[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Chinese University of Hong Kong, Shenzhen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100619331","correcting-hypocapnia-in-aneurysmal-subarachnoid-hemorrhage-100619331",false,"NCT07343232","Correcting Hypocapnia in Aneurysmal Subarachnoid Hemorrhage.","Safety and Efficacy of Normobaric Facemask Oxygen for Hypocapnia in Aneurysmal Subarachnoid Hemorrhage(FOCAL): A Prospective, Multicenter, Proof-of-concept Pilot Study","Inclusion Criteria:\n\n1. Age \\> 18 years.\n2. Confirmed diagnosis of aneurysmal subarachnoid hemorrhage (aSAH), with the presence of an aneurysm verified by computed tomography (CT), CT angiography (CTA), or digital subtraction angiography (DSA).\n3. Hunt-Hess grade II-IV.\n4. Presence of hypocapnia on arterial blood gas analysis, defined as PaCO2 \\\u003C 35 mmH;\n5. PaO2 \\> 90 mmHg.\n\nExclusion Criteria:\n\n1. Presence of brain herniation or refractory intracranial hypertension, defined as a baseline intracranial pressure (ICP) \\> 25 mmHg that responds poorly to conventional ICP-lowering therapy;\n2. Primary respiratory diseases (e.g., chronic obstructive pulmonary disease, severe asthma) known to cause chronically elevated baseline PaCO2;\n3. Severe acid-base disturbances other than respiratory alkalosis.\n4. Severe cardiac insufficiency, severe hepatic or renal dysfunction, malignant tumors, or other severe comorbidities that significantly impact prognosis;\n5. Before the onset of the disease, the mRS score was greater than 2, and there were other factors causing disability.\n6. Life expectancy \\\u003C 3 months;\n7. Any other condition deemed by the investigator to pose a high risk warranting exclusion.","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","90 Days","OBSERVATIONAL","Based on the clinical observation that over half of the patients in the management of aneurysmal subarachnoid hemorrhage(aSAH) present with spontaneous hyperventilation, which is significantly associated with delayed cerebral ischemia and poor neurological outcomes, this prospective pilot study is designed to investigate the safety and efficacy of normobaric facemask oxygen for hypocapnia in aSAH.",[25],"Aneurysmal Subarachnoid Hemorrhage (aSAH)",[25,27],"Hypocapnia","NOT_YET_RECRUITING","2026-01-06",{"date":31,"type":32},"2026-01-15","ACTUAL",{"date":34,"type":20},"2026-01-01",{"date":36,"type":20},"2026-10-30",{"name":38,"class":39},"The Chinese University of Hong Kong, Shenzhen","OTHER",""]