[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tam Anh TP. Ho Chi Minh General Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100504359","dpos-versus-gnrh-antagonist-protocol-for-oocyte-accumulation-in-low-ovarian-reserve-patients-an-rct-100504359",false,"NCT05847283","DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT","Dydrogesterone Primed Ovarian Stimulation Versus Fixed Gonadotropin Releasing Hormone Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: A Randomized Controlled Trial","DPOS","Inclusion Criteria:\n\n* Woman aged between 18 and 37 years\n* AFC ≤ 5 and\u002For AMH ≤ 1.2 ng\u002Fml\n* Agree to perform freeze-all strategy and single frozen blastocyst embryo transfer\n\nExclusion Criteria:\n\n* Oocyte recipient\n* Indication of preimplantation genetic testing\n* Known allergic reactions to medications in the Study (progesterone products, GnRH antagonist….)\n* Basal FSH above 15mIU\u002FmL.\n* Have contraindications of ART treatment (e.g. critical or acute diseases)\n* Retrieved sperm\n* Repeated Implantation failure ( ≥ 3 failed embryo transfers with good-quality embryos)\n* Inability to comply with the study procedures.\n* Patients with a history of thyroid cancer who are on hormone replacement therapy or those diagnosed with thyroid diseases at the time of eligibility assessment",true,"FEMALE","18 Years","37 Years",{"count":22,"type":23},730,"ESTIMATED","INTERVENTIONAL",[26],"NA","One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed. Many ovarian stimulation strategies have been proposed to improve oocyte or embryo quantity which is oocyte accumulation could be a potential option with a comparable success rate and reasonable cost.\n\nProgestin-primed ovarian stimulation (PPOS) protocol could be suggested as an alternative method of premature Luteinizing hormone (LH) prevention in IVF. It favors segment Assisted Reproductive Technology (ART) cycles such as frozen embryo transfer (FET), oocyte donor, fertility preservation, and oocyte accumulation set. The protocol is more patient-friendly and affordable than the GnRH antagonist regimen regarding LH suppression during ovarian stimulation.\n\nMany PPOS protocols have been proposed in which the three most common agents include Dydrogesterone (DYG), Micronised Progesterone (MIP), and Medroxyprogesterone acetate (MPA). Indeed, DYG seems to have some advantages, including oral administration and safety which has been used in the treatment of threatened abortion. Initial evidence of PPOS protocol suggests that oocyte quantity and quality are comparable with other ovarian stimulation regimens. However, data related to the PPOS protocol has not been well documented, including Dydrogesteron-primed ovarian stimulation (DPOS).\n\nThere has not been an RCT with a large sample size and well-designed to provide more substantial evidence. A randomized trial to compare the effectiveness of PPOS and GnRH antagonist protocol in IVF is urgently needed.",[29],"Diminished Ovarian Reserve",[31,32,33,34,35,36],"Progestin priming ovarian stimulation","Oocyte accumulation","Diminished ovarian reserve","GnRH antagonist","Oocyte vitrification","Dydrogesterone","RECRUITING","2025-12-03",{"date":40,"type":41},"2025-12-10","ACTUAL",{"date":43,"type":41},"2023-06-22",{"date":45,"type":23},"2027-12-31",{"name":47,"class":48},"Tam Anh TP. Ho Chi Minh General Hospital","OTHER",2,""]