[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Hong Kong Polytechnic University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":674},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,183,0,25,[9,45,79,114,143,168,190,213,236,268,289,314,345,375,397,425,454,479,502,527,548,573,593,622,645],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100054131","effect-of-inspiratory-muscle-training-on-knee-osteoarthritis-pain-100054131",false,"NCT07698418","Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain","Effect of Inspiratory Muscle Training on Pain in Patients With Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 55 years or older.\n* Knee osteoarthritis (Kellgren-Lawrence grade ≥ 2).\n* Knee pain (Visual Analogue Scale, VAS ≥ 3) on the most days in the past month.\n* Able to walk independently without assitive devices.\n\nExclusion Criteria:\n\n* History of knee replacement surgery, meniscus surgery, or ligament surgery.\n* Received corticosteroid injection within the previous three weeks.\n* Diagnosed with rheumatoid arthritis.\n* Unstable angina, recent myocardial infarction, uncontrolled cardiac arrhythmia, or severe heart failure.\n* History of stroke.\n* Currently receiving steroid therapy, hormonal therapy, or cancer chemotherapy.\n* Pneumothorax, pulmonary bullae, lung surgery within the past 12 months, unstable asthma, or severe dyspnea at rest.\n* Unable to understand the study procedures and potential risks.","ALL","55 Years","80 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Knee osteoarthritis (KOA) is a common joint disease that causes chronic pain and limits daily activities. Current treatments, such as painkillers or surgery, have limitations like side effects or high costs. This study will test whether a safe, non-drug intervention-inspiratory muscle training (breathing exercises against resistance)-can reduce knee pain in people with KOA. The training may work by lowering inflammation and improving the body's nervous system control of pain.\n\nWe plan to enroll 80 patients aged ≥55 years with confirmed KOA and frequent knee pain. Participants will be randomly assigned to either an 8-week inspiratory muscle training program (5 sessions per week, with gradually increasing resistance) or a sham (very low resistance) training program. Neither the patients nor the researchers assessing the outcomes will know who is in which group.\n\nThe main outcome is change in knee pain measured by a visual analog scale (VAS). Secondary outcomes include blood markers of inflammation (TNF-α, IL-6, IL1β), physical function, WOMAC score (a KOA-specific questionnaire), activity level, sleep quality, and quality of life. To explore underlying mechanisms, we will also measure heart rate variability (HRV) as an indicator of autonomic nervous system function, and brain functional connectivity in the prefrontal cortex using functional near-infrared spectroscopy (fNIRS). These mechanistic assessments will be performed at baseline and at the end of 8-week intervention. Additional follow-up assessments for clinical outcomes will be done at 3 and 6 months after the training ends. We will also record any side effects or adverse events.\n\nThis study will provide high-quality evidence on whether inspiratory muscle training is an effective and safe complementary treatment for knee pain in people with knee OA, and will offer new insights into the mechanisms underlying its analgesic effects.",[28,29],"Knee Osteoarthritis","Knee Osteoarthritis (Knee OA)",[28,31,32],"Inspiratory Muscle Training","Chronic Pain","NOT_YET_RECRUITING","2026-07-07",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":22},"2026-07-01",{"date":41,"type":22},"2030-07-01",{"name":43,"class":44},"The Hong Kong Polytechnic University","OTHER",{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100054162","sleep-chronotype-and-prosocial-allocation-decisions-100054162","NCT07697092","Sleep, Chronotype, and Prosocial Allocation Decisions","Associations Between Sleep Quality, Circadian Timing, and Prosocial Allocation Decisions in Adults","SCPAD","Inclusion Criteria:\n\n* Aged 18 years or above.\n* Able to provide informed consent.\n* Able to understand English or Chinese study materials.\n* Able to complete computer-based behavioural tasks and self-report questionnaires.\n* Willing to complete a 7-day sleep diary.\n\nExclusion Criteria:\n\n* Aged under 18 years.\n* Unable to provide informed consent.\n* Unable to complete study materials in English or Chinese.\n* Prior participation in the same study.\n* Self-reported condition or circumstance that would make participation in a brief computer-based decision-making task or sleep-related questionnaires inappropriate or distressing.",true,"18 Years",{"count":56,"type":22},128,"OBSERVATIONAL","This observational behavioural study examines whether individual differences in sleep quality, sleep timing, and chronotype are associated with prosocial allocation decisions in adults. Participants will complete self-report sleep and circadian questionnaires, including the Pittsburgh Sleep Quality Index and the Munich Chronotype Questionnaire, a 7-day sleep diary, and a brief computer-based Dictator Game allocation task.\n\nThe study does not involve sleep deprivation, sleep restriction, treatment, clinical diagnosis, medication, or medical devices. Participants will not be asked to change their sleep schedule. The Dictator Game decisions are hypothetical and do not affect participants' compensation. The study is intended to describe associations between naturally occurring sleep-related individual differences and behavioural allocation choices, not to diagnose or treat sleep or mental health conditions.",[60,61,62,63],"Sleep Quality","Chronotype","Prosocial Decision-Making","Circadian Timing",[60,61,63,65,66,67,68,69,62,70],"Pittsburgh Sleep Quality Index","Munich Chronotype Questionnaire","Sleep Diary","Dictator Game","Prosocial Behavior","Allocation Decisions","2026-07-06",{"date":36,"type":37},{"date":74,"type":22},"2026-07",{"date":76,"type":22},"2028-06",{"name":43,"class":44},1,{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":18,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":78},"100644966","chronotype-alignment-and-time-perception-100644966","NCT07677111","Chronotype Alignment and Time Perception","Circadian Match and Mismatch Effects on Temporal Cognition in Morning- and Evening-Type Adults","Inclusion Criteria:\n\n* Healthy adult, 18-40 years\n* Clear morning-type or evening-type on the Morningness-Eveningness Questionnaire (MEQ-SA); intermediate types excluded (state exact cut-offs, e.g. evening-type 41 or below, morning-type 59 or above)\n* Normal or corrected-to-normal visual acuity\n* Normal colour vision (e.g. Ishihara screening)\n* Fluent in the testing-site language (Danish, Chinese, or English)\n* Able to attend both an early-morning (about 08:00) and a late-evening (about 22:00) session\n\nExclusion Criteria:\n\n* Intermediate chronotype (MEQ in the middle band)\n* Night or rotating shift work in the past 3 months, or recent trans-meridian travel (more than 2 time zones in the past 4 weeks)\n* Diagnosed sleep disorder (e.g. insomnia, sleep apnoea)\n* Current psychiatric or neurological disorder\n* Use of sleep medication or psychoactive or CNS-active drugs\n* Colour-vision deficiency\n* Substance-use disorder",{"count":87,"type":22},240,[25],"People differ in chronotype - whether they function best in the morning (\"larks\") or the evening (\"owls\"). This study asks whether the match or mismatch between a person's chronotype and the time of day at which they are tested changes how they perceive time.\n\nHealthy morning-type and evening-type adults at three sites (Aarhus, Denmark; Changzhou, China; and Hong Kong) complete the same battery of perception and cognition tasks twice - once in the early morning (about 08:00) and once late in the evening (about 22:00), in counterbalanced order. The primary outcome is the accuracy (signed bias) of time-perception judgements; the key comparison is the interaction between chronotype and time of day (the \"synchrony effect\").\n\nSecondary measures include timing precision, the subjective passage of time, sleepiness, mood, colour perception (with and without blue-blocking glasses) and perceptual decision-making. By testing the same protocol across three cultures and latitudes, the study examines whether circadian match\u002Fmismatch effects on temporal cognition generalise across populations.",[61,91,92,93],"Circadian Rhythm","Sleep","Time Perception",[95,96,97,98,99,100,101,102,103,104],"chronotype","morningness-eveningness","synchrony effect","time perception","temporal cognition","circadian rhythm","time-of-day","duration discrimination","arousal","cross-cultural","RECRUITING","2026-06-29",{"date":108,"type":37},"2026-06-30",{"date":110,"type":37},"2025-09-01",{"date":112,"type":22},"2028-06-30",{"name":43,"class":44},{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":140,"leadSponsor":142,"locationsCount":78},"100644589","visual-perception-binocular-competition-and-fatigue-related-individual-differences-in-colour-and-illumination-judgement-100644589","NCT07671144","Visual Perception, Binocular Competition, and Fatigue-Related Individual Differences in Colour and Illumination Judgement","Characterising Individual Differences in Colour Perception and Binocular Rivalry and Their Associations With Chronotype, Sex, and Sleep","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Normal or corrected-to-normal visual acuity.\n* Normal or corrected-to-normal binocular vision.\n* Normal colour vision, or no self-reported colour vision deficiency.\n* Able to understand the study instructions and provide informed consent.\n* Able to complete computer-based visual perception tasks and self-report questionnaires.\n\nExclusion Criteria:\n\n* Self-reported colour vision deficiency.\n* Uncorrected visual impairment or eye conditions that may interfere with visual perception tasks.\n* Strabismus, amblyopia, or other binocular vision problems that may interfere with binocular rivalry testing.\n* History of neurological disorders, photosensitive epilepsy, or severe sensitivity to flickering visual stimuli.\n* Current condition or medication that, in the investigator's judgment, may substantially affect visual perception, attention, or task performance.\n* Inability to complete the task procedures or provide valid responses.","25 Years",{"count":56,"type":22},"This observational study aims to characterise individual differences in colour perception and binocular rivalry. Participants will complete computer-based visual perception tasks, including a colour perception task and a binocular rivalry task. The study will first examine whether individuals show measurable differences in these perceptual responses. It will then explore whether these differences are associated with chronotype, sex, sleep-related measures, and subjective fatigue. The findings may help clarify how stable individual characteristics and daily physiological states relate to visual perception.",[125,126,127],"Colour Perception","Color Perception","Binocular Rivalry",[129,130,131,132,61,92,133,134,135],"Colour perception","Color perception","Binocular rivalry","Individual differences","Subjective fatigue","Sex differences","Visual perception","2026-06-22",{"date":138,"type":37},"2026-06-26",{"date":74,"type":22},{"date":141,"type":22},"2026-12",{"name":43,"class":44},{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":12,"sex":17,"minAge":149,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":23,"phases":153,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":78},"100441986","a-machine-learning-approach-for-predicting-tdcs-treatment-outcomes-of-adolescents-with-autism-spectrum-disorders-100441986","NCT05035511","A Machine Learning Approach for Predicting tDCS Treatment Outcomes of Adolescents With Autism Spectrum Disorders","Inclusion Criteria:\n\n* Individuals who are confirmed by a clinical psychologist based on the Diagnostic and Statistical Manual of Mental Disorders-5th Ed (DSM-V) criteria of Autism spectrum disorder and structured interview with their parents or primary caregivers on their developmental history using the Autism Diagnostic Interview-Revised (ADI-R).\n* Individuals with intelligence quotient above 60.\n* Individuals who demonstrate the ability to comprehend testing and stimulation instructions.\n\nExclusion Criteria:\n\n* Individuals with severe motor dysfunctions that would hinder their participation, and those with history of other neurological and psychiatric disorders and head trauma, or on psychiatric medication will be excluded from the study","12 Years","22 Years",{"count":152,"type":22},90,[25],"Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disturbances in communication, poor social skills, and aberrant behaviors. Particularly detrimental are the presence of restricted and repetitive stereotyped behaviors and uncontrollable temper outbursts over trivial changes in the environment, which often cause emotional stress for the children, their families, schools and neighborhood communities.\n\nFundamental to these cognitive and behavioral problems is the disordered cortical connectivity and resultant executive dysfunction that underpin the use of effective strategies to integrate information across contexts. Brain connectivity problems affect the rate at which information travels across the brain. Slow processing speed relates to a reduced capacity of executive function to recall and formulate thoughts and actions automatically, with the result that autistic children with poor processing speed have great difficulty learning or perceiving relationships across multiple experiences. In consequence, these children compensate for the impaired ability to integrate information from the environment by memorizing visual details or individual rules from each situation. This explains why children with autism tend to follow routines in precise detail and show great distress over seemingly trivial changes in the environment.\n\nTo date, there is no known cure for ASD, and the disorder remains a highly disabling condition. Recently, a non-invasive brain stimulation technique, transcranial direct current Stimulation (tDCS) has shown great promise as a potentially effective and costeffective tool for reducing core symptoms such as anxiety, aggression, impulsivity, and inattention in patients with autism. This technique has been shown to modify behavior by inducing changes in cortical excitability and enhancing connectivity between the targeted brain areas. However, not all ASD patients respond to this intervention the same way and predicting the behavioral impact of tDCS in patients with ASD remains a clinical challenge. This proposed study thus aims to address these challenges by determining whether resting-state EEG and clinical data at baseline can be used to differentiate responders from non-responders to tDCS treatment. Findings from the study will provide new guidance for designing intervention programs for individuals with ASD.",[156,157,158,159],"Transcranial Direct Current Stimulation","Autistic Disorders Spectrum","Electroencephalography","Machine Learning","2026-06-21",{"date":162,"type":37},"2026-06-24",{"date":164,"type":37},"2022-01-05",{"date":166,"type":22},"2026-12-31",{"name":43,"class":44},{"id":169,"slug":170,"hasResults":12,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":12,"sex":17,"minAge":121,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":23,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":189},"100601624","effects-of-combined-neuromuscular-electrical-stimulation-robot-and-trans-spinal-electrical-stimulation-in-poststroke-rehabilitation-100601624","NCT07112911","Effects of Combined Neuromuscular Electrical Stimulation Robot and Trans-Spinal Electrical Stimulation in Poststroke Rehabilitation","Restoring Functional Capacity of the Upper Extremity Using Combined Neuromuscular Electrical Stimulation Robot and Trans-Spinal Electrical Stimulation in Individuals With Chronic Stroke","Inclusion Criteria:\n\n* Subjects in the chronic stage (start from 6 months after the onset of stroke) with a pure unilateral motor paresis after a stroke (ischemic or hemorrhagic);\n* Sufficient cognition to follow simple instructions as well as understand the content and purpose of the experiment (Mini-Mental State Examination (MMSE) score\\>23);\n* Be able to sit up for 60 minutes (with or without assistance);\n* Muscle strength graded from 1 to 3 in biceps brachii, triceps brachii, extensor carpi radialis, flexor carpi radialis, and abductor pollicis brevis in the affected side.\n* The voluntary electromyographic signals of the wrist extensor and wrist flexor muscle groups can be detected.\n\nExclusion Criteria:\n\n* Patients with secondary stroke;\n* Severe dysphasia (either expressive or comprehensive) with inadequate communication;\n* Any additional medical or psychological condition affecting their ability to comply with the study protocol;\n* History of other neurological disease, psychiatric disorder, including alcoholism and substance abuse;\n* currently pregnant;\n* epilepsy;\n* pacemaker implantation or deep brain stimulation;\n* involved in drug studies, other clinical trials, or concurrent medication\u002Foccupational\u002Fphysical treatments on the upper limb;\n* skin disease at the area of the electrodes;\n* High hypertension and cannot maintain normal blood pressure despite daily intake of antihypertensive medication.","70 Years",{"count":177,"type":22},65,[25],"The purpose of this study is to investigate the clinical efficacy and neurological progress of combined training using trans-spinal electrical stimulation (tsES) and neuromuscular electrical stimulation (NMES)-driven robotics on upper limb rehabilitation after stroke",[181],"Stroke","2026-06-18",{"date":136,"type":37},{"date":185,"type":37},"2025-07-28",{"date":187,"type":22},"2027-12-31",{"name":43,"class":44},2,{"id":191,"slug":192,"hasResults":12,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":175,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":199,"briefSummary":200,"conditions":201,"keywords":205,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":208,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":212,"locationsCount":78},"100434258","enms-with-balance-feedback-for-post-stroke-ankle-foot-rehabilitation-100434258","NCT04934787","ENMS With Balance Feedback for Post-stroke Ankle-foot Rehabilitation","Exo-neuro-musculo-skeleton With Balance Sensing Feedback for Ankle-foot Rehabilitation After Stroke","Inclusion Criteria:\n\n* At least 6 months after the onset of stroke\n* Have sufficient cognition to follow simple instructions, as well as understand the content and purpose of the experiment (Mini-Mental State Examination (MMSE) score \\>21).\n* Have mild-to-moderate motor impairment in the affected lower limb with foot drop but be capable of standing and walking without manual assistance.\n* Fugl-Meyer Assessment (FMA), total score on the lower limb \\\u003C20\n* Functional Ambulatory Category (FAC) ≥4\n* Berg Balance Scale (BBS) ≥40\n\nExclusion Criteria:\n\n* The exclusion criteria will be server spasticity at the ankle joint measured by Modified Ashworth Score (MAS) \\>3.\n* Receiving other lower limb rehabilitative interventions at the same time",{"count":198,"type":22},60,[25],"In this work, a novel hybrid ankle-foot robot is designed for gait rehabilitation after stroke, i.e., exoneuromusculoskeleton with balance sensing feedback (ENMS-BSF) by integrating the advantages of soft pneumatic muscle, functional electrical stimulation, exoskeleton and foot balance feedback in one system. With the assistance of the ENMS-BSF the foot drop and foot inversion could be corrected with improved muscle coordination in the paretic lower limb. The device is wearable and light-in-weight for unilateral application during walking. It is hypothesized that with the intervention of the ENMS-BSF the gait pattern of persons after stroke can be improved with long-term rehabilitative effects.",[202,203,204],"Cerebrovascular Stroke","Foot Drop","Foot Inversion Deformity",[206,181,207],"Robot","Lower limb",{"date":136,"type":37},{"date":210,"type":37},"2021-07-01",{"date":187,"type":22},{"name":43,"class":44},{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":175,"enrollmentInfo":220,"targetDuration":4,"studyType":23,"phases":222,"briefSummary":223,"conditions":224,"keywords":226,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":235,"locationsCount":78},"100343525","exoneuromusculoskeleton-for-upper-limb-rehabilitation-after-stroke-100343525","NCT03752775","Exoneuromusculoskeleton for Upper Limb Rehabilitation After Stroke","Mobile Electromyography (EMG)-Driven Exoneuromusculoskeleton for Upper Limb Rehabilitation After Stroke","Inclusion Criteria:\n\nFor the subacute groups:\n\n* Two weeks after the onset of stroke, however less than 0.5 year\n* Mini-Mental State Examination (MMSE)\\>21\n* Able to sit up for at least 1 hour\n* Fugl-Meyer Assessment (FMA) upper limb \\\u003C30\n* Modified Ashworth Score (MAS) at the elbow, wrist and fingers \\\u003C3\n* Detectable EMG on the target driving muscles (i.e., 3 times of the standard deviation above the baseline)\n\nFor the chronic device assisted group:\n\n* At least 0.5 year after the onset of stroke\n* Mini-Mental State Examination (MMSE)\\>21\n* Able to sit up for at least 1 hour\n* Fugl-Meyer Assessment (FMA) upper limb \\\u003C30\n* Modified Ashworth Score (MAS) at the elbow, wrist and fingers \\\u003C3\n* Detectable EMG on the target driving muscles (i.e., 3 times of the standard deviation above the baseline)\n\nExclusion Criteria:\n\nSubjects will be excluded if they do not meet the above inclusion criteria, or had the following conditions:\n\n* Currently pregnant\n* Dysphasia (language deficiency)\n* Post-stroke neglect\n* Pacemaker implantation,\n* Involved in drug studies, other clinical trials, or concurrent medication\u002Foccupational\u002Fphysical treatments on the upper limb\n* The overall medical condition not suitable for the training (e.g., severe cardiac problem, unstable blood pressure, etc.).",{"count":221,"type":22},45,[25],"A new clothing robotic arm was developed for multi-joint coordinated upper limb rehabilitation after stroke. Patients after stroke will be recruited to evaluate the rehabilitation effectiveness of the device assisted upper limb rehabilitation. Both patients with chronic stroke and subacute stroke will be investigated.",[225],"Upper Limb Rehabilitation",[227,228,229],"stroke","upper limb","Joint coordination",{"date":231,"type":37},"2026-06-23",{"date":233,"type":37},"2018-11-01",{"date":187,"type":22},{"name":43,"class":44},{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":12,"sex":17,"minAge":243,"maxAge":54,"enrollmentInfo":244,"targetDuration":4,"studyType":23,"phases":246,"briefSummary":247,"conditions":248,"keywords":254,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":78},"100585491","nurse-parental-support-using-a-proactive-mobile-app-in-symptom-management-for-children-with-mechanical-ventilation-100585491","NCT06903052","Nurse Parental Support Using a Proactive Mobile App in Symptom Management for Children With Mechanical Ventilation","Nurse Parental Support Using a Proactive Mobile App in Symptom Management for Children With Medical Complexity Requiring Mechanical Ventilation: an Effectiveness-implementation Hybrid 2 Study","The inclusion criteria for parents are:\n\n1. parent of a child with mechanical ventilation aged 2-18\n2. having a Smartphone\n3. able to communicate in Chinese and read Chinese\n4. living with his\u002Fher child at home.\n\nThe exclusion criteria for parents are:\n\n1. a reported mental health disorder\n2. engaging in other structured programs related to symptom management 3) living in an area with no internet coverage.","2 Years",{"count":245,"type":22},52,[25],"The aims of this study are to test the effectiveness of a nurse support using a proactive mobile app to enhance parental self-efficacy in symptom management for children using mechanical ventilations, and alongside identify factors facilitating or deterring the program implementation.\n\nA single group pre-post quasi-experimental study on parents of CMC requiring mechanical ventilation.\n\nParents will be recruited from a non-government office, with an estimated sample size of 52 parents. Self-administrated questionnaire, and semi-structured interview guide will be used for data collection.",[249,250,251,252,253],"Child With Medical Complexity","Symptom Management","Self Efficacy","Mobile Application","Nurse-led Supportive Care",[255,256,257,258,259],"parental self-efficacy","children requiring mechanical ventilation","symptom management","mobile application","nurse-led parental support","2026-06-11",{"date":262,"type":37},"2026-06-15",{"date":264,"type":37},"2025-05-06",{"date":266,"type":22},"2028-04-30",{"name":43,"class":44},{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":12,"sex":17,"minAge":275,"maxAge":121,"enrollmentInfo":276,"targetDuration":4,"studyType":23,"phases":278,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":78},"100643068","near-vergence-training-for-distance-control-in-intermittent-exotropia-100643068","NCT07642687","Near Vergence Training for Distance Control in Intermittent Exotropia","Evaluating Near Vergence Training for Distance Control in Basic and Divergence Excess Intermittent Exotropia","Inclusion Criteria\n\n* Age and Diagnosis: Participants must be aged 6 to ≤ 25 years at the time of screening, with a confirmed clinical diagnosis of either Basic or Divergence Excess (DE) Intermittent Exotropia (IXT).\n* Ocular Alignment Magnitude: Distance exodeviation measuring between 10 and 40 prism diopters (pd) inclusive, determined by the prism and alternate cover test (PACT).\n* Distance-Near Disparity Limits: Near exodeviation must not exceed the distance exodeviation by more than 10 pd (to exclude Convergence Insufficiency type exotropia).\n* Baseline Distance Control: A baseline distance IXT Office Control Score (OCS) between Grade 2 and Grade 4 inclusive, based on the mean of 3 standardized assessments.\n* Baseline Near Control: A baseline near IXT control score less than or equal to the distance IXT control score, based on the mean of 3 standardized assessments.\n* Visual Acuity: Best-corrected visual acuity (BCVA) of Logarithm of the Minimum Angle of Resolution (logMAR) 0.1 or better in each eye at both distance and near fixation.\n* Sensory Status: Measurable near stereoacuity of 400 arc seconds or better on the Preschool Randot stereoacuity test.\n* Refractive Correction Stability: Compliance with wearing a stable, appropriate spectacle correction for ≥ 4 months prior to formal baseline assessment if the participant meets any of the following refractive thresholds:\n\n  * Myopia \\\u003C -0.50D spherical equivalent (SE) in either eye.\n  * Hyperopia \\> +2.50D SE in either eye.\n  * Anisometropia \\> 1.00 SE.\n  * Astigmatism \\> 1.50D cylinder in either eye.\n* Treatment History: No history of prior non-surgical interventions for IXT, including patching, vision therapy\u002Forthoptics, or overminus lens therapy (≥ 0.50 D).\n* Surgical History: No prior history of strabismus surgery, extraocular muscle botulinum toxin injections, intraocular surgery, or refractive surgery.\n* Trial Commitment: No planned strabismus surgery or conflicting ocular therapies during the 24-week study period.\n\nExclusion Criteria\n\n* Amblyopia and Co-morbid Strabismus: Presence of amblyopia, nystagmus, restrictive strabismus, or paretic strabismus.\n* Vertical Misalignment: Presence of an associated vertical ocular deviation \\> 5 pd.\n* Significant Pathologies: Co-existing significant ocular disease or neurological disorders (e.g., cerebral palsy) that could confound oculomotor or sensory evaluations.\n* Confounding Medications: Regular use of systemic or topical ocular medications known to alter accommodative or vergence function within the 3 months prior to screening (including, but not limited to, atropine, pirenzepine, or systemic anti-epileptic agents).","6 Years",{"count":277,"type":22},42,[25],"Intermittent Exotropia (IXT) is a common type of eye misalignment where one eye periodically turns outward, and control is typically much worse when looking at objects far away than close up. However, most currently available training programme are focused on near-viewing tasks. The goal of this clinical trial is to investigate if a new, structured, home-based near eye training program works to improve distance eye alignment control in children and young adults with IXT.\n\nThe main questions the study aims to answer are:\n\n* Does a 12-week near eye training program improve a participant's ability to control their eye alignment when looking at a distance?\n* Does using a special reading glasses during near training help to control distance eye alignment better than doing the training without the reading glasses?\n* Do the benefits of this eye training last after the training has stopped?\n\nThis is a two- phase, single- masked (examiner masked), randomized clinical trial with crossover design. The entire study duration is about 24 weeks. A total sample size of 42 participants, aged 6 to 25 years with diagnosed Basic (distance deviation is within 10 prism diopters of the near deviation) or Divergence excess (distance deviation is at least 10 prism diopters greater than the near deviation) IXT, will be recruited.\n\nIn Phase I (Weeks 0 to 12), participants will be randomly allocated into one of three groups, with 14 individuals in each group:\n\n* Group 1 does eye training while wearing special plus-power reading glasses that remove the need to focus up close, mimicking how the eyes look at a distance.\n* Group 2 does the exact same eye training but wears regular distance glasses without the special reading addition.\n* Group 3 serves as a control group that does not do training during the first 12 weeks, but will receive the training in the second phase.\n\nIn Phase II (Weeks 13 to 24), which is a crossover phase, groups 1 and 2 will stop training to see if the visual improvements last, while group 3 will be re-randomized into two subgroups (group 3A, with special plus-power reading glasses, and group 3B with regular glasses with distance correction) that will undertake daily eye training for 12 weeks to ensure ethical treatment access. All participants will have a final eye exam at 24 weeks.\n\nDuring home training, participants will:\n\n* Wear standard glasses provided by the study.\n* Practice daily, home-based eye exercises for 12 weeks using a standardized software program on a computer or tablet.\n* Complete 3 training sessions every day, lasting 7 minutes per session.\n* Wear red-blue 3D glasses during training and press arrow keys or swipe the screen to play a visual game that dynamically changes in difficulty.\n\nPreliminary test and binocular vision assessment with fixed and uniform sequence will be performed at baseline visit, 6th week interim visit, 12th and 24th week evaluation. All eye examinations will be carried out in The Optometry Centre (A034), the School of Optometry, The Hong Kong Polytechnic University.\n\nThe following data will be statistically analyzed. The primary outcome data is distance Office Control Score (OCS) at 12-week visit. Secondary outcomes data include change in deviation angle, near and distance stereopsis and patient- \u002F parent- reported health-related quality-of-life questions at 12-week.",[281],"Intermittent Exotropia","2026-06-10",{"date":260,"type":37},{"date":285,"type":22},"2026-06",{"date":287,"type":22},"2028-12",{"name":43,"class":44},{"id":290,"slug":291,"hasResults":12,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":23,"phases":299,"briefSummary":300,"conditions":301,"keywords":304,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":313,"locationsCount":78},"100643180","a-theory-based-sleep-hygiene-education-for-insomnia-disorder-100643180","NCT07642479","A Theory-based Sleep Hygiene Education for Insomnia Disorder","A Theory-based Sleep Hygiene Education for Insomnia Disorder - A Non-inferiority Randomized Controlled Trial With Mixed-method Process Evaluation and Cost-effectiveness Analysis","Inclusion Criteria:\n\n* Hong Kong residents\n* Ethnic Chinese aged 18-65 years with the ability to communicate in Cantonese or Putonghua\n* Who fulfil the DSM-5 diagnostic criteria for insomnia disorder according to a validated diagnostic tool, the Brief Insomnia Questionnaire\n* Scored at least 10 points in the Insomnia Severity Index\n* Willing to give informed consent\n\nExclusion Criteria:\n\n* Any current diagnosis fulfilling the DSM-IV criteria of a major depressive disorder, generalized anxiety disorders, post-traumatic stress disorder, panic disorder, substance use disorders, or schizophrenia as screened using the Chinese version of the Structured Clinical Interview for DSM-IV\n* Other sleep disorders, including circadian rhythm disorder, narcolepsy, obstructive sleep apnoea (OSA), and restless leg syndrome (RLS)\u002Fperiodic leg movement disorder (PLMD) as determined based on cut-off scores (≥ 7 on narcolepsy; ≥ 8 on circadian rhythm disorder; ≥ 15 on OSA; ≥ 7 on RLS\u002FPLMD) using SLEEP-50. If in doubt, subjects will be referred to our team psychiatrist (KF Chung) for further assessment\n* Any current medical conditions or side-effects of medication that are contributing significantly to the subject's insomnia\n* Taking medications or currently participating in other psychotherapies for insomnia or other psychiatric disorders\n* Impaired cognitive functioning (\\\u003C22 points in HK-MoCA) or with difficulty in giving consent or understanding instructions\n* Pregnant\n* Shift work","65 Years",{"count":298,"type":22},264,[25],"Insomnia is a prevalent sleep disorder associated with numerous adverse health outcomes, including fatigue, irritability, and impaired daytime functioning. Despite the availability of effective pharmacological and psychological treatments, relatively few individuals with insomnia seek professional help, highlighting the need for accessible and acceptable non-pharmacological interventions. Sleep hygiene education (SHE) has the potential to address this gap due to its simplicity, low cost, and ease of self-administration. Building on our previously registered pilot-testing protocol, this study aims to examine the effectiveness of a theory-based SHE program integrated with behavior change techniques in a larger community population. Furthermore, it remains unclear whether theory-based SHE is inferior to gold-standard interventions such as cognitive behavioral therapy for insomnia (CBT-I) delivered via digital applications. Therefore, this study will also compare the effectiveness of theory-based SHE with a CBT-I app using a three-arm randomized controlled trial design.",[302,303],"Insomnia","Adults",[302,305,306,307,303],"Sleep hygiene education","A non-inferiority randomized controlled trial","CBT-I apps","2026-06-07",{"date":260,"type":37},{"date":311,"type":22},"2026-07-10",{"date":112,"type":22},{"name":43,"class":44},{"id":315,"slug":316,"hasResults":12,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":321,"enrollmentInfo":322,"targetDuration":4,"studyType":23,"phases":324,"briefSummary":325,"conditions":326,"keywords":328,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":344},"100639855","ai-integrated-emotional-granularity-training-for-resilience-and-quality-of-life-in-colorectal-cancer-survivors-100639855","NCT07611071","AI-Integrated Emotional Granularity Training for Resilience and Quality of Life in Colorectal Cancer Survivors","Development and Evaluation of an AI-Integrated Emotional Granularity Growth (AI-EGG) on Enhancing Resilience and Improving Quality of Life in Young and Middle-Aged Colorectal Cancer Survivors","Inclusion Criteria:\n\n* (1) young and middle-aged adult patients (age in the range of 18-60 years);\n* (2) patients diagnosed with CRC;\n* (3) patients have completed primary curative-intent treatment for colorectal cancer, and are currently in a stable post-treatment or maintenance phase of care without evidence of active disease progression or acute treatment-related instability;\n* (4) patients able to use a smartphone and agree to participate in the study.\n\nExclusion Criteria:\n\n* (1) patients who have been informed of their cancer diagnosis due to family decision to withhold information;\n* (2) patients suffering from severe comorbidities or conditions that may affect participation or assessment, such as significant cognitive impairment (e.g., dementia, severe memory loss), psychiatric disorders, or other serious medical complications;\n* (3) those who are participating in other psychological intervention studies.","60 Years",{"count":323,"type":22},54,[25],"The goal of this clinical trial is to evaluate an AI-integrated Emotional Granularity Growth intervention (AI-EGG) designed to enhance resilience and improve quality of life in young and middle-aged colorectal cancer (CRC) survivors. Emotional granularity refers to the ability to clearly identify and differentiate subtle emotional experiences, which may help individuals regulate emotions more effectively and build resilience after cancer treatment.\n\nThe main questions it aims to answer are:\n\n* Does the AI-EGG intervention improve resilience in CRC survivors compared with routine psychological care?\n* Does the intervention improve emotional granularity, emotion regulation ability, and quality of life?\n* Is the AI-EGG intervention feasible and acceptable for young and middle-aged CRC survivors?\n\nResearchers will compare the AI-EGG intervention group to a control group receiving routine psychological care and standard educational materials to see whether the intervention leads to better psychological outcomes.\n\nParticipants will:\n\n* Complete baseline assessments measuring emotional granularity, emotion regulation, resilience, and quality of life\n* Be randomly assigned to either the intervention group or the control group\n* In the intervention group, engage in a 4-week AI chatbot-based program focusing on emotional identification, differentiation, regulation, and reflective practice (at least two sessions per week)\n* In the control group, receive routine psychological care and standard educational materials\n* Complete post-intervention assessments immediately after the 4-week program and again at a 1-month follow-up\n* Some participants in the intervention group will be invited to complete interviews about their experience of the program",[327],"Colorectal Cancer (CRC)",[329,330,331,332,333,334,335],"Emotional Granularity","Psychological Resilience","Young and Middle-Aged Adults","Colorectal Neoplasms","Emotional Regulation","Quality of Life","Randomized Controlled Trial","2026-06-03",{"date":338,"type":37},"2026-06-04",{"date":340,"type":22},"2026-06-01",{"date":342,"type":22},"2026-12-01",{"name":43,"class":44},3,{"id":346,"slug":347,"hasResults":12,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":12,"sex":17,"minAge":149,"maxAge":54,"enrollmentInfo":352,"targetDuration":4,"studyType":23,"phases":354,"briefSummary":355,"conditions":356,"keywords":361,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":373,"leadSponsor":374,"locationsCount":4},"100640447","digitalized-exercise-fit-tool-intervention-for-adolescents-with-blood-cancer-100640447","NCT07621887","Digitalized Exercise Fit Tool Intervention for Adolescents With Blood Cancer","Digitalised Exercise Fit Tool Intervention for Adolescents With Hematologic Cancer","Inclusion Criteria:\n\n* (1) they are 12-18 years old;\n* (2) they had been diagnosed with hematologic cancer such as leukaemia and lymphoma;\n* (3) they are regarded by the responsible physicians as stable, able to conduct PA, and without any PA restrictions,\n* (4) they completed all cancer treatment;\n* (5) they speak Cantonese and read Chinese.\n\nExclusion Criteria:\n\n* (1) Receiving palliative care\n* (2) Have physical or cognitive impairment and learning problems as identified from medical records\n* (3) Identified by physicians that no physical activity should be conducted at the time of recruitment",{"count":353,"type":22},30,[25],"The goal of this clinical trial is to learn if a digitalised Exercise Fit Tool (EFT) mobile application can promote physical activity in adolescents aged 12-18 years who have completed treatment for hematologic cancer (e.g., leukaemia and lymphoma). The main questions it aims to answer are:\n\n1. Is it feasible to conduct a larger randomised controlled trial of the digitalised EFT intervention?\n2. Does the digitalised EFT intervention improve physical activity levels, physical activity self-efficacy, and quality of life at 6 months?\n\nResearchers will compare the digitalised EFT intervention group to a usual care group to see if the mobile application can promote physical activity levels, physical activity self-efficacy, and quality of life in adolescents with hematologic cancer.Participants will:\n\n1. Receive a 20-minute educational session on how to use the mobile application\n2. Use the mobile application to self-assess their appropriate physical activity level and exercise with a virtual coach\n3. Complete questionnaires and wear an accelerometer at 1, 3, and 6 months after enrollment\n4. Attend a 20-30-minute individual interview at 6 months (intervention group only, 10 participants)",[357,358,359,360],"Hematologic Cancer","Leukaemia","Lymphoma","Physical Activity",[362,363,364,365,366,367,368,369],"Adolescents","Cancer","Physical activity","Mobile application","Feasibility randomised controlled trial","Exercise Fit Tool","Quality of life","Digital intervention",{"date":371,"type":37},"2026-06-02",{"date":340,"type":22},{"date":187,"type":22},{"name":43,"class":44},{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":19,"enrollmentInfo":382,"targetDuration":4,"studyType":23,"phases":384,"briefSummary":385,"conditions":386,"keywords":387,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":396,"locationsCount":189},"100599716","a-neurofeedback-interface-in-poststroke-neuromodulation-using-tms-fnirs-100599716","NCT07088107","A Neurofeedback Interface in Poststroke Neuromodulation Using TMS-fNIRS","Development and Validation of an Adaptive Neurofeedback Interface Using Transcranial Magnetic Stimulation to Modulate Cortical Excitability","Inclusion Criteria:\n\nParticipants who meet the following criteria will be included:\n\n1. Diagnosed with ischemic subcortical stroke, with stroke onset≥6 months.\n2. Age between 18 and 80 years.\n3. Residual upper limb functions between levels 2-7 in the FTHUE.\n4. Capable of providing informed written consent.\n5. Capable of reading and communicating with Chinese.\n\nExclusion Criteria:\n\nPatients who meet any of the following criteria will be excluded:\n\n1. any contraindications to TMS (screened by the safety checklist by Rossi).\n2. signs of cognitive impairment, with a Montreal cognitive assessment score\\\u003C21\u002F22 out of 30.\n3. any moderate-to-severe chronic illness, such as uncontrolled hypertension, heart disease or renal failure.\n\nHealthy participants should be aged between 18 and 80, with no known history of neurological diseases. They should not have any moderate-to-severe chronic illness, such as uncontrolled hypertension, heart disease or renal failure.",{"count":383,"type":22},20,[25],"Stroke is a type of cerebrovascular disease, and the primary characteristic of post-stroke brains is pathological changes in cerebral hemodynamics. Therefore, hemodynamic signals may provide straightforward information for guiding post-stroke neuromodulation therapy. Transcranial magnetic stimulation (TMS), a non-invasive neurostimulation modality, has been extensively used in post-stroke rehabilitation. However, current TMS-based neuromodulation therapy demonstrates a large treatment response variability due to its open-loop nature. To address this challenge, the research team will develop a novel form of closed-loop neurofeedback interfaces which controls the timing of TMS pulses precisely based on neural biomarkers from functional near-infrared spectroscopy (fNIRS) and test the accuracy of the adaptive neurofeedback system in healthy adults. After establishing the TMS-based neurofeedback interface, a proof-of-concept study enrolling postacute stroke patients will be performed to evaluate the efficacy of the TMS neurofeedback interface in enhancing motor control of the hemiplegic upper extremity and cortical excitability of the ipsilesional motor cortex. These findings will verify whether the proposed fNIRS-controlled TMS neurofeedback interface can be clinically feasible as a form of post-stroke neuromodulation therapy. Additionally, the results will significantly contribute to the scientific understanding of how neuromodulation improves hemodynamic signals in a closed-loop manner, thereby enhancing functional recovery in poststroke survivors.",[181],[181,388,389],"Neurofeedback","Brain Stimulation","2026-05-28",{"date":340,"type":37},{"date":393,"type":37},"2025-08-01",{"date":395,"type":22},"2028-12-30",{"name":43,"class":44},{"id":398,"slug":399,"hasResults":12,"nctId":400,"briefTitle":401,"officialTitle":402,"acronym":4,"eligibilityCriteria":403,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":404,"enrollmentInfo":405,"targetDuration":4,"studyType":23,"phases":407,"briefSummary":408,"conditions":409,"keywords":412,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":4},"100637971","telephone-based-acceptance-and-commitment-therapy-for-young-adult-hazardous-drinkers-100637971","NCT07621822","Telephone-Based Acceptance and Commitment Therapy for Young Adult Hazardous Drinkers","A Randomized Controlled Trial of Telephone-Based Acceptance and Commitment Therapy to Assist Young Adults With Hazardous or Harmful Alcohol Use to Quit Drinking","Inclusion Criteria:\n\n* (1) aged 18-35 years\n* (2) able to read Chinese and speak Cantonese\n* (3) have AUDIT scores ≥ 8\n\nExclusion Criteria:\n\n* (1) currently receiving other behavioural therapies for drinking\n* (2) has serious mental illnesses, defined as a Kessler Psychological Distress Scale score ≥ 13","35 Years",{"count":406,"type":22},226,[25],"The goal of this clinical trial is to learn if telephone-based Acceptance and Commitment Therapy (ACT) works to help young adults with hazardous or harmful alcohol use quit drinking. It will also learn about the psychological effects of ACT on participants.\n\nThe main questions it aims to answer are:\n\n1. Does telephone-based ACT increase the number of participants who quit drinking, as confirmed by a urine test?\n2. Does telephone-based ACT help participants reduce their alcohol consumption and improve their psychological flexibility?\n\nResearchers will compare telephone-based ACT to a telephone-based social support programme to see if ACT works to help young adults quit drinking.\n\nParticipants will:\n\n1. Receive telephone-based ACT or social support once a week for 6 weeks Complete questionnaires about their alcohol use and psychological flexibility.\n2. Keep a record of their daily alcohol consumption throughout the study using a standardised diary method.\n3. Provide a urine sample at the 6-month follow-up if they report having quit drinking",[410,411],"Hazardous Drinking","Harmful Alcohol Use",[413,414,415,416,417],"Acceptance and Commitment Therapy","Telephone-based intervention","Alcohol use","Psychological flexibility","Randomized controlled trial","2026-05-26",{"date":371,"type":37},{"date":421,"type":22},"2026-08-01",{"date":423,"type":22},"2029-08-01",{"name":43,"class":44},{"id":426,"slug":427,"hasResults":12,"nctId":428,"briefTitle":429,"officialTitle":430,"acronym":4,"eligibilityCriteria":431,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":432,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":433,"conditions":434,"keywords":440,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":4},"100638722","act-dad-interview-act-for-fathers-of-children-with-special-needs-100638722","NCT07591636","ACT Dad Interview: ACT for Fathers of Children With Special Needs","A Qualitative Study to Develop a Protocol Using Acceptance and Commitment Therapy (ACT) for Fathers of Children With Special Needs in Improving Their Psychological Flexibility and Mental Health","Informants will include 2 groups, 1) fathers rearing children with special needs and 2) social workers.\n\nFor fathers,\n\nInclusion Criteria:\n\n1. are the biological fathers of children aged 2 to 12 years,\n2. are with a child having a formal diagnosis of a developmental disability, including autism spectrum disorder, attention deficit\u002Fhyperactivity disorder, intellectual disability, or related neurodevelopmental conditions,\n3. are able to speak Cantonese and read Chinese.\n\nExclusion Criteria:\n\n1. Fathers with physical or cognitive impairment\n2. Father with learning problems as identified from NGO or related medical records\n\nFor social workers,\n\nInclusion Criteria:\n\n1. have experience in working with biological fathers of children aged 2 to 12 years who have a formal diagnosis of a developmental disability, including autism spectrum disorder, attention deficit\u002Fhyperactivity disorder, intellectual disability, or related neurodevelopmental conditions,\n2. are able to speak Cantonese and read Chinese.",{"count":383,"type":22},"The goal of this qualitative study is to develop a therapy protocol for fathers of children with special needs in Hong Kong. The therapy is called Acceptance and Commitment Therapy (ACT), which helps people cope with difficult emotions by building psychological flexibility - the ability to accept and adjust to hard situations. The main questions it aims to answer are:\n\n1. What are the experiences and needs of fathers raising children with special needs?\n2. What content and format of an ACT programme would be most helpful for these fathers?\n\nResearchers will conduct focus group interviews with two groups of participants: fathers raising children with special needs and social workers who work with these families. The interviews will take about 60 to 90 minutes each.\n\nParticipants will:\n\n1. Take part in a recorded focus group interview\n2. Share their experiences, challenges, and views on what an ACT program should include\n\nThe findings will be used to develop a protocol for an ACT programme to improve the mental health of fathers raising children with special needs.",[435,436,437,438,439],"Caregiver Mental Health","Parenting Stress","Developmental Disabilities","Special Needs Children","FATHER",[441,442,443,413,444,445],"mental health","Father","psychological flexibility","Qualitative Study","Special Needs","2026-05-09",{"date":448,"type":37},"2026-05-18",{"date":450,"type":22},"2026-05-01",{"date":452,"type":22},"2027-05-01",{"name":43,"class":44},{"id":455,"slug":456,"hasResults":12,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":4,"eligibilityCriteria":460,"healthyVolunteers":12,"sex":17,"minAge":321,"maxAge":4,"enrollmentInfo":461,"targetDuration":4,"studyType":23,"phases":462,"briefSummary":463,"conditions":464,"keywords":465,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":78},"100638423","artificial-intelligence-ai-assisted-sleep-intervention-for-insomnia-in-older-adults-with-subjective-cognitive-decline-100638423","NCT07588035","Artificial Intelligence (AI)-Assisted Sleep Intervention for Insomnia in Older Adults With Subjective Cognitive Decline","Artificial Intelligence (AI)-Assist Sleep Intervention for Insomnia Among Older Adults With Subjective Cognitive Decline: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* older adults aged ≥ 60 years\n* Subjective cognitive decline questionnaire 9 (SCD-Q9) ≥ 5\n* Montreal Cognitive Assessment (MoCA) ≥ 26. If the number of years of education is less than 12, one point will be added to the total score;\n* with insomnia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and Insomnia Severity Index (ISI) ≥ 8\n* reachable by phone\n\nExclusion Criteria:\n\n* having a previously diagnosed primary sleep disorder, such as sleep apnoea\n* suffering from a severe chronic illness that could contribute to sleep problems (e.g., emphysema)\n* currently undergoing medical, psychological, or psychiatric treatment for sleep disturbances or depression\n* having significant visual or hearing impairments.",{"count":198,"type":22},[25],"To assess the feasibility and acceptability of Artificial Intelligence (AI)-assisted sleep intervention on improving the insomnia of older adults with subjective cognitive decline.",[302,92],[466,92,302,467,468,469,470],"Artificial Intelligence","Older adults","Subjective cognitive decline","Pilot randomized controlled trial","Cognitive behavioral therapy for insomnia","2026-05-08",{"date":473,"type":37},"2026-05-14",{"date":475,"type":22},"2026-04-20",{"date":477,"type":22},"2027-09-01",{"name":43,"class":44},{"id":480,"slug":481,"hasResults":12,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":4,"eligibilityCriteria":485,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":296,"enrollmentInfo":486,"targetDuration":4,"studyType":23,"phases":488,"briefSummary":489,"conditions":490,"keywords":491,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":78},"100635947","a-theory-based-sleep-hygiene-education-for-insomnia-patients-100635947","NCT07559305","A Theory-based Sleep Hygiene Education for Insomnia Patients","Developing a Theory-based Sleep Hygiene Education Intervention for Insomnia Patients - A Mixed Method Study","Inclusion Criteria:\n\n* Hong Kong residents\n* Ethnic Chinese aged 18-65 years with the ability to communicate in Cantonese or Putonghua\n* Fulfilled the DSM-5 diagnostic criteria for insomnia disorder according to a validated diagnostic tool, the Brief Insomnia Questionnaire. The criteria included having difficulties falling asleep, staying asleep, or early morning awakening with clinically significant consequences for daily life for at least 3 months\n* Scored at least 10 points in the Insomnia Severity Index (ISI)\n* Willing to give informed consent\n\nExclusion Criteria:\n\n* Any current diagnosis fulfilling the DSM-IV criteria of a major depressive disorder, generalized anxiety disorders, post-traumatic stress disorder, panic disorder, substance use disorders, or schizophrenia as screened using the Chinese version of the Structured Clinical Interview for DSM-IV\n* Other sleep disorders, including circadian rhythm disorder, narcolepsy, obstructive sleep apnoea (OSA), and restless leg syndrome (RLS)\u002Fperiodic leg movement disorder (PLMD) as determined based on cut-off scores (≥ 7 on narcolepsy; ≥ 8 on circadian rhythm disorder; ≥ 15 on OSA; ≥ 7 on RLS\u002FPLMD) using SLEEP-50. If in doubt, subjects will be referred to our team psychiatrist (KF Chung) for further assessment\n* Any current medical conditions or side-effects of medication that are contributing significantly to the subject's insomnia\n* Taking medications or currently participating in other psychotherapies for insomnia or other psychiatric disorders\n* Impaired cognitive functioning (\\\u003C22 points in HK-MoCA) or with difficulty in giving consent or understanding instructions\n* Pregnant\n* Shift work",{"count":487,"type":22},10,[25],"Insomnia is a prevalent sleep disorder associated with substantial negative health consequences, including fatigue, irritability, and impaired daytime functioning. Although effective pharmacological and psychological treatments exist, fewer than half of individuals with insomnia seek professional treatment, highlighting the need for accessible and acceptable non-pharmacological interventions. Sleep hygiene education (SHE) has the potential to address this gap due to its simplicity, low cost, and ease of self-administration. However, previous studies have often underestimated the efficacy of SHE by using it as a passive control condition rather than an active, structured intervention. To address this limitation, the proposed pilot study aims to evaluate the feasibility and effectiveness of a theory-based, structured SHE program integrated with behavior change techniques.",[302,303],[302,492,493,303],"Sleep Hygiene Education","Pilot Testing","2026-05-02",{"date":496,"type":37},"2026-05-07",{"date":498,"type":22},"2026-05-10",{"date":500,"type":22},"2026-07-31",{"name":43,"class":44},{"id":503,"slug":504,"hasResults":12,"nctId":505,"briefTitle":506,"officialTitle":507,"acronym":4,"eligibilityCriteria":508,"healthyVolunteers":12,"sex":17,"minAge":509,"maxAge":149,"enrollmentInfo":510,"targetDuration":4,"studyType":23,"phases":512,"briefSummary":513,"conditions":514,"keywords":516,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":522,"completionDateStruct":524,"leadSponsor":526,"locationsCount":4},"100635007","myopia-control-using-novel-soft-contact-lenses-100635007","NCT07547085","Myopia Control Using Novel Soft Contact Lenses","Advancing Myopia Control in Children: A Randomized Controlled Trial of Two Novel Daily Disposable Contact Lenses","Inclusion Criteria:\n\n* • Age at enrolment: 7 - 12 (both inclusive) years old Hong Kong Chinese schoolchildren\n\n  * Refractive errors in terms of spherical equivalent refraction (SER) determined by cycloplegic autorefraction: -0.75 diopters (D) to -5.00D in both eyes\n  * Astigmatism: equal or less than -1.00D\n  * Anisometropia: equal or less than -1.75D\n  * Previous myopia progression:\n\n    * -0.50D (in SER) per year or more in 1 eye or both eyes OR Axial length elongation: 0.27mm\u002Fyear in 1 eye or both eyes\n    * If myopia is initially detected during screening, eligibility requires an SER below the 3rd percentile curve of refraction in either or both eyes (4)\n  * Best corrected visual acuity: better than 0.04 LogMAR in both eyes\n  * Ocular health: no abnormalities in both internal and external ocular health\n  * Systemic health: no systemic interference with ocular vision functioning\n  * Binocular vision: no strabismus and other binocular abnormalities\n  * No medication or supplements that affect eye growth\n  * Normal colour vision\n  * No previous use of myopic control interventions such as red-light therapy, atropine, orthokeratology, specialized spectacle lenses and contact lenses and oral supplements for myopic control\n  * Agree to maintain the visit schedule and be able to keep all appointments as specified in the informed assent and consent forms throughout study duration.\n  * Agree to accept either the control or study lens as assigned by the randomization scheme\n  * Agree to wear the assigned contact lenses for a minimum of 10 hours per day, at least 6 days per week, for the duration of the 2-year study and to inform the study investigator if this schedule is interrupted. Wearing time may be modified by the study staff for health reasons\n  * Agree to adhere to contact lens use requirements throughout study duration\n  * Acceptance of the masked study design\n\nExclusion Criteria:\n\n* Contraindications for soft contact lenses\n* Dry eye with drug intervention within 30 days\n\n  * Regular use of ocular medication (prescription or over-the-counter), artificial tears, or wetting agents due to dryness, allergies or other conditions that hinder the contact lens wear\n  * Current use of systemic medications that may significantly affect contact lens wear, tear film production, pupil size, accommodation, or refractive state. These include, but not limited to, long term use of nasal decongestants (e.g., pseudoephedrine, phenylephrine), antihistamines (e.g., chlorpheniramine, diphenhydramine, Prednisolone or Ritalin (methylphenidate)\n  * Pre-existing systemic and ocular disease that had an influence on contact lens wearing\n  * History of ocular injury or surgery\n  * Prior use of myopic control interventions such as red-light therapy, atropine, orthokeratology, specialized spectacle lenses and contact lenses and oral supplements\n  * Allergy to cyclopentolate eye drops\n  * Subjects who, in the judgment of the Investigator, are unable to cooperate and follow instructions during eye examination","7 Years",{"count":511,"type":22},126,[25],"The goal of this study is to investigate the myopic control efficacy of two study soft contact lenses in children. Participants will be prescribed Lens A, Lens B or single vision contact lenses for the first year. Participants in single vision contact lenses group will switch to Lens A at 12 months. All participants will then continue lens wear for an additional 12 months. Their cycloplegic refraction and axial length will be monitored every 6 months for 2 years.",[515],"Myopia",[517,518],"Myopia control","soft contact lenses","2026-04-17",{"date":521,"type":37},"2026-04-23",{"date":523,"type":22},"2026-04-16",{"date":525,"type":22},"2029-07-14",{"name":43,"class":44},{"id":528,"slug":529,"hasResults":12,"nctId":530,"briefTitle":531,"officialTitle":532,"acronym":4,"eligibilityCriteria":533,"healthyVolunteers":53,"sex":17,"minAge":275,"maxAge":534,"enrollmentInfo":535,"targetDuration":4,"studyType":23,"phases":537,"briefSummary":538,"conditions":539,"keywords":540,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":542,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":4},"100635006","choroidal-response-to-the-modified-defocus-incorporated-multiple-segments-spectacle-lenses-100635006","NCT07547072","Choroidal Response to the Modified Defocus Incorporated Multiple Segments Spectacle Lenses","Choroidal Responses to the Modified Defocus Incorporated Multiple Segments (DIMS) Spectacle Lenses","Inclusion Criteria:\n\n* Hong Kong Chinese\n* Age at enrolment: 6 - 13 years\n* Myopia in spherical power: -1.00D to -5.00D in both eyes\n* Astigmatism: equal or less than 2.00D\n* The sum of spherical power and astigmatism: equal or less than -7.00D\n* Anisometropia (spherical equivalent refraction (SER)): equal or less than 1.50D\n* Previous myopia progression (valid documentation dated within 2 years before screening):\n\n  * -0.50D (SER) per year or more in both eyes OR Axial length elongation: 0.27mm\u002Fyear in both eyes\n  * If myopia is initially detected during screening, eligibility requires myopia (in SER) below the 3rd percentile curve of refraction in both eyes.12\n* Best corrected visual acuity: LogMAR 0.04 or better in both eyes\n* Ocular health: no abnormalities in both internal and external ocular health\n* Binocular vision: no strabismus and other binocular abnormalities\n* Normal colour vision\n* Willing to wear the study spectacles all the time (10 hours per day, for 7 days per week)\n\nExclusion Criteria:\n\n* Previous or current treatment for myopia control (e.g., red-light therapy, atropine, orthokeratology, specialized spectacle lenses and contact lenses and oral supplements for myopic control)\n* Existing or past eye diseases or surgeries (e.g., strabismus surgery, amblyopia, oculomotor nerve palsies, corneal disease, intraocular disease, etc.) that may have an impact on vision or visual development\n* Long-term medication (intake at least 3 days\u002Fweek) or medication\u002Fsupplements that affect eye health\n* Systemic diseases that may have an impact on vision or visual development (e.g., endocrine, cardiac and respiratory diseases, diabetes, Down syndrome, etc.)\n* Allergic to cyclopentolate eye drops\n* Individuals who, in the judgment of the Investigator, are unable to cooperate and follow instructions during eye examination.","13 Years",{"count":536,"type":22},108,[25],"The goal of this study is to investigate the short-term changes in choroidal thickness and efficacy of the study spectacle lenses in children. Participants will be prescribed with a pair of study spectacle lenses for daily use and visit the clinic once every week for the first month for checkup and tests. After the first month of follow-up, participants will visit at 1 month, 6- and 12-month for checkup. Choroidal thickness, axial length and refractive errors will be monitored.",[515],[515,541],"Choroidal thickness",{"date":521,"type":37},{"date":544,"type":22},"2026-04-25",{"date":546,"type":22},"2028-02-29",{"name":43,"class":44},{"id":549,"slug":550,"hasResults":12,"nctId":551,"briefTitle":552,"officialTitle":553,"acronym":4,"eligibilityCriteria":554,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":555,"targetDuration":4,"studyType":23,"phases":557,"briefSummary":558,"conditions":559,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":572,"locationsCount":78},"100614569","mindfulness-oriented-respiratory-distress-symptom-intervention-for-lung-cancer-100614569","NCT07281300","Mindfulness-Oriented Respiratory Distress Symptom Intervention for Lung Cancer","Mindfulness-Oriented Respiratory Distress Symptom Intervention for Patients With Lung Cancer: A Feasibility Randomized Controlled Trial","Inclusion Criteria:\n\n* HK patients who can understand Cantonese, aged 18 years or older;\n* A confirmed diagnosis of an intrathoracic malignancy, including small cell lung cancer, non-small cell lung cancer, or mesothelioma; at any stage of cancer treatment or palliative care;\n* Self-reported impact on daily life from at least two of the three symptoms, where one symptom is breathlessness;\n* Stability of COPD, if present;\n* WHO Performance Status of 0-2;\n* fMRI can be conducted;\n* Expected lifespan of more than six months.\n\nExclusion Criteria:\n\n* Cognitive impairments, severe psychotic symptoms, or other medical conditions that might hinder participation;\n* Participating in mindfulness or other psychological support interventions or symptom management interventions.",{"count":556,"type":22},64,[25],"Lung cancer is the leading cause of cancer mortality, posing a critical public health challenge in both Hong Kong and global populations. Patients with lung cancer frequently experience a distressing symptom cluster characterized by breathlessness-driven respiratory distress, accompanied by persistent cough and fatigue, which collectively impose a substantial disease burden. While our research team leader previously developed and validated a multi-component Respiratory Distress Symptom Intervention (RDSI) in England, demonstrating clinical efficacy for lung cancer management, its impact on psychological distress (anxiety and depression) proved limited. This limitation may reflect insufficient integration of psychological components, a crucial consideration given the well-established bidirectional relationship between respiratory symptoms and psychological distress. Emerging evidence indicates that mindfulness interventions provide dual therapeutic benefits by improving patient adherence and effectively addressing both physical symptoms, such as breathlessness and fatigue, as well as psychological distress, including anxiety and depression. Meanwhile, current evaluation methodologies have mainly focused on behavioral data collection, such as self-reported questionnaires, to reflect the effect before and after the intervention. Neuroimaging data can help understand the brain mechanisms underlying breathlessness and elucidate the effectiveness of interventions, thereby improving intervention strategies.",[560,561,562,563,564,565],"Symptom Cluster","Breathlessness","Coughing","Fatigue Symptom","Lung Cancer Patients","Brain Activity","2026-04-14",{"date":519,"type":37},{"date":569,"type":37},"2025-08-12",{"date":571,"type":22},"2027-07-30",{"name":43,"class":44},{"id":574,"slug":575,"hasResults":12,"nctId":576,"briefTitle":577,"officialTitle":577,"acronym":578,"eligibilityCriteria":579,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":580,"targetDuration":4,"studyType":23,"phases":582,"briefSummary":583,"conditions":584,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":586,"lastUpdatePostDateStruct":587,"startDateStruct":589,"completionDateStruct":590,"leadSponsor":592,"locationsCount":4},"100633776","effects-of-a-salutogenic-strength-based-social-robot-assisted-intervention-on-the-depressive-symptoms-and-sense-of-coherence-of-family-caregivers-of-persons-with-dementia-100633776","NCT07531082","Effects of a Salutogenic Strength-based Social Robot-assisted Intervention on the Depressive Symptoms and Sense of Coherence of Family Caregivers of Persons With Dementia","social robot","Inclusion Criteria:\n\n* those aged 18 years or older;\n* family caregivers of PwD who had been clinically diagnosed;\n* are living in the same household as the PwD;\n* providing daily caregiving for ≥ 4 hours \u002Fday;\n* have mild-to-moderate depressive symptoms (PHQ-9 score of 5-14) (Yu et al., 2012); and\n* are able to speak Cantonese.\n\nExclusion Criteria:\n\n* those who have been diagnosed with a mental disorder such as bipolar disorder, schizophrenia, dementia, or depression in an acute stage;\n* those with a visual or hearing impairment that would interfere with the use of a robot;\n* those currently using a social robot at home; and\n* who have limited access to electricity at home.",{"count":581,"type":22},148,[25],"Family caregivers of persons with dementia (PwD) are well known to be \"invisible patients.\" Existing studies have suggested that sense of coherence (SOC), a core inner strength, could be a protective factor against depression among family caregivers of PwD. However, few interventions are available to enhance the SOC and thereby the emotional and psychological health of this population. While in-home social robots are viewed as a useful addition to caring for PwD, the use of social robots with family caregivers as the primary audience are vastly under-investigated. In response, the investigators have developed a strength-based, robot-assisted intervention based on Antonovsky's theory of saluotogenesis for family caregivers of PwD. The feasibility, acceptability, and preliminary effects of the robot on family caregivers of PwD have been confirmed, with recommendations for examining its applicability among this population in a full trial.\n\nThis study aims to examine the effects of a salutogenic strength-based, robot-assisted intervention on improving depressive symptoms in family caregivers of PwD. This is a mixed-methods study, including a prospective, single-blinded, two-arm parallel randomized controlled trial and semi-structured individual interviews. A group of 148 family caregivers of PwD will be randomized to the intervention group (IG) or the control group (CG), who will receive reading materials on dementia care weekly. Each IG participant will engage with a robot integrated with an AI-powered chatbot at home for 6 weeks. Individual interviews will be conducted at week-6. Purposive sampling will be used to ensure diversity among the participants. Descriptive statistics, t-test and\u002For Chi square test, generalized estimating equation (GEE), linear regression and thematic analysis will be used.\n\nPrimary hypothesis: Participants in the intervention group (IG) will report a greater improvement in depressive symptoms than the control group (CG) immediately postintervention at 6 weeks (T1), 1-month (T2) and 3-month (T3) after completing the intervention.\n\nSecondary hypothesis: 1) Participants in the IG will report a greater improvement in SOC, perceived caregiving burden, coping, and caregiving self-efficacy than the CG at T1, T2, and T3; 2) The frequency of engaging with specific robot features is associated with improved depressive symptoms, SOC, caregiving burden, coping, and caregiving self-efficacy.\n\nThe findings may: 1) advance the understanding of the application of the salutogenesis theory to robotic technology, 2) boost the inner strength of family caregivers to maintain their emotional and psychological health in stressful situations, and provide a new paradigm to strengthen the informal care system.",[585],"Depressive Sympotoms","2026-04-09",{"date":588,"type":37},"2026-04-15",{"date":340,"type":22},{"date":591,"type":22},"2029-12-30",{"name":43,"class":44},{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":12,"sex":17,"minAge":321,"maxAge":601,"enrollmentInfo":602,"targetDuration":4,"studyType":23,"phases":604,"briefSummary":605,"conditions":606,"keywords":608,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":614,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":621,"locationsCount":78},"100632439","enhancing-physical-reserve-to-promote-resilience-in-physically-frail-older-adults-100632439","NCT07513701","Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults","Enhancing Physical Reserve to Promote Cognitive and Physical Resilience in Physically Frail Older Adults: A 3-Month Randomized Controlled Trial","MRI exercise","Inclusion Criteria:\n\n1. are community-dwelling (i.e., not residing in a nursing home or extended care unit) ;\n2. scored \\\u003C 9\u002F12 on the SPPB;\n3. scored \\>18\u002F30 on the MoCA;\n4. are able to walk independently; use of walking aid is acceptable;\n5. are able to safely engage in exercise as indicated by the Physical Activity Readiness Questionnaire Plus33 and confirmed by their physician;\n6. have internet at home; and\n7. are able to provide written informed consent.\n\nExclusion Criteria:\n\n1. diagnosed with dementia or stroke;\n2. self-report engaging in strength and balance training exercises \\> two-times-per-week in the 3 months prior to screening;\n3. unable to understand, speak, and read Cantonese\u002FChinese\u002FEnglish proficiently; and\n4. contraindications for MRI such as MRI-incompatible implants.","90 Years",{"count":603,"type":22},224,[25],"The goal of this clinical trial is to assess the efficacy of combined aerobic and resistance training in enhancing physical reserve in older adults with physical frailty. Investigator contend that enhanced physical reserve will enable preservation of cognitive and physical function. The main questions aims to answer are: (1) Compared with usual care (i.e., CON), will 3-month aerobic and resistance training (ATRT) improve physical reserve in older adults with physical frailty? (2) Compared with CON, will ATRT lead to changes in the neural network organization? (3) Will improved physical reserve lead to better maintenance of cognitive and physical functioning in spite of presence of white matter hyperintensities (WMH)?",[607],"Frailty at Older Adults",[609,610,611,612,613],"physical frailty","aerobic exercise","resistance training","magnetic resonance imaging","physical reserve","2026-03-30",{"date":616,"type":37},"2026-04-07",{"date":618,"type":37},"2026-01-19",{"date":620,"type":22},"2029-03-31",{"name":43,"class":44},{"id":623,"slug":624,"hasResults":12,"nctId":625,"briefTitle":626,"officialTitle":627,"acronym":4,"eligibilityCriteria":628,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":121,"enrollmentInfo":629,"targetDuration":4,"studyType":23,"phases":630,"briefSummary":631,"conditions":632,"keywords":634,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":614,"lastUpdatePostDateStruct":639,"startDateStruct":641,"completionDateStruct":643,"leadSponsor":644,"locationsCount":78},"100632260","a-randomized-controlled-ecological-momentary-intervention-to-improve-digital-self-regulation-and-well-being-100632260","NCT07511374","A Randomized Controlled Ecological Momentary Intervention to Improve Digital Self-Regulation and Well-Being","Activating Metacognition in Daily Life: A Randomized Controlled Ecological Momentary Intervention to Improve Digital Self-Regulation and Well-Being","Inclusion Criteria:\n\nParticipants must meet all of the following criteria:\n\n1. Age between 18 and 25 years old.\n2. Own and regularly use a smartphone.\n3. Report an average daily recreational screen time of at least 3 hours on weekdays or 4 hours on weekends, based on self-report (Zablotsky et al., 2025).\n4. Be able to access their device's built-in screen time tracking function (or equivalent system-level usage report) and upload screenshots when required.\n5. Be willing and able to complete daily surveys throughout the full study period.\n6. Indicate motivation to reduce or regulate their recreational screen use.\n\nExclusion Criteria:\n\n1. Outside the age range of 18-25 years.\n2. Do not own a smartphone or do not use it regularly.\n3. Report average daily recreational screen time below 3 hours on weekdays and below 4 hours on weekends.\n4. Are unable to access device-based screen time tracking functions or cannot provide valid screenshots when required.\n5. Are unwilling or unable to complete daily surveys across the study period (e.g., anticipated non-compliance, scheduling constraints).\n6. Do not express motivation to reduce or regulate their recreational screen use.",{"count":87,"type":22},[25],"The primary objective of this study is to examine whether an ecological momentary intervention (EMI), combining behavioral self-monitoring (screen time screenshot uploads) and structured reflection, can enhance metacognitive awareness and metacognitive regulation in the context of recreational screen time among young adults.\n\nA secondary objective is to investigate whether improvements in metacognitive processes are associated with subsequent changes in behavioral and psychological outcomes, including recreational screen time (RST), stress, and life satisfaction.\n\nFurthermore, this study aims to elucidate the underlying mechanisms through which the intervention exerts its effects by integrating a randomized controlled trial (RCT) design with intensive longitudinal (daily diary) data.\n\nSpecifically, the study addresses the following research questions:\n\nRQ1 (Primary Intervention Effect on Metacognition): Does the EMI lead to higher levels of daily metacognitive awareness and metacognitive regulation (planning, monitoring, and evaluation) compared to the control group? RQ2 (Within-person Associations): At the within-person level, do day-to-day fluctuations in metacognitive awareness and regulation predict same-day and next-day changes in recreational screen time, stress, and life satisfaction? RQ3 (Mediating Mechanism): Do increases in metacognitive awareness and regulation mediate the effects of the EMI on recreational screen time, stress, and life satisfaction? RQ4 (Between-person Effects): At the between-person level, do individuals in the intervention group exhibit higher average levels of metacognitive awareness and regulation, as well as lower recreational screen time and stress and higher life satisfaction, compared to those in the control group?",[633],"Behavioral Self-monitoring and Metacognitive Reflection",[635,636,637,638],"self-regulation","metacognition-based intervention","reflection","digital ecological momentary intervention",{"date":640,"type":37},"2026-04-06",{"date":642,"type":37},"2026-03-01",{"date":166,"type":22},{"name":43,"class":44},{"id":646,"slug":647,"hasResults":12,"nctId":648,"briefTitle":649,"officialTitle":650,"acronym":4,"eligibilityCriteria":651,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":652,"targetDuration":4,"studyType":23,"phases":654,"briefSummary":655,"conditions":656,"keywords":658,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":667,"startDateStruct":669,"completionDateStruct":671,"leadSponsor":673,"locationsCount":4},"100631826","information-providing-chatbot-100631826","NCT07505732","Information-providing Chatbot","The Development and Evaluation of a Co-designed, AI-based Information-providing Chatbot for Sarcoma Patients: A Pilot Randomised Controlled Trial","Inclusion Criteria:\n\n* (1) diagnosed with soft tissue sarcoma;\n* (2) receiving active treatment at any stage;\n* (3) aged≥18 years;\n* (4) able to speak Cantonese, Mandarin and English;\n* (5) access to an electronic device enabling ASCC use\n\nExclusion Criteria:\n\n* (1) patients with unstable physical or mental conditions;\n* (2) inability to communicate logically;\n* (3) using chatbots (e.g., ChatGPT, Deepseek) for sarcoma information in the last month;\n* (4) mental health disorders documented by the medical system",{"count":653,"type":22},78,[25],"This study aims to develop and examine the feasibility and preliminary effectiveness of an AI-based sarcoma chatbot building on ChatGPT (ASCC) to address the information needs of sarcoma patients. We hypothesized: 1) the ASCC will demonstrate good usability; 2) the study will be feasible in terms of all feasibility indicators; 3) the experimental group will report improved satisfaction and self-efficacy, decreased anxiety and stress than the control groups upon completion of the intervention. The ASCC will be developed using a co-design approach. A pilot randomized controlled trial will then be conducted in the three oncology wards of collaborative hospitals. Seventy-eight sarcoma patients will be recruited and randomized to the experimental group (n=39) and the control group (n=39). The experimental group will use the ASCC available 24\u002F7 via voice or text for disease-related questions for one month while the control group will receive usual care.",[657],"Sarcoma",[659,660,661,662,663,664,665],"sarcoma","health information","artificial intelligence","ChatGPT","chatbot","unmeet needs","cancer","2026-03-26",{"date":668,"type":37},"2026-04-01",{"date":670,"type":22},"2027-04-01",{"date":672,"type":22},"2028-07-31",{"name":43,"class":44},""]