[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Affiliated Hospital of Putian University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":281},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,44,66,93,117,143,170,193,214,238,261],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100612217","effect-of-anal-lift-exercise-on-rehabilitation-after-anal-fistula-surgery-100612217",false,"NCT07250711","Effect of Anal Lift Exercise on Rehabilitation After Anal Fistula Surgery","Effect of Anal Lift Exercise on Rehabilitation After Anal Fistula Surgery: a Single-center, Prospective, Open-label, Randomized Clinical Trial","Inclusion Criteria:\n\n* Aged between 18 and 55 years old\n* Patients diagnosed with anal fistula through digital rectal examination and anoscopy\n* Receive operation\n\nExclusion Criteria:\n\n* The patient has a mental disorder.\n* Patients with hemorrhoids\n* Anal fistula combined with perianal abscess\n* Patients who are unable to cooperate with follow-up visits","ALL","18 Years","55 Years",{"count":20,"type":21},124,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective randomized controlled study aims to include patients who have undergone anal fistula surgery, to observe the impact of early postoperative pelvic floor muscle training combined with dietary intervention on postoperative pain, bleeding, anal distension and defecation function, with the goal of clarifying the value of early rehabilitation intervention in the recovery after anal fistula surgery, and providing a reference for optimizing postoperative management plans in clinical practice.",[27],"Kegel Exercises",[29,30],"anal fistula","Kegel Exercise","NOT_YET_RECRUITING","2026-04-14",{"date":34,"type":35},"2026-04-17","ACTUAL",{"date":37,"type":21},"2026-06-20",{"date":39,"type":21},"2026-06-30",{"name":41,"class":42},"The Affiliated Hospital of Putian University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100608077","comparison-of-the-clinical-effects-of-open-closed-and-semi-close-hemorrhoidectomy-100608077","NCT07196865","Comparison of the Clinical Effects of Open, Closed, and Semi-close Hemorrhoidectomy.","Comparison of the Clinical Effects of Open, Closed, and Semi-close Hemorrhoidectomy: Study Protocol for a Single-center, Prospective, Open-label and Randomized Clinical Trial.","Inclusion Criteria:\n\n1. Patients aged 18 to 75 years.\n2. Clinical diagnosis of mixed hemorrhoids requiring surgical intervention.\n3. Scheduled to undergo hemorrhoidectomy with ligation of internal hemorrhoids and excision of external hemorrhoids.\n4. Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n1. History of mental illness or cognitive impairment that may affect the ability to provide informed consent or comply with the study protocol.\n2. Diagnosis of diabetes mellitus.\n3. Planned concomitant procedures (e.g., radiofrequency ablation, sclerotherapy) in addition to hemorrhoidectomy.\n4. Inability or unwillingness to comply with scheduled follow-up visits.\n5. Presence of severe perioperative comorbidities that render the patient unsuitable for the planned surgical protocol or anesthesia (as determined by the attending anesthesiologist or surgeon).","75 Years",{"count":53,"type":21},378,[24],"This study compares three different ways surgeons close the wound after removing hemorrhoids (piles): leaving it completely open, stitching it completely closed, or stitching only half of it closed (semi-closed). The goal is to see which method leads to faster healing, less pain, fewer complications, and better long-term results. Patients undergoing hemorrhoidectomy will be randomly assigned to one of the three groups. All patients will receive standard post-operative care. Researchers will measure healing time, pain levels, need for pain medication, hospital stay, complications, and check if hemorrhoids come back within one year.",[57],"Hemorrhoids","2026-03-02",{"date":60,"type":35},"2026-03-04",{"date":62,"type":21},"2026-04-01",{"date":64,"type":21},"2026-12-30",{"name":41,"class":42},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100626612","phase-2-neoadjuvant-adebrelimab-plus-chemotherapy-for-esophageal-cancer-a-clinical-study-100626612","NCT07437898","Neoadjuvant Adebrelimab Plus Chemotherapy for Esophageal Cancer: A Clinical Study","An Exploratory, Single-Arm, Multicenter Clinical Study of Neoadjuvant Adebrelimab Plus Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma","Inclusion Criteria:\n\n* Provided written informed consent and voluntarily enrolled in this study;\n* Aged 18-75 years, male or female;\n* Histologically or cytologically confirmed esophageal squamous cell carcinoma (ESCC);\n* Clinical stage: cT1b-cT2N+M0 or cT3-cT4a any N M0;\n* At least one measurable lesion per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) criteria: long axis ≥10 mm on spiral CT for target lesions, or short axis ≥15 mm for malignant lymph nodes;\n* Predicted to be eligible for R0 resection;\n* Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 (see Appendix 1);\n* No prior anti-tumor therapy for esophageal cancer, including radiotherapy, chemotherapy, surgery, etc.;\n* Planned to undergo surgical resection after completion of neoadjuvant therapy;\n* No contraindications to surgery;\n* Adequate organ function, as defined below:\n\n  1. Hematologic parameters (no blood products, colony-stimulating factors, leukocyte-raising agents, platelet-raising agents, or anti-anemia agents permitted within 14 days prior to the first dose of study drug):\n\n     White blood cell (WBC) count ≥ 3.0×10⁹\u002FL Absolute neutrophil count (ANC) ≥ 1.0×10⁹\u002FL Platelet count ≥ 80×10⁹\u002FL Hemoglobin ≥ 90 g\u002FL\n  2. Blood biochemistry:\n\n     Total bilirubin ≤ 1.5×ULN Alanine transaminase (ALT) ≤ 2.5×ULN; aspartate transaminase (AST) ≤ 2.5×ULN Serum creatinine ≤ 1.5×ULN, or creatinine clearance ≥ 50 mL\u002Fmin (calculated by the Cockcroft-Gault formula, see Appendix 2)\n  3. Coagulation function:\n\nInternational normalized ratio (INR) ≤ 1.5×ULN Activated partial thromboplastin time (APTT) ≤ 1.5×ULN\n\n* Female subjects of childbearing potential must have a negative serum or urine pregnancy test within 72 hours before initiation of study drug administration, and use effective contraception (e.g., intrauterine device, oral contraceptives, condoms) during the trial and for at least 3 months after the last dose.Male subjects with female partners of childbearing potential must use effective contraception during the trial and for 3 months after the last dose;\n* Good subject compliance and willingness to comply with study follow-up requirements.\n\nExclusion Criteria:\n\n* Significant tumor invasion into adjacent organs of the esophageal lesion (e.g., major arteries or trachea);\n* Uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage;\n* Poor nutritional status with a Body Mass Index \\\u003C18.5 kg\u002Fm² (BMI \\\u003C18.5 kg\u002Fm²); subjects whose BMI is corrected with targeted nutritional support prior to randomization may be considered for enrollment at the discretion of the principal investigator;\n* History of hypersensitivity to monoclonal antibodies, any component of adebrelimab, paclitaxel, cisplatin, or other platinum-based agents;\n* Previous or ongoing receipt of any of the following therapies:\n\n  1. Any radiotherapy, chemotherapy, immunotherapy, targeted therapy, or other antitumor therapy for malignancy;\n  2. Systemic immunosuppressive therapy or systemic corticosteroid therapy for immunosuppressive purposes (prednisone \\>10 mg\u002Fday or equivalent dose) within 2 weeks prior to the first dose of study drug; Inhaled or topical steroids, and corticosteroid replacement therapy at prednisone \\>10 mg\u002Fday or equivalent dose are permitted in the absence of active autoimmune disease;\n  3. Live attenuated vaccine within 4 weeks prior to the first dose of study drug;\n  4. Major surgery or severe traumatic injury within 4 weeks prior to the first dose of study drug;\n* Any active autoimmune disease or history of autoimmune disease, including but not limited to: interstitial pneumonia, enteritis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism; subjects with hypothyroidism controlled by hormone replacement therapy may be considered for enrollment.\n\nSubjects with fully resolved psoriasis or childhood asthma\u002Fallergies requiring no adult intervention may be considered, while those requiring medical intervention with bronchodilators are excluded;\n\n* History of immunodeficiency, including positive HIV test, other acquired or congenital immunodeficiency disorders, history of organ transplantation, or allogeneic bone marrow transplantation;\n* Poorly controlled cardiac symptoms or diseases, including but not limited to:\n\n  1. Heart failure of New York Heart Association Class II (NYHA Class II) or higher;\n  2. Unstable angina pectoris;\n  3. Myocardial infarction within 1 year;\n  4. Clinically significant supraventricular or ventricular arrhythmias that are either untreated or poorly controlled despite clinical intervention;\n* Severe infection (Common Terminology Criteria for Adverse Events Grade \\>2 (CTCAE Grade \\>2)) within 4 weeks prior to the first dose of study drug, such as severe pneumonia requiring hospitalization, bacteremia, infectious complications, etc.\n\nSubjects with active pulmonary inflammation on baseline chest imaging, signs\u002Fsymptoms of infection, or requiring oral or intravenous antibiotic therapy within 14 days prior to the first dose of study drug are excluded, except for prophylactic antibiotic use;\n\n* Active tuberculosis confirmed by medical history or CT scan, history of active tuberculosis within 1 year prior to enrollment, or history of active tuberculosis more than 1 year prior to enrollment without standard anti-tuberculosis treatment;\n* Hereditary bleeding diathesis or coagulopathy. Clinically significant bleeding or documented bleeding tendency within 3 months prior to enrollment, including gastrointestinal bleeding, hemorrhagic gastric ulcer, and stool occult blood ≥++ at baseline;\n* Diagnosis of another malignancy within 5 years prior to the first dose of study drug, except for malignancies with low metastatic or mortality risk (5-year survival rate \\>90%), such as adequately treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ of the cervix, which may be considered for enrollment;\n* Female subjects who are pregnant or breastfeeding;\n* Any other conditions judged by the investigator that may result in premature study discontinuation, including concurrent treatment for other severe diseases (including psychiatric disorders), alcoholism, substance abuse, or family\u002Fsocial factors that may compromise subject safety or study compliance.",{"count":74,"type":21},42,[76],"PHASE2","This is a domestic exploratory, single-arm clinical study enrolling patients with histologically or cytologically confirmed locally advanced esophageal squamous cell carcinoma (ESCC), aiming to evaluate the efficacy and safety of neoadjuvant adebrelimab plus chemotherapy for locally advanced esophageal squamous cell carcinoma (ESCC).",[79],"Esophageal Squamous Cell Carcinoma",[81,82,83],"Adebrelimab","chemotherapy","Neoadjuvant","RECRUITING","2026-02-24",{"date":87,"type":35},"2026-02-27",{"date":89,"type":35},"2024-09-03",{"date":91,"type":21},"2026-12-01",{"name":41,"class":42},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":104,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":43},"100620472","clinical-application-of-dynamic-multimodal-analgesia-regimen-after-perianal-abscess-surgery-100620472","NCT07358065","Clinical Application of Dynamic Multimodal Analgesia Regimen After Perianal Abscess Surgery","Inclusion Criteria:\n\n* Diagnosed with primary perianal abscess by clinical examinations (digital rectal examination, ultrasound, or MRI) and undergoing incision and drainage or radical surgical treatment;\n* Abscess diameter ≥ 2 cm or accompanied by obvious abscess cavity formation;\n* Patients are willing and able to participate in the pain management plan, understand the importance of pain management, and actively cooperate;\n* No severe coagulation disorders.\n\nExclusion Criteria:\n\n* Complicated with specific infectious diseases such as Crohn's disease or tuberculosis;\n* Unclear source of postoperative pain (i.e., the patient's pain is uncertain or unrelated to the surgery);\n* Having definite contraindications, including drug allergies or inability to accept certain pain management methods adopted in the study;\n* Pregnant or lactating women;\n* Patients unable to cooperate with the study, such as those with cognitive impairment, history of mental illness, or communication difficulties;\n* Patients with long-term use of analgesic drugs and developed drug tolerance;\n* Complicated with uncontrolled cardiovascular and cerebrovascular diseases (NYHA cardiac function Class Ⅲ-Ⅳ), liver or kidney insufficiency (Child-Pugh Class C or eGFR \\\u003C 30 ml\u002Fmin\u002F1.73m²), etc.;\n* Abscess secondary to rectal tumors, trauma, or iatrogenic injury;\n* Postoperative occurrence of severe complications (e.g., massive hemorrhage, sepsis) or combined infection in other parts;\n* Patients receiving only non-surgical treatments such as simple puncture and aspiration of pus.",{"count":100,"type":21},135,[24],"This study aims to investigate whether the full-course multimodal analgesia regimen based on dynamic assessment (including the integrated traditional Chinese and Western medicine mode) can alleviate postoperative pain, reduce opioid dosage, and decrease the incidence of complications in patients with perianal abscess. It also intends to verify the clinical advantages of the integrated traditional Chinese and Western medicine multimodal regimen and establish a promotable standardized pain management pathway. A total of 135 eligible patients will be enrolled and divided into three groups in a 1:1:1 ratio using a single-center, prospective, randomized parallel-controlled design. The specific grouping and intervention methods are as follows: ① Control Group (Group A): Adopts the traditional analgesic mode, where NRS assessment and intervention are conducted only when the patient actively complains of pain (medication administered for scores ≥4 points) without preemptive medication. Medications refer to conventional schemes (e.g., flurbiprofen, diclofenac sodium, etc.). ② Western Medicine Multimodal Analgesia Group (Group B): Implements dynamic assessment + stepwise medication intervention + non-pharmacological auxiliary measures. Baseline NRS score is collected 24 hours before surgery; pain at rest and during activity is assessed at fixed time points after surgery; NSAIDs, opioids, and other medications are administered as needed, combined with potassium permanganate sitz bath, health education, etc. ③ Integrated Traditional Chinese and Western Medicine Multimodal Analgesia Group (Group C): Integrates characteristic traditional Chinese medicine nursing interventions (including auricular point pressing, wrist-ankle acupuncture, traditional Chinese medicine sitz bath, etc.) on the basis of Group B's intervention.\n\nTo evaluate the clinical efficacy of the dynamic multimodal analgesia regimen, this study will compare the following indicators among the three groups: NRS pain scores on postoperative days 1, 2, 3, 4, 5, as well as 2 weeks and 1 month after discharge; total postoperative analgesic consumption converted to morphine equivalent dose (MEDD); quality of life score assessed by the SF-36 scale; incidence of complications (such as urinary retention, secondary hemorrhage, etc.); sexual function recovery (assessed by the IIEF-5 scale for males and the FSFI scale for females); and patient satisfaction and compliance. The primary research hypothesis is: compared with conventional analgesia and western medicine-only multimodal analgesia, the integrated traditional Chinese and Western medicine multimodal analgesia regimen can significantly reduce patients' postoperative pain scores, decrease opioid dosage, improve quality of life and patient satisfaction, lower the incidence of complications, and enhance patients' sexual function recovery.",[97],[105,106,107,108],"Perianal Abscess","Postoperative Pain","Dynamic Assessment","Multimodal Analgesia","2026-01-23",{"date":111,"type":35},"2026-01-26",{"date":113,"type":21},"2026-01-01",{"date":115,"type":21},"2026-12-31",{"name":41,"class":42},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":124,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":43},"100619106","application-effects-of-wrist-ankle-acupuncture-in-patients-with-different-types-of-pain-following-perianal-surgery-100619106","NCT07340307","Application Effects of Wrist-Ankle Acupuncture in Patients With Different Types of Pain Following Perianal Surgery","Application of Wrist-Ankle Acupuncture in Patients With Different Types of Pain Following Perianal Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n* Aged between 18 and 75 years;\n* Patients who underwent perianal surgery;\n* Visual Analog Scale (VAS) score ≥4;\n* Clear consciousness with the ability to articulate their sensations;\n* Voluntary participation with signed informed consent.\n\nExclusion Criteria:\n\n* Pregnant or lactating patients;\n* Patients with a history of needle fainting or needle phobia;\n* Patients with incomplete skin integrity at the wrist or ankle;\n* Patients with comorbid systemic diseases, such as cardiac insufficiency or coagulation disorders;\n* Patients unable to cooperate with follow-up;\n* Patients currently participating in other clinical trials that may influence the outcomes of this study.",{"count":125,"type":21},58,[24],"This study is a prospective clinical observation designed to evaluate the analgesic effect of wrist-ankle acupuncture in patients with different types of pain after perianal surgery, as well as its applicability. A total of 60 eligible postoperative patients were enrolled, with inclusion criteria including age 18-75 years, postoperative Visual Analog Scale (VAS) score ≥4, clear consciousness, and signed informed consent. Exclusion criteria included pregnancy, history of needle fainting, skin lesions at the wrist or ankle, severe systemic diseases, inability to cooperate with follow-up, or participation in other clinical trials. Patients were divided into two groups according to the nature of pain: Group A (sphincter spasm pain, n=30) and Group B (acute incisional pain, n=30). All patients received routine postoperative care (including intravenous flurbiprofen infusion, traditional Chinese medicine soaking, and pain education), and wrist-ankle acupuncture was administered when pain intensity (Verbal Rating Scale, VRS) reached ≥4. The acupuncture method involved superficial subcutaneous insertion in zones 1 and 6 of both lower limbs using disposable sterile needles (0.25 mm × 25 mm). Needles were retained for 0.5-1 hour, once daily, with the treatment course adjusted based on symptom relief. If the VAS score remained ≥4 at 30 minutes post-treatment, adjunctive analgesic medication was administered as prescribed. Observation indicators included postoperative VRS scores, reduction in VAS scores at 5 and 30 minutes after wrist-ankle acupuncture treatment, frequency of analgesic medication use within the first 3 postoperative days, and the Clinical Postoperative Urinary Retention (POUR) score at 24 hours post-surgery. By comparing data between the two groups, the analgesic effect of wrist-ankle acupuncture was analyzed, and the influence of postoperative pain on the occurrence of urinary retention was explored.",[129],"Wrist-Ankle Acupuncture",[129,131,132,133,134,29],"Analgesia","Pain Management","Perianal abscess","hemorrhoids","2026-01-13",{"date":137,"type":35},"2026-01-15",{"date":139,"type":35},"2025-10-25",{"date":141,"type":21},"2026-10-24",{"name":41,"class":42},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":43},"100607037","early-phase-1-application-of-dynamic-pain-assessment-and-management-system-in-perioperative-period-of-patients-with-incarcerated-mixed-hemorrhoids-100607037","NCT07183345","Application of Dynamic Pain Assessment and Management System in Perioperative Period of Patients With Incarcerated Mixed Hemorrhoids","Application of Dynamic Pain Assessment and Management System in Perioperative Period of Patients With Incarcerated Mixed Hemorrhoids: A Single-Center, Prospective, Open-Label, Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 75 years old\n* Diagnosed with grade III-IV incarcerated mixed hemorrhoids according to the Goligher classification\n* Undergoing standard hemorrhoidectomy\n* Receiving simple intraspinal anesthesia\n\nExclusion Criteria:\n\n* Pregnant or lactating patients\n* Patients receiving immunotherapy or with coagulation dysfunction\n* Patients who need to use various analgesic drugs daily\n* Complicated with other anorectal diseases (such as perianal abscess, anal fistula, anal incontinence)\n* Complicated with other systemic diseases (cardiac insufficiency; hepatic or renal insufficiency; diabetes mellitus; coagulation disorders; peptic ulcer, etc.)\n* Incomplete perioperative clinical data\n* Unable to cooperate with follow-up",{"count":151,"type":21},64,[153],"EARLY_PHASE1","This study aims to investigate whether the dynamic pain assessment and management system can alleviate postoperative pain in patients with incarcerated mixed hemorrhoids and reduce the incidence of complications. A total of 64 eligible patients were enrolled and randomly divided into two groups, with the specific grouping and intervention methods as follows:\n\n① Control Group: Routine drug analgesia and conventional nursing education were adopted.\n\n② Study Group: Patients were managed with the dynamic pain assessment and management system, which included preoperative administration of analgesic drugs, postoperative traditional Chinese medicine (TCM) fumigation, wrist-ankle acupuncture for pain relief, and personalized nursing education.\n\nThe study evaluated the effect of the dynamic pain assessment and management system on postoperative analgesia by comparing the Numerical Rating Scale (NRS) scores for pain, recording the Visual Analogue Scale (VAS) scores for quality of life, and analyzing the incidence of complications among patients in different groups. The primary hypothesis of the study is that, compared with routine pain management methods, the dynamic pain assessment and management system can significantly reduce postoperative pain in patients, improve their quality of life, and decrease the incidence of complications (such as bleeding and urinary retention).",[156],"Incarcerated Mixed Hemorrhoids",[132,158,159,160,161],"Preoperative Analgesia","Traditional Chinese Medicine (TCM) Fumigation","Wrist-Ankle Acupuncture (WAA)","Dynamic Pain Management","2025-12-03",{"date":164,"type":35},"2025-12-05",{"date":166,"type":21},"2025-12-01",{"date":168,"type":21},"2026-09-01",{"name":41,"class":42},{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":177,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":180,"conditions":181,"keywords":182,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":43},"100607036","comparison-of-clinical-effects-between-routine-and-high-frequency-follow-up-after-hemorrhoids-surgery-100607036","NCT07183332","Comparison of Clinical Effects Between Routine and High-frequency Follow-up After Hemorrhoids Surgery","Comparison of Clinical Effects Between Routine and High-frequency Follow-up After Hemorrhoids Surgery: a Single-center, Prospective, Open-label, Randomized Clinical Trial","Inclusion Criteria:\n\n* 18 years old \\\u003C age \\\u003C 75 years old;\n* Mixed hemorrhoids were diagnosed;\n* Internal hemorrhoids ligation + external hemorrhoidectomy\n* Complete hospital records;⑤voluntary cooperation in the study\n\nExclusion Criteria:\n\n* The patient had mental illness;\n* Serious underlying diseases;\n* pregnant or lactating women;\n* Serious complications and drug allergy occurred during the treatment;\n* Communication difficulties",{"count":178,"type":21},116,[24],"This study aims to investigate whether frequent follow-ups can enhance the quality of life of patients after hemorrhoid surgery and reduce the incidence of complications. A total of 116 eligible patients were randomly and evenly divided into two groups (58 patients in each group): A. The control group: Patients received routine health education services upon discharge and were then followed up by phone at the regular frequency. B. The high-frequency group: Patients received routine health education services upon discharge and were then followed up by phone at a higher frequency. The quality of life of the patients and the incidence of complications were compared to evaluate the clinical effects of different intervention measures. The main hypothesis is that compared to conventional care, frequent follow-ups can significantly improve the quality of life of patients, promote wound healing, and reduce the incidence of complications and disease recurrence.",[57],[57,183,184],"Follow-up","Quality of Life","2025-09-13",{"date":187,"type":35},"2025-09-19",{"date":189,"type":21},"2025-09-15",{"date":191,"type":21},"2026-09-30",{"name":41,"class":42},{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":202,"briefSummary":203,"conditions":204,"keywords":205,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":212,"leadSponsor":213,"locationsCount":43},"100603889","effect-of-different-sitz-bath-methods-on-perianal-abscess-after-surgery-100603889","NCT07142382","Effect of Different Sitz Bath Methods on Perianal Abscess After Surgery","Effect of Different Hip Bathing Methods on Perianal Abscess After Surgery: a Single-center, Prospective, Open-label Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years\n* Patients were diagnosed with perianal abscess\n* Underwent perianal abscess treatment\n* Underwent sitz bath after surgery\n\nExclusion Criteria:\n\n* Patients with recurrent perianal abscesses or those with concurrent formation of anal fistulas;\n* Patients with Crohn's disease;\n* Patients with mental disorders;\n* Pregnant or lactating women;\n* Patients with diabetes;\n* Patients with a history of malignant tumor treatment within the past 5 years. ； -Patients who are using immunosuppressants or steroids",{"count":201,"type":21},102,[24],"Perianal abscess is a purulent infection of the tissues surrounding the anal canal and rectum. The postoperative wound is prone to infection, and the literature indicates that hip bathing is helpful to prevent infection, reduce edema, and promote healing. Therefore, patients need to use a bidet for medical sitz bath to avoid infection and contamination. The bidet on the market is divided into ordinary type and rinse type (manual or electric). There are no high-quality studies comparing the effects of these sitz baths.\n\nA prospective randomized controlled trial was designed to investigate the effects of regular sitz bath, manual irrigation, and electric irrigation. A total of 102 patients with perianal abscess in the Affiliated Hospital of Putian University were included in the study. The patients were 18-75 years old and underwent surgical treatment. Patients with recurrent abscess, anal fistula, mental disease, pregnant or lactating women, and diabetes were excluded. The patients were divided into general group, manual group and electric group by random number table method, with 34 cases in each group. All patients received hip bathing with 0.02% potassium permanganate solution at 41-43 ° C three times a day for 10-15 minutes each time after surgery.",[105],[206,207,208],"sitz bath","perianal absecess","Wound healing",{"date":210,"type":35},"2025-09-18",{"date":189,"type":21},{"date":64,"type":21},{"name":41,"class":42},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":221,"targetDuration":4,"studyType":22,"phases":223,"briefSummary":225,"conditions":226,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":43},"100605614","phase-4-efficacy-of-methylene-blue-plus-ropivacaine-for-post-hemorrhoidectomy-pain-100605614","NCT07164807","Efficacy of Methylene Blue Plus Ropivacaine for Post-Hemorrhoidectomy Pain.","Comparative Efficacy of Varying Concentrations of Methylene Blue Combined With Ropivacaine for Postoperative Analgesia Following Milligan-Morgan Hemorrhoidectomy: A Single-Center, Prospective, Open-Label, Randomized, Parallel-Controlled Trial","Inclusion Criteria:\n\n1. Aged between 18 and 75 years.\n2. Diagnosed with Grade III-IV hemorrhoids according to the Goligher classification.\n3. Scheduled to undergo standard Milligan-Morgan hemorrhoidectomy.\n4. Procedure performed under spinal anesthesia alone.\n\nExclusion Criteria:\n\n1. Pregnancy or lactation.\n2. Current immunotherapy or coagulopathies.\n3. Contraindications to any protocol-specified agents (e.g., history of severe allergic reactions to methylene blue or ropivacaine).\n4. Concurrent anorectal pathologies (e.g., perianal abscess, anal fistula, fecal incontinence).\n5. Comorbid systemic conditions (e.g., cardiac\u002Fhepatic\u002Frenal insufficiency, diabetes mellitus, coagulopathy, peptic ulcer disease).\n6. Incomplete perioperative documentation.\n7. Inability to comply with follow-up protocols.",{"count":222,"type":21},177,[224],"PHASE4","Revised Translation (Academic English):\n\nAs one of the most prevalent anorectal disorders, mixed hemorrhoids continue to rely on the Milligan-Morgan hemorrhoidectomy as the gold-standard surgical approach. While this technique demonstrates well-established efficacy, managing acute postoperative pain-particularly during the critical 24-72-hour peak pain window-remains a persistent clinical challenge. Recent advancements in multimodal analgesia have highlighted the potential of local nerve blockers, with methylene blue (MB) gaining scientific interest due to its prolonged analgesic properties. This randomized controlled study systematically evaluates the synergistic analgesic effects of gradient concentrations of MB combined with ropivacaine (ROP) following Milligan-Morgan procedures. Therapeutic safety profiles were validated through dual-dimensional monitoring of Visual Analog Scale (VAS) scores and complication rates, aiming to establish evidence-based optimal dosing protocols and refine perioperative pain management strategies.",[227,228,229],"Mixed Hemorrhoids","Milligan-Morgan Hemorrhoidectomy","Methylene Blue","2025-09-08",{"date":232,"type":35},"2025-09-10",{"date":234,"type":21},"2025-08-30",{"date":236,"type":21},"2026-12",{"name":41,"class":42},{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":245,"targetDuration":4,"studyType":22,"phases":247,"briefSummary":248,"conditions":249,"keywords":250,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":259,"leadSponsor":260,"locationsCount":43},"100604887","effect-of-red-and-blue-light-irradiation-on-postoperative-wound-healing-in-perianal-absces-100604887","NCT07155356","Effect of Red and Blue Light Irradiation on Postoperative Wound Healing in Perianal Absces","Effect of Red and Blue Light Irradiation on Postoperative Wound Healing in Perianal Abscess: a Single-center Prospective Open-label Randomized Clinical Trial","Inclusion Criteria:\n\n* Aged between 18 and 75 years;\n* Clinical diagnosis of perianal abscess；\n* Procedure: Radical resection with incision and drainage.\n\nExclusion Criteria:\n\n* Concurrent anorectal disorders (hemorrhoids, anal fissure) or malignancies\u002Finfectious diseases；\n* History of psychiatric disorders；\n* Analgesic use within 7 days preoperatively；\n* Coagulopathy or cardiac\u002Fhepatic dysfunction；\n* Pregnancy or lactation；\n* Contraindications to phototherapy；\n* IBD-related perianal abscess.",{"count":246,"type":21},222,[24],"This study aims to investigate whether specialized red-blue light irradiation facilitates faster postoperative recovery and reduces complication rates in patients following perianal abscess surgery. A total of 222 eligible patients were randomly allocated equally into three groups (74 per group):①Routine Care Group: Standard wound care including cleansing and dressing changes；②Red Light Therapy Group: Routine care plus red light phototherapy；③Combined Red-Blue Light Therapy Group: Routine care plus concurrent red and blue light phototherapy.Wound healing time and incidence of complications were compared to assess postoperative recovery across interventions. The primary hypothesis posits that adjunctive phototherapy-particularly combined red-blue light irradiation-will significantly enhance wound healing, reduce edema and pain, and decrease complication rates (e.g.bleeding, urinary retention) compared to routine care alone.",[105],[251,252,253,254],"perianal abscess","red light phototherapy","red and blue light phototherapy","wound healing","2025-09-01",{"date":257,"type":35},"2025-09-04",{"date":189,"type":21},{"date":191,"type":21},{"name":41,"class":42},{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":270,"briefSummary":271,"conditions":272,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":43},"100602298","effect-of-red-and-blue-light-irradiation-on-wound-healing-after-hemorrhoid-surgery-100602298","NCT07121686","Effect of Red and Blue Light Irradiation on Wound Healing After Hemorrhoid Surgery","Effect of Red and Blue Light Irradiation on Wound Healing After Hemorrhoid Surgery: A Single - Center Prospective Open - Label Randomized Clinical Trial","Inclusion Criteria:\n\n* Aged 18-75 years\n* Diagnosed with Grade III-IV hemorrhoids according to Goligher classification\n* Scheduled to undergo rubber band ligation of internal hemorrhoids + external hemorrhoidectomy\n* Willing and able to provide written informed consent\n* Able to comply with postoperative follow-up and treatment protocol\n\nExclusion Criteria:\n\n* Psychiatric disorders or cognitive impairment\n* Uncontrolled chronic diseases:\n* Diabetes (HbA1c \\>7.5%)\n* Hypertension (BP \\>160\u002F100 mmHg)\n* Coronary artery disease (NYHA Class III-IV heart failure)\n* Concurrent other hemorrhoid treatments (e.g., radiofrequency ablation\u002Fsclerotherapy)\n* Inability to complete follow-up (e.g., living too far away, no stable contact)\n* Concurrent anal disorders:\n* Perianal abscess\n* Anal fissure\n* Anal fistula\n* Hypertrophied anal papilla\n* Pregnancy or lactation (for female patients)\n* History of phototherapy allergy\n* Participation in other clinical trials within 3 months\n\nFor registration, simply copy this structured list directly into the PRS system's eligibility section. The clear formatting will facilitate efficient review.",{"count":269,"type":21},315,[24],"The subjects of this study were patients who took mixed haemorrhoidectomy during the period of December 2024 - December 2025 . The haemorrhoidectomy patients were randomly divided into routine group, red light group and red and blue light group, and were given different ways of trauma care, and the number of cases in each group was 105 , with a total of 305 cases. Observe the difference between red and blue light irradiation and routine care on the healing time of postoperative trauma and postoperative complications after haemorrhoidectomy, and evaluate the patients' quality of life and satisfaction with treatment under both red light irradiation and routine care.",[57],"2025-08-10",{"date":275,"type":35},"2025-08-13",{"date":277,"type":21},"2025-08-15",{"date":279,"type":21},"2026-08-01",{"name":41,"class":42},""]