[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tamas Vegh, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":138},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,63,92,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100618282","monitoring-the-clinical-and-immunological-effects-of-microbiome-changes-following-severe-burn-injury-100618282",false,"NCT07329595","Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury","microbiome","Inclusion Criteria:\n\n* Adult patients (age between 18 and 65 years) meeting the diagnostic criteria for severe burn injury, burns involving more than 20% of the total body surface area (TBSA) and\u002For inhalation injury.\n* Burn injury caused by scalding, flame, electrical, contact, or chemical exposure\n* Hospital admission within 24 hours following injury\n\nExclusion Criteria:\n\n* Patients with inflammatory bowel diseases or malignant neoplasms.\n* Patients with a history of major gastric and\u002For intestinal resections\n* Patients in a pre-injury ECOG performance status of 4.","ALL","18 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","The aim of this study is to longitudinally monitor dynamic changes in the gut microbiome following severe burn injury using fecal samples. Under standard nutritional protocols and intensive care management, serial fecal sampling is performed to assess alterations in microbiome diversity and composition, as well as the indirect effects of these changes on measurable inflammatory biomarkers, endocrine, hematological, immunological, and other organ-specific parameters, the clinical course, and patient outcomes.",[25,26,27],"Severely Burned Patients","Gut Microbiota Diversity and Composition","Inflammatory Responses",[29,30],"severe burn injury","gut microbiome","RECRUITING","2026-01-06",{"date":34,"type":35},"2026-01-09","ACTUAL",{"date":37,"type":35},"2023-12-01",{"date":39,"type":21},"2026-12-31",{"name":41,"class":42},"Tamas Vegh, MD","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":43},"100602906","investigation-of-the-role-of-inflammatory-markers-in-the-early-detection-of-cerebral-vasospasm-delayed-cerebral-ischemia-and-meningitis-associated-with-external-cerebrospinal-fluid-drainage-after-non-traumatic-subarachnoid-hemorrhage---a-prospective-case-control-study-100602906","NCT07129603","Investigation of the Role of Inflammatory Markers in the Early Detection of Cerebral Vasospasm, Delayed Cerebral Ischemia, and Meningitis Associated With External Cerebrospinal Fluid Drainage After Non-Traumatic Subarachnoid Hemorrhage - A Prospective Case-Control Study","Inclusion Criteria:\n\n* Adults (≥18 years).\n* Angiography-identifiable non-traumatic SAH (regardless of source).\n* Requires lumbar or ventricular drain as part of treatment.\n\nExclusion Criteria:\n\n* Traumatic SAH.\n* Patient\u002Flegal representative does not consent.\n* Meningitis within 6 months prior to ictus.\n* Immunosuppressed state (disease or medications affecting WBC number\u002Ffunction).",{"count":51,"type":21},100,"Background Non-traumatic subarachnoid haemorrhage (SAH) is frequently complicated by delayed cerebral ischaemia (DCI) and by ventriculitis\u002Fmeningitis when external CSF drains are used; bedside TCCD has limited accuracy for vasospasm detection, creating a need for early biomarkers.\n\nObjective To assess the predictive and diagnostic performance of IL-6, IL-1β, TNFα, procalcitonin (PCT), C-reactive protein (CRP) and adrenomedullin (ADM) measured in CSF and serum for vasospasm, DCI, and drain-associated ventriculitis\u002Fmeningitis after SAH; to test whether combining biomarkers improves accuracy versus routine parameters; and to explore associations with admission and day-14 serum 25-hydroxy-vitamin D.\n\nMethods Prospective case-control study at the University of Debrecen (planned n≈100; enrolment 01-Nov-2024-31-Dec-2029). Adults with angiography-verified SAH requiring lumbar\u002Fventricular drainage are included; traumatic SAH, prior 6-month meningitis, and immunosuppression are excluded. TCCD is performed daily for 14 days; suspected vasospasm is defined by mean flow velocity \\>120 cm\u002Fs, severe by \\>200 cm\u002Fs, with monitoring extended to day 21 if severe. Sampling: daily CSF IL-6\u002FPCT\u002FCRP until drain removal; IL-1β\u002FTNFα\u002FADM at 0-2, 3-5, 6-8, 9-11, 12-14 days and at meningitis detection; serum 25-OH-D on drain insertion day and day 14. Outcomes at days 30\u002F90\u002F180: mortality, GOSE, Barthel, Karnofsky, mRS. Statistics: normality testing; t-test or non-parametric equivalents; χ² with Yates' correction; Bonferroni for multiplicity; ROC analysis for diagnostic\u002Fpredictive performance.\n\nEndpoints DCI: new unexplained CT ischaemia or a new unexplained neurological deficit \\>1 h. Drain-associated infection: infectologist-adjudicated ventriculitis\u002Fmeningitis. Vasospasm: TCCD-suggested or DSA-confirmed.\n\nExpected impact An accessible CSF\u002Fserum biomarker panel may enable earlier risk stratification and treatment for vasospasm, DCI, and drain-associated infections, and inform future randomized trials of vitamin-D supplementation in SAH.",[54],"Subarachnoid Haemorrhagic Stroke","2025-08-11",{"date":57,"type":35},"2025-08-19",{"date":59,"type":35},"2025-08-01",{"date":61,"type":21},"2029-12-31",{"name":41,"class":42},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":71,"targetDuration":4,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":43},"100596341","phase-4-reversal-of-pipecuronium-induced-neuromuscular-blockade-with-sugammadex-during-sevoflurane-anesthesia-100596341","NCT07044193","Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Sevoflurane Anesthesia","Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Sevoflurane Anesthesia: a Drug Safety Randomised Controlled Trial","RPINMBWS","Inclusion Criteria:\n\n* 80 adult general surgery and neurosurgical patients are enrolled in the study after giving an informed written consent regarding their participation.\n* Age: between 18-65 years;\n* ASA score: 1-3;\n* BMI 18.5-25 (normal body weight);\n* Males and females were recruited in an equal ratio;\n* Minimal surgical time of at least ≥ 40 minutes;\n* Procedures requiring endotracheal intubation;\n\nExclusion Criteria:\n\n* Diseases affecting neuromuscular function (myopathies, severe liver and kidney failure);\n\n  * Drugs affecting neuromuscular function (magnesium, aminoglycosides);\n  * Difficult airway, or anticipated difficult intubation;\n  * Pregnancy (a pregnancy test is performed in women of childbearing age to rule out pregnancy);\n  * Breast-feeding;\n  * Acute surgery;\n  * COPD\n  * Glaucoma\n  * History of previous allergic\u002Fanaphylactic reactions",{"count":72,"type":21},80,"INTERVENTIONAL",[75],"PHASE4","Safety during modern practice of anaesthesia is of great concern. Patients admitted daily for surgical procedures undergoing general anaesthesia for different types of operations are exposed to different risks, starting from the anaesthesia and ending with the surgical intervention. Aim of the study is to provide a comprehensive and evidence based data regarding the safety of the neuromuscular blocking agents used in modern anaesthesia practice, precisely Rocuronium and Pipecuronium, as well as the reversal agents such as Sugammadex, which is the sole agent in use in practice nowadays. A routine anaesthetic practice will be performed during the whole period of our study after strict patient selection criteria. Intraoperative standard monitoring as per local and international guidelines will be applied, this includes Spo2, ECG, NIBP\u002FIBP, etCO2, BIS and Tetragaph for neuromuscular blockade monitoring. After induction of anaesthesia and prior to the administration of the muscle relaxant agent, a TOFC (Train of Four Count) will be registered as the starting point. Throughout the anaesthetic time, there will be continuous TOF monitoring. The anaesthesia will be maintained by sevoflurane. Also, the recruited samples will be divided according to the neuromuscular blockade agents administered, either Rocuronium or Pipecuronium. At the end of the surgical procedure, the time lapse between the administration of the reversal agent Sugammadex and a TOF ratio of 0.9 is registered as our primary end point. TOF measures will be performed in the postoperative period, to make sure there is no residual neuromuscular blockade in the early postoperative phase. The study will not only monitor the safety of the neuromuscular blocking agents in use, but will also monitor any signs of anaphylaxis due to their administration both intra and postoperatively.",[78,79,80],"Neuromuscular Blocking Agents","Residual Neuromuscular Block","Reversal of Neuromuscular Blockade",[82],"reversal of neuromuscular blockade","NOT_YET_RECRUITING","2025-06-27",{"date":86,"type":35},"2025-06-29",{"date":88,"type":21},"2025-06-26",{"date":90,"type":21},"2028-12-31",{"name":41,"class":42},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},"100569204","comparison-of-adductor-pollicis-and-abductor-digiti-minimi-muscles-thumb-vs-fifth-digit-as-sites-for-neuromuscular-monitoring-with-electromyography-100569204","NCT06691204","Comparison of Adductor Pollicis and Abductor Digiti Minimi Muscles (Thumb Vs. Fifth Digit) As Sites for Neuromuscular Monitoring with Electromyography","Inclusion Criteria:\n\n* Age \\> or = 18 years old\n* Patients willing to participate and provide an informed consent\n* Patients undergoing elective surgical procedures that require use of NMBA agents (rocuronium) administered intraoperatively.\n\nExclusion Criteria:\n\n* Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.\n* Patients with systemic neuromuscular diseases such as myasthenia gravis.\n* Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents, i.e., severe renal impairment or end-stage liver disease.\n* Patients having surgery that would involve prepping the arm into the sterile field.\n* Patients receiving a rapid sequence induction.\n* Patients allergic to rocuronium or sugammadex.",{"count":99,"type":21},46,"This study aims to evaluate the performance of the TetraGraph on two muscle groups: the adductor pollicis and the abductor digiti minimi. Theese muscles are located on the arms. Key time points for assessment will include the onset of neuromuscular blockade and the recovery from rocuronium blockade using sugammadex.",[102,103],"Postoperative Residual Curarization","Neuromuscular Blockade",[105],"Electromyography","2024-11-13",{"date":108,"type":35},"2024-11-15",{"date":110,"type":35},"2024-10-18",{"date":112,"type":21},"2026-05-31",{"name":41,"class":42},2,{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":43},"100557966","measuring-upper-airway-cross-sectional-areas-during-residual-neuromuscular-blockade-and-after-reserval-100557966","NCT06544980","Measuring Upper Airway Cross Sectional Areas During Residual Neuromuscular Blockade and After Reserval","Inclusion Criteria:\n\nAge: 18-65 years;\n\n* ASA 1-3;\n* BMI 18.5-25 (normal body weight);\n* men\u002Fwomen in equal proportion;\n* duration of surgeries at least ≥ 30 minutes;\n* intervention requiring intratracheal intubation;\n* patients are in a supine position.\n\nExclusion Criteria:\n\ndiseases affecting neuromuscular function (myopathies, severe liver and kidney failure);\n\n* drugs affecting neuromuscular function (magnesium, aminoglycosides);\n* difficult airway, expected difficult intubation;\n* pregnancy (pregnancy test for women of childbearing age to rule out pregnancy we finish);\n* breastfeeding;\n* acute surgery;\n* COPD\n* glaucoma",{"count":122,"type":21},20,"In our study, the investigators sought to answer the question of how the retroglossal pharyngeal areas measured after extubation of patients compare to baseline (before muscle relaxation) values. The investigators also investigated how these areas change as a function of TOF ratios measured at extubation, thus looking for a correlation between residual muscle relaxant effect and airway area.",[102,125],"Airway Obstruction on Anaesthetic Emergence",[127,128,129],"residual neuromuscular blockade","postoperative airway obstruction","electromyography","2024-08-08",{"date":132,"type":35},"2024-08-12",{"date":134,"type":35},"2024-01-02",{"date":136,"type":21},"2025-12-31",{"name":41,"class":42},""]