[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"TecSalud Investigación Clínica\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":98},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100596458","bilateral-lumbar-decompression-via-uniportal-endoscopic-laminotomy-in-patients-with-lumbar-spinal-stenosis-multicentric-case-series-100596458",false,"NCT07045714","Bilateral Lumbar Decompression Via Uniportal Endoscopic Laminotomy in Patients With Lumbar Spinal Stenosis: Multicentric Case Series","MELD-1","Inclusion Criteria:\n\n* Provision of informed consent to participate in the study.\n* Age ≥18 years and \\\u003C75 years.\n* Patients with lumbar spinal stenosis grade I-III according to the Lee scale.\n* Radicular or myelopathic symptoms.\n* Having undergone complete conservative management, including physical therapy and analgesia, for at least 3 months.\n* Patients who have opted for ULBLD using endoscopic uniportal technique for lumbar spinal stenosis.\n\nExclusion Criteria:\n\n* Inability to read or write.\n* Prior lumbar surgeries at the levels to be treated.\n* Infectious symptoms or concomitant rheumatologic diseases.\n* Criteria of lumbar vertebral instability.\n* Congenital spinal malformations.\n* Disc herniation at the same lumbar level to be operated on.\n* Medullary hyperintensity on T2-weighted magnetic resonance imaging in the levels to be treated.","ALL","18 Years","74 Years",{"count":20,"type":21},78,"ESTIMATED","OBSERVATIONAL","Lumbar spinal stenosis is a condition that can cause pain, sensory disturbances, and motor deficits due to the compression of neural structures in the lumbar spine. While conservative treatments such as physical therapy and pain management can help some patients, others with persistent neurological deficits may require surgical intervention. Traditional surgical approaches, including open laminectomy, have proven effective but carry risks such as extensive muscle damage, considerable blood loss, postoperative spinal instability, and prolonged recovery times.\n\nThis study evaluates a minimally invasive surgical approach called unilateral laminotomy with bilateral lumbar decompression (ULBLD) using endoscopic uniportal technique as an alternative to traditional methods for patients with lumbar spinal stenosis. The main objective is to assess changes in neurological deficits and disability in patients with lumbar spinal stenosis following this procedure. The study will also document hospitalization duration, surgical time, blood loss, and the incidence of postoperative complications.\n\nThis multicenter, prospective case series will recruit 78 patients from three medical centers in Mexico. Participants must have symptomatic lumbar spinal stenosis that persists despite at least three months of conservative treatment. Eligible patients will undergo ULBLD using endoscopic uniportal technique, a method that allows precise nerve decompression through a small incision, minimizing damage to surrounding tissues. Standardized clinical assessment tools, including the Japanese Orthopaedic Association (JOA) scale for lumbar disease, Oswestry Disability Index (ODI), and Visual Analog Scale (VAS) for pain, will be used to evaluate outcomes at multiple time points over 12 months.\n\nBy comparing patients' preoperative and postoperative evaluations, the study aims to determine whether ULBLD using endoscopic uniportal technique effectively improves neurological function and reduces disability while maintaining a favorable safety profile. Findings from this study could lead to a more precise understanding of the impact of ULBLD on disability, pain, and health-related quality of life for patients with lumbar spinal stenosis.",[25],"Spinal Stenosis Lumbar",[27,28,29,30],"Lumbar Spinal Stenosis","Minimally Invasive Surgical Procedures","Endoscopic Spine Surgery","Spinal Degenerative Disease","RECRUITING","2026-03-03",{"date":34,"type":35},"2026-03-04","ACTUAL",{"date":37,"type":35},"2026-02-25",{"date":39,"type":21},"2027-07",{"name":41,"class":42},"TecSalud Investigación Clínica","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":61,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":43},"100584243","multicentric-case-series-of-uniportal-endoscopic-posterior-cervical-decompression-for-cervical-spinal-stenosis-100584243","NCT06886802","Multicentric Case Series of Uniportal Endoscopic Posterior Cervical Decompression for Cervical Spinal Stenosis","DEC-SCM","Inclusion Criteria:\n\n* Provision of informed consent to participate in the study.\n* Patients with cervical canal stenosis grade I-III according to the Kang scale.\n* Radicular or myelopathic symptoms.\n* Having undergone complete conservative management, including physical therapy and analgesia, for at least 3 months.\n* Patients who have opted for posterior uniportal endoscopic cervical decompression for cervical canal stenosis.\n\nExclusion Criteria:\n\n* Inability to read or write.\n* Prior cervical surgeries at the levels to be treated.\n* Infectious symptoms or concomitant rheumatologic diseases.\n* Criteria of cervical vertebral instability.\n* Congenital spinal malformations.\n* Disc herniation at the same cervical level to be operated on.\n* Medullary hyperintensity on T2-weighted magnetic resonance imaging in the level(s) to be treated.",{"count":52,"type":21},50,"Cervical spinal stenosis is a condition that can cause pain, sensory disturbances, and motor deficits due to the compression of neural structures in the cervical spine. While conservative treatments such as physical therapy and pain management can help some patients, others with persistent neurological deficits may require surgical intervention. Traditional surgical approaches, including anterior decompression and posterior open surgery, have proven effective but carry risks such as vascular or nerve injuries and postoperative pain.\n\nThis study evaluates a minimally invasive surgical approach called Posterior Uniportal Endoscopic Cervical Decompression as an alternative to traditional methods for patients with cervical spinal stenosis. The main objective is to assess changes in neurological deficits and disability related to cervical pain following this procedure. The study will also document hospitalization duration, surgical time, blood loss, and the incidence of postoperative complications.\n\nThis multicenter, prospective case series will recruit 50 patients from three medical centers in Mexico. Participants must have symptomatic cervical spinal stenosis that persists despite at least three months of conservative treatment. Eligible patients will undergo Posterior Uniportal Endoscopic Cervical Decompression, a technique that allows precise nerve decompression through a small incision, minimizing damage to surrounding tissues. Standardized clinical assessment tools, including the modified Japanese Orthopaedic Association (mJOA) scale, Neck Disability Index (NDI), and Visual Analog Scale (VAS) for pain, will be used to evaluate outcomes at multiple time points over 12 months.\n\nBy comparing patients' preoperative and postoperative evaluations, the study aims to determine whether Posterior Uniportal Endoscopic Cervical Decompression effectively improves neurological function and reduces disability while maintaining a favorable safety profile. Findings from this study could support the adoption of minimally invasive endoscopic techniques as a viable option for treating cervical spinal stenosis, potentially leading to faster recovery times and reduced surgical complications compared to traditional methods.",[55],"Spinal Stenosis Cervical",[57,58,59,60],"Cervical Spinal Stenosis","► Minimally Invasive Surgical Procedures","► Endoscopic Spine Surgery","► Spinal Degenerative Disease",{"date":34,"type":35},{"date":63,"type":35},"2026-02-18",{"date":65,"type":21},"2027-02",{"name":41,"class":42},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":43},"100605039","iron-metabolism-in-obesity-100605039","NCT07157332","Iron Metabolism in Obesity","Dysregulation of Iron Metabolism in Obese Individuals and Its Implications for Metabolic Health","IRON-XL","Inclusion Criteria:\n\n* Male and female participants aged 18 to 50 years.\n* Premenopausal women (defined as no absence of menstruation in the past 12 months).\n* Body Mass Index (BMI) between 35 and 45 kg\u002Fm² at recruitment.\n* Scheduled to undergo bariatric surgery via sleeve gastrectomy or laparoscopic adjustable gastric banding (LAGB), with indications aligned with international guidelines. Bariatric surgery eligibility includes:\n\n  1. BMI between 35 and 45 kg\u002Fm² with the presence of obesity-related comorbidities (medical, physical, or psychosocial conditions), and a history of unsuccessful attempts at sustained weight loss through non-surgical means.\n  2. Adequately informed, understanding and accepting the potential risks and benefits of the procedure, and expressing commitment to adhere to long-term dietary and physical activity recommendations post-surgery.\n* Willing to maintain consistent dietary iron intake and refrain from taking any iron supplements other than those prescribed by the attending surgeon throughout the study duration.\n* Not pregnant during the study period or in the six months prior to enrollment, and not planning to become pregnant for at least 3 months after the final study visit (at 6 months).\n* Not breastfeeding in the six weeks prior to enrollment, nor planning to breastfeed during the study.\n* No significant weight loss (≥10% of body weight) in the six months prior to the pre-surgical evaluation.\n* Signed informed consent.\n* No night shift work during the two weeks prior to the baseline visit or at any point during the study (night shift defined as work performed between 12:00 AM and 6:00 AM).\n* Not engaging in strenuous physical activity ≥10 hours per week.\n\nExclusion Criteria:\n\n* Participants who have undergone any bariatric procedure other than LAGB or sleeve gastrectomy.\n* Severe anemia (defined as hemoglobin \\\u003C100 g\u002FL).\n* History of previous surgical obesity treatments.\n* Presence of significant medical conditions that may affect iron status or inflammatory markers independently of obesity, including but not limited to: cancer, HIV\u002FAIDS, inflammatory bowel disease, gastrointestinal bleeding, rheumatoid arthritis, and chronic kidney disease (per investigator's judgment).\n* Diagnosed abnormalities in iron metabolism based on routine pre-surgical blood samples and unrelated to obesity (e.g., thalassemia).\n* History of frequent blood transfusions.\n* Chronic liver disease (e.g., alcoholic liver disease, hepatitis C-related liver disease).\n* Use of medications that could interfere with study measurements (per investigator's judgment).\n* Women consuming ≥14 alcoholic beverages per typical week or men consuming \\>21 alcoholic beverages per typical week.","50 Years",{"count":52,"type":21},"This study consists of two phases and aims to understand how obesity and systemic iron deficiency affect iron accumulation in important organs such as the liver and heart, as well as oxidative stress in fat tissue cells. In Phase 1, researchers will compare individuals with obesity who have iron deficiency to those without, to see if there are differences in the amount of iron stored in the liver and heart, measured by magnetic resonance imaging (MRI), and in oxidative stress and labile iron in visceral and subcutaneous fat tissue, assessed through biopsies. Phase 2 is a six-month prospective cohort study following the same individuals after they undergo bariatric surgery, a weight-loss surgery. The goal is to evaluate whether weight and fat loss normalize iron accumulation in the liver and heart, reduce oxidative stress, improve systemic iron metabolism, enhance blood sugar control, support liver function, modulate chronic inflammation, and restore gut microbiota diversity. Researchers will compare these health changes between individuals with and without iron deficiency. The study includes adults aged 18 to 50 with obesity living in the metropolitan area of Monterrey, Mexico, who are scheduled for laparoscopic sleeve gastrectomy surgery and agree to participate. The findings could improve understanding of how iron metabolism interacts with obesity-related complications and may lead to better treatments and management strategies for people with obesity and iron deficiency.",[79],"Obesity (Disorder)",[81,82,83,84,85,86,87,88],"Obesity","Weight loss","Iron metabolism","Metabolic health","Bariatric surgery","Body composition","Inflammation markers","Dietary assessment","NOT_YET_RECRUITING","2025-08-28",{"date":92,"type":35},"2025-09-05",{"date":94,"type":21},"2025-09-15",{"date":96,"type":21},"2027-08-15",{"name":41,"class":42},""]