[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Miriam Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":429},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,47,81,104,131,165,192,220,245,269,310,335,363,387,409],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100583634","type-1-diabetes-adolescents-for-healthier-lifestyles-study-100583634",false,"NCT06878872","Type 1 Diabetes Adolescents for Healthier Lifestyles Study","Adapting an Adolescent Weight Management Program for a Type 1 Diabetes Population","T1DAL","Inclusion Criteria:\n\n* Teen diagnosed with type 1 diabetes at least 6 months ago\n* Teen's body mass index greater than or equal to the 70th percentile for age and sex\n* Teen lives with parent\u002Fcaregiver\n* Teen has access to a smart phone\n* Teen and caregiver speak and write in fluent English\n\nExclusion Criteria:\n\n* Teen has a medical condition that precludes them from participating in a group activity and\u002For any physical activity\n* Teen experiencing psychosis or suicidality\n* Teen lost a significant amount of weight in the 3 months prior to the study\n* Teen currently in another intensive health behavior and lifestyle treatment and\u002For sees a dietician more than once per month on average\n* Teen currently or planning to become pregnant\n* Teen unwilling to wear a continuous glucose monitor for assessments\n* Teen taking a medication known to impact weight and\u002For appetite","ALL","13 Years","18 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","Before the 1990s, obesity was rare among young people with type 1 diabetes (T1D), but now it is more common. Recent studies show that over 50% of young people with T1D will have overweight or obesity within five years of being diagnosed with T1D. Both obesity and T1D increase the risk of heart disease, and combined, these risks are even higher. Intensive health behavior and lifestyle treatments (IHBLTs) are proven to be effective for treating childhood obesity. However, managing T1D creates unique challenges that require adjustments to these treatments. For example, people with T1D need to eat even when they're not hungry to treat low blood sugar, blood sugar changes can make exercise harder, and some recommended \"free foods\" are high in unhealthy fats. Young people with T1D are also more likely to develop eating disorders. There is a need for IHBLTs that address these specific challenges and focus on preventing eating disorders in this group.\n\nTo address these needs, we developed the Type 1 Diabetes Adolescents for healthier Lifestyles (T1DAL) program, based on feedback from teenagers with T1D, their parents\u002Fcaregivers, and pediatric endocrinologists. The goal of this study is to test whether the T1DAL program can improve the health and wellbeing of teens compared to usual care.\n\nIn this study, about 50 teens will be randomly assigned to either the T1DAL program or to Usual Care. Those in the T1DAL group will take part in a 16-week program designed specifically for teens with T1D to improve eating habits and diabetes management. Those in the Usual Care group will continue with their regular endocrinology appointments. At the end of the study, the Usual Care group will be offered a shortened version of the T1DAL program. All participants will have their height, weight, blood glucose, eating habits, diabetes management behaviors, and mood measured at the start and end of the study. They will also answer questions to track unhealthy eating and weight control behaviors over time. Additional analyses will look at factors that may lead to these behaviors in real life.\n\nThis project builds on Dr. Warnick's previous work in pediatric obesity and T1D, and it supports the NIDDK's goal of reducing diabetes-related heart problems. T1DAL could become an important public health program to improve the health of teens with T1D.",[28,29,30],"Type 1 Diabetes","Eating Behavior","Adolescent Obesity",[32,33,28],"Teenagers","Diabetes","RECRUITING","2026-05-12",{"date":37,"type":38},"2026-05-13","ACTUAL",{"date":40,"type":38},"2025-08-01",{"date":42,"type":22},"2027-06-01",{"name":44,"class":45},"The Miriam Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":46},"100584242","smart-to-optimize-an-intervention-to-maintain-health-improvements-after-cardiac-rehabilitation-100584242","NCT06886789","SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation","An Application of SMART Methodology to Optimize an Intervention to Maintain Improvements in Health Behaviors in Under-resourced Patients After Phase II Cardiac Rehabilitation","EMPOWER ME","Inclusion Criteria:\n\n* ≥18 years of age or older\n* Have completed at least 6 CR sessions\n* Must enroll within 6 weeks of their final CR session\n* BMI ≥27\n* Own an internet-connected device\n* Home internet access\n* English proficiency\n* Able to walk ≥1 block without stopping\n\nLastly, the participant MUST belong to ≥1 of the following groups or identities:\n\n* Identifies as a woman\n* Identifies as LGBTQIA+\n* Identifies as a racial or ethnic minority\n* Insecure transportation for medical appointments\n* Self-reported trouble paying for healthcare needs (e.g., copays)\n* Receive income-based subsidized benefits (e.g., state-funded health insurance for low-income residents)\n* Reside in a small town or rural area per 2010 United States Department of Agriculture Rural-Urban Commuting Area zip code or the Distressed Communities Index\n* Low educational attainment (≤high school diploma)\n* Low household income (less than twice the Federal Poverty Level) or meeting federal poverty guidelines per the National Committee on Vital and Health Statistics and the Department of Health and Human Services)\n\nExclusion Criteria:\n\n* New York Heart Association Class IV heart failure\n* Heart transplant in the last 5 months\n* Left ventricular assist device in the last 4 months\n* Physician diagnosis of dementia\n* Physician prescription for 24 hours of oxygen therapy daily\n* Coronary artery bypass surgery in the last 3 months\n* Current dialysis\n* Chronic gait or balance disturbances that would make unsupervised exercise unsafe\n* Current pregnancy\n* Report of conditions that the investigators believe would render them potentially unlikely to follow the protocol including terminal illness, active substance dependence, or other significant psychiatric problems that require inpatient hospitalization",{"count":56,"type":22},400,[25],"The study is sponsored by the National Heart, Lung, and Blood Institute, which is part of the National Institutes of Health. The study expects to enroll 400 subjects. The research team will recruit research participants that are finishing or will finish cardiac rehabilitation soon. Participants belong to one or more groups of people who are less often studied in cardiac rehabilitation research, may have less access to a formal cardiac rehabilitation maintenance program, or they may especially benefit from additional support after cardiac rehabilitation ends. The main purposes of this study are to evaluate which treatments work the best after cardiac rehabilitation, which order to deliver the treatments in, and which treatments are as minimally burdensome as possible while still working well. This study will make two comparisons (one comparison between a set of low-intensity interventions and another between a set of higher-intensity interventions) to determine which produces the best behavioral adherence immediately after Phase II (outpatient) cardiac rehabilitation",[60,61],"Cardiovascular Diseases","Cardiac Rehabilitation",[63,64,65,66,67,68,69,70,71,72],"Cardiovascular disease","Cardiac rehabilitation","Medication adherence","Weight loss","Weight management","Weight maintenance","Physical activity","Intervention optimization","Sequential, multiple assignment, randomized trials","Digital health","2026-04-27",{"date":75,"type":38},"2026-04-28",{"date":77,"type":38},"2026-04-01",{"date":79,"type":22},"2030-08",{"name":44,"class":45},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100472385","mind-your-heart-ii-100472385","NCT05431192","Mind Your Heart-II","Targeting Cognitive Function and Interoceptive Awareness to Improve Self-management in Patients With Co-morbid Heart Failure and Cognitive Impairment.","MYH-II","Inclusion Criteria:\n\n* Age \\> 18 years old\n* A documented diagnosis of HF\n* Access to a telephone\n* Mild cognitive impairment (MoCA score \\\u003C = 26)\n* Ability to understand and speak English or Spanish\n\nExclusion Criteria:\n\n* Unwillingness\u002Finability to provide informed consent\n* Reversible causes of HF (e.g., takotsubo syndrome; myocarditis)\n* Severe hearing impairment not allowing phone delivery\n* Suicidal ideation or plan\n* Current (at least once a month) mind\u002Fbody practice\n* Planning to move out of the area during the study period\n* Severe cognitive impairment (MoCA scores \\\u003C 15)\n* New York Heart Association (NYHA) class IV heart failure or clinically unstable\n* Ongoing psychiatric or neurologic conditions\n* Current enrollment in another study",{"count":90,"type":22},176,[25],"This projects studies the role of mindfulness training (MT) to improve self-care among patients with heart failure and cognitive impairment.",[94,95],"Heart Failure","Cognitive Impairment","2026-03-18",{"date":98,"type":38},"2026-03-19",{"date":100,"type":38},"2022-11-30",{"date":102,"type":22},"2026-12",{"name":44,"class":45},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":46},"100610480","microrandomized-trial-to-optimize-use-of-burden-reducing-self-monitoring-approaches-in-behavioral-obesity-treatment-100610480","NCT07228130","Microrandomized Trial to Optimize Use of Burden-reducing Self-monitoring Approaches in Behavioral Obesity Treatment","* English language fluent and literate at the 6th grade level\n* Body mass index (BMI) above 25 kg\u002Fm-squared\n* Able to walk 2 city blocks without stopping\n* Not currently participating in another weight loss program\n* Not currently taking weight loss medication\n* Has not lost ≥5% of body weight in the 6 months prior to enrolling\n* Has not been pregnant within the 6 months prior to enrolling\n* Does not plan to become pregnant within 12 months of enrolling\n* Denies having a heart condition, chest pain during periods of activity or rest, or loss of consciousness in the 12 months prior to enrolling\n* Denies any medical condition that would affect the safety of participating in unsupervised physical activity\n* Denies any condition that would result in inability to follow the study protocol, including terminal illness, substance abuse, eating disorder (not including Binge Eating Disorder) and untreated major psychiatric illness\n* Owns a smartphone compatible with study procedures and is willing to use it for study participation","70 Years",{"count":112,"type":22},275,[25],"This clinical trial is focused on testing dietary self-monitoring strategies used in behavioral obesity treatment. The goal is to determine which self-monitoring strategies are most useful for whom, at which points in treatment, and under what circumstances.\n\nResearchers will provide a 24-week online behavioral obesity treatment program, and will randomize participants to use one of 5 dietary self-monitoring strategies every two weeks. The five strategies include: recording all food and drink consumed and corresponding energy intake (i.e., \"calories\") on 7 days per week; recording all food and drink consumed and corresponding energy intake (i.e., \"calories\") on 3 days per week; self-monitoring of dietary lapses (i.e. any eating\u002Fdrinking likely to cause weight gain or put weight loss at risk); smartwatch-based monitoring of energy intake (i.e., \"calories\"); and self-monitoring of body weight only via smart scale.\n\nParticipants will:\n\n* Follow a 24-week online program for weight loss and health improvement\n* Use the assigned self-monitoring strategy every two weeks\n* Meet with the researchers periodically via online video call and provide research data by answering questions via periodic online surveys.",[116],"Obesity & Overweight",[118,119,120,121,122],"Online","Obesity","Weight Loss","Diet","Physical Activity","2026-02-03",{"date":125,"type":38},"2026-02-04",{"date":127,"type":38},"2026-01-07",{"date":129,"type":22},"2029-03-01",{"name":44,"class":45},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":139,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":145,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":46},"100620899","pilot-test-of-five-weight-neutral-interventions-to-improve-health-among-adults-of-higher-body-weight-100620899","NCT07363616","Pilot Test of Five Weight Neutral Interventions to Improve Health Among Adults of Higher Body Weight","Optimizing a Weight Neutral Intervention to Improve Health Among Adults of Higher Body Weight: A MOST Preparation Phase Study","NEW PATH","Inclusion Criteria:\n\n* 18 years and older\n* BMI between 25-40 (if BMI is between 25-30 then additional cardiometabolic risk factor must be present including hypertension, high cholesterol, prediabetes or type 2 diabetes)\n\nExclusion Criteria:\n\n* current participation in a formal weight loss program\n* current use of weight loss medication\n* history of bariatric surgery\n* physical condition that would limit the ability to engage in moderate intensity physical activity\n* current pregnancy\n* recent weight loss of 5% body weight\n* condition that may interfere with ability to complete the study procedures",true,{"count":21,"type":22},[25],"The purpose of this research study is to pilot test five different, group based and remotely delivered programs designed to support healthy eating and regular physical activity. Each group will contain information and support for healthy eating and physical activity. Groups may also include support to 1) eat with more awareness of hunger and fullness, 2) improve how people think and feel about their bodies, and\u002For 3) identify ways to be physically active that are more enjoyable. Each group will include a unique combination of these components and the goal is to assess overall satisfaction and engagement with each of the programs.",[116,144],"Cardiometabolic Risk Factors",[146,122,147,148,149,150,151,119,152,153,154,155,156],"Mediterannean diet","Weight Neutral","Lifestyle intervention","Mindful eating","Mindfulness-based Eating Awareness Training","Body Image","Overweight","Cardiometabolic health","Multiphase Optimization STrategy (MOST)","MOST Preparation Phase","Body appreciation","2026-01-22",{"date":159,"type":38},"2026-01-23",{"date":161,"type":38},"2025-12-31",{"date":163,"type":22},"2026-11-15",{"name":44,"class":45},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":176,"conditions":177,"keywords":179,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":46},"100592553","weight-management-intervention-in-college-a-pilot-100592553","NCT06994923","Weight Management Intervention in College: A Pilot","Testing a Behavioral Weight Loss Intervention for Emerging Adults Implemented Within College Health Service Centers","Inclusion Criteria:\n\n* BMI of 25 or greater\n* Enrolled at college\u002Funiversity where study will take place\n* English-speaking\n\nExclusion Criteria:\n\n* History or current diagnosis of anorexia nervosa, bulimia nervosa, or alcohol use disorder (current symptoms also assessed at screening using validated screening questionnaires)\n* Participation in another formal weight loss program or current utilization of obesity medications\n* Current or recent pregnancy\n* Psychiatric hospitalization in the past 12 months\n* Recent weight loss of 5% body weight or more\n* History of bariatric surgery\n* Severe food or physical activity restrictions that would interfere with treatment recommendations","29 Years",{"count":174,"type":22},60,[25],"This pilot randomized controlled trial will examine a behavioral weight loss intervention that uses a \"small change\" approach fro emerging adult college students with overweight\u002Fobesity. The primary aim is to assess student acceptability and clinically-meaningful weight changes.",[178],"Obesity and Overweight",[180,181,182,183],"obesity","college students","behavioral weight loss intervention","small changes","2025-09-26",{"date":186,"type":38},"2025-10-01",{"date":188,"type":38},"2025-01-20",{"date":190,"type":22},"2027-04-01",{"name":44,"class":45},{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":23,"phases":202,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":211,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":46},"100608165","2-hoba-supplementation-in-people-with-elevated-lipoproteina-100608165","NCT07198009","2-HOBA Supplementation in People With Elevated Lipoprotein(a)","Modulation of Bioactive Lipids in Lipid Disorders: a Pilot Study of 2-HOBA Supplementation in Individuals With Elevated Lipoprotein(a)","Inclusion Criteria:\n\n* Males and females aged 18-69 years.\n* Elevated Lp(a) levels ≥ 90 mg\u002FdL.\n* Able to provide informed consent and adhere to study schedules.\n* Willing to follow a physician-recommended diet during the study.\n\nExclusion Criteria:\n\n* Pregnant, planning pregnancy during the study period, or currently breastfeeding.\n* Individuals with established cardiovascular disease\n* Planning major changes in diet or exercise routines.\n* Experienced \\>20% weight change in the past 3 months.\n* Diagnosed with malabsorption syndrome or chronic diarrhea.\n* Abnormal liver, kidney, or thyroid function.\n* Drug or alcohol abuse within the past 6 months, or significant mental\u002Fpsychological impairment.\n* Have known bleeding disorders (e.g., hemophilia).\n* Planned surgery during the study period.\n* Donated blood within the last 2 weeks or planning to donate during the study.\n* Require regular blood transfusions.","69 Years",{"count":201,"type":22},10,[25],"The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with high lipoprotein(a) levels.\n\nThe main questions it aims to answer are:\n\nDoes 2-HOBA lower oxidized phospholipids on lipoprotein(a)? Does 2-HOBA reduce markers of inflammation and blood clotting in the blood?\n\nParticipants will:\n\nTake 2-HOBA capsules (400 mg, three times daily with meals) for 6 weeks Provide blood and urine samples at the beginning, middle, and end of the study Have lab tests to measure changes in lipids, inflammation, and clotting markers",[205,206],"Hyperlipidemia","Elevated Lp(a)",[208,209,210],"Oxidized Phospholipids","lp(a)","2HOBA","NOT_YET_RECRUITING","2025-09-25",{"date":214,"type":38},"2025-09-30",{"date":216,"type":22},"2025-11-01",{"date":218,"type":22},"2026-11",{"name":44,"class":45},{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":139,"sex":17,"minAge":19,"maxAge":199,"enrollmentInfo":227,"targetDuration":4,"studyType":229,"phases":4,"briefSummary":230,"conditions":231,"keywords":233,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":238,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":244},"100573493","lipoprotein-interactions-and-platelet-function-in-healthy-individuals-and-those-with-lipid-disorders-100573493","NCT06747000","Lipoprotein Interactions and Platelet Function in Healthy Individuals and Those With Lipid Disorders","Lipoprotein Functions in Healthy Individuals and Subjects With Lipid Disorders","Inclusion Criteria:\n\n* Healthy volunteers\n* Abnormalities in lipid panels\n* Able to provide informed consent\n* Between the age of 18 and 69\n\nExclusion Criteria:\n\n* Drug or alcohol abuse within 6 months or significant mental\u002Fpsychological impairment\n* Current smokers\n* Subjects with known bleeding disorders (for example, hemophilia)\n* Subjects requiring regular transfusions for any reason\n* No ethnic\u002Fracial groups will be excluded",{"count":228,"type":22},80,"OBSERVATIONAL","This study looks at how lipoproteins, which are particles in the blood that transport cholesterol, influence heart and blood vessel health. Beyond just their levels, the way these particles function plays a key role in preventing or contributing to disease. In some conditions, like high cholesterol or diabetes, lipoproteins may not work properly, increasing the risk of clogged arteries and other complications.\n\nThe investigators aim to study these changes in people with lipid disorders to better understand their impact on blood health and to find new ways to prevent and treat heart disease.",[232],"Lipid Disorders",[234,235,236,237],"lipids","lipoproteins","platelets","high cholesterol",{"date":186,"type":38},{"date":240,"type":38},"2024-07-18",{"date":242,"type":22},"2029-07-18",{"name":44,"class":45},2,{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":199,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":253,"briefSummary":255,"conditions":256,"keywords":259,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":263,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":46},"100554084","early-phase-1-differential-thrombogenesis-by-epa-and-dha-mediated-by-hdl-100554084","NCT06494488","Differential Thrombogenesis by EPA and DHA Mediated by HDL","Differential Thrombogenesis Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Mediated by High-Density Lipoprotein (HDL)","Inclusion Criteria:\n\n* Fasting TG levels ≥ 150 mg\u002FdL and \\\u003C 500 mg\u002FdL and HDL-C ≤ 40 (men) or ≤ 50 (women)\n* LDL-C \\> 40 mg\u002FdL and ≤ 130 mg\u002FdL\n* Able to provide informed consent and adhere to study schedules\n* Agree to follow and maintain a relatively stable and low fatty fish intake diet (\\\u003C3 servings per week)\n\nExclusion Criteria:\n\n* Female with pregnancy, planned pregnancy (within the study period), or currently breastfeeding.\n* Subjects with weight changes greater than 20% over the past 3 months\n* Subjects planning a significant change in diet or exercise levels\n* Malabsorption syndrome and\u002For chronic diarrhea\n* Use of dietary supplements containing n-3 PUFA fatty acids\n* Frequent consumption of n-3 PUFA-enriched fish (\\>3 times a week)\n* Abnormal liver, kidney, or thyroid functions\n* Drug or alcohol abuse within 6 months or significant mental\u002Fpsychological impairment\n* Current smokers\n* Subjects taking daily aspirin, NSAIDs, anticoagulant, or corticosteroids\n* Subjects with known bleeding disorders (for example, hemophilia)\n* Known sensitivity or allergy to fish, shellfish, or omega-3 fatty acid supplements\n* Subjects requiring regular transfusions for any reason\n* No ethnic\u002Fracial groups will be excluded",{"count":228,"type":22},[254],"EARLY_PHASE1","The goal of this study is to learn more about omega-3 polyunsaturated fatty acids supplementation on blood lipid profile and platelets in patients with high cholesterol levels.\n\nThe purpose of this research is to gather information on the safety and effect of two different fish oils, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).\n\nParticipants will:\n\nVisit the clinic 3 times during study checkups, tests and blood collection. Randomized to either the EPA or the DHA supplementation group. Be given a 28-day food and activity log.",[257,258],"Lipid Metabolism Disorders","Hypertriglyceridemia",[260,261,262],"Fish oil","Atherogenic lipidemia","Lipoproteins",{"date":186,"type":38},{"date":265,"type":38},"2025-07-10",{"date":267,"type":22},"2028-03-31",{"name":44,"class":45},{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":277,"enrollmentInfo":278,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":291,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":46},"100582507","addressing-weight-bias-internalization-to-improve-adolescent-weight-management-outcomes-randomized-pilot-trial-100582507","NCT06864208","Addressing Weight Bias Internalization to Improve Adolescent Weight Management Outcomes: Randomized Pilot Trial","Piloting an Intervention to Address Weight Bias Internalization to Improve Adolescent Weight Management Outcomes","SWIFT","Inclusion Criteria:\n\n* Speak English;\n* 13-17 years of age;\n* BMI at or above \\>95th%ile for age and sex;\n* Have at least one caregiver available to provide consent and participate in sessions;\n* Agree to study participation;\n\nExclusion Criteria:\n\n* Cognitive impairment or developmental delay impairing participation in a group setting;\n* Current participation in a weight management program or recent weight loss of 5% of body weight or more;\n* Medical condition known to impact weight or that would otherwise prevent participation;\n* Current use of glucagon-like peptide-1 (GLP-1) receptor agonists;","17 Years",{"count":279,"type":22},64,[25],"Weight stigma and weight bias internalization (WBI) are common among adolescents at higher weight statuses. WBI is associated with negative physical and mental health outcomes. The current study aims to test an intervention for weight stigma and WBI combined with an evidence-based adolescent weight management program. Eligible adolescents (13-17) will be assigned by chance to one of two groups: 1) a 4-week intervention focused on weight stigma and WBI followed by a 16-week behavioral weight management program; or 2) a 4-week health information control (to include non-weight-related health promotion topics such as smoking and skin cancer prevention) followed by the same 16-week weight management program but without the WBI and weight stigma content. Study outcomes will be assessed at the 4-week and post-treatment (20 week) timepoints.",[283,284,285,286,287,288,289,290],"Weight","Body Weight","Weight Bias","Weight Stigma","Physiological Stress","Biological Markers of Stress","Biological Markers of Inflammation","Eating Behaviors",[292,293,283,294,295,296,297,298,299,300,301],"Adolescents","Teens","C-reactive protein","CRP","Interleukin-6","IL-6","Eating behaviors","Behavioral weight management","Weight bias","Weight stigma","2025-09-22",{"date":304,"type":38},"2025-09-24",{"date":306,"type":38},"2025-03-25",{"date":308,"type":22},"2027-02",{"name":44,"class":45},{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":139,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":23,"phases":319,"briefSummary":320,"conditions":321,"keywords":323,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":46},"100583384","remote-approaches-for-optimizing-weight-loss-elevate-weight-loss-trial-100583384","NCT06875622","Remote Approaches for Optimizing Weight Loss (Elevate Weight Loss Trial)","Comparison of Behaviorally-Based Remote Approaches to Optimize Weight Loss and Identification of Factors Which Characterize Treatment Response","Inclusion Criteria:\n\n* Body Mass Index between 25-45 kg\u002Fm2\n* Daily, home Internet access\n\nExclusion Criteria:\n\n* Currently pregnant, planning to become pregnant within the next 18 months, or pregnant within the past 6 months\n* Current or recent enrollment (\\\u003C2 years) in a weight loss program\n* Presence of any medical condition for which exercise, weight loss, or dietary restriction is contraindicated\n* Recent weight loss (≥10 pounds within the past 6 months)\n* Currently taking weight loss medications or history of bariatric surgery\n* Inability to walk 2 blocks without stopping\n* Non-English speaking\n* A member of one's household is participating in the study\n* History of anorexia or bulimia nervosa",{"count":318,"type":22},490,[25],"The purpose of this trial is to compare two delivery formats for weight loss (automated online program vs. group-based videoconference program) and to examine the added effect of individual coaching (vs. no coaching) for individuals with overweight or obesity. All participants enrolled in this study will receive a 12-month behavioral weight loss program (varying in delivery format and individual support), and will be provided with weight loss, calorie intake, and exercise goals. Assessments will occur at baseline, 6 (mid-treatment), 12 (post-treatment), and 18 months (following 6 months of no intervention). We will also seek to determine which combination of intervention approaches works best for whom and develop algorithms which can be used to refer patients into remote programs in clinical settings or future trials.",[322],"Obesity\u002Ftherapy",[324,325,326],"behavioral weight loss","remote interventions","diet and exercise","2025-03-14",{"date":329,"type":38},"2025-03-18",{"date":331,"type":38},"2025-03-03",{"date":333,"type":22},"2028-10-31",{"name":44,"class":45},{"id":336,"slug":337,"hasResults":11,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":342,"targetDuration":344,"studyType":229,"phases":4,"briefSummary":345,"conditions":346,"keywords":348,"overallStatus":211,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":4},"100570204","long-acting-injectable-antiretroviral-treatment-to-improve-hiv-treatment-among-justice-involved-persons-being-released-to-the-community-100570204","NCT06704204","Long-acting Injectable Antiretroviral Treatment to Improve HIV Treatment Among Justice-involved Persons Being Released to the Community","Long-acting Injectable Antiretroviral Treatment to Improve HIV Treatment Among Justice-involved Persons Being Released to the Community (Study #3; Aim 2 Injectable CAB\u002FRPV Pilot)","Inclusion Criteria:\n\n* 1\\) ≥18 years of age; 2) English speaking; 3) HIV positive (confirmed by medical record review); 4) receiving oral ART; 5) documentation of HIV viral suppression (\\\u003C 50 copies\u002FmL) on oral ART within 12 weeks of recruitment; 5) eligible to transition from oral ART to injectable CAB\u002FRPV based upon medical record review and pre-treatment evaluation; 6) willing to transition ART to injectable CAB\u002FRPV; 7) anticipated release from MDPSCS facility within 12 weeks; 8) anticipated release to Baltimore City; 9) willing to receive post-release CAB\u002FRPV injections at community-based sites; and 10) able to provide informed consent for study participation.\n\nExclusion Criteria:\n\n* Persons who are currently prescribed injectable CAB\u002FRPV within MDPSCS will not be eligible for study enrollment, however, we do not anticipate use of injectable CAB\u002FRPV will be common in this population during the conduct of this study given slow roll out in the community to date and no experience within carceral facilities. Potential participants unable to provide informed consent, including people with severe mental illness (e.g., untreated psychosis, bipolar disorder with mania; adequately treated psychiatric disorders and appropriate psychotropic medications will be allowed) requiring immediate treatment or with mental illness limiting their ability to participate (e.g., dementia), will be excluded.",{"count":343,"type":22},20,"6 Months","The federal research award entitles \"Long-acting injectable antiretroviral treatment to improve HIV treatment among justice-involved persons being released to the community\" aims to Conduct interviews with justice and treatment experienced PWH (n=20), and carceral and community key stakeholders (n=20), to obtain guidance on the development and implementation of a protocol to transition PWH with viral suppression on oral ART to LAI ART in prison with continuation during community re-entry; develop an initial LAI ART community re-entry protocol based on Aim 1 findings and conduct an open label pilot study. Post-release follow up will occur for three months among 20-30 incarcerated PWH eligible for LAI ART who are near release from prison in order to optimize protocol procedures including participant recruitment, initiation of LAI ART in prison, transition of LAI ART to community providers, and to pilot study retention methods and assessments, including post-release HIV viral loads and urine drug testing, during the follow-up period.",[347],"HIV",[349,350,351,352,353,354],"HIV infection","substance use disorders","community re-entry","HIV treatment","long-acting injectable","incarceration","2025-01-13",{"date":357,"type":38},"2025-01-15",{"date":359,"type":22},"2025-02",{"date":361,"type":22},"2025-07-31",{"name":44,"class":45},{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":11,"sex":370,"minAge":19,"maxAge":110,"enrollmentInfo":371,"targetDuration":4,"studyType":23,"phases":373,"briefSummary":374,"conditions":375,"keywords":376,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":382,"completionDateStruct":384,"leadSponsor":386,"locationsCount":46},"100498841","optimizing-an-online-behavioral-weight-loss-intervention-and-novel-culturally-tailored-components-for-sexual-minority-women-100498841","NCT05775497","Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women","Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women: MOST Optimization Phase","* Assigned female at birth and currently identify as female\n* Self-identify a minority sexual orientation (e.g.,lesbian, bisexual)\n* BMI=25-50kg\u002Fm2\n* 18-70 years old\n* Interested in losing weight\n* Regular internet and e-mail access\n* No significant weight loss within past 6 months (\\>5%)\n* Fluent in English\n* Able to participate in moderate physical activity\n* Not currently enrolled in a weight loss program\n* Not currently taking weight-loss medication\n* Not currently pregnant or trying to get pregnant\n* Participated in a previous Phase of this study\n* Reports a serious mental\u002Fphysical health condition that would increase potential risks of treatment to the participant (e.g., active symptoms of psychosis, suicidality, mania, alcohol\u002Fsubstance use, or a medical condition that is serious, active, unstable, and degenerative (e.g., CHF)).","FEMALE",{"count":372,"type":22},88,[25],"Obesity disproportionately impacts sexual minority women. Behavioral weight loss programs are the gold standard treatment for mild to moderate obesity. The investigators have developed an online behavioral weight loss program that is effective, low-cost, and highly scalable. However, existing research suggests that tailoring treatment to address 3 well-established weight loss barriers in sexual minority women will be critical for maximizing the relevance and efficacy of behavioral weight loss for this group. In the Preparation Phase of this K23, the investigators developed 3 novel treatment components targeting sexual minority women's weight loss barriers (i.e., minority stress, low social support, and negative body image), the investigators piloted the program among sexual minority women of higher weight, and the investigators conducted individual qualitative interviews to elicit feedback on the intervention's acceptability, cultural relevance, usability, and feasibility, and this feedback was used to refine the program.\n\nIn the Optimization Phase of this K23 (the current phase), 88 women will receive 12 weeks of Rx Weight Loss and will be randomized to receive 0-3 tailored components in a full factorial design with 23 (8) distinct combinations of components. Novel components that increase mean weight loss (by ≥2%) or the proportion of women achieving clinically meaningful weight loss (by ≥10%) at 6 months will be retained in a finalized obesity treatment package that the investigators will evaluate in a future randomized controlled trial (RCT) (Evaluation Phase). The aims of this study are to:\n\nAim 2A (Optimization): Use a factorial experiment to determine how 3 novel components impact mean weight loss and the proportion of women achieving a 5+% weight loss at 6 months.\n\nAim 2B (Mediation): Clarify how tailored components impact weight loss by testing hypothesized mechanisms of action (i.e., coping with stress, perceived social support, weight and shape concerns).\n\nThis project will tailor and optimize an evidence-based online behavioral obesity treatment to enhance weight loss outcomes in sexual minority women.",[119],[377,378,66],"Sexual minority women","LGBTQ health","2024-12-23",{"date":381,"type":38},"2024-12-27",{"date":383,"type":38},"2024-05-01",{"date":385,"type":22},"2025-12-29",{"name":44,"class":45},{"id":388,"slug":389,"hasResults":11,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":110,"enrollmentInfo":394,"targetDuration":4,"studyType":23,"phases":396,"briefSummary":398,"conditions":399,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":46},"100534904","phase-2-control-systems-engineering-for-weight-loss-maintenance-100534904","NCT06244888","Control Systems Engineering for Weight Loss Maintenance","Control Systems Engineering to Address the Problem of Weight Loss Maintenance: A System Identification Experiment to Model Behavioral & Psychosocial Factors Measured by Ecological Momentary Assessment","Inclusion Criteria:\n\n* English language fluent and literate at the 6th grade level\n* Body mass index (BMI) between 25 and 50 kg\u002Fm-squared\n* Able to walk 2 city blocks without stopping\n* Owns a smartphone\n\nExclusion Criteria:\n\n* Report of a heart condition, chest pain during periods of activity or rest, or loss of consciousness in the 12 months prior to enrolling.\n* Currently participating in another weight loss program\n* Currently taking weight loss medication\n* Has lost ≥5% of body weight in the 6 months prior to enrolling\n* Has been pregnant within the 6 months prior to enrolling\n* Plans to become pregnant within 18 months of enrolling\n* Any medical condition that would affect the safety of participating in unsupervised physical activity\n* Any condition that would result in inability to follow the study protocol, including terminal illness and untreated major psychiatric illness",{"count":395,"type":22},180,[397],"PHASE2","This project capitalizes on principles of control systems engineering to build a dynamical model that predicts weight change during weight loss maintenance using behavioral, psychosocial, and environmental indicators evaluated in a system identification experiment. A 6-month behavioral obesity treatment will be administered to produce weight loss. Participants losing at least 3% of initial body weight will be followed for an additional 12 months via daily smartphone surveys that incorporates passive sensing to objectively monitor key behaviors. Survey data pertaining to behavioral, psychosocial, and environmental indicators will be used to develop a controller algorithm that can predict when an individual is entering a heightened period of risk for regain and why risk is elevated. Interventions targeting key risk indicators will be randomly administered during the system ID experiment. Survey and passive sensing data documenting the effects of the interventions will likewise drive development of the controller algorithm, allowing it to determine which interventions are most likely to counter risk of regain.",[400],"Overweight and Obesity","2024-04-01",{"date":403,"type":38},"2024-04-02",{"date":405,"type":38},"2024-02-26",{"date":407,"type":22},"2027-12-31",{"name":44,"class":45},{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":139,"sex":17,"minAge":19,"maxAge":110,"enrollmentInfo":416,"targetDuration":4,"studyType":23,"phases":418,"briefSummary":419,"conditions":420,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":46},"100500714","cognitive-strategies-for-weight-loss-100500714","NCT05799846","Cognitive Strategies for Weight Loss","Adapting Episodic Future Thinking for Behavioral Weight Loss: Comparing Strategies and Characterizing Treatment Response","Inclusion Criteria:\n\n* Participants will be between the ages of 18 and 70, have a BMI between 25 and 45 kg\u002Fm2, and have regular (i.e., weekly) access to the Internet, defined as owning a smart phone with Internet capabilities, and\u002For having a broadband or Wi-Fi connection at home or work.\n\nExclusion Criteria:\n\n* Exclusionary criteria include: 1) current enrollment in a weight loss program, 2) currently taking weight loss medications, 3) history of bariatric surgery or planned bariatric surgery in the next 18 months, 4) individuals who are pregnant, nursing, or have plans to become pregnant within the next 18 months, 5) individuals planning to relocate outside the area in the next 18 months, 6) any medical condition for which weight loss would be contraindicated, 7) neurological or psychiatric conditions including but not limited to schizophrenia and bipolar disorder, 8) inability to attend assessments at the Weight Control and Diabetes Research Center in Providence, RI.\n\nIndividuals with mobility issues, dizziness, or history of heart disease, diabetes, or cancer will be required to provide physician consent prior to enrolling.",{"count":417,"type":22},360,[25],"The goal of this clinical trial is to compare weight change and other related outcomes associated with three different behavioral weight loss interventions (STANDARD Behavioral, PREVENT, and PROMOTE) in adults with obesity. The main questions it aims to answer are:\n\n* Which of the three Internet-delivered weight loss programs results in the greatest weight loss?\n* How do key weight-related behaviors (e.g., adherence, diet, physical activity) differ across the arms?\n* What individual characteristics predict success in each arm?\n* What are the underlying mechanisms of each approach?\n* Are there any potential adverse outcomes associated with any of the conditions (e.g., depression, weight stigmatization, increased body image concerns).\n\nParticipants will:\n\n* signed informed consent\n* complete a baseline assessment\n* be randomized to 12 months of either Standard iBWL, PREVENT or PROMOTE\n* complete a training workshop to learn arm-specific cognitive strategies\n* complete a 12-month Internet-delivered weight loss program, requiring self-monitoring of intake and exercise and viewing of 12 weekly lessons followed by 9 monthly lessons\n* complete an assessment at 3 months (during treatment)\n* complete a refresher workshop on arm-specific cognitive strategies at 3 months\n* complete an assessment at 6 months (during treatment), 12 months (at the conclusion of treatment), and 18 months (6 months after treatment",[119],"2023-03-22",{"date":423,"type":38},"2023-04-05",{"date":425,"type":38},"2023-03-01",{"date":427,"type":22},"2026-08-31",{"name":44,"class":45},""]