[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tel Aviv University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":511},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,40,66,100,128,155,179,200,230,256,283,308,333,377,403,424,441,465,488],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100641178","exposure-by-assessment-effects-of-daily-amq-based-ema-of-an-intrusive-trauma-memory-in-ptsd-100641178",false,"NCT07658157","Exposure by Assessment: Effects of Daily AMQ-Based EMA of an Intrusive Trauma Memory in PTSD","Inclusion Criteria:\n\n* Adults aged 18-70\n* Posttraumatic stress disorder\n* intrusive symptoms.\n\nExclusion Criteria:\n\n* Psychotic or bipolar disorder\n* Heavy use of drugs or alcohol\n* Prominent personality disorder\n* Significant risk of harm to self or others\n* Current trauma-focused treatment\n* Reporting intrusions as thoughts only rather than as memories","ALL","18 Years","70 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","Intrusive re-experiencing is a hallmark of PTSD. The study applies ecological momentary assessment (EMA) of participants' trauma memories (active group) vs. EMA of a neutral memory (control group) to test whether the active intervention can reduce intrusive symptoms severity and overal PTSD symptom severity in general.",[26],"PTSD","RECRUITING","2026-06-20",{"date":30,"type":31},"2026-06-25","ACTUAL",{"date":33,"type":31},"2026-06-14",{"date":35,"type":20},"2027-06",{"name":37,"class":38},"Tel Aviv University","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":56,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":39},"100644084","efficacy-of-attention-bias-modification-vs-placebo-for-social-anxiety-disorder-100644084","NCT07666776","Efficacy of Attention Bias Modification vs. Placebo for Social Anxiety Disorder","Placebo Effects in Dot-Probe Attention Bias Modification (ABM) Among Adults With Social Anxiety Disorder.","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Primary diagnosis of generalized Social Anxiety Disorder based on clinical evaluation, the MINI International Neuropsychiatric Interview (MINI), and a Liebowitz Social Anxiety Scale (LSAS) score greater than 50\n* Normal or corrected-to-normal vision without color blindness\n* Sufficient Hebrew proficiency to complete clinical interviews, self-report questionnaires, and computerized cognitive tasks\n\nExclusion Criteria:\n\n* Previous participation in attention bias modification training using a dot-probe task\n* Previous participation in eye-tracking-based attention training\n* Current diagnosis of Post-Traumatic Stress Disorder\n* Current or past diagnosis of psychotic disorder or bipolar disorder\n* Neurological disorder (e.g., epilepsy or traumatic brain injury)\n* Severe suicidal ideation\n* Current substance or alcohol use disorder\n* Concurrent pharmacological or psychosocial treatment, unless medication has been stable for at least 45 days\n* Pregnancy\n* Uncorrected visual impairment or use of multifocal glasses","65 Years",{"count":49,"type":20},90,[23],"This study examines whether a computerized attention-training intervention called attention bias modification (ABM) can reduce symptoms of social anxiety disorder (SAD) in adults, and whether symptom improvement is specifically related to changes in attentional processing or to nonspecific factors such as expectancy and placebo effects.",[53,54,55],"Social Anxiety Disorder (SAD)","Attention Bias Modification Treatment (ABMT)","Placebo Effect",[57],"Social Anxiety; Placebo; Treatment; Attention Bias","2026-06-18",{"date":60,"type":31},"2026-06-24",{"date":62,"type":31},"2026-06-15",{"date":64,"type":20},"2027-06-30",{"name":37,"class":38},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":15,"minAge":74,"maxAge":16,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":39},"100642442","brief-crisis-therapy-for-suicidal-children-and-adolescents-100642442","NCT07627243","Brief Crisis Therapy for Suicidal Children and Adolescents","Ultra-Brief Crisis IPT-A Based Intervention for Suicidal Children and Adolescents (IPT-A-SCI): Understanding Mechanisms of Change","IPT-A-SCI","Inclusion Criteria:\n\n* Children and adolescents aged 8-18 years presenting with suicidal ideation or behavior\n* Suicide risk assessment indicating suitability for outpatient treatment,\n* Fluency in Hebrew\n* Ability to attend five weekly treatment sessions\n* Written informed consent provided by parents or legal guardians\n* Written informed assent\u002Fconsent provided by participants in accordance with age and local ethical regulations\n\nExclusion Criteria:\n\n* Acute medical or psychiatric condition requiring immediate inpatient treatment\n* Linguistic, developmental, neurological, or intellectual limitations that prevent understanding of the treatment protocol or study procedures\n* Inability to participate in outpatient psychotherapy","8 Years",{"count":76,"type":20},120,[23],"The goal of this clinical trial is to learn if the Ultra-Brief Interpersonal Psychotherapy for Adolescents with Suicidal Ideation (IPT-A-SCI) works to reduce suicidal thoughts and behaviors in children and adolescents. The study will also examine whether treatment effects continue after treatment ends and whether some participants benefit more from the intervention than others. The main questions it aims to answer are:\n\nDoes IPT-A-SCI reduce suicidal thoughts and behaviors in children and adolescents? Do the effects of IPT-A-SCI continue three months after treatment ends? Do some children and adolescents benefit more from IPT-A-SCI than others?\n\nParticipants will:\n\nReceive IPT-A-SCI treatment consisting of five weekly sessions Complete questionnaires before treatment, during treatment, at the end of treatment, and three months after treatment ends Have their parents complete questionnaires at the same time points",[80,81],"Suicidal Ideation","Suicidal Behavior",[83,84,85,86,87,88,89,90],"suicidal ideation","suicidal behavior","Interpersonal psychotherapy","children","adolescents","Suicide prevention","Safety planning","Brief intervention","NOT_YET_RECRUITING","2026-06-08",{"date":94,"type":31},"2026-06-11",{"date":96,"type":20},"2026-06",{"date":98,"type":20},"2028-06",{"name":37,"class":38},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":107,"sex":15,"minAge":16,"maxAge":47,"enrollmentInfo":108,"targetDuration":4,"studyType":110,"phases":4,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":4},"100639591","within-individual-variability-of-resting-metabolic-rate-over-12-weeks-100639591","NCT07628764","Within-Individual Variability of Resting Metabolic Rate Over 12 Weeks","Within-Individual Variability of Resting Metabolic Rate Assessed Repeatedly Over 12 Weeks Using Whole-Room Calorimetry","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Clinically healthy individuals\n* Stable body weight (±2 kg) over the past 3 months\n* Ability and willingness to attend morning measurements three times per week for 12 weeks\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known uncontrolled endocrine or metabolic disease\n* Use of medications known to significantly affect resting metabolic rate (e.g., systemic corticosteroids, unstable thyroid hormone therapy)\n* Acute illness within 14 days prior to enrollment\n* Pregnancy or lactation\n* Any medical condition that, in the opinion of the investigators, may interfere with safe participation",true,{"count":109,"type":20},30,"OBSERVATIONAL","This prospective observational study aims to characterize within-individual variability in resting metabolic rate (RMR) over a 12-week period using high-frequency repeated measurements under standardized conditions. Participants will undergo RMR assessments three times per week using whole-room indirect calorimetry.\n\nThe study will quantify the magnitude of physiological variability in RMR, distinguish true biological variation from measurement error, and estimate the minimal detectable change required to identify meaningful metabolic adaptations.",[113,114],"Resting Metabolic Rate","Energy Metabolism",[113,116,117,118,119],"Energy Expenditure","Metabolism","Indirect Calorimetry","Variability","2026-06-01",{"date":122,"type":31},"2026-06-05",{"date":124,"type":20},"2026-07",{"date":126,"type":20},"2027-12",{"name":37,"class":38},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":107,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":21,"phases":137,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":153,"leadSponsor":154,"locationsCount":4},"100639295","weight-loss-composition-and-metabolic-adaptation-during-hypocaloric-dieting-100639295","NCT07627256","Weight Loss Composition and Metabolic Adaptation During Hypocaloric Dieting","The Relationship Between Weight Loss Composition, Body Composition Changes, and Metabolic Adaptation During a Hypocaloric Dietary Intervention","Inclusion Criteria\n\n* Adults aged 18 years and older.\n* Individuals living with overweight or obesity.\n* Willingness and ability to comply with dietary recommendations and study procedures.\n* Provision of written informed consent.\n\nExclusion Criteria\n\n* Diagnosed metabolic or endocrine disorders known to affect energy expenditure.\n* Use of medications known to substantially affect metabolism or body composition.\n* Pregnancy or breastfeeding.\n* Any medical condition that, in the opinion of the investigators, precludes safe participation.",{"count":136,"type":20},150,[23],"Weight loss induced by hypocaloric dietary interventions is commonly accompanied by reductions in resting metabolic rate (RMR), a phenomenon often described as metabolic adaptation. The magnitude of this decline varies substantially between individuals and may depend not only on the amount of weight lost but also on the composition of weight loss, particularly the relative contributions of fat mass and fat-free mass.\n\nThis prospective interventional study will investigate whether changes in body composition during a hypocaloric dietary intervention are associated with changes in RMR and metabolic adaptation. Approximately 150 adults with overweight or obesity will participate in a structured dietary program designed to induce moderate energy restriction. Body composition and resting metabolic rate will be assessed before and after the intervention to evaluate associations between fat mass loss, fat-free mass loss, and metabolic responses to weight reduction.",[140],"Obesity",[142,143,144,145,146,147,148],"Weight loss","Metabolic adaptation","Resting metabolic rate","Body composition","Fat-free mass","Energy expenditure","Hypocaloric diet","2026-05-31",{"date":151,"type":31},"2026-06-04",{"date":96,"type":20},{"date":126,"type":20},{"name":37,"class":38},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":107,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":21,"phases":163,"briefSummary":164,"conditions":165,"keywords":167,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":177,"leadSponsor":178,"locationsCount":39},"100639386","inter-individual-variability-in-early-diet-induced-thermogenesis-after-a-standardized-meal-100639386","NCT07610759","Inter-Individual Variability in Early Diet-Induced Thermogenesis After a Standardized Meal","Inter-Individual Variability in Early Postprandial Thermogenesis Following a Standardized Liquid Meal","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Stable body weight (±2 kg over the previous 3 months)\n* Generally healthy individuals\n* Ability to comply with study procedures, including fasting and remaining at rest - during measurements\n\nExclusion Criteria:\n\n* Use of medications known to affect metabolism (e.g., GLP-1 receptor agonists, systemic corticosteroids, uncontrolled thyroid disease)\n* Insulin-treated diabetes\n* Pregnancy or lactation\n* Acute illness at the time of testing\n* Inability to comply with pre-test requirements (e.g., fasting, avoiding caffeine, alcohol, or physical activity)",{"count":109,"type":20},[23],"This study aims to characterize how individuals differ in their metabolic response to food intake, specifically focusing on early diet-induced thermogenesis (DIT). DIT refers to the increase in energy expenditure that occurs after eating and reflects the body's metabolic response to processing nutrients.\n\nHealthy adult participants will complete a single laboratory visit under standardized conditions. Resting metabolic rate will first be measured, followed by consumption of a standardized liquid meal (550 kcal). Energy expenditure will then be continuously monitored for 3 hours using indirect calorimetry.\n\nThe primary objective is to quantify inter-individual variability in early postprandial thermogenesis. Rather than estimating total daily energy expenditure, this study focuses on the early metabolic response following meal ingestion. Findings will improve understanding of differences in metabolic efficiency between individuals and support future research in metabolism and personalized nutrition.",[166],"Diet-induced Thermogenesis",[168,169,147,170,171,172],"Diet-induced thermogenesis","Postprandial metabolism","Metabolic variability","Indirect calorimetry","Standardized meal","2026-05-27",{"date":175,"type":31},"2026-05-28",{"date":96,"type":20},{"date":35,"type":20},{"name":37,"class":38},{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":107,"sex":15,"minAge":16,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":110,"phases":4,"briefSummary":188,"conditions":189,"keywords":191,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":198,"leadSponsor":199,"locationsCount":39},"100637572","family-patterns-in-resting-metabolic-rate-between-parents-and-adult-children-100637572","NCT07594613","Family Patterns in Resting Metabolic Rate Between Parents and Adult Children","Familial Determinants of Resting Metabolic Rate: A Parent-Adult Child Comparative Study","Inclusion Criteria:\n\n* Biological parent-adult child pairs\n* Adult children aged ≥18 years\n* Parents aged 40-60 years\n* Ability to comply with study procedures, including fasting and resting conditions\n* Generally healthy individuals without acute illness\n\nExclusion Criteria:\n\n* Current weight loss or active dieting\n* Known metabolic disorders (e.g., thyroid disease)\n* Use of medications affecting metabolic rate\n* Pregnancy\n* Acute illness at the time of testing\n* Inability to comply with pre-test requirements (e.g., fasting, avoiding exercise or caffeine)","60 Years",{"count":109,"type":20},"This study examines whether resting metabolic rate (RMR)-the amount of energy the body uses at rest-is similar between biological parents and their adult children (aged 18 years and older). RMR is the largest component of daily energy expenditure and plays an important role in body weight regulation and overall metabolic health.\n\nParticipants from the same family will undergo a single testing session in a metabolic laboratory. RMR will be measured using indirect calorimetry under standardized conditions, along with body composition assessment and basic health information.\n\nThe primary goal is to determine whether RMR is correlated within families. The study will also assess whether these similarities remain after accounting for differences in body composition, age, and sex.\n\nThis observational study will help improve understanding of how metabolism varies between individuals and the extent to which these differences may be influenced by familial or inherited factors. Findings may contribute to future research on personalized nutrition, obesity risk, and metabolic health.",[113,190],"Metabolism Disorders",[144,147,192,145,193],"Heritability","metabolic disorder","2026-05-13",{"date":196,"type":31},"2026-05-19",{"date":96,"type":20},{"date":35,"type":20},{"name":37,"class":38},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":107,"sex":207,"minAge":16,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":21,"phases":211,"briefSummary":212,"conditions":213,"keywords":215,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":4},"100626632","protein-distribution-and-leucine-supplementation-effects-on-body-composition-and-performance-in-tactical-athletes-100626632","NCT07438158","Protein Distribution and Leucine Supplementation Effects on Body Composition and Performance in Tactical Athletes","The Effect of Protein Distribution and Leucine Supplementation on Body Composition, Physical Performance, and Myofibrillar Damage in Tactical Athletes: a Randomized Controlled Trial During 8 Weeks of Intensive Training","Inclusion Criteria:\n\n* Male participants aged 18-35 years\n* Enrolled in an active Ministry of Defense tactical training program\n* Physically active and medically cleared to participate in intensive training\n* Willing and able to comply with the dietary intervention and training protocol\n* Provide written informed consent prior to participation\n\nExclusion Criteria:\n\n* Musculoskeletal or neuromuscular injury or impairment limiting participation in exercise training\n* Cardiopulmonary disease (including recent myocardial infarction or unstable angina)\n* History of cancer, diabetes, thyroid disease, hypertension, or chronic renal failure\n* Cognitive impairment affecting ability to provide informed consent\n* Use of medications that may affect metabolism, muscle physiology, or exercise performance\n* Known allergy or intolerance to study dietary components or leucine supplementation\n* Non-compliance with study protocol requirements","MALE","35 Years",{"count":210,"type":20},69,[23],"This randomized controlled trial will examine the effects of within-day protein distribution and leucine supplementation on body composition, physical performance, and biomarkers of muscle damage in tactical athletes during an 8-week intensive training program. Sixty-nine healthy male participants (18-35 years) enrolled in a Ministry of Defense training course will be randomly assigned to one of three iso-caloric dietary groups providing 1.6 g\u002Fkg\u002Fday of protein: (1) evenly distributed protein across three meals (EVEN), (2) a 16-hour daily protein fasting pattern with protein concentrated at lunch and dinner (FAST), or (3) the same fasting pattern with 5 g leucine supplementation at breakfast (FAST-RESCUE).\n\nPrimary outcomes include changes in lean body mass. Secondary outcomes include strength, anaerobic performance, and biochemical markers of muscle damage, including urinary titin N-terminal fragment (UTF). Assessments will be conducted at baseline, Week 5, and Week 8.",[214],"Muscle Damage",[216,217,218,219,220,221],"Tactical Athletes","Protein Distribution","Leucine Supplementation","Lean Body Mass","Muscle Protein Synthesis","Resistance Training","2026-02-26",{"date":224,"type":31},"2026-03-02",{"date":226,"type":20},"2026-03",{"date":228,"type":20},"2028-12",{"name":37,"class":38},{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":237,"targetDuration":4,"studyType":21,"phases":239,"briefSummary":240,"conditions":241,"keywords":245,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":39},"100627245","adjunctive-diode-laser-therapy-in-non-surgical-periodontal-therapy-100627245","NCT07446127","Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy","Evaluation of the Effect of Adjunctive Diode Laser Therapy in Mechanical Scaling and Root Surface Debridement in Non-Surgical Periodontal Therapy","Inclusion Criteria:\n\n1. Systemically healthy patients\n2. Each patient should have more than 20 teeth remaining, and at least 5 teeth per quadrant\n3. Each patient presented ≥ 30% of sites involved\n4. At least 2 teeth with a probing depth of ≥ 5 mm in each quadrant, with evident radiographic bone loss.\n\nExclusion Criteria:\n\n1. History of systemic diseases affecting the periodontium\n2. Smokers and alcoholic patients\n3. Use of medication within the last 6 months, which might affect the periodontal status\n4. Pregnant and lactating women\n5. Patients who had any periodontal treatment ≤ 12 months before the examination.",{"count":238,"type":20},20,[23],"The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office. The main question it aims to answer is:\n\nTo compare the clinical effectiveness of adjunctive application of a 940-nm diode laser with root surface debridement to the effectiveness of root surface debridement alone.\n\nThis study is a split-mouth design, where each quadrant will be randomly allocated to one of the following groups:\n\nControl group (root surface debridement - RsD): scaling and root planing alone. Laser group (RsD + laser): scaling and root planing with adjunctive diode laser therapy Quadrants will be randomly allocated to the treatment groups",[242,243,244],"Periodontal Disease","Periodontal Pockets","Periodontal Attachment Loss",[246,247],"diode laser","non surgical periodontal treatment","2026-02-25",{"date":250,"type":31},"2026-03-03",{"date":252,"type":31},"2026-01-01",{"date":254,"type":20},"2026-12-31",{"name":37,"class":38},{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":15,"minAge":263,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":21,"phases":267,"briefSummary":268,"conditions":269,"keywords":271,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":280,"leadSponsor":282,"locationsCount":39},"100626038","improving-self-regulation-in-individuals-with-adhd-through-adapted-karate-training-100626038","NCT07430436","Improving Self-regulation in Individuals With ADHD Through Adapted Karate Training","Improving Self-regulation, Social Participation, and Functional Performance in Individuals With ADHD Through Adapted Karate Training: A Randomized Controlled Crossover Trial","Inclusion Criteria:\n\n* Diagnosed by a developmental neurologist with ADHD\n* Age 6-12 years\n* Fluent in Hebrew\n\nExclusion Criteria:\n\n* Comorbidity with another psychiatric or neurological diagnosis, or a developmental syndrome\n* Chronic pain\n* enrolled in a special education system\n* substance abuse (i.e., reporting more than 10 cups of alcohol a week)\n* currently participating in other non-pharmaceutical therapies (e.g., cognitive therapies) started during the past 6 months.","6 Years","12 Years",{"count":266,"type":20},55,[23],"The goal of this clinical trial is to examine the effectiveness of Adaptive Karate Training (AKT) in improving self-regulation and daily function in children with ADHD, exploring the underlying mechanisms.\n\nThe main questions it aims to answer are:\n\n1. Is the AKT more effective than no karate training in enhancing functional performance, self-regulation and school QoL?\n2. Are poorer executive functions, emotional regulation, and sensory processing associated with higher gains?\n\nResearchers will compare two sequences: (1) A group receiving AKT followed by a no-intervention period; (2) A group receiving no intervention, followed by the AKT intervention, to see if differences are observed between intervention and no-intervention periods, both between groups and within participants over time.\n\nParticipants will engage in AKT sessions twice a week, each session lasting 60 minutes, over a period of two months.",[270],"Attention Deficit Hyperactivity Disorder",[270,272,273,274,275],"Self Regulation","Karate","Occupational Therapy","Participation","2026-02-23",{"date":278,"type":31},"2026-02-24",{"date":222,"type":20},{"date":281,"type":20},"2027-12-30",{"name":37,"class":38},{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":47,"enrollmentInfo":290,"targetDuration":4,"studyType":21,"phases":292,"briefSummary":293,"conditions":294,"keywords":296,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":305,"leadSponsor":307,"locationsCount":39},"100621004","gaze-contingent-attentional-reinforcement-in-major-depressive-disorder-100621004","NCT07364981","Gaze Contingent Attentional Reinforcement in Major Depressive Disorder","Gaze Contingent Attentional Reinforcement Treatment of MDD","Inclusion Criteria:\n\n* Primary diagnosis of MDD\n* MADRS\\>=7\n* Normal or corrected-t-normal vision\n\nExclusion Criteria:\n\n* Present or past psychosis, manic or hypomanic episode, PTSD\n* High suicidal ideation or behavior\n* Severe alcohol or cannabis use disorder, and\u002For any severity of other substance use disorder (exepct nicotine use)\n* Pharmacological treatment if not stabilized for at least three months or concurrent psychotherapy\n* Current unstable or untreated medical illness\n* Current or past organic mental disorder, seizure or brain injury\n* Eye-tracking calibration difficulties\n* Post-ECT treatment",{"count":291,"type":20},60,[23],"The main objective of this randomized controlled trial is to evaluate whether a gaze-contingent feedback task using negative reinforcement can serve as an effective attention-modification procedure and contribute to the treatment of Major Depressive Disorder (MDD).",[295],"Major Depressive Disorder (MDD)",[297,298,299,300],"MDD","attention allocation","positive reinforcement","negative reinforcement","2026-01-18",{"date":303,"type":31},"2026-01-23",{"date":252,"type":20},{"date":306,"type":20},"2030-01-01",{"name":37,"class":38},{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":11,"sex":15,"minAge":315,"maxAge":316,"enrollmentInfo":317,"targetDuration":4,"studyType":21,"phases":318,"briefSummary":319,"conditions":320,"keywords":322,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":39},"100596659","cognitive-behavioral-therapy-for-insomnia-in-school-aged-children-100596659","NCT07048340","Cognitive-behavioral Therapy for Insomnia in School-aged Children","The Role of Sleep Restriction Therapy in Cognitive-behavioral Therapy for Insomnia in School-aged Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Child aged 7-11 years\n* Parents aged over 18 years\n* Child meets the International Classification of Sleep Disorders - Third Edition (ICSD-3) criteria for chronic insomnia disorder with sleep difficulties occurring at least 3 times a week and lasting at least 3 months (Insomnia diagnosis will be determined during a clinical interview).\n\nExclusion Criteria:\n\n* Child receiving concurrent CBT treatment for sleep or anxiety disorders.\n* Child diagnosed with a medical sleep problem (e.g., OSA, RLS)\n* Significant health or neurodevelopmental problems (e.g., intellectual disability)\n* Current psychotropic medications, or sleep aid medications\n* Lack of Hebrew reading and writing\n* Total sleep time that is shorter than 6 hours on average per night at baseline","7 Years","11 Years",{"count":76,"type":20},[23],"This randomized controlled trial will test the efficacy of CBT-I intervention for school-aged children (7-11 years old) with insomnia. The trial will focus on the role of sleep restriction therapy in treatment. Children will be randomized to one of three groups: (1) CBT-I; (2) CBT-I without SRT; or (3) a waitlist control group. Assessments will occur at baseline, mid-treatment, post-treatment, and a 3-month follow up. Some measures (e.g., child motivation) will also be assessed after each therapy session. Insomnia and sleep-wake patterns will be assessed objectively using actigraphy, and subjectively using sleep diaries, a clinical diagnostic interview, and questionnaires. Parent and child questionnaires will be administered to assess moderators and mediators of treatment outcomes.",[321],"Insomnia",[321,323,324],"Pediatric insomnia","CBT-I","2025-09-13",{"date":327,"type":31},"2025-09-18",{"date":329,"type":31},"2025-07-10",{"date":331,"type":20},"2029-12-01",{"name":37,"class":38},{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":339,"eligibilityCriteria":340,"healthyVolunteers":11,"sex":15,"minAge":341,"maxAge":16,"enrollmentInfo":342,"targetDuration":4,"studyType":21,"phases":344,"briefSummary":345,"conditions":346,"keywords":355,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":376},"100587531","shiatsu-for-chronic-non-inflammatory-pain-in-children-and-adolescents-100587531","NCT06929598","Shiatsu for Chronic Non-Inflammatory Pain in Children and Adolescents","The Efficacy of Adjunctive Shiatsu Therapy for Non-Inflammatory Chronic Pain in Pediatric Patients: A Single-Arm Prospective Trial","ShiQoL","Inclusion Criteria:\n\n* Children and adolescents aged 10-18 years\n* Diagnosed with non-inflammatory chronic pain syndromes\n* Actively followed by the Pediatric Rheumatology and\u002For Pediatric Pain Clinics at Tel Aviv Sourasky Medical Center (at least twice a year)\n* Informed consent signed by at least one legal guardian (or both guardians in cases of separated parents)\n* If participant is 16 years or older, they must also sign the informed consent\n\nExclusion Criteria:\n\n* Informed consent cannot be obtained from the participant or their legal guardians\n* Legal guardians unable to provide informed consent\n* Patients with severe conditions (e.g., bone metastasis)\n* Patients unable to participate in Shiatsu therapy sessions\n* Participation in Shiatsu therapy within 6 months prior to study enrollment\n* Participant or legal guardian refuses participation","10 Years",{"count":343,"type":20},40,[23],"The goal of this clinical trial is to learn if adding Shiatsu therapy to standard treatment can improve quality of life in children and adolescents with chronic pain that is not caused by inflammation. The main question it aims to answer is: Does Shiatsu therapy help improve the quality of life in children with long-lasting pain?\n\nAll participants will continue their regular treatment and will also:\n\n* Receive a 30-minute Shiatsu session once a week for six weeks\n* Complete questionnaires about their quality of life and family impact before, during, and after the treatment period\n\nThe study includes about 40 participants between the ages of 10 and 18, who are already being followed at the pediatric pain and rheumatology clinics at Tel Aviv Sourasky Medical Center.",[347,348,349,350,351,352,353,354],"Chronic Pain","Chronic Pain Syndrome","Chronic Pain and Comorbid Emotional Problems","Chronic Pain, Psychogenic","Chronic Pain, Widespread","Fibromyalgia","Fibromyalgia Syndrome","Functional Pain",[356,357,358,359,360,361,362,363,364,365,366,354,367],"Shiatsu","Complementary and Integrative Medicine","Pediatric Chronic Pain","Non-inflammatory Pain","Quality of Life","PedsQL","Adolescent Pain","Manual Therapy","Mind-Body Therapy","Pediatric Rheumatology","Integrative Medicine","Pain Management","2025-08-27",{"date":370,"type":31},"2025-09-04",{"date":372,"type":31},"2025-05-01",{"date":374,"type":20},"2027-04-30",{"name":37,"class":38},2,{"id":378,"slug":379,"hasResults":11,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":384,"targetDuration":4,"studyType":21,"phases":385,"briefSummary":386,"conditions":387,"keywords":389,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":39},"100590507","hexadecanal-as-an-addon-to-cognitive-processing-therapy-for-ptsd-100590507","NCT06968312","Hexadecanal as an Addon to Cognitive Processing Therapy for PTSD","Testing Potential Enhancement of Standard Cognitive Processing Therapy for PTSD Using Hexadecanal: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of PTSD according to DSM-5\n* Age 18 years and over\n* Eligible for CPT treatment at the National Center for Traumatic Stress and Resilience\n\nExclusion Criteria:\n\n* Bipolar disorder, psychosis, neurological disorders\n* Drug Addiction\n* Parallel psychotherapy\n* Congenital or acquired anosmia.",{"count":343,"type":20},[23],"This RCT investigates whether Cognitive Processing Therapy, a first line treatment for PTSD, can be enhanced by the use of the odor molecule Hexadecenal (HEX). HEX is secreted from body odor and has been shown to promotes psychological well-being and positive social interaction. For the active group Hex will be diffused in the treatment room during all treatment sessions. For the control group a vehicle placebo molecule will be diffused. Both therapists and patients will be blind to study condition.",[388],"Post Traumatic Stress Disorder (PTSD)",[26,390,391,392,393,394],"Posttraumatic Stress Disorder","Hexadecanal","treatment","CPT","Cognitive Processing Therapy","2025-05-13",{"date":397,"type":31},"2025-05-16",{"date":399,"type":31},"2025-05-05",{"date":401,"type":20},"2026-12-30",{"name":37,"class":38},{"id":404,"slug":405,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":407,"acronym":4,"eligibilityCriteria":408,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":47,"enrollmentInfo":409,"targetDuration":4,"studyType":21,"phases":411,"briefSummary":412,"conditions":413,"keywords":414,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":39},"100588604","emotion-regulation-selection-flexibility-training-for-ptsd-patients-100588604","NCT06943560","Emotion Regulation Selection Flexibility Training for PTSD Patients","Inclusion Criteria:\n\n* native Hebrew speakers\n* age between 18 - 65\n* normal or corrected to normal vision\n* computer and internet access\n* fulfill screening criteria of DSM-V for PTSD\n\nExclusion Criteria:\n\n* Complex PTSD\n* Psychotic disorders\n* substance dependence or abuse other than nicotine\n* Neurological condition\n* suicidal ideation or attempt\n* change in psychotherapy or pharmacological treatment in the past 3 months.\n* Diagnosed\u002Fsuspected personality Disorder\n* Cognitive impairments",{"count":410,"type":20},80,[23],"This clinical study will examine the efficacy of a novel intervention aimed at improving Regulatory Selection Flexibility and PTSD symptoms among adult individuals with PTSD symptoms, compared to a tight active control group.",[26],[415],"EMOTION REGULATION","2025-04-17",{"date":418,"type":31},"2025-04-24",{"date":420,"type":31},"2022-10-01",{"date":422,"type":20},"2026-04-01",{"name":37,"class":38},{"id":425,"slug":426,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":110,"phases":4,"briefSummary":432,"conditions":433,"keywords":4,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":439,"leadSponsor":440,"locationsCount":39},"100570661","the-effect-of-using-the-combat-attention-app-on-the-risk-of-post-traumatic-symptoms-100570661","NCT06710145","The Effect of Using the Combat Attention App on the Risk of Post-traumatic Symptoms","Inclusion criteria:\n\n* Age over 18 years.\n* Served as an enlisted soldier or reservist during the Iron Swards War.\n* Used the Combat Attention App or can serve as a matched control who did not use the App.\n* Colloquial Hebrew sufficient to fill out the research questionnaires.\n\nExclusion criteria:\n\n* Below 18 years of age.\n* Colloquial Hebrew that is insufficient to fill out the research questionnaires.",{"count":431,"type":20},1000,"Military service and reserve duty in combat units entails exposure to traumatic events that require mental adjustment. In light of the results of controlled studies that proved the effectiveness an response-time based mechanized training protocol in reducing risk for post-trauma symptoms in deployed combat soldiers, the Israeli Defense Forces decided at the beginning of the Iron Swords War to implement an internet-based App of the intervention. Soldiers and combat reservists were invited to use the Combat Attention App. The purpose of this study is to examine the effectiveness of the Combat Attention App in relation to a control group of soldiers who did not use the App in reducing risk for post-traumatic stress symptoms of deployed soldiers.",[434],"PTSD - Post Traumatic Stress Disorder","2025-04-08",{"date":437,"type":31},"2025-04-11",{"date":252,"type":20},{"date":254,"type":20},{"name":37,"class":38},{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":11,"sex":15,"minAge":448,"maxAge":47,"enrollmentInfo":449,"targetDuration":4,"studyType":21,"phases":450,"briefSummary":452,"conditions":453,"keywords":455,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":462,"leadSponsor":464,"locationsCount":39},"100565198","phase-2-neuromodulation-of-the-hippocampus-to-reduce-intrusive-re-experiencing-in-ptsd-a-randomized-controlled-trial-100565198","NCT06639061","Neuromodulation of the Hippocampus to Reduce Intrusive Re-Experiencing in PTSD: A Randomized Controlled Trial","Characterization and Modulation of Traumatic Memories in PTSD Patients Using Transcranial Magnetic Stimulation (TMS)","Inclusion Criteria:\n\n* Aged of 20-65 years.\n* Meet a diagnosis of PTSD according to DSM-5 as tested by a structured clinical interview (Clinician-Administered PTSD Scale for DSM-5 - CAPS-5).\n* CAPS-5 total score greater or equal to 33.\n* Endorsement of intrusive symptoms (flashbacks, nightmares, or intrusive memories) with a frequency of at least 3 times a week.\n* Meeting the accepted criteria for inclusion in an MRI examination.\n\nExclusion Criteria:\n\n* Meeting a diagnosis of Complex PTSD or personality disorder.\n* Psychotic disorder, bipolar disorder, or a developmental neuropsychological disorder (autism, mental retardation).\n* Use of psychiatric medications (except for the medications listed in section 4.a of the study protocol if the medication dosage is stable in the last three months and does not change during the study.\n* Exclusion rules in TMS research (see guidelines).\n* Use of the following drugs: imipramine, amitriptyline, doxepin, nortriptyline, maprotiline, chlorpromazine, clozapine, foscarnet, ganciclovir, ritonavir, amphetamines, cocaine, (MDMA, ecstasy), phencyclidine (PCP, angel's dust), ketamine, gamma- hydroxybutyrate (GHB), alcohol, theophylline\n* Epilepsy or use of anti-epileptic drugs.\n* Traumatic head injuries or head surgery.\n* Implanted metallic body (except fillings\u002Famalgam bites\u002Forthodontic fixations approved for MRI), electrodes or a pacemaker.\n* Migraines\n* Pregnant women\n* Hearing problems\n* Drinking alcohol 24 hours before the TMS session\n* Repeated episodes of fainting with loss of consciousness and\u002For an event of fainting with loss of consciousness in the past year.\n* The accepted exclusion criteria for an MRI examination","20 Years",{"count":291,"type":20},[451],"PHASE2","The goal of this clinical trial is to learn if non-invasive neurostimulation of memory-related brain areas works to treat intrusive memory symptoms in adults patients with posttraumatic stress disorder (PTSD). It will also learn about the effect of this neuromodulation procedure on reorganization of memory-related brain networks. The main questions it aims to answer are:\n\nDoes neuromodulation lower the number of times and the emotional severity participants intrusive memories? Does neuromodulation reduces the overall severity of PTSD? Researchers will compare neuromodulation targeting the hippocampus (a memory-related brain structure) to a control stimulation in an area not related to memory processes to see if hippocampus neuromodulation works to treat intrusive trauma memories and PTSD.\n\nParticipants will:\n\n1. Undergo magnetic resonance imaging (MRI) scans before and after neuromodulation to: a) determine a personalized neuromodulation target; and b) to measure changes in brain function from before to after treatment.\n2. Receive hippocampus neuromodulation or a control neuromodulation once a week for 5 weeks.\n\nKeep a daily diary of their symptoms and the number of times they experience intrusive trauma memories.",[434,454],"Intrusive Memories of Traumatic Event(s)",[26,456,457],"TMS","MRI","2024-10-31",{"date":460,"type":31},"2024-11-01",{"date":460,"type":31},{"date":463,"type":20},"2028-11",{"name":37,"class":38},{"id":466,"slug":467,"hasResults":11,"nctId":468,"briefTitle":469,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":11,"sex":15,"minAge":471,"maxAge":47,"enrollmentInfo":472,"targetDuration":4,"studyType":21,"phases":474,"briefSummary":475,"conditions":476,"keywords":478,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":39},"100507770","the-efficacy-of-hand-injuries-rehabilitation-intervention-program-that-incorporated-ethnic-and-cultural-reference-100507770","NCT05891704","The Efficacy of Hand Injuries Rehabilitation Intervention Program That Incorporated Ethnic and Cultural Reference","Inclusion Criteria: Participants will include people after acute traumatic injuries below the elbow, 16-65 years old, who were employed or functioning as active housewives prior to the injury. All participants will be Palestinian Arabs living in the West Bank\n\nExclusion Criteria: People with drug\u002Falcohol abuse, central nervous lesions, psychiatric, cognitive or developmental disorder, people with bilateral injury, hand burns, rheumatoid arthritis, osteoarthritis, brachial plexus lesion, shoulder or elbow problems, complex regional pain syndrome, or any surgery during the study period. People with non-traumatic hand injuries (tendonitis, carpal tunnel syndrome, trigger finger, De Quervain's disease, and Mallet finger) will not be included","16 Years",{"count":473,"type":20},100,[23],"The study has three main phases. The first phase included A. Adjustment of research tools. Phase B. will examine the efficacy of the cultural intervention. Phase C. Follow-up study will be conducted after three, six, and nine months.",[477],"Multiple Injuries of Hand (Disorder)",[479],"Hand Injury, Values, Culture, ACT, Hand Injury Intervention","2024-09-06",{"date":482,"type":31},"2024-09-19",{"date":484,"type":31},"2023-06-01",{"date":486,"type":20},"2025-01-01",{"name":37,"class":38},{"id":489,"slug":490,"hasResults":11,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":107,"sex":495,"minAge":16,"maxAge":496,"enrollmentInfo":497,"targetDuration":4,"studyType":21,"phases":499,"briefSummary":500,"conditions":501,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":510,"locationsCount":39},"100553746","impact-of-ibsr-on-postpartum-mothers-mental-health-100553746","NCT06490094","Impact of IBSR on Postpartum Mothers' Mental Health.","Impact of Inquiry-Based Stress Reduction (IBSR) on Postpartum Mothers' Mental Health.","Inclusion Criteria:\n\n* Mothers up to two years after giving birth, between the ages of 18 and 45 (at the time of birth), without a history of mental disorders or illnesses\n\nExclusion Criteria:\n\n* Mothers with a history of illness or mental disorders\n* mothers who have passed more than two years since their last birth","FEMALE","45 Years",{"count":498,"type":20},68,[23],"The period of pregnancy, childbirth, and the postpartum phase significantly impacts the mental health of women and their families. Mental health is crucial for overall well-being, quality of life, and is associated with healthcare costs. Therefore, promoting mental health should be a top priority in public health and health promotion efforts.\n\nThe Inquiry-Based Stress Reduction (IBSR) intervention, developed by Byron Katie (\"The Work\"), enables participants to identify and question the stressful thoughts that cause their suffering. The core of IBSR involves a contemplative \"inquiry\" process and a \"turnaround,\" which is a method of experiencing the opposite of what the participant believes. This process equips individuals with skills for self-inquiry and management of stressful thoughts that can be easily integrated into daily life.\n\nBased on previous research, we hypothesize that the IBSR intervention can improve postpartum mothers' mental health.",[502],"Postpartum Mothers","2024-06-29",{"date":505,"type":31},"2024-07-08",{"date":507,"type":31},"2024-06-09",{"date":509,"type":20},"2025-06",{"name":37,"class":38},""]