[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Technical University of Madrid\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":109},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100581945","behavioral-and-adherence-model-for-improving-quality-health-outcomes-and-cost-effectiveness-of-healthcare-100581945",false,"NCT06856902","BEhavioral and Adherence Model for Improving Quality, Health Outcomes and Cost-Effectiveness of healthcaRe","BEAMER","Inclusion Criteria:\n\n* Having the diagnosis of the pilot sites target groups described above as per clinical assessment or validated diagnosis criteria\n* Having the age of the pilot sites target groups described above\n* Having accepted to participate in the study and provided written informed consent\n* Having the availability to participate on all study activities\n\nExclusion Criteria:\n\n* Individuals that do not fulfil ALL the inclusion criteria will be excluded to participate.","ALL",{"count":18,"type":19},3100,"ESTIMATED","INTERVENTIONAL",[22],"NA","Lack of adherence to treatment is a widespread issue worldwide, which leads to higher healthcare utilisation rates and even premature death. While the level of adherence may differ based on the specific condition and treatment, studies estimate that approximately 50% of medications are not taken according to the prescribed instructions. In addition, adherence rates tend to decrease even further when the treatment requires a behavioural change. Literature reviews about factors that affect people's adherence show that it is challenging to predict whom can be considered to have adherent and non-adherent behaviours. In addition, the studies highlight that it is challenging to support a person to be adherent. Based on this knowledge the BEAMER project was established (Behavioural and Adherence Model for improving quality, health outcomes and cost-Effectiveness of healthcaRe). The overall goal of the project is to improve the quality of life of individuals, enhance healthcare accessibility and sustainability, thereby transforming the way healthcare stakeholders engage with patients to understand their condition and adherence levels throughout their healthcare journey. To address the overall goal, the BEAMER project has developed a disease agnostic model named \"B-COMPASS: BEAMER-COmputational Model for Patient Adherence and Support Solutions\". The aim of the B-COMPASS is to identify patients' needs and preferences which enables the creation of patient-specific supports, with the intention of improving their adherence to treatment within the heterogeneity of the different disease-areas and healthcare contexts. Based on the validated BEAMER questionnaire, the B-COMPASS predicts relative adherence and offers an elicitation process of patient needs and preferences to enable targeted supports to improve patient adherence. This results in an allocation of patients to different groups based on their needs and preferences. Overall, the B-COMPASS provides patient insights that will enable more effective design of patient support, most likely resulting in better patient experience, improved adherence and lower healthcare and societal costs.\n\nSo far, several activities from a technical and user perspective have already been conducted in the project to refine the B-COMPASS. This has been done by applying an iterative mixed method approach were both stakeholders (regulator, pharma, academic\u002Fresearch and small and medium-sized enterprises) and end users (patients, health providers and health systems) have been involved. Despite the finetuning of the B-COMPASS, the effectiveness of the B-COMPASS hinges on empirical investigations into the structural elements that impact patient behaviour and the identification of predictive factors that can assist healthcare providers' (HCP) and Research Leads in designing more effective treatment plans (the term HCPs\u002FResearch Lead include both the individuals and the institutions where care is delivered). Therefore, validation studies will be conducted to assess the B-COMPASS's performance in six therapeutic areas (cardiovascular, endocrinology, immunology, neurology, oncology and rare diseases) with patients recruited in at least Italy (FISM), Portugal (APDP and MEDIDA) Norway (AHUS), Spain (FHUNJ and FIIBAP), The Netherlands (WDO), and Germany (UDUS). The collected data will be used to evaluate the B-COMPASS's capacity to attend to a variety of needs and challenges for adherence.",[25,26,27,28,29,30],"Cardiovascular Diseases","Endocrinology","Inmunology","Neurology","Oncology","Rare Diseases",[32,33,34],"Digital health","adherence to treatment","healthcare","RECRUITING","2026-03-26",{"date":38,"type":39},"2026-04-01","ACTUAL",{"date":41,"type":39},"2025-03-01",{"date":43,"type":19},"2026-09-30",{"name":45,"class":46},"Technical University of Madrid","OTHER",10,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":20,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100524087","erythrocyte-transport-of-lactate-during-exercise-tele-project-100524087","NCT06104150","Erythrocyte Transport of Lactate During Exercise (TELE Project)","Transporte Eritrocitario de Lactato en Ejercicio","TELE","Inclusion Criteria:\n\n* BMI between 18 and 25 kg\u002Fm2\n* Not smoker\n* In the case of trained participants: training at least 5 hours\u002Fweek, of which at least 3 must be aerobic\u002Fanaerobic endurance training. Presentation of a medical certificate attesting to their medical fitness (capability) to perform intense physical exercise.\n* In the case of sedentary participants, less than 1 day of training per week or less than 2 hours of structured exercise per week.\n\nExclusion Criteria:\n\n* Presenting any pathology that could impede the correct performance of the tests, or could influence the main study variables.\n* In the case of the female sample, having irregular menstrual cycles, oligomenorrhea or amenorrhea.",true,"18 Years","30 Years",{"count":60,"type":19},84,[22],"The goals of this clinical trial are:\n\n1. to study lactate kinetic between plasma and erythrocytes during an intervallic exercise and its subsequent recovery, considering the blood pH, the genotype for the T1470A polymorphism of the SLC16A1 gene (rs1049434), and the amount of MCT1 in erythrocytes membrane;\n2. to analyze the levels of MCT1 in the erythrocytes membrane according to training status and genotype for the T1470A polymorphism of SLC16A1 (rs1049434).\n\nFor this, the project will have two phases:\n\n* In phase I, trained participants will perform one maximal incremental test and one intervallic submaximal test with a final active recovery.\n* Phase II, levels of the MCT1 protein in the erythrocyte membrane will be quantified from trained and sedentary participants.",[64],"Energy Metabolism",[66,67,68,69,70],"lactate kinetics","MCT1","erythrocyte lactate","T1470A polymorphism","exercise","2025-09-05",{"date":73,"type":39},"2025-09-12",{"date":75,"type":39},"2020-02-03",{"date":77,"type":19},"2027-07-31",{"name":45,"class":46},2,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":56,"sex":16,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},"100594870","the-link-between-physical-activity-and-brain-health-in-healthy-adults-100594870","NCT07025070","The Link Between Physical Activity and Brain Health in Healthy Adults","The Link Between Strength and Endurance Training and Brain Health in Healthy Adults: A Comparative Study of Former Professional Athletes and Sedentary Individuals","MINA","Inclusion Criteria:\n\n* Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days\u002Fweek of moderate-vigorous intensity).\n* Group B: sedentary individuals, (i.e., perform \\\u003C150 min of moderate intensity exercise per week or IPAQ score\\\u003C600 MET min\u002Fweek).\n* In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.\n* Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition\n\nExclusion Criteria:\n\n* Medical conditions that have a high risk of associated cognitive symptoms.\n* Severe head injury with loss of consciousness within the previous 5 years.\n* Alcoholism (\\>3 alcoholic drinks per day).\n* Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.\n* Hearing or visual impairment that would preclude testing\n* History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).\n* Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).\n* Presence of severe systemic disease (e.g., cancer under treatment).\n* Consumption of anabolic substances.\n* Problems understanding spoken or written Spanish.\n* Those with pacemakers or metallic implants that may interfere with the MRI.","40 Years","75 Years",{"count":91,"type":19},60,"OBSERVATIONAL","The goal of this observational study is to investigate the cross-sectional relationship between physical activity and brain health from a multiscale approach (neuropsychology, neuroimaging, peripheral biomarkers and genetics) in former athletes and sedentary individuals. The main question it aims to answer is:\n\nDo former athletes have better brain structure than sedentary people? Evaluating the differences in neurodegenerative processes between competitive training and sedentary and inactivity.",[95,96,97],"Alzheimer Disease","Inactivity","Preventive Therapy",[99],"physical activity","2025-06-09",{"date":102,"type":39},"2025-06-17",{"date":104,"type":39},"2024-11-25",{"date":106,"type":19},"2026-09",{"name":45,"class":46},1,""]