[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Telethon Kids Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":172},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,81,112,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100608702","beluga-better-to-exchange-ett-for-lma-before-extubation-in-children-under-general-anaesthesia-100608702",false,"NCT07204990","BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia","BELUGA","Participant Inclusion Criteria\n\n* Children 0-16 years,\n* 5kg and above,\n* presenting for elective, semi-elective or emergency surgery under general anaesthesia\n* With airway management planned with an endotracheal tube.\n\nExclusion Criteria:\n\n* Children with severe cardiopulmonary disease or syndrome\n* Children \\\u003C 5kg\n* Children with a contraindication to deep removal of ETT deep or exchange of ETT to LMA at the end of the case (e.g. high risk of aspiration)\n* Children with a known or anticipated difficult airway\n* Children remaining intubated post-procedure\n* Children undergoing major airway surgery or bronchoscopies","ALL","0 Years","16 Years",{"count":20,"type":21},1400,"ESTIMATED","INTERVENTIONAL",[24],"NA","During surgery, anaesthetists can use an endotracheal tube (ETT) to facilitate ventilation. At emergence from general anaesthesia, there are two techniques for removal of the ETT: (1) the ETT is removed when the child is waking up in (awake removal); or (2) the ETT is removed while still under anaesthesia(deep removal).\n\nCurrently there is no evidence to suggest either technique is safer - deep removal of the ETT may decrease the risk of overall airway complications, including cough and desaturations. However, it may be associated with increased airway obstruction compared with awake extubation in paediatric patients. In our institution, a further technique has become increasingly common practice: removing ETT deep to avoid coughing and desaturation, then inserting a laryngeal mask airway (LMA) which can be removed once the patient is awake in the postoperative care unit (PACU), avoiding the risk of airway obstruction coupled with deep airway removal. The aim of the study is to assess whether deep removal of an ETT and exchange to an LMA, is superior to awake ETT removal with regards to the occurrence of postoperative respiratory adverse events.\n\nIn this study, patients will be randomised to awake removal of ETT or deep removal of an ETT and exchange to an LMA. Data will be collected regarding the rate of respiratory adverse events in either group, as well as the incidence of post-operative pain, delirium and nausea and vomiting.",[27,28,29],"Endotracheal Extubation","Airway Anesthesia","Paediatric",[31,32,33,34,35],"Paediatrics","Anaesthesia","Surgery","Extubation","Respiratory adverse events","RECRUITING","2026-05-28",{"date":39,"type":40},"2026-06-01","ACTUAL",{"date":42,"type":40},"2026-02-06",{"date":44,"type":21},"2029-02-28",{"name":46,"class":47},"Telethon Kids Institute","OTHER",8,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},"100638796","ibis---investigating-reliability-of-bis-and-sedline-monitoring-in-children-with-developmental-and-epileptic-encephalopathies-dee-100638796","NCT07585643","IBIS - Investigating Reliability of BIS and SEDLINE Monitoring in Children With Developmental and Epileptic Encephalopathies (DEE).","IBIS","Inclusion Criteria:\n\n* Children (\\\u003C16 years old) with a confirmed diagnosis of early onset EE or DEE due to any cause (prior to age 2 years).\n\nExclusion Criteria:\n\n* Language barriers impeding data collection\n* Department for Child Protection and Family Support is involved in the care of the child.","15 Years",{"count":58,"type":21},40,"OBSERVATIONAL","When children have surgery, anaesthetists carefully monitor the depth of anaesthesia by using sensors on the forehead that measure brain activity, also known as processed electroencephalogram (pEEG). These monitors are routinely used in paediatric anaesthesia; however, investigators do not know if they work accurately in babies and young children with seizure disorders or on anti-seizure medications.\n\nChildren with developmental and epileptic encephalopathies may need anaesthesia for tests or procedures. It is important that their treating doctors understand whether these monitors truly reflect how awake or asleep the children are. This study aims to compare a child's electrical brain activity using two commonly used devices in paediatric anaesthesia with the conventional 21-lead EEG patterns in children with seizure disorders. The results of this research may help improve the safety and perioperative care of children with seizure disorders who require general anaesthesia in the future.",[62,63,64,65],"Epileptic Encephalopathy","Early Infantile Epileptic Encephalopathy","Infantile Spasm","Developmental and Epileptic Encephalopathies",[67,68,69,70],"epileptic encepthalopathy","anaesthesia","PILOT STUDY","MULTICENTRE","NOT_YET_RECRUITING","2026-05-27",{"date":74,"type":40},"2026-05-29",{"date":76,"type":21},"2026-05-20",{"date":78,"type":21},"2029-06-20",{"name":46,"class":47},2,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":56,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":80},"100613702","sensory-toys-for-anxiety-reduction---can-fidget-toys-improve-stress-and-help-children-to-cope-before-surgery-starfish-100613702","NCT07270029","Sensory Toys for Anxiety Reduction - Can Fidget Toys Improve Stress and Help Children to Cope Before Surgery (STARFISH)","STARFISH","Inclusion Criteria:\n\n* Children aged 5-15.99 years of age\n* Children admitted to the day of surgery unit undergoing elective surgery at Perth Children's Hospital or Hospital das Clinicas HCFMUSP as day case surgeries or with a maximum hospital stay of one night postoperatively\n\nExclusion Criteria:\n\n* Children coming for surgery via wards other than the day of surgery unit\n* Language barriers impeding data collection\n* Department for Child Protection and Family Support is involved in the care of the child\n* Inability for the child to interact with the sensory toy safely, such as children with severe global developmental delay (GDD).","5 Years",{"count":90,"type":21},500,[24],"Anxiety associated with medical procedures is common, with 40-80% of children experiencing significant symptoms and postoperative consequences, including distress and delirium, increased intensity\u002Fduration of pain, prolonged hospital stays, behavioural\u002Fsleep disturbance and avoidance of medical encounters, which often remain into adulthood.\n\nExtensive consumer research has shown that a key priority for Australian consumers of all ages in relation to paediatric hospital care is addressing the fear and anxiety in children throughout the hospital experience (second only to anaesthesia safety for adults and third following anaesthesia safety and pain management for children).\n\nThe STARFISH trial was driven by our consumer partners, particularly our youth consumers. It is well known that distraction is a coping strategy that can help with perioperative anxiety, and all members of the perioperative team commonly employ distraction techniques with patients during routine clinical care. One potential form of distraction involves sensory activities - fidget devices or sensory toys such as spinners, putty, and stability balls are increasingly being used within school settings to help students academically and behaviourally, with applicability for neurodiverse (e.g., autistic, Attention Deficit Hyperactivity Disorder (ADHD)) children being one area of particular interest. However, the research behind sensory toys is inconclusive.\n\nSensory toys have been suggested to our team-from numerous consumers of all ages, including neurodiverse and neurotypical consumers-as a method to reduce anxiety in the preoperative period, thus leading to the design of the STARFISH trial.\n\nThis project aims to assess the use of a sensory toy (of the child's choice) in the perioperative period on the day of surgery to reduce perioperative anxiety and distress.",[94],"Perioperative Anxiety",[96,97,98,99,100,101,102,103],"children","pediatrics","surgery","pediatric anaesthesia","anxiety","perioperative anxiety","fidget toys","sensory toys","2026-03-23",{"date":106,"type":40},"2026-03-24",{"date":108,"type":40},"2026-01-08",{"date":110,"type":21},"2028-12-30",{"name":46,"class":47},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":120,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":144},"100593010","phase-4-nasal-decongestant-to-reduce-perioperative-adverse-events-in-children-with-upper-respiratory-track-infections-having-anesthesia-100593010","NCT07000877","Nasal Decongestant to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having Anesthesia.","Nasal Decongestant Administration to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having General Anesthesia - a Low Risk Intervention. (NARWHAL)","NARWHAL","Inclusion Criteria:\n\n* Children aged 1 to 8.99 years with a current or recent upper respiratory tract infection (\\\u003C2 weeks).\n* Undergoing interventions or surgery under general anesthesia (elective or urgent not emergency).\n\nExclusion Criteria:\n\n* Currently taking nasal decongestants (past 24 hours) or receiving co-phenylocaine or decongestion for surgery.\n* Surgery impacting the nasal airflow, e.g. adenoidectomy, cautery of inferior turbinates.\n* Airway management with an endotracheal tube, face mask or high flow nasal oxygen.\n* Known cardiovascular, respiratory or neurological disorders giving an ASA III or above.\n* Thyroid disease.\n* Diabetes.\n* Known hypersensitivity to the interventional products.\n* Department of Child Protection and Family Services involved in their care.\n* Planned admissions to the Paediatric Intensive Care Unit (PICU).","1 Year","8 Years",{"count":123,"type":21},200,[125],"PHASE4","The goal of this multicentre, double-blind, randomised controlled trial study is to learn if the use of a nasal spray to open the nasal passages and increase airflow before surgery can reduce the occurrence of perioperative respiratory adverse events in children with upper respiratory tract infection who are undergoing anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does use of a nasal decongestant (Oxymetazoline 0.05%) reduce perioperative respiratory adverse events during emergence (when waking up from anesthesia) or in the post-anesthesia care unit in children.\n* Is it easy and acceptable to doctors, children and parents to use the nasal decongestant treatment? Researchers will compare the nasal decongestant to a placebo (a look-alike substance that contains no drug) to see if it works to reduce perioperative respiratory adverse effects.\n\nParticipants will:\n\n* Take a nasal decongestant or a placebo prior to surgery (just before anaesthesia is given)\n* Be monitored during and after surgery in the post-anaesthesia care unit for any perioperative respiratory adverse events.\n* Be asked about how acceptable they found the treatment.",[128,129],"Perioperative Respiratory Adverse Events","Anesthesia Outcomes",[131,132,133,134,98,97,135],"perioperative respiratory adverse events","nasal decongestant","upper respiratory tract infection","Children","anesthesia","2025-11-17",{"date":138,"type":40},"2025-11-19",{"date":140,"type":40},"2025-06-25",{"date":142,"type":21},"2028-05-30",{"name":46,"class":47},1,{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":153,"sex":16,"minAge":4,"maxAge":18,"enrollmentInfo":154,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},"100543348","a-longitudinal-study-looking-at-the-prevalence-risk-factors--consequences-of-persistent-post-surgical-pain-in-children-100543348","NCT06354699","A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children","POPSICLE (Postoperative Pain Study in Children - a Longitudinal Evaluation)","POPSICLE","Inclusion Criteria:\n\nThe patient is undergoing a surgical procedure in either group elective (circumcision, hypospadias, orchidopexy, laparoscopic appendicectomy) or group emergency (laparoscopic appendicectomy, scrotal exploration)\n\nExclusion Criteria:\n\nThe parent and child have inadequate English language skills to understand the questionnaires\n\nChildren with significant\u002Fsevere developmental or cognitive delay based on a formal diagnosis.\n\nFamilies that are unable to complete the long-term follow up surveys.",true,{"count":155,"type":21},5000,"The purpose of this study is to investigate the prevalence, risk factors and consequences of chronic post-surgical pain in children aged 0-16 years through a number of questionnaires completed at various timepoints, from before surgery up to 1 year post surgery.",[158],"Chronic Pain",[160,161,162],"Chronic pain","Post-operative pain","Paediatric surgery","2025-10-21",{"date":165,"type":40},"2025-10-23",{"date":167,"type":40},"2023-06-26",{"date":169,"type":21},"2028-07",{"name":46,"class":47},16,""]