[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Texas Tech University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":290},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,47,78,99,123,151,170,194,211,236,262],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100560731","heat-and-exercise-in-aging-as-therapy-heat-100560731",false,"NCT06580964","Heat and Exercise in Aging as Therapy (HEAT)","Glycemic Control and Frailty Risk in Older People at Risk for Type 2 Diabetes: Impact of Local Heat Therapy","HEAT","Inclusion Criteria:\n\n* Age ≥ 50 years\n* Women who are postmenopausal, defined as no menstrual period for at least 12 consecutive months.\n* Sedentary (structured exercise \\\u003C30 minutes, 3x\u002Fweek)\n* Body weight is at least 110 lbs\n* Meet criteria for prediabetes (fasting blood glucose 100-125 mg\u002Fdl, hemoglobin A1c 5.7-6.4%)\n* Consume \\\u003C8 (women) or \\\u003C15 (men) alcohol-containing beverages per week\n* Do not use nicotine or cannabis\n* Not taking any medications that could interfere with responses to the interventions (e.g., corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, metformin, anticoagulants, barbiturates, insulin sensitizers, fibrates, immunosuppressants). If you don't know, that's okay. We'll ask what medications you are on and check whether they fall into one of these categories.\n\nExclusion Criteria:\n\n* History of peripheral neuropathies\n* Currently taking prescription blood thinners\n* Medical complications that could would contraindicate participation in the high intensity interval training (HIIT) intervention including: orthopedic complications that would limit your ability to perform cycling exercise, significant cardiovascular impairments (e.g., history of arrhythmias, severe uncontrolled hypertension, etc.), diagnosed metabolic disease (e.g., diabetes), renal disease, sickle cell anemia, or cancer in remission for \\\u003C6 months.\n* Known history of slow wound healing\n* Lidocaine allergy\n* Latex allergy\n* Currently pregnant\n* \\>1.5\" subcutaneous fat over the thigh muscle\n* Symptoms suggestive of cardiovascular, respiratory, metabolic, or renal diseases including discomfort, pressure, or pain in your chest, neck, jaw, arms, calves, or other areas potentially related to ischemia; shortness of breath at rest or with mild exertion; dizziness or fainting (syncope); difficulty breathing while lying flat (orthopnea) or sudden nighttime breathing difficulties (paroxysmal nocturnal dyspnea); palpitations or rapid heartbeat (tachycardia); pain or cramping in your legs during physical activity (intermittent claudication); a known heart murmur; swelling in your ankles (edema); unusual fatigue or shortness of breath during routine activities or at rest.","ALL","50 Years",{"count":20,"type":21},54,"ESTIMATED","INTERVENTIONAL",[24],"NA","The main goal of this two-phase clinical trial is to learn whether local heat therapy, using heat pads applied to the legs, can enhance skeletal muscle health, physical function, and blood sugar control in a manner comparable to exercise, specifically High-Intensity Interval Training (HIIT), in older individuals with prediabetes. The study aims to answer the following questions:\n\n1. Does local heat therapy improve muscle architecture (e.g., muscle cross-sectional area, capillary density, mitochondrial content), glucose tolerance, and frailty indicators similarly to HIIT in older individuals with prediabetes?\n2. Does local heat therapy as a pre-conditioning method enhance the skeletal muscle response to HIIT in older individuals with prediabetes?",[27],"Prediabetic State",[29,30,31,32,33],"Exercise","Heat","Aging","Prediabetes","Skeletal Muscle","RECRUITING","2026-06-18",{"date":37,"type":38},"2026-06-23","ACTUAL",{"date":40,"type":38},"2025-11-06",{"date":42,"type":21},"2029-07-31",{"name":44,"class":45},"Texas Tech University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100611363","phase-1-act-for-individuals-with-mncd-and-their-care-partners-100611363","NCT07239609","ACT for Individuals With MNCD and Their Care Partners","Acceptance and Commitment Therapy for Individuals With MNCD and Their Care Partners: An In-Person and Telehealth Individual Therapy Approach","ACT","Inclusion Criteria\n\nInclusion (person with MCI or MNCD):\n\n* 18+\n* MMSE= 21-27\n* Able to communicate in English\n\nInclusion (care partner):\n\n* 18+\n* Identifies as a care partner of a person with MNCD\n* Able to communicate in English\n* MMSE= 28-30\n* Is a family member or friend of the person with MNCD\n\nExclusion Criteria\n\nExclusion (person with MCI or MNCD):\n\n* Currently in an intervention for reducing anxiety or depression related to their dementia\n* MMSE= 28+ or less than 21\n\nExclusion (care partner):\n\n* MMSE= \\\u003C28\n* Is a formal (paid) caregiver",true,"18 Years",{"count":58,"type":21},100,[60],"PHASE1","This project aims to implement and evaluate a dyadic intervention (i.e., acceptance commitment therapy) for persons with AD\u002FADRD and their care partners. We hypothesize the intervention will be feasible, acceptable, and show preliminary efficacy of the dyadic interveniotns.",[63,64,65],"Depression in Adults","Anxiety Disorder Generalized","Grief",[67,68,69],"Mild Cognitive Impariment","Mild Neurocognitive Disorder","Dyadic intervention","2026-05-13",{"date":72,"type":38},"2026-05-15",{"date":74,"type":38},"2026-04-01",{"date":76,"type":21},"2027-12-31",{"name":44,"class":45},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":46},"100602146","telehealth-to-improve-quality-of-life-in-persons-living-in-rural-texas-100602146","NCT07119710","Telehealth to Improve Quality of Life in Persons Living in Rural Texas","Improving Quality of Life in Persons Living in Rural Texas","Inclusion Criteria:\n\n* family caregiver of person with all forms of dementia\n\nExclusion Criteria:\n\n* not in another clinical intervention","110 Years",{"count":87,"type":21},60,[24],"The overarching goal of this project is to evaluate a current evidence-based practice, Cognitive Behavioral Therapy, for mental health conditions against Cognitive Behavioral Therapy plus two check-in calls a week for adults living in rural Texas.",[91,92],"Mental Health Issue","Quality of Life",{"date":72,"type":38},{"date":95,"type":38},"2023-03-24",{"date":97,"type":21},"2028-12-01",{"name":44,"class":45},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":117,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":46},"100576812","study-of-patients-being-treated-with-anti-obesity-medication-100576812","NCT06790160","Study of Patients Being Treated With Anti-obesity Medication","Observational Study of Patients Being Treated With Anti-obesity Medication","Inclusion Criteria:\n\n* Patient who is beginning treatment through Vineyard Virtual Health Clinic using semaglutide or tirzepatide. While the physician will individualize the treatment plans, the criteria for these medications will include, at a minimum: (A) a body mass index ≥30 kg\u002Fm2; OR (B) a BMI ≥27 kg\u002Fm2 plus at least one comorbidity.\n* Patient who lives in drivable proximity to a city with an accepted DXA testing facility and is willing to report to the facility for periodic body composition testing.\n\nExclusion Criteria:\n\n* Patients with type 2 diabetes.\n* Patients who report not being willing or able to complete the assessments included in this research study.\n* Patients who are currently pregnant or trying to become pregnant.",{"count":58,"type":21},"OBSERVATIONAL","The goal of this observational study is to learn about the real-world effects of selected obesity medications in adults undergoing medical weight management. The main outcomes of interest are changes in body composition, routine clinical markers, muscular performance, and nutritional intake over the course of treatment. Additionally, the influence of lifestyle factors on changes in these outcome variables will be examined.\n\nParticipants beginning treatment with selected obesity medications will undergo periodic body composition and muscular performance testing, as well as complete online surveys about their nutritional intake and physical activity and exercise participation. Additionally, routinely collected clinical information will be evaluated.",[110],"Obesity and Overweight",[112,113,114,115,116],"obesity","GLP-1","body composition","nutrition","exercise",{"date":72,"type":38},{"date":119,"type":38},"2025-01-31",{"date":121,"type":21},"2027-12",{"name":44,"class":45},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":136,"conditions":137,"keywords":140,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":145,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":46},"100574172","phase-1-pilot-testing-a-novel-approach-to-pediatric-obesity-treatment-100574172","NCT06755827","Pilot Testing a Novel Approach to Pediatric Obesity Treatment","Emotion Regulation Intervention to Improve Neural Responsiveness and Health","Inclusion Criteria:\n\n* Being English-proficient\n* Ages 11-14\n* At or above the 85th BMI percentile based on age and sex norms\n* Having access to WIFI or cellular data to attend the telehealth groups\n* Living in a home in Lubbock County (TX) or surrounding areas.\n\nExclusion Criteria:\n\n* Having a psychiatric or medical diagnosis that interferes with participation (e.g., significant developmental delay; pregnancy)\n* Current enrollment in overweight\u002Fobesity treatment.\n* Because the study will include entering an MRI scanner, additional standard exclusion criteria will be considered (e.g., having immovable medical devices with batteries, body piercings on the head\u002Fface, and having substantial visual impairment that cannot be corrected with staff-provided glasses)","11 Years","14 Years",{"count":133,"type":21},30,[60,135],"PHASE2","The goal of this clinical trial is to learn if an emotion regulation and self-monitoring intervention can help treat overweight and obesity in teens. The main question it aims to answer is:\n\n* Does emotion regulation and self-monitoring help reduce biases in teens with overweight and obesity?\n* Do changes in biases relate to changes in health functioning and health behavior?\n\nResearchers will compare the intervention to the provision of educational handouts about overweight and obesity to see if the intervention is more effective.\n\nParticipants will:\n\n* Complete self-report questionnaires, an fMRI scan, and have their blood drawn\n* Received educational handouts or attend weekly telehealth group sessions weekly for four weeks and be asked to self-monitor their mood and behavior between sessions\n* Return to complete the same questionnaires, fMRI and blood draw procedures",[138,139],"Overweight Adolescents","Obese Adolescents",[141,112,142,143,144],"overweight","adolescents","neuronal responsiveness","emotion regulation",{"date":72,"type":38},{"date":147,"type":38},"2026-03-24",{"date":149,"type":21},"2026-12-31",{"name":44,"class":45},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":164,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":46},"100492788","telehealth-to-reduce-mental-health-in-family-caregivers-100492788","NCT05696704","Telehealth to Reduce Mental Health in Family Caregivers","Utilizing Telehealth to Reduce Pre-Death Grief, Burden, and Stress in Family Caregivers","Inclusion Criteria:\n\n* Participants must be informal caregivers (e.g., spouse; child; close friend) of individuals with dementia\n* Informal caregivers can be family members or close friends\n* Adults (18 to 89 years old) who read, write, and speak in English\n* Mental Health Diagnosis (e.g., Generalized Anxiety Disorder; Major Depressive Disorder\n\nExclusion Criteria:\n\n* Formal caregivers (who are being paid to take care of the patient)\n* Any informal caregivers with cognitive impairment is identified during the assessment.","120 Years",{"count":87,"type":21},[24],"The overarching goal of this project is to evaluate if evidence-based interventions can reduce PDG, burden, and stress in informal caregivers of individuals with dementia when provided over telehealth.",[91,65,163],"Burden, Caregiver",{"date":72,"type":38},{"date":166,"type":38},"2023-01-30",{"date":168,"type":21},"2028-12-31",{"name":44,"class":45},{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":180,"conditions":181,"keywords":183,"overallStatus":187,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":192,"leadSponsor":193,"locationsCount":4},"100635845","comparison-between-the-health-effects-of-an-ai-driven-model-with-those-of-human-professional-guidelines-for-the-treatment-of-obesity-100635845","NCT07557979","Comparison Between the Health Effects of an AI-driven Model With Those of Human Professional Guidelines for the Treatment of Obesity","Inclusion Criteria:\n\n* Participants with age 18 to 60 years,\n* BMI\\>30\n* Living in Lubbock-TX\n* Willing to participate in the study\n\nExclusion Criteria:\n\n* Pregnant women\n* Breastfeeding women\n* Recent diagnosis of a severe\u002Facute medical condition within 6 months\n* Any other chronic diseases except obesity (e.g., diabetes, chronic kidney diseases, psychiatric conditions, cancer, acute pancreatitis)\n* Taking any anti-obesity medications","60 Years",{"count":178,"type":21},21,[24],"Many non-communicable diseases are diet-related and have a significant impact on public health. It is stated that global dietary shifts are needed to change disease patterns, highlighting the importance of nutrition in addressing public health issues, such as obesity. The field of nutrition has been dependent on clinical and observational studies; however, the emergence of Artificial Intelligence (AI) is transforming these approaches.\n\nChatGPT may be used to provide dietary recommendations due to its high speed, extensive access to a variety of meal data, and low complexity. However, initial evaluations have shown that ChatGPT may be inaccurate in terms of safety and reliability, and traditional nutrition approaches are highly reliant on experts' knowledge and the validity of nutritional guidelines. It has been suggested that AI in nutrition may be beneficial; however, further investigations are needed. Our proposal aims to fill the represented critical evidence gaps.\n\nThe study aims to compare the health effects of an AI-driven model with those of human professional guidelines for the treatment of obesity. Furthermore, investigators seek better strategies to utilize AI, if appropriate, for weight loss and other health benefits.",[182],"Obesity (BMI>30)",[184,185,186],"An AI-driven model","Human professional guidelines","Treatment of obesity","NOT_YET_RECRUITING","2026-05-01",{"date":190,"type":38},"2026-05-07",{"date":72,"type":21},{"date":149,"type":21},{"name":44,"class":45},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":158,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":210,"locationsCount":46},"100464999","improving-mental-health-for-care-partners-of-persons-with-adadrd-100464999","NCT05334992","Improving Mental Health for Care Partners of Persons With AD\u002FADRD","Reducing Pre-Death Grief, Burden, and Stress in Informal Caregivers: A Group and Individual Therapy Approach",{"count":87,"type":21},[24],"The overarching goal of this project is to evaluate if evidence-based interventions can reduce PDG, burden, and stress in informal caregivers of individuals with dementia",[91,65,163],"2026-02-09",{"date":206,"type":38},"2026-02-12",{"date":208,"type":38},"2022-02-01",{"date":168,"type":21},{"name":44,"class":45},{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":22,"phases":219,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":235,"locationsCount":46},"100541764","mitochondrial-dna-signatures-of-poor-aerobic-exercise-trainability-in-young-adults-born-preterm-100541764","NCT06334107","Mitochondrial DNA Signatures of Poor Aerobic Exercise Trainability in Young Adults Born Preterm","Inclusion Criteria:\n\n* Preterm born (PTB)young adult group: Participants must be inactive (reported exercise \\< 150 mins\u002Fweek; See IPAQ Attachment), males and females aged 18-35 years born preterm with a gestational age \\<37 weeks.\n* Normal term-born (NTB) young adult control group: Participants must be inactive (reported exercise \\< 150 mins\u002Fweek) and will be age- and sex-matched and born at term (37 gestational age).\n* The biological mother of PTB participants: The PTB biological birth mother must be the one who gave birth to the participant and the one from whom the child inherited half of its genetic background (i.e., DNA).\n* PTB and NTB young adults must pass the PAR-Q+ Questionnaire assessment, indicating readiness to begin a moderate-intensity exercise training program. We will follow the American College of Sports Medicine\\'s aerobic exercise training program participation guidelines. Subjects who are cleared via the PAR-Q+ assessment will be permitted to participate in the training program.\n\nExclusion Criteria:\n\n• PTB and NTB young adults only: Having a diagnosed bronchopulmonary hyperplasia, cardiovascular (cardiac or peripheral arterial disease), metabolic (Diabetes Mellitus Type 1 or 2), or renal or liver disease, and signs or symptoms of these conditions, including pain: discomfort in the chest, neck, jaw, arms, or other areas that may result from ischemia; shortness of breath at rest or with mild exertion; dizziness or syncope; orthopnea or paroxysmal nocturnal dyspnea; ankle edema; palpitations or tachycardia; intermittent claudication; known heart murmur; unusual fatigue or shortness of breath with usual activity.","35 Years",{"count":87,"type":21},[24],"Young adults born very preterm (32 weeks gestation or earlier) do not respond well to aerobic exercise training, meeting the recommendations set by the Physical Activity Guidelines for Americans, where they do not increase their fitness level (or cardiorespiratory fitness). Thus, they do not receive the health benefits of exercise. Achieving physical fitness through aerobic exercise training is the most cost-effective method for preventing and treating many diseases. Young adults born very preterm also have a higher risk of these conditions. Thus, their inability to respond to increase their fitness is a major problem.\n\nOne likely explanation for poor exercise trainability and increased heart disease risk in young adults born very preterm is the effect of the early birth on the major energy producers in all our cells: Mitochondria. During late-stage gestation, mitochondria change from relying on sugar as a major fuel source to fat. Unfortunately, individuals born very preterm miss this transition in fuel source reliance, which causes significant stress and damage to mitochondria. Mitochondria are critical for post-natal organ development; thus, it is thought that preterm birth-induced mitochondrial dysfunction is the underlying cause of poor trainability and high disease risk in young adults born very preterm. Indeed, mitochondrial dysfunction is evident in these individuals.\n\nTo date, there is not a way to help young adults born preterm improve their fitness level. One likely target is in the mitochondria: it's DNA. Mitochondrial DNA helps determine how mitochondria function and can be damaged under stress. Our goal in this proposed work is to determine the role of mitochondrial DNA in mitochondrial dysfunction and its link to their poor trainability.\n\nQuestions:\n\n1. Are there mitochondrial DNA markers linked to mitochondrial dysfunction and poor exercise trainability in young adults very born preterm?\n2. Do mitochondrial DNA in young adults born very preterm respond differently to aerobic exercise training than those born at term?\n\nThe investigators expect this work will show mitochondrial DNA changes linked to mitochondrial dysfunction and poor trainability, which can be used for future targets to improve health. This work supports AHA mission by helping to identify a marker in individuals born very preterm linked to their higher heart disease risk and death early in life.",[222],"Preterm Birth",[224,225,226,227,228],"Preterm birth","Aerobic capacity trainability","mitochondrial DNA","heteroplasmy","mitochondrial oxidative capacity","2025-12-11",{"date":231,"type":38},"2025-12-18",{"date":233,"type":38},"2024-05-01",{"date":149,"type":21},{"name":44,"class":45},{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":55,"sex":17,"minAge":244,"maxAge":245,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":248,"briefSummary":249,"conditions":250,"keywords":251,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":46},"100599452","dehydration-rehydration-and-impact-on-physiology-100599452","NCT07084675","Dehydration, Rehydration, and Impact on Physiology","Impact of Mild Dehydration and Subsequent Rehydration on Cellular Stress and Physiological Performance","DRIP","Inclusion Criteria:\n\n* Apparently Healthy\n* BMI \\\u003C 30 kg\u002Fm2\n* Body weight is at least 110 lbs\n\nExclusion Criteria:\n\n* Currently pregnant\n* Have Type 1 Diabetes or Type 2 Diabetes\n* Have chronic kidney disease or a history of kidney stones\n* Have hypertension\n* Take medications that can cause fluid retention, such as corticosteroids, chronic use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Hormonal Therapies (e.g., estrogen, androgens or anabolic steroids), Antihypertensives, Psychiatric Medications (e.g., Lithium), Vasodilators\n* Take medications that reduce fluid retention: diuretics, and RAAS Inhibitors (e.g., ACE inhibitors and ARBs)","45 Years","65 Years",{"count":247,"type":21},15,[24],"Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65.\n\nAim 1: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on H2O2, upstream inflammatory signal (NFkB), mitochondrial fragmentation, and autophagy in circulating PBMCs.\n\nAim 2: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on fasting glucose, sleep performance, and strength performance.\n\nParticipant will:\n\ncomplete a 4-day hydration protocol, followed by a 4-day dehydration protocol, and then a 4-day rehydration protocol.\n\nattend five laboratory visits for testing: Day 1: Informed consent and familiarization Day 2: Pre-hydration testing (before the 4-day hydration protocol) Day 3: Pre-dehydration testing (before the dehyration protocol) Day 4: Post-dehydration testing (after the dehydration protocol) Day 5: Post-rehydration testing (after the rehydration protocol)",[31],[252,253],"rehydration","hypohydration","2025-09-11",{"date":256,"type":38},"2025-09-17",{"date":258,"type":38},"2025-07-15",{"date":260,"type":21},"2026-12",{"name":44,"class":45},{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":55,"sex":17,"minAge":176,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":22,"phases":272,"briefSummary":273,"conditions":274,"keywords":277,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":46},"100561108","strength-training-and-resveratrol-100561108","NCT06585865","Strength Training and Resveratrol","Resveratrol-mediated Changes in Extracellular Vesicle microRNA Cargo as a Novel Contributor to Resistance Training-induced Skeletal Muscle Adaptations in Older Adults","STaR","Inclusion Criteria:\n\n* Age 60+\n* Minimally active (less than 1 hour of structured exercise\u002Fweek other than walking)\n* No resistance training for the previous 6 months\n* Not currently taking resveratrol supplements\n* Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period\n* Body mass at least 110 lbs\n\nExclusion Criteria:\n\n* Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.)\n* Cannabis or nicotine use\n* Consume more than 7 alcohol-containing beverages per week",{"count":271,"type":21},36,[24],"The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.",[275,276],"Sarcopenia","Anabolic Resistance",[278,31,279,275,280,281],"Resistance training","Resveratrol","Extracellular Vesicles","MicroRNAs","2025-06-27",{"date":284,"type":38},"2025-06-29",{"date":286,"type":38},"2025-06-13",{"date":288,"type":21},"2026-08",{"name":44,"class":45},""]