[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":87},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":4},"100591617","phase-1-acupuncture-versus-compound-diclofenac-sodium-for-pain-relief-in-non-traumatic-acute-abdominal-100591617",false,"NCT06982755","Acupuncture Versus Compound Diclofenac Sodium for Pain Relief in Non-Traumatic Acute Abdominal","Effect of Acupuncture on Early Analgesia of Non-traumatic Acute Abdomen is Discussed Based on the Experience of Sanli Acupoint for Du-fu Diseases :A Prospective Randomized Controlled pRCT Study","ACU-NTAA","Inclusion Criteria:\n\n1. The diagnostic criteria of NTAA were as follows: ① abdominal pain was the main symptom; ② The onset time was less than 1 week; ③ The cause of abdominal pain could be traced to intra-abdominal abdominal wall chest or systemic diseases;\n2. Patients with NRS scores ≥4 (mild pain and above) were evaluated before inclusion; （3）16 years \\\u003C age \\\u003C75 years;\n\n（4）Those who were considered not to need surgery within 2 hours after initial assessment by a specialist.\n\nExclusion Criteria:\n\nParticipants meeting any of the following criteria were excluded from the study:\n\n1. Acute abdomen caused by trauma;\n2. Super sudden diseases (e.g. acute myocardial infarction rupture of abdominal aortic aneurysm pulmonary embolism aortic dissection pericardial tamponade);\n3. Emergent conditions requiring surgical treatment within 3 hours (e.g. rupture of liver cancer ectopic pregnancy ischemic bowel disease severe acute cholangitis peritonitis with septic shock);\n4. Extremely severe pain (NRS ≥ 8) with an undetermined diagnosis and requiring further assessment for a super sudden disease;\n5. Inability to select acupuncture points due to skin injury or ulceration at Zusanli (ST36) on the lower limb;\n6. Induration or infection at the hip injection site;\n7. Patients with altered consciousness mental illness other severe chronic diseases or those who are unlikely to cooperate with acupuncture treatment;\n8. Contraindications to Western medicine:\n\n   * Known allergies to diclofenac sodium or acetaminophen; ②History of asthma urticaria or allergic reactions induced by aspirin or other NSAIDs.\n\n     * Undergoing coronary artery bypass grafting (CABG) surgery. ④History of gastrointestinal bleeding or perforation following non-steroidal anti-inflammatory drugs (NSAIDs).\n\n       * Active gastrointestinal ulcers or bleeding or a history of recurrent ulcers or bleeding.\n\n         * Severe heart failure.\n9. Use of any pain medication or acupuncture within the past 6 hours;\n10. Previous participation in this study;\n11. Pregnant or lactating individuals.","ALL","16 Years","75 Years",{"count":21,"type":22},176,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","The investigators designed this clinical study to evaluate the efficacy and safety of semi-standardized acupuncture and moxibustion combined with compound diclofenac sodium injection in the emergency department (ED) compared with acupuncture or compound diclofenac sodium injection alone.",[29,30,31,32],"Acute Abdominal Pain","Acupuncture Therapy","Acupuncture","Opioids",[34,35,36,37,31,38,39,40,32,41,42],"Acute abdominal pain","Non-Traumatic Acute Abdomen","Non-traumatic acute abdomen early analgesia","Acupuncture therapy","Zusanli point, ST36","Diclofenac sodium","Emergency environment","Non-steroidal anti-inflammatory drugs ，NSAIDs","Acetaminophen","NOT_YET_RECRUITING","2025-05-20",{"date":46,"type":47},"2025-05-21","ACTUAL",{"date":49,"type":22},"2025-06-01",{"date":51,"type":22},"2026-12-31",{"name":53,"class":54},"The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine","OTHER",{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":17,"minAge":63,"maxAge":19,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},"100580149","research-on-gut-microbiota-and-metabolomics-in-diabetic-kidney-disease-100580149","NCT06833541","Research on Gut Microbiota and Metabolomics in Diabetic Kidney Disease","Research on Gut-kidney Axis Regulation of Diabetic Kidney Disease Based on Multi-omics and Bacterio-drug Interaction Control Mechanism","Patient inclusion criteria：\n\n1. Age ≥18 years old and ≤75 years old, gender is not limited.\n2. Complete demographic data.\n3. Meet the diagnostic criteria of the Chinese Guidelines for the Prevention and Treatment of Diabetic Kidney Disease (2021 edition), the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes Mellitus (2020 edition), and the Guidelines for the Screening, Diagnosis, Prevention and Treatment of Chronic Kidney Disease (2017 edition).\n4. The patient is informed of the study as approved by the ethics committee.\n\nHealthy population inclusion criteria:\n\n(1) The patient has no known history of infection or risk factors including HIV hepatitis B or C virus syphilis etc. and no current systemic infection; (2) No obesity (body mass index \\>30) and\u002For diabetes no history of chronic kidney disease; (3) Approved by the ethics committee patients were informed about the study. Exclusion criteria：\n\n1. A history of infection or other acute disease within one month prior to enrollment.\n2. Current state of stress.\n3. Other unstable chronic diseases;\n4. A history of acute and chronic gastrointestinal diseases, including acute gastroenteritis, functional gastrointestinal diseases, inflammatory bowel disease, celiac disease, and other chronic gastrointestinal diseases.\n5. Individuals who have received systemic antibiotics, immunosuppressants, chemotherapy, or chronic treatment with proton pump inhibitors within the past three months will be excluded from participation.\n6. Pregnant or lactating women will also be excluded.\n7. Individuals who have participated in other drug clinical trials within the past three months will be excluded.\n8. Individuals who suffer from mental illness, intellectual disability, confusion, or other conditions that may interfere with their ability to cooperate with the completion of relevant information collection will also be excluded.\n\nThose who were unable to cooperate with the collection of pertinent data were likewise excluded from the study.",true,"18 Years",{"count":65,"type":22},720,"OBSERVATIONAL","Diabetic kidney disease (DKD) is characterized by high prevalence, multiple pathogenesis, and lack of effective treatment and management strategies. Early detection helps overcome treatment inertia, enables timely medical intervention, maximizes renal function in diabetic patients, and is essential to avoid renal failure and improve clinical outcomes. The gold standard for diagnosis of DKD is renal biopsy, which has the highest accuracy. However, due to the trauma of renal biopsy, the patient acceptance is low, the application scenario is not universal, and it is only used when it is difficult to distinguish diabetic nephropathy from non-diabetic nephropathy, and it is not the preferred diagnostic method for DKD.\n\nIn the past decade, with the emergence and application of metabonomics, proteomics, genomics and other multi-omics techniques, more and more studies have recognized the prominent role of intestinal flora disorders and gut-derived metabolites in the occurrence of DKD. Therefore, from the perspective of intestinal flora, using multi-omics techniques to identify enterogenic metabolic markers of DKD and restore intestinal flora balance may be potential strategies for prevention and management of DKD. Modern medicine believes that intestinal flora is not only closely related to diet and digestion, participating in the synthesis, absorption and metabolism of nutrients, but also constituting intestinal barrier and participating in immune defense of the body. Its function is similar to the physiological function of \"The spleen governs transportation and transformation\".\n\nBased on the traditional Chinese medicine（TCM） pathogenesis of DKD \"Spleen Failure to Disperse Essence and Poison Damage Kidney Collateral\" proposed by the previous research group, this study intends to use microbiology-metabolomics to deeply study the TCM pathogenesis of DKD, provide scientific basis for it, and guide the theory of traditional Chinese medicine widely used in clinical work of prevention and treatment of diabetic nephropathy.",[69,70,71],"Diabetic Nephropathy Type 2","Type 2 Diabetes Mellitus (T2DM)","Chronic Kidney Disease",[69,73,74,75,76],"Type 2 diabetes mellitus","chronic kidney disease","intestinal microbiota","metabolomics","RECRUITING","2025-02-13",{"date":80,"type":47},"2025-02-18",{"date":82,"type":47},"2022-04-18",{"date":84,"type":22},"2025-12-01",{"name":53,"class":54},1,""]