbidities, including a history of stroke, diabetes with severe complications, or cardiovascular diseases\n* (5) chronic lung conditions (e.g., obstructive pulmonary disease, asthma), and\n* (6) have participated in a structured exercise training program within the past 3 months at a frequency exceeding three sessions per week.",{"count":188,"type":21},30,[24],"This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults. Outcomes of interest include feasibility, physical function, respiratory muscle strength, handgrip strength, five-times sit-to-stand performance, body composition, frailty level, fall efficacy, blood pressure, and adverse events.",[192,193,194,195],"Frailty Syndrome","Older Adults","Blood Flow Restriction (BFR) Training Effects","Inspiratory Muscle Training",[197,198,199,200],"frailty","older adults","blood flow restriction","inspiratory muscle training","2026-05-01",{"date":203,"type":32},"2026-05-07",{"date":205,"type":21},"2026-05",{"date":207,"type":21},"2026-10",{"name":38,"class":39},{"id":210,"slug":211,"hasResults":12,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":218,"phases":4,"briefSummary":219,"conditions":220,"keywords":224,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":239,"locationsCount":4},"100631129","nutritional-status-nutritional-knowledge-and-mental-health-among-indonesian-migrant-workers-in-taiwan-100631129","NCT07496658","Nutritional Status, Nutritional Knowledge and Mental Health Among Indonesian Migrant Workers in Taiwan","The Relationship of Nutritional Knowledge and Nutritional Status Screening With Incidence of Mental Health Among Indonesian Live-in Home Care Migrant Workers in Taiwan","Inclusion Criteria:\n\n* Indonesian Migrant Worker that Live in Employee Home\n* Aged 20 years or older\n* Able to read the Indonesian version of the questionnaire\n* Involved in the informal care of patients\n* Willing to participate in the study\n\nExclusion Criteria:\n\n* Workers with pre-existing severe mental health conditions.\n* Workers unwilling to provide informed consent.",{"count":217,"type":21},277,"OBSERVATIONAL","The goal of this observational study is to understand more about the nutritional knowledge, nutritional status, and mental health conditions (depression, anxiety, and stress) of Indonesian live-in domestic migrant workers in Taiwan.\n\nParticipants must be 20 years or older and currently working and living in their employer's home. They will be asked to fill out a set of simple surveys, either online or on paper. These surveys will include questions about nutrition knowledge, food intake, and mental health.\n\nThe main goal is to find out how common malnutrition and emotional stress are in this group. The study will also look at how nutrition knowledge and food habits are connected to mental well-being. The results may help create better health programs for migrant care workers in the future.",[221,222,223],"Nutritional Status","Mental Health","Migrant Domestic Workers",[225,226,227,228,229,230,231,232],"Migrant domestic workers","Indonesian workers","Live-in caregivers","Taiwan","Nutritional status","Mental health","Depression","Quality of life","2026-03-26",{"date":235,"type":32},"2026-04-01",{"date":237,"type":21},"2026-04-30",{"date":36,"type":21},{"name":38,"class":39},{"id":241,"slug":242,"hasResults":12,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":108,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":249,"briefSummary":250,"conditions":251,"keywords":254,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":122},"100470201","effects-of-nurse-guided-bbti-for-improving-insomnia--in-patients-at-the-recovery-following-traumatic-brain-injury-100470201","NCT05402761","Effects of Nurse-Guided BBTi for Improving Insomnia : in Patients at the Recovery Following Traumatic Brain Injury","Effects of Nurse-Guided Brief Behavioral Treatment for Insomnia on Sleep, Mood, and Cognition: Model Establishment and Application in Patients at the Recovery Phase Following Traumatic Brain Injury","Inclusion Criteria:\n\n* have received a diagnosis of TBI at least 3 months before enrollment (TBI in chronic stage),\n* yield an initial (i.e., rated in the emergency room) GCS score of 3-15 (mild to severe) and have GCS score of 15 when enrolling into the study,\n* report lying awake for ≥30 min a night for ≥3 nights per week for ≥3 months,\n* have post-TBI insomnia with a total score \\> 7 on the Chinese version of the insomnia severity scale (CISI) at screening,\n* be able to communicate in Mandarin Chinese, and be able to complete cognitive tasks (having Rancho Los Amigos Levels of Cognitive Functioning scale score \\> 9)\n\nExclusion Criteria:\n\n* include premorbid diagnoses of seizure,\n* sleep disorders (e.g., sleep apnea, screened by using the STOP-Bang questionnaire with a score \\> 3),\n* psychiatric diseases,\n* substance abuse,\n* alcoholism\n* Shift workers and women who are pregnant, breastfeeding, or in the menopausal transition",{"count":248,"type":21},93,[24],"nsomnia is a frequent complaint reported by patients with TBI, and exacerbates their ability to return to productive activity, which subsequently elevate related healthcare costs and burden. Existing literatures found that effects of CBTi, first-line therapy for insomnia, on post-traumatic insomnia is still debated, indicating that developing an alternative nonpharmacological therapy for alleviating insomnia following TBI is required. Besides, digital health is one of strategies to achieve precision health. Thus far, knowledge regarding whether mobile-delivered BBTi has non-inferiority effects as BBTi in treating insomnia is still lacking. Therefore, a RCT with a large sample size to examine the immediate and lasting effects of BBTi and mobile-delivered BBTi on insomnia, mood disturbances, and cognitive dysfunctions in patients following TBI at the recovery stage compared with the control participants.",[252,253],"Insomnia","Traumatic Brain Injury",[255,256,253],"Insominia","BBTi","2026-03-25",{"date":259,"type":32},"2026-03-31",{"date":261,"type":32},"2022-08-15",{"date":263,"type":21},"2026-12",{"name":38,"class":39},{"id":266,"slug":267,"hasResults":12,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":78,"sex":16,"minAge":48,"maxAge":108,"enrollmentInfo":273,"targetDuration":4,"studyType":22,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":40},"100614113","using-virtual-humans-to-teach-cognitive-function-assessment-to-nursing-students-100614113","NCT07275372","Using Virtual Humans to Teach Cognitive Function Assessment to Nursing Students","Effectiveness of Virtual Humans in Learning Cognitive Function Assessment Among Nursing Students","VHCT-NS","Inclusion Criteria:\n\n* Nursing students currently enrolled in a bachelor's or post-baccalaureate nursing program.\n* Students who have not previously received instruction on the SPMSQ cognitive function assessment,\n\nExclusion Criteria:\n\n* no",{"count":51,"type":21},[24],"Purpose of the Study This study wants to find out whether a virtual human (a computer-based simulated person) can help nursing students learn how to assess someone's thinking and memory skills.\n\nMain Question Do nursing students learn cognitive function assessment better when they use a virtual human compared with reading printed materials?\n\nWhat Participants Will Do Participants will learn how to do a cognitive function assessment for about 60 minutes, either by using a virtual human or by reading printed materials.",[277],"Nursing Students","2026-01-16",{"date":280,"type":32},"2026-01-20",{"date":282,"type":32},"2025-12-02",{"date":284,"type":21},"2026-12-31",{"name":38,"class":39},{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":16,"minAge":293,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":22,"phases":295,"briefSummary":296,"conditions":297,"keywords":301,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":308,"completionDateStruct":309,"leadSponsor":311,"locationsCount":40},"100619809","effects-of-circadian-based-acupressure-on-sleep-quality-in-nursing-home-residents-100619809","NCT07349446","Effects of Circadian-Based Acupressure on Sleep Quality in Nursing Home Residents","Effects of Circadian-Based Acupressure on Sleep Quality in Nursing Home Residents: A Randomized Controlled Trial","Inclusion Criteria:\n\n* age ≥60 years\n* ability to communicate and complete the questionnaires in Indonesian\n* had lived in the nursing home for at least 3 months,\n* had a Mini-Mental State Examination score of ≥25, had self-reported PSQI Indonesian version scores of ≥5 (where higher scores indicate worse sleep) over the past 4 weeks,\n* agreed to participate in the research\n\nExclusion Criteria:\n\n* The exclusion criteria in this study were severe psychiatric disorders, such as schizophrenia, bipolar disorder, or current receipt of intensive psychiatric treatment.","60 Years",{"count":20,"type":21},[24],"This randomized controlled trial aims to evaluate the effectiveness of circadian-based acupressure compared with sham acupressure in improving sleep quality among nursing home residents. Additionally, the study will examine the effects of the intervention on insomnia severity, heart rate variability, and psychological distress, including depression, anxiety, and stress. A total of 80 older adults aged 60 years and above residing in a nursing home in Jakarta, Indonesia, will be randomly assigned to either the circadian-based acupressure group or the sham acupressure group. Participants in the intervention group will receive circadian-based acupressure twice daily, five days per week for four weeks, with acupoints selected and administered according to circadian meridian activity, while the control group will receive sham acupressure at non-acupuncture points with the same frequency and duration. Outcome measures will be assessed at baseline and immediately post-intervention.",[298,299,231,300,252],"Poor Sleep Quality","Anxiety","Stress",[302,252,303,304,305],"poor sleep quality","depression","anxiety","stress","2026-01-15",{"date":280,"type":32},{"date":280,"type":21},{"date":310,"type":21},"2026-06-30",{"name":38,"class":39},{"id":313,"slug":314,"hasResults":12,"nctId":315,"briefTitle":316,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":12,"sex":16,"minAge":318,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":22,"phases":322,"briefSummary":323,"conditions":324,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":333,"locationsCount":4},"100613911","effects-of-a-social-robot-cognitive-game-intervention-in-older-adults-with-mild-cognitive-impairment-and-dementia-100613911","NCT07272746","Effects of a Social Robot Cognitive-Game Intervention in Older Adults With Mild Cognitive Impairment and Dementia","Inclusion Criteria:\n\n1. Aged 50 years or older\n2. Diagnosed by a physician with Mild Cognitive Impairment, mild, or moderate dementia\n3. Able to communicate in Mandarin or Taiwanese\n4. Willing to participate and provides informed consent signed by the participant or their family member\u002Flegal representative\n\nExclusion Criteria:\n\n1. Individuals who experience fear or aversion toward interactive robots or related equipment\n2. Individuals with severe hearing or visual impairments that affect participation in activities\n3. Individuals unable to complete the entire intervention due to unstable physical or mental conditions\n4. Individuals deemed unsuitable for this study by physician assessment","50 Years","100 Years",{"count":321,"type":21},200,[24],"This study aims to evaluate the effects of interactive robot-based games on cognitive function, neuropsychiatric symptoms, and quality of life in patients with mild cognitive impairment and dementia. The investigators plan to recruit 80 participants and randomly assign them to a control group or an experimental group; the experimental group will participate in robot games for 12 weeks, while the control group will receive routine care. Data will be collected via questionnaires to investigate whether robot games can improve cognitive function, neuropsychiatric symptoms, and quality of life in patients with mild cognitive impairment and dementia.",[325,326],"Dementia","Mild Cognitive Impairment (MCI)","2025-11-26",{"date":329,"type":32},"2025-12-09",{"date":331,"type":21},"2025-12",{"date":263,"type":21},{"name":38,"class":39},{"id":335,"slug":336,"hasResults":12,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":12,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":341,"targetDuration":4,"studyType":22,"phases":343,"briefSummary":344,"conditions":345,"keywords":348,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":355,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":40},"100612883","the-effects-of-an-app-based-acupressure-on-alleviating-fatigue-pruritus-and-sleep-quality-among-hemodialysis-patients-100612883","NCT07259369","The Effects of an App-based Acupressure on Alleviating Fatigue, Pruritus, and Sleep Quality Among Hemodialysis Patients","The Effects of an App-based Acupressure Intervention on Alleviating Fatigue, Pruritus, and Sleep Quality Among Hemodialysis Patients","Inclusion Criteria: The patients are\n\n* 18 years old or over\n* are able to speak and understand Vietnamese,\n* receive hemodialysis at least three times a week for three months or longer\n* have a score equal to or greater than 4 on a numeric rating scale (NRS, 0-10)\n* has a smartphone or tablet\n* can provide written informed consent. Exclusion Criteria: The patients who have\n* advanced cancer\n* cognitive impairment\n* chronic obstructive pulmonary disease\n* severe edema\n* have already used or plan to use acupressure or acupuncture in the following 3 months\n* have soft tissue or vascular disease in their lower extremities",{"count":342,"type":21},70,[24],"Objectives: To evaluate the effectiveness of an app-based self-guided acupressure intervention in alleviating fatigue and pruritus, and in improving sleep quality among hemodialysis patients.\n\nDesign and subjects: The parallel randomized controlled trial will be employed in one hospital. Block randomization in a 1:1 ratio will be used to assign the patients to the intervention and control groups. It is estimated that 50 to 100 participants receiving hemodialysis will be recruited.\n\nInstrument: The demographic and health-related information questionnaire, the Post-dialysis Fatigue (PDF), 5-D Itch, and Pittsburgh Sleep Quality Index will be used in this study.\n\nInterventions: The intervention group will use an app-based self-guided acupressure program to do the acupressure by themselves once daily for 4 weeks. Participants in the control group will receive usual care and no other intervention.\n\nData analysis: Both intention-to-treat and per-protocol analysis approaches will be performed. Generalized Estimating Equations (GEE) analysis will be used to assess the effectiveness of the interventions. Sensitivity analysis will be conducted to assess the impact of missing data on the treatment effect if necessary.\n\nExpected outcomes: Participants in the intervention group will know how to do the self-guided acupressure by themselves. If the intervention is effective, the App can be introduced to the hemodialysis patients who need it.",[346,347],"Hemodialysis Patient","Fatigue",[349,350,351,352,353,354],"chronic kidney disease","fatigue","App","pruritus","self-acupressure","sleep quality",{"date":282,"type":32},{"date":357,"type":21},"2025-12-15",{"date":359,"type":21},"2026-03-15",{"name":38,"class":39},{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":78,"sex":16,"minAge":108,"maxAge":319,"enrollmentInfo":368,"targetDuration":4,"studyType":22,"phases":369,"briefSummary":370,"conditions":371,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":4},"100612234","exploring-the-effectiveness-of-somatosensory-cognitive-game-intervention-on-cognitive-and-physical-functions-100612234","NCT07250932","Exploring the Effectiveness of Somatosensory Cognitive Game Intervention on Cognitive and Physical Functions","Exploring the Effectiveness of Somatosensory Cognitive Game Intervention on Cognitive and Physical Functions in Older Adults","Inclusion Criteria:\n\n1. Elderly individuals aged 65 and above.\n2. Able to communicate in Chinese (Mandarin or Taiwanese).\n3. Voluntarily participate in this study and sign a written consent form.\n\nExclusion Criteria:\n\n1. Individuals with severe visual impairments or physical mobility disabilities that prevent them from participating in the game activities designed in this study.\n2. Individuals diagnosed with severe dementia who are unable to understand or participate in the research process.",{"count":20,"type":21},[24],"This study investigates the effects of somatosensory cognitive games interventions on older adults' cognitive and physical functions. The investigators plan to recruit up to 100 participants and randomly assign them to a control group or an experimental group. The experimental group will participate in somatosensory cognitive games for 12 weeks, while the control group will receive routine care. Data will be collected via questionnaires to examine whether somatosensory cognitive games can delay declines in cognitive and physical functions in older adults.",[372],"Cognitive Function","2025-11-18",{"date":327,"type":32},{"date":376,"type":21},"2025-11",{"date":378,"type":21},"2027-12",{"name":38,"class":39},{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":12,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":387,"targetDuration":4,"studyType":22,"phases":388,"briefSummary":389,"conditions":390,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":40},"100610587","effects-of-nattokinase-on-cardiovascular-risk-gut-microbiota-sleep-and-cognition-in-metabolic-syndrome-with-sleep-disorders-100610587","NCT07229521","Effects of Nattokinase on Cardiovascular Risk, Gut Microbiota, Sleep, and Cognition in Metabolic Syndrome With Sleep Disorders.","Effects of Nattokinase on Cardiovascular Disease Risk Factors, Gut Microbiota, Sleeping and Cognitive Function in Patients With Risk of Metabolic Syndrome Along With Sleeping Disorder.","Inclusion Criteria:\n\n1. Over 18 years old\n2. Meet the criteria of MetS: meet at least two of the following four items will be recognized as at risk of metabolic syndrome:\n\n   1. Abdominal obesity: Male≧90cm (35 inches); Female≧80cm (31inches)\n   2. High blood pressure: Systolic blood pressure≧120mmHg or diastolic blood pressure≧80mmHg\n   3. High fasting blood glucose: Fasting blood glucose≧100mg\u002FdL\n   4. Dyslipidemia: High fasting triglycerides (≧150mg\u002FdL) or low high-density lipoprotein cholesterol (HDL-C) (\\\u003C40mg\u002FdL for male, \\\u003C50mg\u002FdL for female)\n3. The Apnea Hypopnea Index (AHI) was diagnosed by overnight multi-channel sleep physiology examination (Polysomnography, PSG) or Home Sleep Apnea Test (HSAT) to be between 5 and 30, indicating mild or moderate sleep apnea.\n4. No major mental illness or obvious symptoms of anxiety or depression\n5. No combination with other primary sleep diseases\n\nExclusion Criteria:\n\n1. Body mass index (BMI) \\>30 kg\u002Fm\\^2\n2. Chronic diseases: abnormal liver and kidney function, abnormal gastrointestinal function, cardiovascular disease, high blood pressure, diabetes mellitus, and hyperlipidemia, etc.\n3. Participants requiring medication for conditions not specified in exclusion criterion (2), who are unable to maintain a stable treatment regimen throughout the trial\n4. Malignant tumors\n5. Pregnancy or breastfeeding\n6. Person expected to perform the surgery.\n7. Those who have participated in other clinical trials in the past 28 days.\n8. May be allergic to the ingredients in the test materials, or take drugs or dietary supplements that may affect the test results",{"count":20,"type":21},[24],"Nattokinase has been confirmed by many experiments to have a thrombolytic effect, but there are currently very few studies on nattokinase's effect on gut microbiota, sleeping status, and age-related cognitive function. Therefore, this study intends to explore the effect of nattokinase on cardiovascular disease risk factors, intestinal microbiota, sleep status and cognitive function in patients with metabolic syndrome risk and sleep disorders. This study will be a double-blind, self-control, placebo, crossover trial, and recruit 70-80 participants over 18 years old, and have risk of metabolic syndrome and sleep disorders. They will be divided into a placebo group and an experimental group. The experimental period was divided into two phases (12 weeks for each) and a 2-week washout period. In the first phase, 2 placebo or nattokinase capsules were given each day (each capsule contained nattokinase 3000FU, 2 capsules per day). After 12 weeks, a 2-week washout period was entered, and the second phase was entered for a crossover trial. At the 0th and 12th weeks of each stage, body position, blood pressure, blood biochemical values, sleep quality questionnaire, and cognitive function questionnaire will be measured, and feces will be collected for bacterial analysis. In addition, to improve the compliance of the trial, it is planned to ask the subjects to return for a follow-up visit in the 6th week of each phase, and to measure the subject's body composition and blood pressure. This study expects that daily supplementation of 2 nattokinase capsules for 12 weeks can improve cardiovascular risk factors, sleep quality and cognitive function, while also maintaining healthy intestinal flora.",[391,392],"Metabolic Syndrome","Sleeping Disorders","2025-11-13",{"date":395,"type":32},"2025-11-17",{"date":397,"type":32},"2025-03-15",{"date":399,"type":21},"2027-02-11",{"name":38,"class":39},{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":406,"acronym":4,"eligibilityCriteria":407,"healthyVolunteers":78,"sex":16,"minAge":48,"maxAge":408,"enrollmentInfo":409,"targetDuration":4,"studyType":22,"phases":410,"briefSummary":411,"conditions":412,"keywords":413,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":424,"locationsCount":40},"100601731","digitally-assisted-brief-behavioral-treatment-for-insomnia-in-college-students-100601731","NCT07114302","Digitally-Assisted Brief Behavioral Treatment for Insomnia in College Students","Effects of Digitally-Assisted Brief Behavioral Treatment for Insomnia in College Students: A Randomized Controlled Trial","Inclusion Criteria: With an electronic mobile device that can access the Internet, reporting insomnia including falling asleep more than three days a week or being awake at night for ≥30 minutes for more than 3 months, screened by the Chinese version of the Insomnia Severity Index- Chinese Version -C, with a total score of ≥10 points, can communicate in Chinese and complete the research questionnaire -\n\nExclusion Criteria: Those entering internship, shift workers, those with a history of epilepsy, those with other sleep disorders such as sleep apnea, those currently diagnosed with mental illness, substance abuse or alcohol addiction.\n\n\\-","35 Years",{"count":188,"type":21},[24],"The study is a single-blind study, parallel randomized controlled trial method. The purpose of this study was to explore the effectiveness of the mobile version of Application based Brief Behavioral Treatment for Insomnia (BBTI-APP) and the interactive e-book version of BBTI in improving the severity of insomnia, sleep quality and mood among college students. Measurement outcomes are sleep parameters measured by the Chinese version of Insomnia Severity Index, Chinese version of The Depression, Anxiety and Stress Scale - 21 Items, and sleep diary. Questionnaires will be assessed in pretreatment, posttreatment, and one-month follow-up. We hypothesized that compared with the sleep hygiene group, both the BBTI-APP and the interactive e-book BBTI can significantly improve college students' insomnia symptoms, emotional distress, and quality of life.",[252],[414,415,416,417],"college students","Digitally-Assisted BBTI","BBTI","undergrate students","2025-08-04",{"date":420,"type":32},"2025-08-11",{"date":422,"type":21},"2025-08-15",{"date":284,"type":21},{"name":38,"class":39},{"id":426,"slug":427,"hasResults":12,"nctId":428,"briefTitle":429,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":22,"phases":433,"briefSummary":434,"conditions":435,"keywords":439,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":40},"100492117","innovative-approaches-in-diabetes-care-100492117","NCT05687968","Innovative Approaches in Diabetes Care","Inclusion Criteria:\n\n1. 20 years old or older\n2. Pre-diabetes or diabetes\n3. Taiwan nationality or fluent in Mandarin or Taiwanese\n4. Not pregnant or breastfeeding\n5. Capable (or assisted by a caregiver) of using a smartphone to photograph and record meals\n\nExclusion Criteria:\n\n1. Eating disorders\n2. Undergoing treatment for severe illnesses that could affect normal dietary intake (e.g., cancer)\n3. Unable to use a smartphone to take photos and record food intake.",{"count":432,"type":21},39,[24],"In Taiwan, an estimated 2.3 million individuals have diabetes, with a 44% increase observed among young adults and adolescents. Poor dietary habits and sedentary lifestyles are major risk factors for type 2 diabetes. The widespread use of smartphones has facilitated the development of digital health technologies, including digital food photography and artificial intelligence (AI), which show promise for personalized nutrition care and health promotion. While such technologies have demonstrated short-term success in diabetes management, their long-term effectiveness remains uncertain.\n\nThis study aims to evaluate the effectiveness of a digital eHealth care intervention for individuals with diabetes. Participants will be recruited from the Diabetes Shared Care Network and community care centers in Taiwan and followed for 12 months. Eligible participants will be randomly assigned by computer to either a control or an eHealth care group.\n\n• eHealth Group: Receives a 10-minute digital nutrition education session using the lab-developed \"3D\u002FAR MetaFood food portion education platform\" (https:\u002F\u002Fsketchfab.com\u002Fsusanlab108\u002Fcollections) and is required to submit weekly dietary records through food images using the \"Formosa FoodAPP.\" Participants will receive immediate dietary feedback from nutritionists, followed by AI-generated personalized feedback on the glycemic index (GI) and glycemic load (GL) of their meals. They will also be provided with educational videos on healthy eating, physical activity, and selecting low-GI\u002FGL foods.\n\nAnthropometric measurements and baseline questionnaires will be collected at enrollment. Blood biochemistry, including HbA1c, will be measured at baseline, and at 3, 6, 9, and 12 months. Collected food image data will be used to train AI systems for real-time dietary feedback and to explore the relationship between nutrient intake and long-term glycemic control.",[436,437,438],"Type 2 Diabetes","AI-supported Real-time Dietary Feedback","M-health",[440,441,438],"Diabetes Mellitus","AI-supported real-time dietary feedback","2025-07-24",{"date":444,"type":32},"2025-07-30",{"date":446,"type":32},"2022-10-19",{"date":448,"type":21},"2025-10-01",{"name":38,"class":39},{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":456,"eligibilityCriteria":457,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":22,"phases":460,"briefSummary":461,"conditions":462,"keywords":464,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":40},"100587586","compassion-based-intervention-for-lung-cancer-caregivers-cbi-lcc-100587586","NCT06930313","Compassion-Based Intervention for Lung Cancer Caregivers (CBI-LCC)","Development and Evaluation of a Brief Compassion-Based Intervention for Managing Depression and Anxiety in Family Caregivers of Lung Cancer Patients: A Mixed Methods Randomized Controlled Trial","CBI-LCC","Inclusion Criteria:\n\n* Primary family caregiver of a person with newly diagnosed lung cancer (within one year of diagnosis)\n* Aged 20 years or older\n* Access to a computer or smartphone with internet connection at home\n\nExclusion Criteria:\n\n* Currently receiving psychological therapy\n* Diagnosed with a severe mental illness and taking medication for it (e.g.,psychosis, bipolar disorder)\n* Previous experience with mindfulness or self-compassion training",{"count":459,"type":21},84,[24],"Objectives: This 3-year study aims to develop, refine, and evaluate a brief compassion-based intervention specifically designed for family caregivers of lung cancer patients. In the first year, the primary focus will be on developing the intervention content and assessing its feasibility and acceptability. In the second and third years, the goal will be to assess the intervention's effects on depression and anxiety.\n\nMethod: In the first year, the intervention will be developed in three stages. Initially, the intervention will be created based on compassion-focused theory and evidence-based exercises, incorporating feedback from family caregivers in previous studies and insights from professionals to ensure its relevance to lung cancer caregivers. Next, a pilot study will test the intervention's feasibility and acceptability with 30 family caregivers, using mixed methods to gather session-by-session feedback and assess recruitment, retention, and adherence. Following the pilot, the intervention will be revised based on participant and researcher feedback, preparing it for further study. In the second and third years, a randomized controlled trial (RCT) will be conducted with 84 participants randomly assigned to either the 4-session Brief Compassion-Based Intervention (BCI) or a single-session Telephone-Based Support and Education (TSE) control group. Outcomes, including depression, anxiety, caregiver stress, mindfulness, self-compassion, and self-efficacy, will be measured at baseline, immediately post-intervention, and at 3- and 6-month follow-ups. For data analysis, long-term follow-up quantitative data will be analyzed using the Generalized Estimating Equation (GEE) to examine group differences. Moderation and mediation analyses will be conducted to explore potential moderators and mechanisms of the intervention. Qualitative data from interviews will be analyzed using content analysis.\n\nExpected Results: This study is expected to provide a comprehensive understanding of the feasibility, acceptability, and effectiveness of compassion-based interventions for lung cancer caregivers, contributing to their application in clinical care practice.",[463],"Compassion",[465,466,467,468,303,304,469,470],"compassion-based intervention","lung cancer","family caregivers","caregiver stress","mindfulness","self-compassion","2025-04-08",{"date":473,"type":32},"2025-04-16",{"date":475,"type":21},"2026-03-01",{"date":477,"type":21},"2028-02-28",{"name":38,"class":39},{"id":480,"slug":481,"hasResults":12,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":485,"eligibilityCriteria":486,"healthyVolunteers":12,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":487,"targetDuration":4,"studyType":22,"phases":489,"briefSummary":490,"conditions":491,"keywords":494,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":503,"locationsCount":4},"100586125","exploring-the-effectiveness-of-unpowered-negative-pressure-wound-therapy-100586125","NCT06911307","Exploring the Effectiveness of Unpowered Negative Pressure Wound Therapy","Exploring the Effectiveness of Unpowered Negative Pressure Wound Therapy: a Randomized Controlled Trial","NPWT","Inclusion Criteria:\n\n1. Patients with acute wounds (wound duration \\\u003C4 weeks) or chronic wounds (wound duration ≥4 weeks).\n2. Wound depth \\\u003C2 cm.\n3. Age ≥18 years.\n4. Patients who have been evaluated and approved for participation by their attending physician.\n\nExclusion Criteria:\n\n1. Patients with unstable vital signs.\n2. Presence of ischemia in the wound or surrounding tissues.\n3. Fragile skin around the wound.\n4. Severe wound infection or necrotic tissue.\n5. Wound size \\>10 × 20 cm.",{"count":488,"type":21},160,[24],"The aim of this study is to investigate the effectiveness of Non-powered Negative Pressure Wound Therapy (NPWT) on the healing of abdominal surgical wounds. It is designed as a randomized controlled trial with an experimental group (using NPWT) and a control group (conventional wound care). The study aims to recruit 160 participants: 80 with acute wounds and 80 with chronic wounds. Participants will be randomly assigned to either the experimental group (40 acute wounds, 40 chronic wounds) or the control group (40 acute wounds, 40 chronic wounds). The study will assess wound healing rates and speed, quality of life, self-perceived health status, pain levels, complications, and wound care costs using indicators. Effectiveness will be analyzed using Generalized Estimating Equations (GEE). The study anticipates that results will contribute to evaluating the effects of Non-powered NPWT on wound healing, quality of life, pain, and cost-effectiveness in patients with acute and chronic wounds.",[492,493],"Chronic Wound","Acute Wound",[495,496,170],"Negative Pressure Wound Therapy;","wound care","2025-03-28",{"date":499,"type":32},"2025-04-04",{"date":501,"type":21},"2025-05-01",{"date":259,"type":21},{"name":38,"class":39},{"id":505,"slug":506,"hasResults":12,"nctId":507,"briefTitle":508,"officialTitle":509,"acronym":510,"eligibilityCriteria":511,"healthyVolunteers":78,"sex":16,"minAge":158,"maxAge":4,"enrollmentInfo":512,"targetDuration":4,"studyType":22,"phases":513,"briefSummary":514,"conditions":515,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":517,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":522,"locationsCount":40},"100586101","augmented-reality-location-based-games-on-physical-activity-100586101","NCT06910995","Augmented Reality Location-Based Games on Physical Activity","The Impact of Augmented Reality Location-Based Games on Physical Activity in Middle-Aged and Older Adults.","AR on PA","Inclusion Criteria:\n\n1. Meet one of the following conditions: middle-aged to senior citizens aged 40 to 59 years old or senior citizens aged 60 years old or older who work more than 6 hours a day in a sedentary lifestyle\n2. Able to walk independently without the use of aids.\n3. Have a smart phone with an application (Pikmin Bloom) that can be installed and can access the Internet and GPS.\n\nExclusion Criteria:\n\n1. Patients who have been diagnosed by a doctor as suffering from dementia, mental illness or major diseases.\n2. Those who are unable to do intense exercise as mentioned in the medical advice.\n3. Those who cannot go out for long time, such as family caregivers.\n4. Those who have regular exercise habits: average daily steps over 5,000 steps or 30 minutes of leisure-type physical activity more than 3 times a week.\n5. Those who will not use the AR adaptive game (Pikmin Bloom) at the end of the 2-day test period.",{"count":321,"type":21},[24],"This study aims to examine the effects of an augmented reality location-based game intervention on behavioral and psychological factors related to physical activity among middle-aged and older adults. The study adopts a quasi-experimental design, targeting community-dwelling individuals aged 40-59 or 60 and above, who engage in sedentary work patterns exceeding 6 hours daily. Recruitment is scheduled to commence in February 2025 at the Xinyi Health Service Center in Taipei City. Participants will be assigned to either the experimental group or the control group based on enrollment timing. A minimum of 41 participants will be recruited, divided into two experimental groups and two control groups. The experimental group will participate in an augmented reality location-based game featuring different step count goals every two weeks, daily step count reporting, and goal achievement encouragement. The control group will maintain their usual routines without any intervention. The intervention will last for 8 weeks. Research instruments will include a basic demographic questionnaire, the short-form Taiwan Physical Activity Questionnaire, the Exercise Self-Efficacy Scale, the Exercise Motivation and Barriers Scale, blood pressure measurements, and the Quality of Life Scale.",[516,61],"Physical Activity",{"date":499,"type":32},{"date":519,"type":32},"2025-02-24",{"date":521,"type":21},"2025-07-31",{"name":38,"class":39},{"id":524,"slug":525,"hasResults":12,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":529,"eligibilityCriteria":530,"healthyVolunteers":78,"sex":16,"minAge":48,"maxAge":531,"enrollmentInfo":532,"targetDuration":4,"studyType":22,"phases":534,"briefSummary":535,"conditions":536,"keywords":537,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":544,"startDateStruct":546,"completionDateStruct":548,"leadSponsor":550,"locationsCount":40},"100581653","digital-sleep-program-for-college-students-with-insomnia-100581653","NCT06853106","Digital Sleep Program for College Students with Insomnia","Digital-Based Multimodal Sleep Management Program for College Students with Insomnia: Randomized Controlled Trial","DSP-CS","Inclusion Criteria:\n\n1. Registered as a full-time student\n2. Aged 18 to 26 years old\n3. Experiencing insomnia for at least three months\n4. Currently own and use a personal mobile device\n5. Ability to read and speak Chinese\n6. Not taking hypnotics, sedatives, or antidepressants\n7. Not pregnant or lactating\n\nExclusion Criteria:\n\n1. Using a smartphone model that cannot support the app\n2. Currently using other sleep program apps\n3. Meeting a STOP-BANG score of ≥3","26 Years",{"count":533,"type":21},90,[24],"This randomized controlled trial (RCT) study aims to evaluate the effectiveness of a digital-based multimodal sleep management program compared to a waitlist control group in improving sleep-related outcomes, including insomnia severity, daytime sleepiness, objective sleep parameters, and sleep reactivity to stress, as well as psychological health indices, such as depression, anxiety, and resilience. Additionally, this study seeks to examine the mediating role of different chronotypes in the effectiveness of the sleep intervention on the outcomes of interest.",[252],[299,538,539,231,540,252,541,542,543],"Chronotypes","Daytime Sleepiness","Digital-based Sleep Management","Resilience","Sleep Reactivity","Mindfulness-based Breathing",{"date":545,"type":32},"2025-02-28",{"date":547,"type":32},"2024-04-24",{"date":549,"type":21},"2027-07-31",{"name":38,"class":39},{"id":552,"slug":553,"hasResults":12,"nctId":554,"briefTitle":555,"officialTitle":556,"acronym":4,"eligibilityCriteria":557,"healthyVolunteers":78,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":558,"targetDuration":4,"studyType":22,"phases":559,"briefSummary":560,"conditions":561,"keywords":563,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":568,"lastUpdatePostDateStruct":569,"startDateStruct":571,"completionDateStruct":573,"leadSponsor":575,"locationsCount":576},"100573069","feasibility-study-of-caregiver-assist-strategy-training-100573069","NCT06741475","Feasibility Study of Caregiver-Assist Strategy Training","Optimizing Activity Performance of Stroke Patients Through Caregiver-Assisted Rehabilitation With Strategy Training: A Feasibility Study","Inclusion Criteria:\n\n* Being willing to provide informed consent\n* Diagnosis with ischemic and\u002For hemorrhagic stroke\n* Modified Rankin Scale (mRS) ranges from 2 to 4\n* Rehabilitation frequency less than 3 days per week\n* Having a healthy caregiver\n\nExclusion Criteria:\n\n* Undergoing palliative care\n* Major diseases or severe conditions influencing study participation, such as global aphasia, dementia, multiple organ failure, immobilization due to fracture, etc Moderate post-stroke cognitive impairment, with Montreal Cognitive Assessment score \\\u003C22\n* Pre-stroke mRS \\> 1\n* Participating in other interventional study concurrently.",{"count":188,"type":21},[24],"The goal of this study is to examine the feasibility of delivering an innovative intervention, caregiver-assisted strategy training (CaST), targeting enhancing activity functions in community-dwelling adults after stroke. The main questions it aims to answer are:\n\n* Is CaST acceptable to stroke survivors with functional limitations?\n* Does CaST show positive effects on functional outcomes?\n\nResearchers will compare the CaST program to a control education program to investigate the interventional effect size for the selected stroke participants.\n\nParticipants will:\n\n* Receive CAST or an education program 1 to 2 sessions per week until finishing 10 sessions.\n* Be assessed clinical outcomes at 4 times: pre-intervention, post-intervention, 3-month, and 6-month follow-up.\n* Be interviewed once after finishing their intervention.",[562],"Stroke",[564,565,566,567],"Stroke rehabilitation","Caregiver","Strategy training","Activity function","2025-02-13",{"date":570,"type":32},"2025-02-17",{"date":572,"type":32},"2025-02-04",{"date":574,"type":21},"2027-12-31",{"name":38,"class":39},3,{"id":578,"slug":579,"hasResults":12,"nctId":580,"briefTitle":581,"officialTitle":582,"acronym":583,"eligibilityCriteria":584,"healthyVolunteers":78,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":585,"targetDuration":4,"studyType":22,"phases":587,"briefSummary":588,"conditions":589,"keywords":590,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":568,"lastUpdatePostDateStruct":593,"startDateStruct":594,"completionDateStruct":596,"leadSponsor":598,"locationsCount":599},"100574075","a-caregiver-assisted-rehabilitation-with-strategy-training-car-st-for-stroke-patients-100574075","NCT06754566","A Caregiver-Assisted Rehabilitation With Strategy Training (CAR-ST) for Stroke Patients","A Caregiver-Assisted Rehabilitation With Strategy Training (CAR-ST) for Stroke Patients With Functional Limitations: A MultiCenter, 3-Arm Randomized Trial","CAR-ST","Inclusion Criteria:\n\n* Being willing to provide informed consent\n* Diagnosis with ischemic and\u002For hemorrhagic stroke\n* Modified Rankin Scale (mRS) ranges from 2 to 4\n* Rehabilitation frequency less than 3 days per week\n* Having a healthy caregiver\n\nExclusion Criteria:\n\n* Undergoing palliative care\n* Major diseases or severe conditions influencing study participation, such as global aphasia, dementia, multiple organ failure, immobilization due to fracture, etc\n* Moderate post-stroke cognitive impairment, with Montreal Cognitive Assessment score \\\u003C22\n* Pre-stroke mRS \\> 1\n* Participating in other interventional study concurrently.",{"count":586,"type":21},261,[24],"The goal of this randomized controlled trial is to examine if involving the caregivers in the strategy training (i.e. caregiver-assisted rehabilitation with strategy training, CAR-ST) works to improve activity functions in community-dwelling adults after stroke. The main questions it aims to answer are:\n\nDoes CAR-ST and strategy training alone lead to greater improvements in activity performance among stroke survivors relative to the control intervention with education? Does CAR-ST outperform strategy training alone in the efficacy of activity outcomes? Do the activity effects of CAR-ST transfer to the impairment and participation domains of outcomes?\n\nResearchers will compare the efficacy of the CAR-ST intervention against strategy training alone or control intervention (education program) to see if caregivers contribute to post-stroke functional improvements.\n\nParticipants will:\n\n* receive CAR-ST, strategy training only, or an education program 1 to 2 sessions per week until finishing 10 sessions.\n* be assessed clinical outcomes at 4 times: pre-intervention, post-intervention, 3-month, and 6-month follow-up.",[562],[562,591,566,592],"Caregiver-assisted rehabilitation","Activity limitations",{"date":570,"type":32},{"date":595,"type":32},"2025-01-17",{"date":597,"type":21},"2028-12-31",{"name":38,"class":39},5,{"id":601,"slug":602,"hasResults":12,"nctId":603,"briefTitle":604,"officialTitle":605,"acronym":4,"eligibilityCriteria":606,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":293,"enrollmentInfo":607,"targetDuration":4,"studyType":22,"phases":609,"briefSummary":610,"conditions":611,"keywords":615,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":625,"completionDateStruct":627,"leadSponsor":629,"locationsCount":40},"100437857","the-development-and-evaluation-of-a-web-based-childbirth-and-parenting-intervention-program-100437857","NCT04981730","The Development and Evaluation of a Web-based Childbirth and Parenting Intervention Program","The Development and Evaluation of a Web-based Childbirth and Parenting Intervention Program: A Randomized Controlled Trial","Inclusion Criteria: for this study are first-time mothers and fathers who are\n\n1. 20 years old and above;\n2. primipara with a singleton pregnancy at second and third-trimester gestation;\n3. able to read and write in Mandarin;\n4. the husband or support partner will be willing to attend the intervention program;\n5. able to access and use the Internet by computer and\u002For smartphone daily.\n\nExclusion Criteria: are the first-time mothers and fathers who have\n\n1. chronic diseases;\n2. obstetric complications;\n3. an abnormal fetal screening;\n4. unable or unwilling to comply with the requirements of the research protocol;\n5. women and their partners did not have time for the web-based intervention program;\n6. participation on any other interventional study.",{"count":608,"type":21},600,[24],"Background: The transition to parenthood is stressful for first-time mothers and fathers and links to adverse health outcomes. Despite Internet use's popularity, an effective web-based, individually-tailored intervention to enhance parental self-efficacy and infant health for first-time parents remains lacking.\n\nObjectives: This study aims to develop and evaluate the effectiveness of a web-based, individually-tailored childbirth and parenting intervention program on parenting self-efficacy and infant health outcomes. The feasibility and acceptability of a theory-driven intervention will be examined in first-time mothers and fathers.\n\nMethods: A two-arm, single-blind randomized controlled trial will be conducted to investigate the effects of web-based intervention in the first-time mother and father. Participants will be randomly allocated to a web-based intervention or a control condition. A repeated measurement will be performed.\n\nAnticipatory results: The efficacy of a theory-driven web-based, individually tailored intervention program will provide a valuable contribution to perinatal health care for first-time mothers and fathers.",[612,613,614],"Parenting","Self Efficacy","Psychological Distress",[616,617,618,619,620,621],"parenting","parenthood","web-based intervention","self-efficacy","psychological distress","infant health","2025-01-24",{"date":624,"type":32},"2025-01-28",{"date":626,"type":32},"2023-12-14",{"date":628,"type":21},"2025-10-14",{"name":38,"class":39},{"id":631,"slug":632,"hasResults":12,"nctId":633,"briefTitle":634,"officialTitle":635,"acronym":4,"eligibilityCriteria":636,"healthyVolunteers":78,"sex":637,"minAge":17,"maxAge":293,"enrollmentInfo":638,"targetDuration":4,"studyType":22,"phases":640,"briefSummary":641,"conditions":642,"keywords":646,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":651,"startDateStruct":653,"completionDateStruct":655,"leadSponsor":657,"locationsCount":40},"100426198","trajectory-of-psychological-distress-among-infertility-women-100426198","NCT04829877","Trajectory of Psychological Distress Among Infertility Women","Trajectory of Psychological Distress Among Infertility Women: Efficacy and Mechanism of Mind-body Intervention With Heart Rate Variability Biofeedback","Inclusion Criteria:\n\n* 20-year-old and above\n* Seeking infertility care\n* Contemplating pregnancy\n* Intended to start their ART cycle\n* Able to speak Taiwanese or Mandarin\n\nExclusion Criteria:\n\n* Diagnosis of cardiovascular disease, depressive disorder, anxiety disorder, cardiac arrhythmia\n* Already had started their ART treatment\n* Taking medications that might affect ANS activity","FEMALE",{"count":639,"type":21},750,[24],"Background: Infertility is a serious reproductive health issue and affects 48.5 million couples worldwide. Women undergoing fertility treatment often experienced psychological distress but also social stigma that is close linked to later pregnancy outcome. Despite the advancement in assisted reproductive technology, effective interventions for reducing stress, anxiety, and depressive symptoms for infertility women remain lacking.\n\nObjectives: The objective of this proposal is to evaluate the efficacy of web-based mind-body intervention combining HRV biofeedback on the infertility women's anxiety symptoms, levels of depression, HRV function, mindful awareness, infertility self-efficacy, and pregnancy rates.\n\nMethods: We plan to conduct a randomized controlled trial on the web-based mind-body intervention combining heart rate variability biofeedback. Eligible women will be recruited and randomized into three groups. Intention-to-treat analysis and mixed regression modeling will be used to estimate the effectiveness of the interventions.\n\nAnticipatory results: Effective strategies will be determined for infertility women.",[643,644,645],"Infertility","Heart Rate Variability","Biofeedback",[647,648,649,650,620],"infertility","mind-body intervention","heart rate variability","biofeedback",{"date":652,"type":32},"2025-01-27",{"date":654,"type":32},"2022-04-19",{"date":656,"type":21},"2025-04",{"name":38,"class":39},""]