[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Mind Research Network\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":127},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,76,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100591509","matching-treatments-to-cognitive-deficits-in-offenders-with-substance-use-disorders-100591509",false,"NCT06981351","Matching Treatments to Cognitive Deficits in Offenders With Substance Use Disorders","MCT","Inclusion Criteria:\n\n* Currently incarcerated\n* No uncorrectable auditory or visual deficits\n* Able to speak and\u002For understand English\n* 5th grade reading level or higher\n* IQ score = 80 or above\n* Lifetime history of substance use disorder based on DSM criteria\n* No history of dementia or other cognitive disability\n* No indication of current psychotic disorder\n* No major medical illness or CNS disease\n* Scores from the Psychopathy Checklist-Revised (PCL-R) meet criteria for one of the designated treatment groups\n\nExclusion Criteria:\n\n\\-","MALE","18 Years","55 Years",{"count":20,"type":21},288,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to investigate the effect of two types of cognitive remediation training on real-world behavioral outcomes including substance use, institutional adjustment, and recidivism following release from prison. Each training type is designed to target one of two subtypes of antisocial criminal offenders, who are characterized by either: 1) Attention to context-based deficits, or 2) Affective cognitive control-based deficits.\n\nThe main questions it aims to answer are:\n\nDoes matching deficit type with targeted cognitive training improve outcomes (relative to mismatched training)? What are the functional brain mechanisms that underlie treatment change?\n\nParticipants will:\n\nBe assigned to cognitive training that either does or does not match their deficit type.\n\nComplete six one-hour sessions of cognitive skills training. Complete pre and post-training behavioral tasks assessing self-regulation deficits.\n\nComplete structural MRI scans and functional MRI scans assessing cognitive control.\n\nComplete post-treatment follow-up assessments evaluating self-regulation, adjustment, and stressful life events, substance use and recidivism.",[27],"Antisocial Behavior",[29,30,31],"Cognitive skills training","Attention to Context","Affective Cognitive Control","RECRUITING","2025-05-12",{"date":35,"type":36},"2025-05-20","ACTUAL",{"date":38,"type":36},"2025-03-18",{"date":40,"type":21},"2029-05-31",{"name":42,"class":43},"The Mind Research Network","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":44},"100421609","phase-2-a-pilot-study-of-non-invasive-brain-stimulation-to-boost-the-efficacy-of-psychotherapy-in-a-community-sample-of-people-who-drink-alcohol-100421609","NCT04770025","A Pilot Study of Non-invasive Brain Stimulation to Boost the Efficacy of Psychotherapy in a Community Sample of People Who Drink Alcohol","Transcranial Alternating Current Stimulation to Boost the Efficacy of Motivational Interviewing","tACS-MI","Inclusion criteria:\n\n* Self-identify as having problem drinking\n* Right-handed\n* Age 21-60 years\n* AUDIT score indicating risky drinking\n\nExclusion criteria:\n\n* Left-handed or ambidextrous\n* Currently engaged in treatment for alcohol use disorder\n* Receiving treatment for alcohol use disorder within the prior 12 months\n* History of brain injury or neurological diagnosis\n* Evidence of current psychosis\n* Past-year substance use disorder other than alcohol, marijuana, or nicotine\n* Current or history of severe alcohol withdrawal\n* MRI\u002FtACS contraindications including pregnancy\n* Impaired hearing (psychotherapy using American Sign Language is not possible within the scope of the proposed study)\n* Insufficient corrected visual acuity to complete the assessment instruments\n* Unable to read\u002Fspeak English fluently\n* Unable to provide valid informed consent",true,"ALL","21 Years","60 Years",{"count":58,"type":21},75,[60],"PHASE2","The goal of this small (n=75) proof-of-concept randomized clinical trial is to test the effects of transcranial alternating current stimulation (tACS) during motivational interviewing (MI) sessions with participants who drink at above the low-risk level. Participants will be randomized to receive either MI with active stimulation, MI with sham stimulation, or a delayed treatment group that receives MI with no stimulation. Measures will include brain imaging, alcohol use, cannabis use, risk-taking behavior, emotions, and others. Participants who are randomized to the delayed-treatment group will not receive brain imaging.",[63],"Alcohol Use Disorder",[63,65,66,67],"Motivational Interviewing","Transcranial Electrical Stimulation","Alcohol Drinking","2025-05-06",{"date":70,"type":36},"2025-05-08",{"date":72,"type":36},"2020-09-01",{"date":74,"type":21},"2026-02-28",{"name":42,"class":43},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":53,"sex":82,"minAge":17,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":44},"100504211","neurocognitive-abnormalities-in-stimulant-abuse-among-high-risk-women-100504211","NCT05845333","Neurocognitive Abnormalities in Stimulant Abuse Among High-Risk Women","Inclusion Criteria:\n\n* Biological sex is female\n* Intelligence Quotient 70 or higher\n* Reading level 5th grade or higher\n* Able to speak and understand English\n\nExclusion Criteria:\n\n* Uncorrectable auditory or visual deficits\n* Currently pregnant\n* MRI contraindication\n* Central nervous system disease\n* Current major medical condition\n* Hypertension with complications (e.g., stroke)\n* Diabetes with complications\n* Lifetime history of psychotic disorder\n* Self-report of psychotic disorder (with psychiatric hospitalization) in first degree relative\n* Drug use in past three months\n\n(Healthy controls only):\n\n* History of arrest\n* Substance use beyond light alcohol or marijuana use\n* Currently taking psychotropic medications","FEMALE","70 Years",{"count":85,"type":21},334,"OBSERVATIONAL","Substance use disorders and psychopathy are serious and costly mental health issues. Psychopathy is known to be associated with aberrant moral decision making and there is considerable interest in determining whether substance use disorders lead to impairments in these same cognitive processes. Recent large-scale research initiatives in forensic settings have begun to identify substance abuse and psychopathy-related disruption in the neural mechanisms involved in moral decision-making processes, and associations between these neural networks and future relapse and antisocial behavior. Here the investigators extend prior work (with incarcerated men) to examine these issues among incarcerated women in order to better understand sex differences. This project addresses the overall lack of neurocognitive research in criminal offenders with substance use disorders, thereby focusing on a major public health issue in an underserved and understudied population.",[89,90],"Stimulant Abuse","Criminal Behavior","2025-05-05",{"date":70,"type":36},{"date":94,"type":36},"2022-08-01",{"date":96,"type":21},"2027-05-31",{"name":42,"class":43},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":54,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":44},"100516489","the-synchrony-study-examining-music-training-for-children-with-fasd-100516489","NCT06005181","The Synchrony Study: Examining Music Training for Children With FASD","The Synchrony Study: A Randomized Controlled Trial of Music Training for Children With a Fetal Alcohol Spectrum Disorder (FASD)","Synchrony","Inclusion Criteria:\n\n* Children must receive a research designation of FASD\n* Children must have confirmed prenatal alcohol exposure\n\nExclusion Criteria:\n\n* Children with other confirmed developmental disorders that are not deemed associated with FASD (e.g. autism spectrum disorder, Down Syndrome). Children with attention deficits (e.g. ADHD) are not excluded.\n* Children with neurological disorders (epilepsy, cerebral palsy, etc.)\n* Children who have experienced a traumatic brain injury with loss of consciousness \\>10 minutes\n* Children with intelligence quotient scores \\\u003C70\n* Children who are, or become, a ward of the state; however children with a legal representative who can consent on their behalf will not be excluded\n* Children with ongoing music training outside of school or \\>1 year of prior private music lessons.","8 Years","16 Years",{"count":109,"type":21},32,[24],"The goal of this clinical trial is to examine if music training improves behavioral or cognitive performance in children with prenatal alcohol exposure who meet research criteria for a fetal alcohol spectrum disorder. The main questions it aims to answer are:\n\n* Does music training improve behavioral regulation for children with an FASD\n* Does music training improve cognitive performance (attention and working memory) for children with an FASD.\n\nThe study has two interventions for each participant: music listening and piano training. Each participant will either practice piano daily for 12 weeks or listen to pre-selected music daily for 12 weeks. The order of the interventions will be randomized across participants. Assessment will occur before and after participation in each 12 week intervention.",[113],"Fetal Alcohol Spectrum Disorders",[115,116,117,118],"music training","music listening","piano training","attention","2024-03-12",{"date":121,"type":36},"2024-03-15",{"date":123,"type":36},"2023-10-02",{"date":125,"type":21},"2028-09",{"name":42,"class":43},""]