[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tampere University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":294},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,50,76,112,136,159,183,209,236,266],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100645211","app-based-motor-skills-intervention-in-primary-school-and-home-settings-100645211",false,"NCT07679633","App-based Motor Skills Intervention in Primary School and Home Settings","DigiKids C-RCT: App-based Motor Skills Intervention in Primary School and Home Settings","DigiKids RCT","Inclusion Criteria:\n\n* Children enrolled in the first grade of primary school\n* Sufficient Finnish language proficiency\n* Written informed consent from the guardian and written assent from the child\n\nExclusion Criteria:\n\n* Age under 6 or over 8 years\n* Medical or physical conditions preventing participation in the assessments (including severe musculoskeletal complaints or concussions within the preceding 3 months)\n* Refusal to participate in baseline assessments",true,"ALL","6 Years","8 Years",{"count":22,"type":23},314,"ESTIMATED","INTERVENTIONAL",[26],"NA","The objective of this trial is to evaluate the effectiveness of a mobile app-based motor skills intervention (DigiKids RCT) on motor competence, physical activity, and perceived motor competence compared with standard school practices in primary school children. In addition, the study will examine other factors such as child-specific and family-related factors that might influence the findings.",[29,30],"Healthy","Motor Activity",[32,33,34,35,36],"Physical Activity","Mobile Applications","Child","Behavior","Motor Skills","NOT_YET_RECRUITING","2026-06-28",{"date":40,"type":41},"2026-07-01","ACTUAL",{"date":43,"type":23},"2026-08-10",{"date":45,"type":23},"2027-05-31",{"name":47,"class":48},"Tampere University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":17,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100644117","impedance-plethysmography-based-deep-vein-thrombosis-monitoring-during-catheter-directed-thrombolysis-100644117","NCT07665320","Impedance Plethysmography Based Deep Vein Thrombosis Monitoring During Catheter-directed Thrombolysis","Inclusion Criteria for Patients group:\n\n* Age: 18 or older;\n* DVT detected on other lower limb;\n* Suitable for CDT treatment;\n* Ability to give informed consent;\n* Volunteering for the study.\n\nExclusion Criteria for Patients group:\n\n* Age under 18 years;\n* Inability to give informed consent;\n* Denial;\n* Too injured skin in the measurement area\n\nInclusion Criteria for Healthy volunteers group:\n\n* Age: 18 or older;\n* Ability to give informed consent;\n* Volunteering for the study\n\nExclusion Criteria for Healthy volunteers group:\n\n* Diagnosed DVT in lower limbs;\n* Age under 18 years;\n* Inability to give informed consent;\n* Denial;\n* Too injured skin in the measurement area.","18 Years",{"count":58,"type":23},40,"OBSERVATIONAL","The purpose of this study is to collect data on blood circulation using a multi-frequency impedance plethysmography device developed in the ThrombUS+ project. Impedance plethysmography (IPG) is a non-invasive method that measures changes in blood volume using electrodes placed on the skin. The collected data will be used for device development, the improvement of diagnostic data analysis methods, and AI training.\n\nA total of 40 participants will be recruited for this study, with 20 healthy volunteers in Tampere University and 20 patients undergoing thrombolytic therapy for DVT at Tampere University Hospital.",[62],"Deep Vein Thrombosis (DVT)",[64,65],"deep vein thrombosis","DVT","RECRUITING","2026-06-24",{"date":69,"type":41},"2026-06-29",{"date":71,"type":41},"2025-07-17",{"date":73,"type":23},"2027-12",{"name":47,"class":48},2,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":17,"sex":18,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":24,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":49},"100641910","physical-activity-intervention-for-older-family-carers-100641910","NCT07653061","Physical Activity Intervention for Older Family Carers","Supporting Physical Activity and Functional Capacity Among Older Family Caregivers (CAREFIT): A Six-month, Randomised Controlled Pilot Trial","CAREFIT","Inclusion Criteria:\n\n* Aged 65 years or older\n* Spousal family caregiver living in the same household as the care recipient (a formal caregiving agreement is not required)\n* Participating in moderate- or vigorous-intensity physical activity fewer than two times per week\n* Able to safely engage in light-to-moderate physical activity based on self-report and health screening conducted by the study nurse, with consultation from the study physician if required\n* Able to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosed dementia, substantial cognitive impairment, or other significant neurological disease that would interfere with participation in the study\n* Inability to provide informed consent or complete study assessments, as determined by study personnel\n* Medical conditions that may compromise safe participation in physical activity, including but not limited to active malignant disease, severe major depression, symptomatic cardiovascular disease, or coronary or vascular revascularization within the previous 12 months\n* Severe visual, hearing, speech, or other sensory or communication impairments that would prevent meaningful participation in the intervention, as determined by the study nurse\n* Concurrent participation in another interventional clinical trial","65 Years",{"count":86,"type":23},50,[26],"The goal of this pilot trial is to learn whether a six-month physical activity program tailored for older family caregivers can be successfully delivered and whether participants are willing and able to take part in it. The study will also explore possible effects of the programme on physical activity, physical function, health, and well-being.\n\nThe main questions it aims to answer are:\n\n* Can enough participants be recruited to the study?\n* Do participants adhere to the study and complete follow-up assessments?\n* How often do participants take part in the program activities?\n* How acceptable and useful do participants find the program?\n* What are the possible effects of the programme on physical activity, health, and wellbeing.\n\nResearchers will compare the physical activity program with a control group that receives health information and education about healthy ageing.\n\nParticipants will:\n\n* Complete health, physical functioning, and questionnaire assessments at the beginning of the study, after 6 months, and after 12 months\n* Wear an activity monitor on their wrist for 7 days and nights at the beginning of the study and after 6 months\n* Will be randomly assigned to either a six-month physical activity program designed for older family caregivers, or a control group that receives health information and education about healthy ageing.\n* If assigned to the physical activity program, participants will take part in weekly group-based and remote exercise sessions for 6 months.\n* Provide feedback about their experiences of the program",[90,91],"Feasibility Studies","Physical Activity and Wellbeing",[93,94,95,96,97,98,99,100,101,102,103],"family caregivers","older adults","physical activity","exercise","physical functioning","feasibility","pilot study","health behavior","positive mental health","cognition","stress","2026-06-11",{"date":106,"type":41},"2026-06-17",{"date":108,"type":23},"2026-06-15",{"date":110,"type":23},"2027-08-31",{"name":47,"class":48},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":24,"phases":121,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100637939","the-effect-of-ecg-rhythm-virtual-interventions-to-ecg-interpretation-and-competence-100637939","NCT07615114","The Effect of ECG Rhythm Virtual Interventions to ECG Interpretation and Competence","The Effect of ECG Rhythm Virtual Interventions to ECG Interpretation and Competence in Finnish University Hospitals","Inclusion Criteria:\n\n* cardiology nurses\n\nExclusion Criteria:\n\n* doctors",{"count":120,"type":23},508,[26],"The aim of this study is to develop, implement, and evaluate the effects of a virtual ECG rhythm intervention on the interpretation and competence of cardiology nurses in Finnish university hospitals. The virtual ECG rhythm intervention consists of a virtual animation component and a virtual simulation component, both incorporating cardiological patient cases with corresponding ECG rhythms. The virtual animation includes educational content on a total of 31 different ECG rhythms, as well as a virtual simulation containing 6-8 different cardiological patient cases with ECG rhythms (covering 11 distinct rhythms).\n\nThe study employs a quasi-experimental design. Cardiology nurses are divided into two groups based on hospital: an intervention group and a control group.\n\nIn this study, data will first be collected for the virtual animation component during 2026-2027, followed by data collection for the virtual simulation component during 2027-2028. A baseline measurement of ECG interpretation and competence will be conducted for both groups (n = 508) using an online survey (LimeSurvey) prior to the intervention.\n\nThe same measurement schedule will be applied to the virtual simulation component during the 2027-2028 data collection period.\n\nIn this study, three (3) reminder letters will be sent at weekly intervals to encourage participation in the study, its surveys, and the virtual interventions. These reminder messages will be distributed via email by unit managers or equivalent personnel in each hospital to the participants.\n\nThe virtual intervention will be delivered online via a web service (GitHub) link. Research data on ECG interpretation and competence will be collected using an ECG interpretation measurement instrument administered through an electronic survey (LimeSurvey).\n\nThe ECG interpretation instrument was previously developed by the researcher and includes ECG recordings from real patient cases, for which prior permission has been obtained in accordance with the practices of a cardiac care unit in a central hospital. The instrument has been partially updated in terms of ECG rhythms, with additional new ECG recordings included. Permission for the new ECG recordings was obtained in April 2023 from a Finnish wellbeing services county. The instrument also includes ECG recordings from a simulation monitor display.\n\nThe ECG interpretation instrument begins with 14 background questions. It includes five questions assessing ECG competence and currently contains 31 ECG interpretation questions, compared to the previous 21 items. Additionally, the end of the instrument includes seven questions assessing the experiences of participants in the intervention group regarding the virtual intervention.\n\nThese implementation methods aim to control for the potential influence of external variables, as the intervention and survey are identical for all participants. This consistency could not be guaranteed if the virtual ECG interpretation intervention were delivered, for example, as a traditional theory-based lecture.\n\nThe results of the study will be analyzed using statistical methods. The findings can be utilized, for example, in the development of ECG rhythm interpretation and competence training programs for cardiology nurses.",[124,125],"Electrocardiogram","Electrocardiogram Interpretation",[127],"ECG virtual intervention","2026-05-22",{"date":130,"type":41},"2026-05-29",{"date":132,"type":23},"2026-08-01",{"date":134,"type":23},"2028-12-31",{"name":47,"class":48},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":24,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":158},"100383017","acute-atrial-fibrillation-and-flutter-treated-electively-100383017","NCT04267159","Acute Atrial Fibrillation and Flutter Treated Electively","Acute Atrial Fibrillation and Flutter Treated Electively - A Randomized Controlled Clinical Trial on the Safety of Elective Management of Acute Atrial Fibrillation and Flutter","AFFELECT","Inclusion Criteria:\n\n* Patients presenting with acute (\\\u003C48hours) atrial fibrillation or atrial flutter to ER\n* Planned acute rhythm control for the arrhythmia by the attending physician in ER\n* Good perceived health as assessed by attending physician in ER\n* Resting heart rate 110bpm or lower before or after adequate rate control therapy\n\nExclusion Criteria:\n\n* Haemodynamically stable (mean arterial pressure above 60mmHg)\n* Need for acute restoration of sinus rhythm due to some other somatic cause\n* No other major complicating acute illness (e.g. decompensated HF or acute MI)\n* Anticoagulation not safe\n* Mechanical heart valve or mitral stenosis\n* The need for prolonged (\\>24h) hospitalization due to any cause\n* Exceptionally high risk for thromboembolic events (e.g. history of thromboembolic stroke regardless of adequate anticoagulation)\n* Transesophageal echocardiography contraindicated",{"count":145,"type":23},500,[26],"The AFFELECT -study compares two types of treatment modalities for acute atrial fibrillation or flutter for patients in whom rhythm control is desirable. The main purpose is to observe if these arrhythmias can be safely treated electively (within 5-9 days).\n\nAll patients are recruited in the emergency department. Patients must be in good clinical condition so that they can be discharged regardless to which treatment modality is randomly selected to them. Patients randomized to conventional care are treated conventionally which means acute rhythm control is applied by electrical or medical cardioversion in the emergency department (within 48 hours of onset of the arrhythmia). Patients randomized to elective care are discharged immediately after adequate temporary rhythm control is assured.\n\nAll patients will visit a cardiologist out-patient clinic at approximately one week after the emergency room visit. Patients randomized to elective treatment and still in atrial fibrillation or in atrial flutter will be restored to sinus rhythm by electrical or medical cardioversion at the out-patient clinic. Cardiovascular status and treatment options are evaluated for all patients.\n\nAnticoagulation is managed according existing guidelines for all patients. Due to possibility of delayed cardioversion in the interventional group (elective care group), all patients receive anticoagulation before the out-patient clinic despite their thromboembolic risk. All patients who have not received adequate anticoagulation for three weeks prior to the delayed cardioversion will undergo a transesophageal cardiac ultrasound to ensure they are not in excess risk for thromboembolic events. Patients randomized to elective treatment have the possibility to opt-out and undergo acute cardioversion if their symptoms are unmanageable during the first week before the out-patient clinical.\n\nAll patients are monitored for their symptoms by a standardized quality-of-life questionnaire and for possibly required acute medical interventions during the first week and one month after the out-patient clinic. After one month, all patients undergo an electrocardiography (ECG) to ensure the maintenance of normal rhythm in both treatment groups. After the months follow-up all patients are subsequently monitored for a maximum of five years for need of medical interventions due to atrial fibrillation of atrial flutter. New antiarrhythmics such as flecainide are not prescribed during the first month.",[149,150],"Atrial Fibrillation","Atrial Flutter","2026-05-19",{"date":128,"type":41},{"date":154,"type":41},"2020-02-10",{"date":156,"type":23},"2029-06",{"name":47,"class":48},4,{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":24,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":49},"100538137","initiation-of-noninvasive-ventilation-in-als-patients-with-chronic-respiratory-insufficiency-100538137","NCT06286917","Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency","InNIVALS","Inclusion Criteria:\n\n* ALS diagnosed by a neurology and\n* chronic respiratory insufficiency or significant respiratory muscle weakness caused by ALS\n\nExclusion Criteria:\n\n* impaired cognition to give informed consent to participation\n* contraindication to NIV therapy\n* another severe disease with a prognosis of less than one year\n* ventilation via an artificial airway, tracheostomy","99 Years",{"count":168,"type":23},120,[26],"This research will study whether noninvasive ventilation (NIV) used to treat chronic respiratory insufficiency in patients with amyotrophic lateral sclerosis (ALS) can be initiated as successfully in the outpatient setting as in the conventional inpatient setting, and what the costs of these alternative initiation methods are.",[172,173,174],"Ventilation Therapy","ALS","Chronic Respiratory Failure","2026-01-23",{"date":177,"type":41},"2026-01-27",{"date":179,"type":41},"2024-03-05",{"date":181,"type":23},"2029-12",{"name":47,"class":48},{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":17,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":49},"100499649","multimodal-noninvasive-assessment-of-peripheral-circulation-in-chronic-limb-threatening-ischemia-100499649","NCT05786001","Multimodal Noninvasive Assessment of Peripheral Circulation in Chronic Limb-threatening Ischemia","Evaluation of Lower Limb Angiosome Perfusion and Oxygenation Using Thermal and Hyperspectral Imaging","Inclusion Criteria:\n\n* for CLTI patients age \\>50\n* for age control group age \\>50 and not diagnosed with cardiovascular diseases. 0.9 \\\u003C ABI \\\u003C 1.3\n* for healthy group 18 \\\u003C= age \\\u003C= 50 and no history of cardiovascular disease\n* volunteering for study\n\nExclusion Criteria:\n\n* inability to give informed consent\n* denial",{"count":191,"type":23},150,"Assessment of a novel diagnostic method for screening and diagnosing chronic limb-threatening ischemia (CLTI). Using hyperspectral and thermal imaging, the perfusion and oxygenation in the lower limbs will be studied in healthy and unhealthy individuals.",[194],"Chronic Limb Threatening Ischemia",[196,197,198,199,200],"hyperspectral imaging","thermal imaging","angiosomes","CLTI","diabetes","2024-06-18",{"date":203,"type":41},"2024-06-20",{"date":205,"type":41},"2024-06-17",{"date":207,"type":23},"2025-12-31",{"name":47,"class":48},{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":217,"targetDuration":219,"studyType":59,"phases":4,"briefSummary":220,"conditions":221,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":49},"100541523","allergy-asthma-and-atopic-eczema-in-finland-100541523","NCT06330974","Allergy, Asthma, and Atopic Eczema in Finland","Allergy, Asthma, and Atopic Eczema in Finland - A Nationwide Study on Prevalence, Comorbidities, Treatment and Economic Burden","FinnATOPY","Inclusion\u002FExclusion Criteria ---\\> https:\u002F\u002Fwww.finnatopy.fi\u002Fmethods",{"count":218,"type":23},2000000,"7 Years","The summary is available at --\\> https:\u002F\u002Fwww.finnatopy.fi\u002Fsummary",[222,223,224,225,226,227],"Asthma","Asthma in Children","Allergy","Rhinitis, Allergic","Atopic Dermatitis","Allergen Immunotherapy","2024-03-19",{"date":230,"type":41},"2024-03-26",{"date":232,"type":23},"2024-10",{"date":234,"type":23},"2034-12",{"name":47,"class":48},{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":18,"minAge":244,"maxAge":245,"enrollmentInfo":246,"targetDuration":4,"studyType":24,"phases":247,"briefSummary":248,"conditions":249,"keywords":253,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":49},"100540874","dialogical-family-guidance-postdoc-study-100540874","NCT06322511","Dialogical Family Guidance PostDoc Study","The Effectiveness of Dialogical Family Guidance in Families With a Child With Neurodevelopmental Disorders","DFG II","Inclusion Criteria:\n\n* Families with a child with clinical diagnosis within neurodevelopmental ambrella (ADHD, Tourette, Autism disorder, OCD...).\n* the child must be between 4-13 years.\n\nExclusion Criteria:\n\n* Families who do not understand finnish language (because they can not fill the questionnaires and professionals offering DFG are all finnish speaking). At least one parent needs to talk finnish.\n* Families who are not motivated to receive DFG.\n* Families who do not have a child with neurodevelopmental disorders.","4 Years","13 Years",{"count":86,"type":23},[26],"This new family intervention, called Dialogical Family Guidance (DFG) is developed to target family needs especially in families with a child with neurodevelopmental disorders. PhD study showed, that this intervention is functioning with this target group. Participants (families) experienced that they got information, guidance to ordinary life and that the DFG-therapists were listening to them and above all, helping with individual problems and questions. DFG include six meetings and professionals need to attend on a 3-day long education before using this intervention.",[250,251,252],"Family Dynamics","Family Relations","Family Support",[254,255,256,257],"neurodevelopmental disorders","family health","family functionality","family support","2024-03-13",{"date":260,"type":41},"2024-03-21",{"date":262,"type":41},"2024-01-02",{"date":264,"type":23},"2027-12-31",{"name":47,"class":48},{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":18,"minAge":273,"maxAge":274,"enrollmentInfo":275,"targetDuration":4,"studyType":24,"phases":277,"briefSummary":278,"conditions":279,"keywords":281,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":293},"100395742","clinical-value-and-cost-effectiveness-of-a-personalized-prevention-program-ppp-in-patients-with-high-risk-stable-chd-100395742","NCT04433052","Clinical Value and Cost-effectiveness of a Personalized Prevention Program (PPP) in Patients With High Risk Stable CHD","A Prospective Clinical Trial to Evaluate the Clinical Value and Cost-effectiveness of a Personalized Prevention Program in Patients With High Risk Stable Coronary Heart Disease","Eligible study subjects must meet all of the following inclusion criteria:\n\n1. Informed consent form signed by the study subjects.\n2. Male or female aged 30 to 80 years on the day of enrolment.\n3. \\> 50% stenosis in one or more major coronary arteries on angiography or computerised tomography (CT) performed within the preceding one year (from enrolment visit).\n\nor Myocardial infarction (type I, II) during the preceding year.\n\nEligible study subjects must not meet any of the following exclusion criteria:\n\n1. Hospitalisation for acute coronary syndrome, myocardial infarction, stroke, coronary revascularisation or acute heart failure within the preceding one month (30 days). These subjects can be enrolled after a one-month stabilisation period, which begins from the time of the event.\n2. Subjects with NYHA class III-IV heart failure i.e. marked limitation in activity due to symptoms, comfortable only at rest.\n3. Uncontrolled arrhythmias such as ventricular tachycardias.\n4. Subjects undergoing dialysis due to severe renal disease.\n5. Diseases that severely disable exercising (per investigator's judgement), such as rheumatoid arthritis, neurological or orthopaedic diseases.\n6. Known aplastic or haemolytic anaemia.\n7. Concomitant non-coronary disease, such as malignancy that limits life expectancy to less than three years.\n8. Concurrent participation in another interventional study.\n9. Subjects not able and\u002For willing to attend all scheduled visits and comply with all study procedures and use a smartphone application.","30 Years","80 Years",{"count":276,"type":23},12000,[26],"Prospective clinical study with two parts:\n\nPART A: a prospective biomarker-based risk screening study in coronary heart disease (CHD) subjects PART B: a nested randomized clinical trial (RCT) in an enriched subpopulation of high-risk stable CHD subjects\n\nPART A: 12 000 subjects with stable CHD\n\nPART B: 2000 subjects with high risk of CV events will be randomized to usual care (UC) or personalised prevention program (PPP) i.e. 1000 subjects per arm.\n\nStudy purpose is to assess the clinical value and cost-effectiveness of a personalised prevention program (PPP) in high-risk, stable coronary heart disease (CHD) subjects and to prospectively validate risk screening biomarkers",[280],"Coronary Heart Disease",[282,280,283,284],"Prevention","Biomarkers","Lifestyle","2023-06-09",{"date":287,"type":41},"2023-06-12",{"date":289,"type":41},"2023-02-01",{"date":291,"type":23},"2026-12",{"name":47,"class":48},26,""]