[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Temple University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":620},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,47,80,112,142,169,200,221,248,281,312,337,363,385,411,432,451,484,507,529,552,574,595],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100463679","phase-2-using-smartphones-to-improve-physical-activity-levels-of-individuals-with-spinal-cord-injury-100463679",false,"NCT05317832","Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury","mHealth-based Just-In-Time Adaptive Intervention to Improve Physical Activity Levels of Individuals With Spinal Cord Injury","Inclusion Criteria: Participants with SCI will be included if they are:\n\n* 18-75 years of age\n* have a traumatic or non-traumatic SCI (classification of neurological level of injury at cervical level 5 (C5) and below)\n* are at least 6-months post-SCI\n* use a manual or a power wheelchair as their primary means of mobility (\\>80% of time)\n* can use their arms to exercise\n* show readiness to physical activity as assessed by the Physical Activity Readiness Questionnaire\n* have experience using a smartphone and smartwatch.\n\nExclusion Criteria: Participants will be excluded if they have:\n\n* any secondary complications that medically restrict their activity in any way such as cardiovascular disease, pressure injuries, contractures, and infections\n* are diagnosed with traumatic brain injury.","ALL","18 Years","75 Years",{"count":20,"type":21},196,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in their communities. A primary objective of this study is to evaluate the integration of a JITAI with a web-based physical activity intervention program. We hypothesize that the integration of web-based physical activity intervention program with JITAI will result in significantly higher physical activity levels compared to the standard web-based physical activity intervention program alone. A secondary objective of this study is to extend existing algorithms that use commercial wearable technology to robustly detect physical activity behaviors to facilitate the delivery of tailored just-in-time actionable feedback and physical activity recommendations for individuals with SCI.",[27],"Spinal Cord Injuries",[29,30,31,32,33],"spinal cord injuries","physical activity","wearable sensors","mobile health","just-in-time adaptive intervention","RECRUITING","2026-06-19",{"date":37,"type":38},"2026-06-24","ACTUAL",{"date":40,"type":38},"2023-05-25",{"date":42,"type":21},"2027-06-30",{"name":44,"class":45},"Temple University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":46},"100497742","oropharyngeal-candidiasis-opc-and-s-ecc-100497742","NCT05761197","Oropharyngeal Candidiasis (OPC) and S-ECC","Association Between Early Candida Infection (Oral Thrush) and Severe Early Childhood Caries (S-ECC)","Oral-Thrush","Inclusion Criteria:\n\n* Male or female individuals at the age of 9-15-month-old\n* Must have at least one fully erupted tooth at baseline visit\n* Parent\u002Fguardian willing and able to provide informed consent\n* With or without a history of OPC (the study team will enroll 35 participants with and 35 participants without a history of OPC)\n\nExclusion Criteria:\n\n* Presence of a systemic medical condition (e.g. Down syndrome etc.)\n* Presence of an orofacial deformity\n* Presence of dental caries\n* Use of systemic antimicrobial therapy within 30 days of the baseline visit\n* Presence of any condition which, in the opinion of the investigator, makes participation in the project not in the individual's best interest.",true,"9 Months","15 Months",{"count":59,"type":21},70,"OBSERVATIONAL","The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).",[63,64,65],"Candida Infection","Oral Thrush","Early Childhood Caries",[67,68,69,70,71],"Oral candidiasis","Candida infection","Oral thrush","Early childhood caries","Oral Health","2026-06-18",{"date":74,"type":38},"2026-06-22",{"date":76,"type":38},"2024-09-01",{"date":78,"type":21},"2028-08-31",{"name":44,"class":45},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},"100530107","development-and-test-of-a-communication-skills-training-for-transplant-providers---aims-2--3-100530107","NCT06182475","Development and Test of a Communication Skills Training for Transplant Providers - Aims 2 & 3","Increasing Equity in Live Donor Kidney Transplantation Through Effective Patient-Provider Communication","EPPComm","Inclusion Criteria:\n\n* (1) appear for a kidney transplant evaluation at Cooperman Barnabas Medical Center (CBMC) or Temple University Hospital (TUH)\n* (2) speak English\n* (3) be of self-reported Black or Caucasian ethnicity\n* (4) be ≥18 years of age.\n\nIncluding patients who:\n\n1. have received prior kidney transplants\n2. patients with limited English proficiency, as long as they speak with the physician via a translator\n3. patients evaluated at offsite satellite locations that are not actually at CBMC or TUHS.\n\nAll transplant nephrologists, nurses, and social workers employed at the kidney transplant programs at CBMC and TUH who are actively involved in patient evaluations for transplant will be eligible for participation in the study. Providers refusing to permit digital audio recording of the transplant consultation will be deemed ineligible.\n\nExclusion Criteria:\n\n* (1) are non-verbal or otherwise unable to converse with providers\n* (2) are already listed for kidney transplant at CBMC or TUHS or at another transplant center\n* (3) have limited English proficiency and speak directly with the physician in a language other than English.\n\nPatients having (1) received an offer to donate a kidney from a family member or friend, or (2) explicitly asked a family member or friend to consider serving as a LD will be excluded, along with any patients refusing to permit digital audio recording of the transplant consultation will also be deemed ineligible to participate.\n\nThe following special populations will be excluded: adults unable to consent, individuals who are not yet adults (infants, children, teenagers), prisoners, and individuals who do not understand English.\n\nIt is unlikely that any female patient will be pregnant while awaiting kidney transplant; however, we will not exclude pregnant women.","80 Years",{"count":59,"type":21},[91],"NA","The goal of this clinical trial is to understand the communication occurring between Black and Caucasian patients and their transplant providers during transplant evaluation consultations and assess relationships between these communicative elements and patient and provider factors, patient-reported outcomes and living donor transplant outcomes - living donor referrals, evaluations, and transplants. We will use these findings to inform the development of a communication skills training for transplant providers and test the impact of the training on providers' communication about live donor kidney transplants with Black and Caucasian patients and living donor transplant outcomes.\n\nThe main questions it aims to answer are:\n\n* How does the use of the use of instrumental, relational and affective communication by patients and providers during the transplant consultation differ by patient and provider factors, patient-reported outcomes and patient ethnicity?\n* What elements of instrumental, relational and affective communication will be predictive of live donor kidney transplant (LDKT) process outcomes (LD inquiries and evaluations, and actual LDKTs)?\n\nParticipants will be asked to complete brief surveys before and after the transplant consultation and to give permission for the consultation to be audiorecorded.\n\nThis data will be used to develop a training to educate providers on the key communication factors predictive of LDKT process outcomes specific to Black and Caucasian patients, and provide guidance on their application during patient consultations. Researchers will then compare communication and patient-reported and LDKT process outcomes between trained and untrained providers to see whether the training has any effect on living donor inquiries and evaluations, and actual LDKTs.",[94,95,96],"Kidney Disease, Chronic","End Stage Renal Disease","Kidney Replacement",[98,99,100,101],"Patient-Provider Communication","Live Donor Kideny Transplantation","Provider Training","Communication Skills Training","NOT_YET_RECRUITING","2026-06-10",{"date":105,"type":38},"2026-06-12",{"date":107,"type":21},"2026-09",{"date":109,"type":21},"2027-05",{"name":44,"class":45},2,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":120,"minAge":17,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":124,"conditions":125,"keywords":128,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":46},"100626201","testing-a-mobile-health-application-to-improve-hiv-prevention-and-substance-use-treatment-among-women-involved-in-the-carceral-system-100626201","NCT07432555","Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System","Development and Pilot Testing of a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Service Access Among Women Involved in the Carceral System","PA-Links","Inclusion Criteria:\n\n* 18 of years of age or older\n* Self-identified woman\n* Previous experience (past six months) with the carceral system (jail, prison, on parole or under supervision)\n* Speaks and reads English\n* Self-reported negative HIV status\n* Indicates at least one HIV risk (i.e. any of the following in the past 6 months or in the six months prior to the most recent incarceration that call for consideration of PrEP as per the CDC risk indices: have engaged in condomless sex; have an HIV-positive sex partner; have had an STI; have had multiple \\[\\>6\\] partners; have engaged in transactional sex; have injected drugs, shared injection or drug use preparation equipment, or have been enrolled in opiate substitution therapy because of IDU; previous overdose)\n* Self-report using opioids in the past six months or six months prior to the most recent incarceration (prescription or not) OR self-report using medications for opioid use disorder in the past year.\n* Have access to the internet through some device - smart phone, computer or tablet (personal or at community location such as library or organization)\n\nExclusion Criteria:\n\n* Under 18 years old\n* Does not read or speak English\n* Does not identify as a woman\n* Has been diagnosed with HIV\n* Does not have previous experience with the criminal legal system within the last 6 months\n* Does not have HIV risk in last six months or six months prior to being incarcerated\n* Has not used opioids in past six months or six months prior to being incarcerated or MOUD in last year\n* Does not have access to internet\n* Cannot provide informed consent","FEMALE",{"count":122,"type":21},74,[91],"Women involved in the carceral system (WICS) are at higher risk for both HIV and substance use than the general public. WICS are also more likely to engage in behaviors both before and after release that put them at risk for HIV and for overdose, due to opioid use. Despite these risk factors, WICS are less likely to be aware of, use, or adhere to pre-exposure prophylaxis (PrEP) and have less access to medications for opioid use disorder (MOUD). The primary goal of the proposed research is to pilot test a systematically developed PrEP and MOUD uptake intervention for WICS using contextually relevant messages developed through novel formative research methods and embedded in a web-based application in a rigorous research design. The investigators will then test this approach (called PA-LINKS) in a pilot randomized trial with women who have recently been incarcerated in Philadelphia in partnership with Philadelphia FIGHT, a federally qualified health center, for promise of efficacy, and to assess feasibility and acceptability.",[126,127],"Substance Abuse","HIV",[126,129,130,131,132,133],"HIV prevention","PreEP","Medications for Opioid Use Disorder","Re-entry","Women Involved in the Carceral System (WICS)","2026-05-12",{"date":136,"type":38},"2026-05-13",{"date":138,"type":21},"2026-08-01",{"date":140,"type":21},"2026-08-30",{"name":44,"class":45},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":157,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":111},"100538599","remi-for-post-bariatric-surgery-weight-regain-100538599","NCT06292936","RemI for Post-Bariatric Surgery Weight Regain","Evaluation of a Remotely-Delivered Behavioral Intervention for Post-Bariatric Surgery Weight Regain","Inclusion Criteria:\n\n* Men and women\n* Ages 18-70 years old\n* Weight regain of at least 5% from lowest postoperative weight\n* Body mass index (BMI) 25 or above\n* Underwent gastric bypass or sleeve gastrectomy within 6 to 48 months prior to enrollment\n* Ability to give consent\n* Ability to speak, write, and understand English\n\nExclusion Criteria:\n\n* Long-term treatment with oral steroids\n* Current use of weight loss medication (OTC or prescription)\n* Current pregnancy, plan to become pregnant within 12 months, lactation within the past 6 months\n* Psychiatric hospitalization in the past 6 months\n* Documented or self-reported psychiatric diagnosis that would interfere with adherence to the study protocol or acute suicidality\n* Self-report of alcohol or substance abuse within the past 12 months\n* Current, self-reported use of tobacco products\n* Weight loss \\> 10 lbs in the past 3 month\n* History of more than one bariatric procedure\n* Inability to walk at least one city block without assistance","70 Years",{"count":151,"type":21},200,[91],"The goal of this clinical trial is to test the effectiveness of remotely-delivered interventions (utilizing acceptance-based behavioral treatment skills (ABTi)) amongst bariatric surgery populations who are experiencing weight regain postoperatively (\\> 5% from their lowest postoperative weight and after postoperative Month 6). Investigators aim to evaluate ABTi's efficacy for reversing weight regain and its effect on targeted weight control behaviors and weight-related comorbidities by comparing participants randomly assigned ABTi (n = 100) to those assigned to a Control group that also receives brief phone calls but that focus on reiterating instruction on the dietary and behavioral changes required of surgery and initially taught preoperatively (C, n = 100).\n\nThe main research aims are:\n\n1. To compare changes in body weight over 12 months in 200 bariatric patients who have regained \\> 5% of their weight and are randomly assigned to ABTi or Control.\n2. To compare changes in eating behaviors (i.e., caloric intake, frequency of maladaptive eating behaviors), physical activity, and weight-related comorbidities (i.e., biomarkers of diabetes, hypertension) over 12 months in the two groups.\n3. Exploratory - To test ABTi's theoretical mechanisms of action, including a) effects of theory-based active ingredients (i.e., acceptance, defusion, values clarity, mindfulness) on weight outcomes and b) changes in impact of internal states (i.e., hunger, cravings) on eating behavior.",[155,156],"Obesity","Bariatric Surgery Candidate",[158,159,160],"Acceptance-Based Behavioral Therapy","Postoperative Outcomes","Weight Regain","2026-04-02",{"date":163,"type":38},"2026-04-03",{"date":165,"type":38},"2024-04-15",{"date":167,"type":21},"2028-05-31",{"name":44,"class":45},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":185,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":199},"100631779","comparing-the-impact-of-peer-support-vs-staff-delivered-transportation-interventions-for-young-adults-with-intellectual-and-developmental-disabilities-100631779","NCT07505121","Comparing the Impact of Peer Support vs. Staff-Delivered Transportation Interventions for Young Adults With Intellectual and Developmental Disabilities.","Comparing Peer Support and Staff-Delivered Transportation Interventions for Young Adults With Intellectual and Developmental Disabilities (YA-IDD) on Loneliness, Social Participation, and Transportation Skills","YA-IDD","Inclusion Criteria:\n\n* Between the ages of 18 to 27 years old during the start of the study\n* Receives services at one of the eight community service organizations participating in the study.\n* Meets the federal diagnosis of a developmental disability (DD)\n* Qualifies for services related to their DD.\n* Scores \\>28 on the Transportation Prescreening Assessment (indicating readiness for travel).\n\nExclusion Criteria:\n\n* Independently uses public transportation \\>4 times\u002Fmonth.\n* Is not able to independently mobilize through walking or use of a mobility device.\n* Has significant non-corrected visual impairments.","27 Years",{"count":179,"type":21},325,[91],"This clinical trial will look at whether young adults with intellectual and developmental disabilities (YA-IDD) have better outcomes when a travel training intervention called Ready to Ride (R2R) is taught by a specially trained Peer Supporter (PS) who shares the lived experience of having an IDD than YA-IDD who are taught Ready to Ride by staff at their community services organization. The aspects of life being looked at are loneliness, satisfaction with social activities, travel skills, service use and access, employment, and health related quality of life.\n\nThe researchers think the following things will happen.\n\n1. YA-IDD who learn from a Peer Supporter will report significantly higher satisfaction with social activities, increased social connectedness and significantly less loneliness compared to YA who are taught organization staff.\n2. Both groups will learn the same amount of travel skills.\n3. YA-IDD who learn from a Peer Supporter will show larger increases in access to community-based services, transportation use, employment and health related services after 4 months than the YA taught by organizational staff.",[183,184],"Intellectual Disability, Mild to Moderate","Developmental Disability",[186,187,188,184,189,190],"Travel Training Intervention","Young Adults","Intellectual Disability","Transportation","Peer Support","2026-03-26",{"date":193,"type":38},"2026-04-01",{"date":195,"type":21},"2026-05",{"date":197,"type":21},"2030-06",{"name":44,"class":45},3,{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":22,"phases":209,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":111},"100556867","optimizing-the-prehospital-use-of-stroke-systems-of-care-reacting-to-changing-paradigms-implementation-opus-i-100556867","NCT06530693","Optimizing the Prehospital Use of Stroke Systems of Care-Reacting to Changing Paradigms-Implementation (OPUS-i)","OPUS-i","Inclusion Criteria:\n\n* Clinical impression of stroke\u002FTIA by EMS clinicians\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Prisoner",{"count":208,"type":21},360,[91],"This interventional trial will compare a novel prehospital stroke transport algorithm (OPUS-i) to a traditional prehospital stroke transport algorithm to improve outcomes in rural stroke patients by determining the effect of implementing a data-driven prehospital stroke algorithm on time to and endovascular therapy. The study consists of a multicenter cohort and will last 24 months but individual subject study duration is 90 days.",[212],"Stroke","2026-03-10",{"date":215,"type":38},"2026-03-12",{"date":217,"type":38},"2025-04-01",{"date":219,"type":21},"2027-09",{"name":44,"class":45},{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":229,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":46},"100577885","non-invasive-vagus-nerve-stimulation-nvns-and-cognition-in-young-adult-vapers---a-pilot-study-100577885","NCT06804109","Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study","Vaping and Vagal Neuromodulation of Cognition","nVNS","Inclusion Criteria:\n\n* Healthy young adults\n* Age range 18-25 years\n* Current or prior users of e-cigarettes\n\nExclusion Criteria:\n\nParticipants will be excluded from the study if they:\n\n* Have any rash, infection, swelling, cut, soreness, drug patch, surgical scar on the neck area\n* Have any implantable medical device in their body such as a pacemaker, hearing aid implant, or any other metallic\u002Felectronic device\n* Have any hearing or vision problems that are not corrected\n* Are pregnant or breastfeeding\n* Have any learning disabilities\n* Have a medical history of any of the following condition\n* Meningitis\n* Traumatic brain injury\n* Seizure\n* Syncope\n* Schizophrenia\n* Schizoaffective disorder\n* Bulimia (eating disorder)\n* Other serious neurological illness\n* Have a medical history of any of the following cardiac disorder\n\n  * Carotid atherosclerosis or carotid artery disease\n  * Cervical vagotomy\n  * First degree atrioventricular block or prolonged QT interval\n* Are taking any medications for to treat hypertension, arrhythmias, or are on calcium channel blockers","25 Years",{"count":231,"type":21},100,[91],"The purpose of this study is to assess the effects of non-invasive vagus nerve stimulation (nNVS) on cognitive functioning in the users of e-cigarettes or vaping products. The investigators will use a digital wellness companion product (TRUVAGA™ device) that provides mild transcutaneous nVNS. The participants will be randomized to receive either a 2-min nNVS stimulation or control stimulation in the neck region followed by completion of three cognitive tests of attention and executive function.",[235],"Vaping",[237,238,239],"vaping","attention","non-invasive vagus nerve stimulation","2026-03-05",{"date":242,"type":38},"2026-03-06",{"date":244,"type":38},"2025-03-18",{"date":246,"type":21},"2028-02-09",{"name":44,"class":45},{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":16,"minAge":256,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":22,"phases":260,"briefSummary":261,"conditions":262,"keywords":266,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":46},"100578381","brief-behavioral-sleep-intervention-for-obesity-prevention-in-primary-care-100578381","NCT06810557","Brief Behavioral Sleep Intervention for Obesity Prevention in Primary Care","Feasibility and Preliminary Efficacy of a Brief Behavioral Sleep Intervention for Excessive Weight Gain Prevention in Primary Care","Rx SLEEP","Inclusion Criteria:\n\n* Patient at Temple Pediatrics\n* Child age 6-11 years\n* Child time in bed of less than 9 hours per night on most days per week\n* Body Mass Index (BMI) for age and biological sex great than the 10th percentile but less than the 95th percentile\n* Understanding of and ability to complete the protocol\n* Parent age at least 18 years and primary caregiver\n* Willingness to be randomized to either condition\n\nExclusion Criteria:\n\n* Diagnosed sleep disorder\n* Medication use or diagnosis of medical or psychiatric condition that may impact sleep or weight status\n* Current or planned treatment for weight control","6 Years","11 Years",{"count":259,"type":21},50,[91],"The goal of this study is to compare two different approaches to help families with children 6-11 years enhance nighttime sleep: 1) working one-on-one with a nurse to learn effective behavioral strategies to try to improve children's sleep or 2) receiving education on a good night's sleep and its benefits. Participating families will meet with a nurse 6 times or receive 6 educational handouts. Participating families will also complete three assessments (start of the study, 2 months and 6 months) during which study questionnaires will be completed, participating children will wear devices that assess sleep and physical activity, participating families will report on what the child ate on two separate days and will be measured for height and weight.",[263,264,265],"Obesity, Childhood","Short Sleep","Obesity Prevention",[267,268,269,270,271,272],"sleep","behavioral intervention","primary care","obesity prevention","child","pediatric","2026-02-10",{"date":275,"type":38},"2026-02-12",{"date":277,"type":38},"2025-05-15",{"date":279,"type":21},"2027-03-31",{"name":44,"class":45},{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":289,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":297,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":46},"100555311","need-to-be-needed-n2bn-intervention-100555311","NCT06510439","Need to be Needed (N2BN) Intervention","Randomized, Controlled Trial of Need to be Needed (N2BN) Intervention to Improve Social Connection, Reduce Social Isolation and Loneliness","N2BN RCT","Inclusion Criteria:\n\n1. A research diagnosis of Major Depression, Bipolar I, II, or Schizophrenia Spectrum disorder.\n\n   Participants will be screened by research staff using sections of the Mini-International Neuropsychiatric Interview (MINI; Sheehan et al., 1998) that will identify research diagnoses of: Major Depression, Bipolar I, II, or Schizophrenia Spectrum disorder.\n2. Ages 18 years old and older\n3. Living in the community\n4. Able to communicate in written and oral English\n5. UCLA-Loneliness Scale score of 6 or higher\n\nExclusion Criteria:\n\n1. Having a legal guardian\n2. Unable to give informed consent.\n3. Living situation which restricts their ability to move freely\n\nPotential participants failing to meet screening criteria will be informed at the time that we are not able to enroll them in the study at this time. Any interview notes, or information recorded on the MINI will be destroyed or securely deleted.\n\nThe study will not enroll any vulnerable populations.","99 Years",{"count":291,"type":21},120,[91],"The proposed study is a randomized, controlled trial (RCT) that will examine the effectiveness of an intervention designed to reduce social isolation and loneliness of adults with serious mental illness (SMI). The intervention will focus on improving their sense of mattering by using acts of kindness and experiencing gratitude through volunteering. 120 participants will be randomly assigned to the intervention group or the attention control group. Over the course of the 6-month intervention, participants in the intervention arm, will receive weekly support from the interventionist. The interventionist and the participant will collaboratively set goals and develop an initial intervention plan, which is informed by the participants interests, values and goals. The attention control group will receive non-directive listening support through research assistants.\n\nData collection for all participants will occur at baseline, at the mid-point of the intervention at 3 months, and at the end of the 6-month intervention. Participants will be asked questions about quality of experience, social context and satisfaction, mattering components, kindness, gratitude, and loneliness. We will gather data on demographic background, life transitions, social network characteristics, internalized stigma, neighborhood climate, depression, and trait measures of mattering and loneliness during intake and exit interviews. Additionally, participants of the intervention arm will be asked to provide feedback about the intervention.",[295,296],"Loneliness","Social Isolation",[298,299,300,301,302,303],"mattering","loneliness","social isolation","need to be needed","neededness","volunteering","2026-01-16",{"date":306,"type":38},"2026-01-21",{"date":308,"type":38},"2024-10-07",{"date":310,"type":21},"2035-05-31",{"name":44,"class":45},{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":4,"eligibilityCriteria":318,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":319,"targetDuration":4,"studyType":22,"phases":321,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":336,"locationsCount":46},"100614301","photo-experiencing-and-reflective-listening-pearl-to-promote-healing-engagement-for-survivors-of-violence-100614301","NCT07277816","Photo-experiencing and Reflective Listening (PEARL) to Promote Healing Engagement for Survivors of Violence","Photo-experiencing and Reflective Listening (PEARL) to Promote Healing Engagement for Survivors of Violence: A Feasibility Study","Inclusion Criteria:\n\n* Age 18 years or older\n* History of interpersonal violence (IV) - identifies as a survivor of interpersonal violence\n* Able to complete an interview in English\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Does not identify as a woman (male participants excluded)\n* No history of interpersonal violence\n* Unable to complete an interview in English\n* Unable to provide informed consent",{"count":320,"type":21},40,[91],"The goal of this clinical trial is to learn if a photo-elicitation intervention called PEARL (Photo-experiencing and Reflective Listening) can promote healing engagement in survivors of interpersonal violence. It will also learn about the feasibility and acceptability of PEARL. The main questions it aims to answer are:\n\nDoes PEARL reduce barriers to help-seeking for trauma? Does PEARL improve trauma coping self-efficacy? Does PEARL change post-trauma cognitions and readiness for recovery? Is PEARL feasible and acceptable to survivors of interpersonal violence?\n\nResearchers will compare people who receive PEARL immediately to people on a waitlist (who receive PEARL three months later) to see if PEARL improves healing engagement and help-seeking behaviors.\n\nParticipants will:\n\n* Complete baseline surveys about their trauma history, mental health, healing, and help-seeking behaviors\n* Be randomly assigned to receive PEARL immediately or after a 3-month wait\n* Receive a photography-focusing prompt and create photos over two weeks (those in the immediate group or after the waiting period)\n* Participate in a reflective listening interview about their photos\n* Complete follow-up surveys immediately after the intervention and one month later\n* Participate in a one-month follow-up interview about their experience",[324],"Violence and Victimization",[326,327,328,329],"healing","recovery","violence","trauma","2025-12-21",{"date":332,"type":38},"2025-12-23",{"date":334,"type":38},"2025-12-01",{"date":138,"type":21},{"name":44,"class":45},{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":344,"targetDuration":4,"studyType":22,"phases":346,"briefSummary":347,"conditions":348,"keywords":352,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":361,"leadSponsor":362,"locationsCount":46},"100569950","taking-action-for-college-students-100569950","NCT06700902","Taking Action for College Students","A Randomized Controlled Trial of Taking Action Planning for College Students With Serious Mental Illnesses","Inclusion Criteria:\n\n* Currently enrolled in a 2- or 4-year postsecondary educational institution in the United States (and are able to present a valid student ID card)\n* Experiencing a serious mental illness, as operationalized by either:\n* A score of 13 or higher on the K-6 Screening Scale for serious mental illness\n* Self-reported psychiatric diagnosis of schizophrenia-spectrum or major affective disorder and self-reported lifetime functional impairment due to experiencing mental health challenges\n* 18 years of age or older\n* Have consistent access to a computer or smartphone and the Internet for communications\n* No prior WRAP or Taking Action education\n\nExclusion Criteria:\n\n* Expected to graduate or complete their program within 2 semesters\n* Unable to provide informed consent",{"count":345,"type":21},300,[91],"The goal of this research is to investigate whether a peer-delivered illness self-management program called Taking Action can help college students with serious mental illnesses. Participants will be randomly assigned to either the experimental condition (Taking Action) or the control condition (information only). Participants in the experimental condition will attend five 2.5-hour Taking Action sessions. Participants will complete three interviews (baseline, post-intervention, and follow-up) to assess how well the program works, is liked, and benefits students clinically and academically. The investigators seek to test the following hypotheses: Compared to controls, students who do the Taking Action program will report greater improvements in mental health self-management attitudes, skills, and behaviors and will report greater improvements in mental health symptoms and recovery, and better academic outcomes.",[349,350,351],"Major Depressive Disorder","Bipolar Disorder","Schizophrenia",[353,354,355,356,357],"Taking Action","Recovery","Wellness","Serious Mental Illness","College Students",{"date":359,"type":38},"2025-12-29",{"date":76,"type":38},{"date":109,"type":21},{"name":44,"class":45},{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":367,"acronym":4,"eligibilityCriteria":368,"healthyVolunteers":55,"sex":120,"minAge":17,"maxAge":4,"enrollmentInfo":369,"targetDuration":4,"studyType":22,"phases":371,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":46},"100477633","the-path-to-optimal-black-maternal-heart-health-comparing-two-cvd-risk-reduction-interventions-change-of-heart-100477633","NCT05499507","The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)","Inclusion Criteria:\n\n* age ≥18 years\n* baseline BMI ≥30 kg\u002Fm2 and\u002For diagnosis of HTN (≥130\u002F80 x 2)\n* gestational age \\\u003C24 weeks by last menstrual period\n* smartphone ownership\n* self-identification as Black or African American",{"count":370,"type":21},432,[91],"The overarching goal of our proposal is to reduce disparities in perinatal cardiovascular disease risk factors among Black women utilizing a community-driven, social ecological framework.",[374,375,155,376],"Pregnancy Related","Hypertension","Racism","2025-12-04",{"date":379,"type":38},"2025-12-11",{"date":381,"type":38},"2023-01-24",{"date":383,"type":21},"2028-12-10",{"name":44,"class":45},{"id":386,"slug":387,"hasResults":11,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":4,"eligibilityCriteria":391,"healthyVolunteers":55,"sex":16,"minAge":392,"maxAge":393,"enrollmentInfo":394,"targetDuration":4,"studyType":22,"phases":396,"briefSummary":397,"conditions":398,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":111},"100524615","nurturing-needs-study-parenting-food-motivated-children-100524615","NCT06111040","Nurturing Needs Study: Parenting Food Motivated Children","Deconstructing Food Parenting Approaches to Obesity Prevention for the Highly Food Motivated Child","Inclusion Criteria:\n\n1. Child ages 4 or 5 years at baseline;\n2. Parent\u002F primary caregiver with legal representation (having 50% or more custody of child);\n3. Parent\u002Fprimary caregiver reporting primary responsibility for child feeding outside of childcare (being with child when they are eating at least two times daily);\n4. Caregiver with a cell phone that can be used to send and receive text messages. If there is more than one age-eligible child in the family, we will ask the caregiver to pick the index child.\n\nExclusion Criteria:\n\n1. Parent\u002Fprimary caregiver \\\u003C18 years of age;\n2. Child history of major food allergies (e.g., peanuts);\n3. Child medication use (e.g., insulin), developmental disability (e.g., autism) or medical condition(s) (e.g., diabetes) known to affect food intake and growth;\n4. Foster child.","4 Years","5 Years",{"count":395,"type":21},416,[91],"High food motivation among children is trait-like and increases risks of unhealthy dietary intake and obesity. Scientific knowledge of how parenting can best support healthy eating habits and growth among children who are predisposed to overeating is surprisingly limited. This investigation will identify supportive food parenting approaches for obesity prevention that address the needs of highly food motivated children.",[399,400,401,402],"Parenting","Eating Behavior","Diet, Healthy","Pediatric Obesity","2025-11-03",{"date":405,"type":38},"2025-11-05",{"date":407,"type":38},"2023-09-07",{"date":409,"type":21},"2027-10-31",{"name":44,"class":45},{"id":412,"slug":413,"hasResults":11,"nctId":414,"briefTitle":415,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":22,"phases":421,"briefSummary":422,"conditions":423,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":431,"locationsCount":46},"100535869","informationseekingmesolimbicengagementstudy2-100535869","NCT06257433","InformationSeekingMesolimbicEngagementStudy2","The Influence of Mesolimbic-hippocampal Interactions on Episodic Memory During Active Information Seeking","Inclusion Criteria:\n\n* 20\u002F40 far acuity (either corrected or uncorrected)\n* In good medical health\n\nExclusion Criteria:\n\n* History of head injury\n* History of illness with Central Nervous Systems implications\n* On Medications that Affect blood flow response and alertness\n* Consumption of smoking and\u002For coffee 30 minutes prior to laboratory testing\n* Placement of a device contraindicated for magnetic resonance imaging including cardia pacemaker, aneurysm clip, cochlear implants, pregnancy, intra-uterine device, shrapnel, metal fragments in the eyes, neurostimulators\n* Weight \\> 250lbs\n* Claustrophobia","45 Years",{"count":420,"type":21},80,[91],"Participants will complete a treasure task during neuroimaging where they have to learn which keys open a treasure chest, and then they are tested on the contents of the treasure chest.",[424],"Motivation","2025-08-28",{"date":427,"type":38},"2025-09-05",{"date":429,"type":38},"2023-10-24",{"date":138,"type":21},{"name":44,"class":45},{"id":433,"slug":434,"hasResults":11,"nctId":435,"briefTitle":436,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":289,"enrollmentInfo":438,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":439,"conditions":440,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":46},"100604611","prospective-validation-of-the-novel-pvd-b65-risk-score-in-patients-with-chronic-lung-disease-and-pulmonary-hypertension-100604611","NCT07151768","Prospective Validation of the Novel PVD-B65 Risk Score in Patients With Chronic Lung Disease and Pulmonary Hypertension","Inclusion Criteria:\n\n* Eligibility criteria\n\n  1. Adult patients ≥ 18 years of age with chronic lung disease diagnosed via CT chest and\u002For PFT data and pre-capillary pulmonary hypertension diagnosed via right-heart catheterization (RHC, mPAP \\> 20 mmHg, PVR \\> 2 WU, and PCWP ≤ 15 mmHg)\n\n     1. Chronic lung disease diagnoses will include: COPD, IPF, other pulmonary fibrosis, non-fibrotic ILD, combined pulmonary fibrosis and emphysema, and advanced pulmonary sarcoidosis with parenchymal involvement\n     2. PFT criteria will include an FEV1\u002FFVC \\\u003C 0.70 for the diagnosis of COPD\n  2. Willingness to make return visits and be available by telephone for the duration of the study.\n  3. Ability to participate in necessary testing, including ambulatory testing\n\nExclusion Criteria:\n\n* Exclusion criteria\n\n  1. Patients with pulmonary hypertension but without associated chronic lung disease (i.e. idiopathic or group 1 PAH, PH with post-capillary component defined as PCWP \\> 15 mmHg or group 2 PAH, CTEPH or group 4 PH, group 5 PH aside from sarcoidosis with parenchymal involvement)\n  2. Patients with uncontrolled severe systemic disease that could influence life expectancy (i.e. uncontrolled cardiovascular disease, active malignancy, etc.)\n  3. Prior lung and\u002For heart transplantation",{"count":231,"type":21},"Prospective observational study to determine if the PVD-B65 risk score for one-year mortality in patients with chronic lung disease and pulmonary hypertension (CLD-PH) can accurately risk stratify these patients and successfully predict one-year mortality from time of pulmonary hypertension diagnosis. PVD-B65 risk score was developed in a retrospective cohort of patients with CLD-PH, utilizing the presence of pulmonary fibrosis without emphysema, pulmonary vascular resistance (PVR) \\> 5 woods units (WU), 6-minute walk distance (6MWD) \\\u003C 150 meters, B-natriuretic type peptide (BNP) \\> 200 pg\u002FmL or N-terminal pro-natriuretic type peptide (NT-proBNP) \\> 300 pg\u002FdL, and age \\> 65 years as the score components.",[441,442],"Chronic Lung Disease","Pulmonary Hypertension","2025-08-25",{"date":445,"type":38},"2025-09-03",{"date":447,"type":21},"2025-09-01",{"date":449,"type":21},"2028-09-01",{"name":44,"class":45},{"id":452,"slug":453,"hasResults":11,"nctId":454,"briefTitle":455,"officialTitle":456,"acronym":457,"eligibilityCriteria":458,"healthyVolunteers":11,"sex":459,"minAge":17,"maxAge":4,"enrollmentInfo":460,"targetDuration":4,"studyType":22,"phases":461,"briefSummary":462,"conditions":463,"keywords":467,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":479,"completionDateStruct":481,"leadSponsor":483,"locationsCount":4},"100597197","a-trauma-informed-intervention-for-the-newly-hiv-diagnosed-100597197","NCT07055360","A Trauma-Informed Intervention for the Newly HIV-Diagnosed","A Trauma-Informed Intervention for Sexual Minority Men Recently Diagnosed With HIV","RISE","Inclusion Criteria:\n\n* Diagnosed with HIV within the past 3 months\n* Self-identification as Black or African American\n* Aged 18-39 years\n* Elevated traumatic stress as indicated by scores above clinical cutoffs on either of the following subscales of the Impact of Event Scale--Revised: Intrusion (score of 5 or greater) and Avoidance (score of 7 or greater)\n* Owning a phone with short-message service or messaging\n* Access to a device with a screen, a web browser, and adequate internet speed for videoconferencing (e.g., smartphone, computer).\n\nExclusion Criteria:\n\n* Demonstrating cognitive impairment or acute psychosis\n* Reporting unvailability to participate in the Baseline Assessment, the RISE intervention, and 3-, 6, and 9-Month Follow-Up Assessments","MALE",{"count":420,"type":21},[91],"The current approach to HIV prevention emphasizes: (1) achieving viral suppression among HIV+ people in order to reduce HIV transmissibility, particularly for disproportionately affected groups such as Black sexual minority men (BSMM), by increasing retention in HIV care, and (2) addressing comorbidities and complications, which include mental health concerns such as trauma symptomology and severe acute stress reactivity. Despite the disproportionate impact of both HIV and traumatic stress on BSMM and the adverse effects of stress on engagement in HIV care, BSMM remain grossly underserved with respect to mental health. To address these gaps, the proposed study will develop an intervention that will: (1) provide a brief, resilience-oriented, trauma-informed intervention that combines online sessions and highly tailored text-messaging to reduce participant burden and motivate clients between sessions, (2) provide preliminary treatment for HIV+ BSMM's unaddressed mental health needs, and (3) be embedded early in the HIV continuum of care immediately after diagnosis to facilitate linkage to and retention in HIV care.",[464,465,466],"Stress","HIV Care Loss to Followup","HIV Treatment Cascade",[468,329,469,470,127,471,472,473,474,475],"resilience","intervention","mental health","HIV care","newly-diagnosed","mHealth","eHealth","stress","2025-06-27",{"date":478,"type":38},"2025-07-08",{"date":480,"type":21},"2026-01-05",{"date":482,"type":21},"2026-09-12",{"name":44,"class":45},{"id":485,"slug":486,"hasResults":11,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":4,"eligibilityCriteria":490,"healthyVolunteers":55,"sex":16,"minAge":491,"maxAge":88,"enrollmentInfo":492,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":494,"conditions":495,"keywords":497,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":46},"100587851","temple-health-chest-initiative-thci-20-100587851","NCT06933758","Temple Health Chest Initiative (THCI 2.0)","Temple Health Chest Initiative (THCI 2.0) - Lung Cancer Screening Project With COPD Detection","Inclusion Criteria:\n\n* 50 to 80 years old\n* Screened for early lung cancer using low dose CT imaging\n\nExclusion Criteria:\n\n* Under 50; over 80 years old\n* No lung cancer screening","50 Years",{"count":493,"type":21},1000,"Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare utilization including hospitalization. Population-based screening for COPD has not been recommended by the US Preventative Services Task Force (USPSTF). However, LDCT screening for lung cancer in patients aged 50- 80 with ≥ 20 pack year smoking has been shown to improve survival. COPD is highly prevalent within LCS programs, with estimated rates of obstructive lung function of up to 59% and evidence of emphysema on CT scan in around 70%.",[496],"Chronic Obstructive Pulmonary Disease (COPD)",[498],"COPD","2025-04-10",{"date":501,"type":38},"2025-04-18",{"date":503,"type":38},"2025-02-28",{"date":505,"type":21},"2026-06-30",{"name":44,"class":45},{"id":508,"slug":509,"hasResults":11,"nctId":510,"briefTitle":511,"officialTitle":512,"acronym":4,"eligibilityCriteria":513,"healthyVolunteers":55,"sex":16,"minAge":392,"maxAge":256,"enrollmentInfo":514,"targetDuration":4,"studyType":22,"phases":516,"briefSummary":517,"conditions":518,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":46},"100524392","food-for-thought-executive-functioning-around-eating-among-children-100524392","NCT06108128","Food for Thought: Executive Functioning Around Eating Among Children","Characterizing Top-down Dimensions of Appetite Self-regulation Among Preschoolers","Inclusion Criteria:\n\n1. Child ages 4 to 6 years of age\n2. Caregiver reporting primary responsibility for child feeding outside of childcare\n3. Caregiver legal guardian\n\nExclusion Criteria:\n\n1. Caregiver \\\u003C18 years of age\n2. Child major food allergies\n3. Child medication use, developmental disability, or medical conditions known to affect food intake and\u002For growth; color blindness\n4. Child in foster care",{"count":515,"type":21},125,[91],"Scientific knowledge of the cognitive-developmental processes that serve to support children's appetite self-regulation are surprisingly limited. This investigation will provide new scientific directions for obesity prevention by elucidating cognitive-developmental influences on young children's ability to make healthy food choices and eat in moderation.",[519,520,400,521],"Self-regulation","Appetitive Behavior","Child Obesity","2025-04-07",{"date":499,"type":38},{"date":525,"type":38},"2023-10-05",{"date":527,"type":21},"2025-12-31",{"name":44,"class":45},{"id":530,"slug":531,"hasResults":11,"nctId":532,"briefTitle":533,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":55,"sex":16,"minAge":535,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":22,"phases":537,"briefSummary":538,"conditions":539,"keywords":540,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":546,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":4},"100470475","machine-learning-to-reduce-hypertension-treatment-clinical-inertia-100470475","NCT05406336","Machine Learning to Reduce Hypertension Treatment Clinical Inertia","Inclusion Criteria: practicing primary care clinicians who see patients (i.e., internal medicine, family medicine, attending physicians, nurse practitioners) will be eligible to participate -\n\nExclusion Criteria:\n\n\\-","20 Years",{"count":259,"type":21},[91],"Among individuals with an uncontrolled BP at the current visit, the objective of this study is to compare clinical management of hypertension with and without information from a machine learning algorithm on whether a patient will have uncontrolled blood pressure at their next follow up visit through a case-vignette study.",[375],[541,542,543,544,545],"Uncontrolled blood pressure","Antihypertensive medication","Hypertension treatment","Clinical inertia","Machine learning",{"date":499,"type":38},{"date":548,"type":21},"2025-04-25",{"date":550,"type":21},"2025-07-31",{"name":44,"class":45},{"id":553,"slug":554,"hasResults":11,"nctId":555,"briefTitle":556,"officialTitle":557,"acronym":4,"eligibilityCriteria":558,"healthyVolunteers":11,"sex":16,"minAge":559,"maxAge":4,"enrollmentInfo":560,"targetDuration":4,"studyType":22,"phases":562,"briefSummary":563,"conditions":564,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":566,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":572,"locationsCount":573},"100455003","myairvo-3-high-flow-nasal-therapy-hfnt-for-copd-patients-in-the-home-100455003","NCT05204888","myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home","myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home - a Multi-center Randomized Controlled Trial","To be eligible to participate in this study, an individual must meet all the following criteria:\n\n1. Provision of signed and dated informed consent form\n2. Stated willingness to comply with all study procedures and availability for the duration of the study\n3. Male or female, aged 30 years or greater\n4. FEV1\u002FFVC of \\\u003C 70% and an FEV1 of \\\u003C 80% (GOLD stages II - IV, Grade E)\n\n   • Spirometry performed during the screening visit will be used to confirm GOLD stage. A prior spirometric test within the past 6 months can be substituted if available.\n5. MRC ≥ 2 or CAT ≥ 10\n6. Former smokers or current smokers and never-smokers are eligible for study inclusion\n\n   • Current smokers must refrain from smoking when using supplemental oxygen or the myAirvo-3 device\n7. History of a severe COPD exacerbation requiring hospitalization in the previous six weeks\n8. COPD in a stable state after hospitalization defined as:\n\n   * Clinically stable condition and have had no parenteral therapy for 24 hours.\n   * Inhaled bronchodilators are required less than four-hourly.\n   * Oxygen delivery has ceased for 24 hours (unless home oxygen is indicated).\n   * If previously able, the patient is ambulating safely and independently, and performing activities of daily living.\n   * The patient can eat and sleep without significant episodes of dyspnea.\n   * The patient or caregiver understands and can administer medications.\n   * Follow-up and home care arrangements (e.g., home oxygen, homecare, Meals on Wheels, community nurse, allied health, GP, specialist) have been completed.\n9. Willing to adhere to the daily use of the myAirvo 3 regimen for at least 8 hours each day preferably at night following being shown and using the device\n10. Willing to record daily symptoms and pulse oximetry and heart rate on daily basis\n11. For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation\n\n    Highly effective contraception is defined as:\n    * A tubal ligation:\n    * An approved hormonal contraceptive such as oral contraceptives, emergency contraception used as directed, patches, implants, injections, rings or intrauterine devices\n12. Able to read and communicate in English\n13. Have a home environment suitable for myAirvo 3 use.\n14. Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration - refraining from smoking while receiving supplemental oxygen or the myAirvo-3 device\n\nExclusion Criteria:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Current self-reported chronic use of positive airway pressure (PAP) therapy; continuous positive airway pressure (CPAP), or non-invasive positive pressure ventilation (NPPV)\n2. A STOPBang Questionnaire score \\> 5\\*\n3. Pregnancy or lactation\n4. Treatment with another investigational drug or other intervention within the previous 30 days\n5. Life expectancy less than 12 months due to COPD or other comorbid condition.\n6. Recent upper airway surgery (within the previous month)\n7. Recent head or neck trauma (within the previous month)\n8. Inability to tolerate nasal prongs\n9. Requirement of oxygen greater than 15 L\u002Fmin\n\n   * subjects with a STOPBang questionnaire score of \\> 5 may be eligible if a recent sleep study (within the previous 3 months) shows the absence of obstructive sleep apnea or the subject has, or is at risk of OSA, but refuses to use an OSA device and all other eligibility criteria are met.","30 Years",{"count":561,"type":21},642,[91],"Parallel-group, prospective, randomized, controlled phase III trial of home High flow Nasal Therapy (HFNT) via myAirvo 3 plus usual COPD medical care vs. usual COPD medical care, for at least 1 year and up to two years in 642 GOLD Grade D, Stages II-IV patients with moderate to very severe COPD at risk for moderate and severe exacerbations with a prior history of severe exacerbation requiring hospitalization within the past 6 weeks.",[498],"2025-02-05",{"date":567,"type":38},"2025-02-06",{"date":569,"type":38},"2022-02-02",{"date":571,"type":21},"2027-03",{"name":44,"class":45},27,{"id":575,"slug":576,"hasResults":11,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":4,"eligibilityCriteria":580,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":581,"enrollmentInfo":582,"targetDuration":4,"studyType":22,"phases":584,"briefSummary":585,"conditions":586,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":587,"lastUpdatePostDateStruct":588,"startDateStruct":590,"completionDateStruct":592,"leadSponsor":594,"locationsCount":46},"100544583","peer-facilitated-waitlist-controlled-transportation-study-100544583","NCT06370767","Peer Facilitated Waitlist Controlled Transportation Study","Enhancing Community Mobility in Individuals With Serious Mental Illnesses Through Peer-Facilitated Travel Training: A Two-armed Waitlist Controlled Trial","Inclusion Criteria:\n\n* are between the ages of 18 and 65\n* are diagnosed with a SMI (confirmed via the MINI)\n* score at least an 8 on a travel skills assessment\n* indicates that they can ride a bicycle\n* have expressed interest in using a bikeshare and public transportation\n* are able to provide informed consent\n\nExclusion Criteria:\n\n* score less than 8 on a travel skills assessment\n* express no interest in independent transportation\n* are non-English speaking individuals\n* are unable to provide consent\n* are living in a setting where mobility and participation is restricted\n* have a limiting physical condition that would prevent their ability to ride a bicycle independently","65 Years",{"count":583,"type":21},180,[91],"The goal of this clinical trial is to test the effectiveness of a peer-facilitated travel intervention in adults with serious mental illnesses. This project aims to address the following hypotheses:\n\n1. Individuals with SMI receiving either of the two peer-mediated travel training transportation interventions will experience an increase in transportation self-efficacy and transportation skills.\n2. Participants in the intervention arms will increase their transport utilization, participate in significantly more activities in the community, and make significantly more trips in the community.\n3. Individuals with SMI receiving peer-mediated travel training interventions will retain post-test levels of community participation and self-efficacy 2 months after intervention.\n\nParticipants will be assigned to an 8-week travel-training intervention either using a bike-share program or public transportation. All participants will complete three data-collection research interviews.",[356],"2024-10-30",{"date":589,"type":38},"2024-11-01",{"date":591,"type":38},"2024-09-12",{"date":593,"type":21},"2025-05",{"name":44,"class":45},{"id":596,"slug":597,"hasResults":11,"nctId":598,"briefTitle":599,"officialTitle":600,"acronym":601,"eligibilityCriteria":602,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":289,"enrollmentInfo":603,"targetDuration":4,"studyType":22,"phases":605,"briefSummary":606,"conditions":607,"keywords":609,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":4},"100561735","community-navigators-100561735","NCT06594029","Community Navigators","Community Participation Navigators: Testing a Peer Intervention for Adults With Serious Mental Illnesses","Navigators","Inclusion Criteria:\n\n1. meet the criteria for an SMI diagnosis of schizophrenia, schizoaffective, bipolar, or major depression diagnosis based on the MINI,\n2. are over the age of 18-years-old\n3. are fluent in English: As current intervention materials and research and intervention personnel are only fluent in English, only participants who can communicate in written and spoken English are eligible for enrollment.\n4. have a permanent residence without constraints on participation (free to come and go from residence without restrictions) 2\n5. have the ability to provide informed consent.\n\nExclusion Criteria:\n\n* inability to provide consent (legal guardian)\n* unable to speak and understand English",{"count":604,"type":21},96,[91],"The Temple University Collaborative on Community Inclusion (TU Collaborative) is testing a community navigation intervention study based upon effective health navigation models by conducting a randomized controlled trial of the intervention to establish feasibility, efficacy, and outcomes among adults with serious mental illness (SMI).",[295,296,608],"Mental Health Issue",[610,611,356],"peer support","community participation","2024-09-10",{"date":614,"type":38},"2024-09-19",{"date":616,"type":21},"2024-09",{"date":618,"type":21},"2032-06",{"name":44,"class":45},""]