[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Royal Ottawa Mental Health Centre\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":368},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,50,84,111,132,153,177,199,220,260,293,316,348],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100643449","comparing-outcomes-of-theta-burst-stimulation-in-depression-using-advanced-pet-imaging-100643449",false,"NCT07620288","Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging","Measuring Neuroplasticity Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging","Inclusion Criteria\n\nFor inclusion in the study, participants must fulfill all the following criteria:\n\n1. 18 to 55 years old.\n2. Competent to provide voluntary informed consent.\n3. English comprehension and verbal communication (participants must be able to both understand and speak English sufficiently to follow study procedures and be understood by study personnel\n4. Referred by their treating physician.\n5. Mini-International Neuropsychiatric Interview-confirmed diagnosis of MDD, as a single or recurring episode.\n6. Symptoms of MDD have not improved after ≥ 1 adequate antidepressant medication trial in the current depressive episode29.\n7. Baseline score of ≥18 on the 17-item Hamilton Rating Scale for Depression (HRSD-17).\n8. Maintained a stable treatment regimen for at least four weeks prior to entering the study, defined as being on a stable antidepressant regimen, a stable psychotherapy regimen, both, or neither (i.e., no treatment), with no changes during this period.\n\nExclusion Criteria\n\nParticipants fulfilling any of the following criteria will be excluded from the study:\n\n1. Any comorbid mental health disorders (including, but not limited to lifetime history of psychotic disorders, OCD, and\u002For bipolar I or II disorder) with the exception of anxiety\u002Fpanic disorders, posttraumatic stress disorder and ADHD\n2. Current or past (\\\u003C 3 months) substance (including nicotine) or alcohol abuse\u002Fdependence, as defined in DSM-5 criteria.\n3. Positive urine test for illegal substances, cannabis, or cotinine.\n4. Significant unstable medical or neurologic illness confirmed by medical history (e.g. uncontrolled diabetes, or renal dysfunction).\n5. Breastfeeding or pregnant (confirmed via urine test).\n6. BMI \\> 30 or BMI \\\u003C 18.\n7. Contraindication for TMS (e.g., personal history of epilepsy or convulsion, metallic head implant, pacemaker).\n8. Contraindication for MRI (e.g. metallic implant, claustrophobia).\n9. Have received a cumulative radioactivity dose \\> 15.2mSv during the last 12 months.\n10. Have active malignancies (due to high chance of undergoing radiation therapy).\n11. Suicide attempt in the past three months and\u002For active suicidal intent.\n12. Failed (non-response) course of ECT or rTMS treatment in the current depressive episode.\n13. Benzodiazepine or lithium use. Other psychotropic medications (e.g. ADHD medications) are permitted, if stable in the 4 weeks prior to and during the treatment course)\n14. Any other condition that, in the opinion of the investigators, would adversely affect the participant's ability to complete the study.","ALL","18 Years","55 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The proposed project will investigate the neurobiological mechanisms of accelerated intermittent Theta Burst Stimulation (iTBS) in major depressive disorder (MDD) using an advanced multimodal imaging approach. This single-arm, within-subject study will deliver one week of accelerated iTBS and use pre-\u002Fpost-treatment PET\u002FMRI to quantify changes in synaptic density, functional connectivity, and microstructural integrity. We will combine \\[¹⁸F\\]SynVesT-1 PET with functional, neurochemical and anatomical MRI, such as resting-state fMRI, magnetic resonance spectroscopy (MRS) and neurite orientation dispersion and density imaging (NODDI), to capture treatment-related plasticity. This integrated design will link molecular and network-level mechanisms to clinical improvement, providing an unprecedented mechanistic map of how accelerated iTBS restores brain function in depression.",[27,28,29,30],"Depression","Depression - Major Depressive Disorder","Depressive Episode","Major Depressive Disorder (MDD)",[32,33,34,35,36],"PET","iTBS","accelerated iTBS","rTMS","MRI","NOT_YET_RECRUITING","2026-06-05",{"date":40,"type":41},"2026-06-09","ACTUAL",{"date":43,"type":21},"2026-08-01",{"date":45,"type":21},"2028-07-30",{"name":47,"class":48},"The Royal Ottawa Mental Health Centre","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100631852","implementing-action-based-cognitive-remediation-for-transdiagnostic-cognitive-difficulties-in-a-tertiary-mental-health-hospital-100631852","NCT07506070","Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital","Inclusion Criteria:\n\n* Participants must have been given a diagnosis of a psychiatric disorder (such as mood anxiety, psychotic disorders, etc.\n* Participants must have reported subjective cognitive difficulties associated with their psychiatric disorder\n* Participants must be capable of providing informed consent\n* Participants must have the ability to speak and read in either English or French\n* Participants must have no changes to their medication intake (such as starting or stopping medication or changing doses) within the past month before providing consent for participation\n\nExclusion Criteria:\n\n* Participants will be excluded if they are hospitalized at the time of recruitment\n* Participants will be excluded if they have a confirmed diagnosis of an intellectual disability","60 Years",{"count":58,"type":21},160,[24],"Psychiatric conditions are each defined by different set of symptoms, however, they often share common characteristics such as impairments in cognitive and social functioning. These impairments can cause significant distress and disrupt daily functioning by preventing individuals from actively participating in school or work, maintaining healthy relationships with others, and engaging in everyday activities independently. The goal of this clinical trial is to examine if action-based cognitive remediation (ABCR) therapy, a type of cognitive training program, works to treat cognitive impairments in participants with psychiatric disorders.\n\nThe main questions it aims to answer are:\n\n* Whether the intervention will improve the thinking skills of participants with different types of psychiatric conditions\n* Whether the intervention will improve social skills and work performance\n* Can this program be easily used in a regular hospital, and do the people who take part in it find it helpful and worth their time\n* Whether the improvements from the intervention last for a long time after the training is over.\n\nResearchers will compare how much the thinking skills of participants change during an 8-week waiting period (where they get no treatment) to how much they change during the 8-week training program to see if the training makes a bigger difference in helping them think and live better.\n\nParticipants will :\n\n* Complete a series of questionnaires on memory, thinking skills, and mental health at the beginning of the study\n* Wait 8 weeks without any intervention or training\n* Complete the series of questionnaires again\n* Complete an 8-week training intervention of ABCR where they will use special computer programs to practice real-life skills and tasks like planning a meal or making an appointment\n* Complete the series of questionnaires and an additional structured interview to assess acceptability and feasibility of the intervention.\n* 3 month later, complete questionnaires for a final time.",[62,28,63,64,65,66,67],"Psychiatric Disorders","Schizophrenia and Other Psychotic Disorders","Anxiety and Mood Disorders","Bipolar and Related Disorders","PTSD - Post Traumatic Stress Disorder","Autism Spectrum Disorder",[69,70,71,62,72,73,74,75],"Transdiagnostic","Action-Based Cognitive Remediation","Cognitive Remediation Therapy","Cognitive Impairments","Cognitive Deficits","Neurocognition","Social Cognition","2026-04-15",{"date":78,"type":41},"2026-04-20",{"date":80,"type":21},"2026-05-01",{"date":82,"type":21},"2031-05-01",{"name":47,"class":48},{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":49},"100514025","examining-the-efficacy-of-a-virtual-reality-cognitive-remediation-program-for-people-living-with-psychosis-100514025","NCT05973110","Examining the Efficacy of a Virtual Reality Cognitive Remediation Program for People Living With Psychosis","Inclusion Criteria:\n\n* Diagnosis of a psychosis-spectrum disorder\n* Equal or between 18 to 60 years old\n* Ability to read and speak English\n* Be clinically stable, as defined as a total Positive And Negative Severity Symptoms score equal or between 30 - 95\n* No changes to their medication dosage, starting a new medication, or stopping a medication within the past month before signing the consent form\n\nExclusion Criteria:\n\n* Neurological or medical disorders that may produce cognitive impairment (including head injury with more than 1 minute of loss of consciousness)\n* Intellectual disability or a score equal or below 70 on the Wechsler Abbreviated Scale of Intelligence.\n* Any vision conditions that cannot be corrected with contact lenses or glasses that can fit in the virtual reality googles.\n* Past history of seizures, fit, and epilepsy\n* Any severe medical condition related to the eyes, ears, and balance\n* History of substance use disorder within the last 3 months",{"count":91,"type":21},52,[24],"Individuals living with a psychotic disorder often experience changes to their thinking and social skills that can lead to challenges with work, school, relationships and living independently. One intervention to target these areas is cognitive remediation therapy, which can be delivered in virtual reality to help apply the skills and strategies learned to day-to-day life. Over the past few years, our team has co-developed a cognitive remediation program in virtual reality with healthcare professionals and people with lived experiences of psychosis. The current trial tests the feasibility and efficacy of this cognitive remediation program in virtual reality at improving thinking skills, social skills, and daily life functioning.",[95,96,97],"Psychotic Disorders","Schizophrenia","Schizo Affective Disorder",[95,99,100,74,75,101],"Cognitive Remediation","Virtual Reality","Community Functioning","RECRUITING","2026-04-13",{"date":105,"type":41},"2026-04-16",{"date":107,"type":41},"2023-07-31",{"date":109,"type":21},"2026-12",{"name":47,"class":48},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":117,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":49},"100374761","brain-imaging-of-cognition-inn-schizophrenia-and-depression-100374761","NCT04159662","Brain Imaging of Cognition Inn Schizophrenia and Depression","Inclusion Criteria:\n\n* age 18-60 years\n* current Intelligence Quotient (IQ) \\> 70 as measured by the Wechsler Abbreviated Scale of Intelligence (WASI)\n* the ability to read and speak fluent English\n* a diagnosis of schizophrenia, schizoaffective or major depression disorder\n* stable medication for more than one month\n\nExclusion Criteria:\n\n* significant neurological or other medical disorders that may produce cognitive impairment\n* a recent history of substance abuse or dependence (within the past 3 months)\n* any magnetic resonance imaging (MRI) contraindications (e.g. metallic head implant, history of seizure, pacemaker)\n* decisional incapacity requiring a guardian\n* taking medications that are rated as Anticholinergic Burden (ACB) Score 3 (severe) or taking benzodiazepines on a daily basis\n* Finally, participants could not be severely symptomatic at the time of study enrolment to ensure that they could understand and complete all study assessments. This criterion was defined as a score ≤34 on the Montgomery-Åsberg Depression Rating Scale (MADRS; Montgomery \\& Åsberg, 1979) for the MDD group and a score ≤95 on the Positive and Negative Syndrome Scale (PANSS; Kay et al., 1987) for the SZ group.",{"count":118,"type":21},90,"OBSERVATIONAL","Schizophrenia and depression are among the most disabling disorders in all of medicine. Cognitive deficits play a key role in patients' disability, affecting their capacity to contribute actively to society by sustaining employment or academic activity. Moreover, cognitive difficulties tend to persist even after the stabilization of other clinical symptoms. Verbal memory and emotion regulation are two important cognitive domains that are impaired in schizophrenia and depression and are associated with patients' functional outcomes. In this study, brain imaging is used to investigate the brain mechanisms underlying these cognitive deficits in these populations.",[122,123],"Schizophrenia \u002F Schizoaffective Disorder","Depression \u002F Major Depressive Disorder","2026-03-19",{"date":126,"type":41},"2026-03-23",{"date":128,"type":41},"2019-12-12",{"date":130,"type":21},"2026-10-01",{"name":47,"class":48},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":4},"100627246","evaluating-the-feasibility-acceptability-and-initial-clinical-effectiveness-of-implementing-a-cognitive-remediation-program-within-psychiatric-services-100627246","NCT07446140","Evaluating the Feasibility, Acceptability, and Initial Clinical Effectiveness of Implementing a Cognitive Remediation Program Within Psychiatric Services.","Inclusion Criteria:\n\n* Aged 18 years or older.\n* Present cognitive difficulties in the context of a diagnosed severe and persistent mental illness.\n* Report recurrent complaints related to cognitive challenges affecting multiple areas of daily functioning.\n* Able to provide free and informed consent.\n* Fluent in French.\n* Clinically stable (No change in psychotropic medication for at least one month).\n\nExclusion Criteria:\n\n* Intellectual disability diagnosis and confirmed in medical record.\n* A major medical condition other than the mental health disorder that affects cognitive functioning.",{"count":139,"type":21},87,[24],"Severe and persistent mental health disorders are associated with impairments in cognitive, emotional, and social functioning. Some of these disorders involve cognitive challenges that are likely to negatively affect quality of life. In this context, the early identification of cognitive difficulties and intervention through cognitive remediation become priority therapeutic targets to facilitate individual rehabilitation. From this perspective, the present study aims to determine the relevance of a personalized cognitive remediation program developed by neuropsychologists at Pierre-Janet Hospital, called RECAMEX, to guide its sustainable adoption and to support its implementation in other clinical settings.",[143],"Severe and Persistent Mental Illness",[99,74,75],"2026-02-25",{"date":147,"type":41},"2026-03-03",{"date":149,"type":21},"2026-03-01",{"date":151,"type":21},"2029-03-01",{"name":47,"class":48},{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":162,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":49},"100575566","feasibility-trial-of-exercise-as-a-priming-strategy-for-rtms-treatment-in-difficult-to-treat-depression-100575566","NCT06773949","Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression","Randomized Trial Assessing the Feasibility of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression","Inclusion Criteria:\n\n1. Are between 18-75 years old.\n2. Able to provide voluntary informed consent.\n3. Diagnosis of MDD or Persistent Depressive Disorder, without psychotic features, confirmed by MINI for DSM-5.\n4. Depressive symptoms have not improved after ≥ 1 adequate antidepressant trial in the current episode (i.e., difficult-to-treat MDD), based on the Antidepressant Treatment History Form (ATHF).\n5. Baseline score of ≥15 on the HRSD-17.\n6. No change in psychotropic medications or psychotherapy regimen at least 4 weeks prior to entering the trial\n7. Physically inactive as per the International Physical Activity Questionnaire - Short Form (IPAQ-SF).\n8. Able to engage in structured exercise as per the Get Active Questionnaire (GAQ).\n9. Able to adhere to the proposed treatment schedule.\n\nExclusion Criteria:\n\n1. Diagnosis of bipolar I or II disorder, based on DSM-5 criteria.\n2. Current or past (\\\u003C3 months) substance (excluding caffeine or nicotine) or alcohol abuse\u002Fdependence, as defined in DSM-5 criteria.\n3. Current use of illegal substances.\n4. Current use of cannabis.\n5. Concomitant major unstable medical or neurologic illness (e.g., uncontrolled diabetes or renal dysfunction).\n6. Organic cause of the depressive symptoms (e.g. thyroid dysfunctions), determined by the referring physician.\n7. Acute suicidality or threat to life from self-neglect.\n8. Pregnant or breastfeeding, or thinking of becoming pregnant during course of treatment.\n9. Contraindication for TMS and MRI (e.g., personal history of epilepsy or seizure, metallic head implant, pacemaker), confirmed by TMS Adult Safety Scale (TASS) and MRI pre-screener.\n10. Unwilling to maintain current psychotropic medication and\u002For psychotherapy regimen for the four weeks prior to and for the duration of the study.\n11. Taking more than 1 mg\u002Fday of lorazepam or equivalent.\n12. Any other condition that, in the opinion of the investigators which would adversely affect the participant's ability to complete the study.\n13. Physically active: performing exercise and\u002For physical activity levels meeting the cut-off for \"minimally active\" on the IPAQ-SF.","75 Years",{"count":20,"type":21},[24],"The goal of this study is to collect feasibility data on combining structured exercise aimed to improve physical fitness, and intermittent TBS (iTBS) in treating individuals diagnosed with difficult-to-treat depression who are physically inactive. By conducting this trial, we will compare the therapeutic benefits of the combined approach against the standard treatment of iTBS alone (without exercise). These findings will be used to inform future large-scale projects in which we will investigate, in a larger sample size, whether structured exercise aimed to improve fitness as recommended by most public exercise guidelines (i.e., ≥3x\u002Fweek, moderate-to-vigorous intensity) serves as an active ingredient that amplifies the effectiveness of iTBS. Ultimately, the insights gained from this study will be valuable for clinicians seeking to alleviate depressive symptoms in MDD through neuromodulation techniques such as iTBS.",[30,165],"Treatment Resistant Depression (TRD)",[33,35,167,168],"Exercise","Physical inactivity","2025-12-09",{"date":171,"type":41},"2025-12-17",{"date":173,"type":21},"2025-12-15",{"date":175,"type":21},"2027-01-31",{"name":47,"class":48},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":22,"phases":186,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":193,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":49},"100527818","comparing-the-efficacy-of-fmri-guided-vs-standard-itbs-in-treating-depression-100527818","NCT06152705","Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression","Triple-blind Randomized Trial Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression","Inclusion criteria:\n\nFor inclusion in the study, participants must fulfill all the following criteria:\n\n1. voluntary and competent to consent to study,\n2. Adults aged 18 years old or older,\n3. can speak and read English,\n4. primary and\u002For predominant diagnosis of major depressive episode without psychotic features in the current episode (confirmed by a Mini-International Neuropsychiatric Interview),\n5. depressive symptoms have not improved after ≥ 1 adequate dose of antidepressant trial in the current depressive episode,\n6. moderate symptoms in the current depressive episode as indexed by a score of at least 15 on the Grid 17-item Hamilton Rating Scale for Depression (Grid HRSD-17),\n7. have been referred to rTMS treatment by their treating physician, and took a free and informed decision to follow this treatment,\n8. are able to adhere to treatment schedule,\n9. have stable psychotropic medications (including prescribed cannabis) or psychotherapy regimen for at least four weeks prior to entering the trial,\n10. have an education-adjusted score of ≥ 24 at the Mini-Mental State Evaluation (MMSE) if they are aged ≥ 65.\n\nExclusion criteria:\n\nParticipants fulfilling any of the following criteria will be excluded from the study:\n\n1. diagnosis of bipolar I or II disorder, based on the DSM-5 criteria\n2. current or past (\\\u003C 3 months) substance (excluding caffeine or nicotine) or alcohol use disorder, as defined in DSM-5 criteria. Based on the DSM-5 criteria, mild cannabis or alcohol use disorder would be permissible in the past 3 months, moderate to severe would be an exclusion.\n3. current use of illegal substances or cannabis (unless medical use, see note below), confirmed by urine drug screen\n4. have a concomitant major unstable medical or neurologic illness (e.g. uncontrolled diabetes or renal dysfunction),\n5. organic cause to the depressive symptoms (e.g. thyroid dysfunctions), as ruled out by the referring physician\n6. acute suicidality or threat to life from self-neglect,\n7. are pregnant or breastfeeding, or thinking of becoming pregnant during course of treatment (pregnancy will be assessed by a urine test),\n8. have a specific contraindication for TMS (e.g., personal history of epilepsy or seizure, metallic head implant, pacemaker),\n9. unwilling to maintain current antidepressant regimen,\n10. are taking more than 1 mg of lorazepam per day or equivalent,\n11. any other condition that, in the opinion of the investigators, would adversely affect the participant's ability to complete the study,\n12. any contraindications for MRI\n13. have failed a course of ECT within the current depressive episode due to the lower likelihood of response to rTMS (if they have had failed ECT in the past, this does not exclude them)",{"count":185,"type":21},210,[24],"In this triple-blind randomized controlled trial, we ask if targeting intermittent theta burst stimulation (iTBS) based on individual resting state connectivity improves treatment outcomes in major depressive disorder (MDD). For the trial, we will recruit 210 patients with major depressive disorder. Each patient will undergo a 30-40-minute MRI scan, after which they will receive a 6-week standard iTBS treatment. Participants will be randomized to receive iTBS either to the standard neuronavigated target (a technique for treatment location targeting, based on group-average connectivity) or to a personalized connectivity-guided target selected based on individual functional connectivity scans. The main outcome of this trial is response rate as determined by ≥ 50% reduction in Grid HRSD-17 scores. Secondary outcomes include remission rate, change in depression, anxiety and anhedonia symptoms, quality of life, and biological measures of heart rate variability, objective sleep measures and daily activity as a proxy of anhedonia - defined as a reduced ability to experience pleasure.",[27,189,29],"Depressive Disorder, Major",[191,33,192],"fMRI","neuronavigation",{"date":171,"type":41},{"date":195,"type":41},"2024-09-16",{"date":197,"type":21},"2027-10-01",{"name":47,"class":48},{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":205,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":206,"targetDuration":4,"studyType":22,"phases":208,"briefSummary":209,"conditions":210,"keywords":4,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":49},"100538160","preliminary-evaluation-of-a-mental-health-program-a-comparison-study-100538160","NCT06287216","Preliminary Evaluation of a Mental Health Program: a Comparison Study","Inclusion Criteria:\n\n* 18 years and above\n* can speak English\n\nExclusion Criteria:\n\n* Have previously participated in the mental hygiene challenge (exclusion for the control group).",true,{"count":207,"type":21},200,[24],"The mental hygiene challenge is a Royal Ottawa Health Care Group led initiative to engage the staff, clients and community members to attend to their mental well-being by way of practicing mental hygiene activities for 10 min on a daily basis, throughout the month of March. Participants are encouraged to choose one or many of the practices recommended and do them for about 10 minutes a day. Participants are encouraged to make it their own, in that they can combine the practice or tailor them in a way that suits them best. When signing up for the challenge, participants receive free access to a toolkit with brief outlines and instructional videos on various mental hygiene practices.\n\nStudy investigators also encourage participants to divide the 10 minutes in whatever way best works for them, such as 10 minutes all at once, 5 minutes twice, or even 2 minutes five times. This study aims to expand on the work that was done in 2022 and 2023, when the World Health Organization - 5 Wellbeing Index (WHO-5) and the Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) were collected from participants to ascertain the impact of mental hygiene, by way of including a control group.",[211],"Mental Wellbeing","2025-12-04",{"date":214,"type":41},"2025-12-12",{"date":216,"type":41},"2024-02-29",{"date":218,"type":21},"2026-04-30",{"name":47,"class":48},{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":229,"briefSummary":230,"conditions":231,"keywords":241,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":254,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":49},"100409377","cognitive-remediation-in-forensic-mental-health-care-100409377","NCT04610697","Cognitive Remediation in Forensic Mental Health Care","CRFMHC","Inclusion Criteria:\n\ni1. Age 18 - 55; i2. Ability to read and speak in fluent English; i3. Current status as inpatient on the Forensic Treatment Unit.\n\nExclusion Criteria:\n\ne1. Intellectual disability; e2. TBI with loss of consciousness followed by known severe neurological sequelae requiring hospitalisation and rehabilitation.",{"count":228,"type":21},30,[24],"Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation.\n\nOne empirically-validated method to train executive functions is cognitive remediation, which consists of cognitive exercises combined with coaching.\n\nThis trial investigates whether cognitive remediation can improve cognitive, functional, and clinical outcomes in forensic inpatients.",[95,232,233,234,235,236,237,238,27,96,239,240],"ADHD","TBI (Traumatic Brain Injury)","Aggression","Substance Use Disorders","Violence","Cognitive Dysfunction","Anxiety","Offenders","Antisocial",[99,242,243,244,245,246,247,248,249,250,251,252,253],"Cognitive Training","Cognitive Enhancement","Cognitive Rehabilitation","Neuropsychological Rehabilitation","Executive Function","Forensic Mental Health","Forensic Psychology","Forensic Neuropsychology","Forensic Neuroscience","Forensic Rehabilitation","Cognition","Executive Functioning",{"date":214,"type":41},{"date":256,"type":41},"2020-02-10",{"date":258,"type":21},"2026-02-10",{"name":47,"class":48},{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":16,"minAge":268,"maxAge":4,"enrollmentInfo":269,"targetDuration":4,"studyType":22,"phases":271,"briefSummary":272,"conditions":273,"keywords":277,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":292,"locationsCount":4},"100606521","a-b-c-program-for-sedentary-older-adults-with-depressive-symptoms-100606521","NCT07176637","A-B-C Program for Sedentary Older Adults With Depressive Symptoms","A-B-C Program: a Brief Intervention to Promote an Active Lifestyle by Addressing Behavioral Economics Cognitive Biases Among Sedentary Older Adults With Depressive Symptoms-a Randomized Controlled Trial","A-B-C","Inclusion Criteria:\n\n* 1\\. All sex and gender inclusive 2. Age 65 and over 3. Cognitive telephone screening via the 20-point Tele-MoCA with a score of 16 or higher.\n\n  4\\. Score on the PHQ-9 is between 2-14. 5. The participant agrees to attend all the meetings for the duration of the study, and to practice home assignments.\n\n  6\\. Adequate command of English to be able to participate in the group sessions. 7. Current weekly duration of exercise\\* ≤60 minutes\u002Fweek. (\\*Exercise: a specific type of physical activity \\[PA\\], which is structured, and has the intention of improving either health or fitness. Exercise differs from PA, which includes any physical effort, however without the intention of improving health or fitness \\[e.g., driving, cleaning, standing, etc. are examples for PA, not exercise\\]) 8. Participants have interest in increasing their weekly time of physical activity, and willingness to practice skills learned during the program.\n\n  9\\. Agree to participate in any of the study groups according to a randomized allocation.\n\nExclusion Criteria:\n\n* 1\\. Acute medical condition that requires treatment. 2. Existing medical conditions that contra-indicate or limit physical activity (e.g., post-surgery, recurrent falls, etc.) 3. Unstable psychiatric condition that requires acute care. 4. Current use of psychoactive medication that might compromise balance or induce risk when performing physical activity (e.g., high dose of sedative medications) 5. Current use of recreational drug use (must be free of substance use for 12 months).\n\n  6\\. Patients currently involved in routine intensive exercise\\* \\> 1 hour\u002F week. 7. Lack of interest to increase their daily time of physical activity 8. Refuse to participate in any of the study groups according to a randomized allocation.\n\n  9\\. PHQ-9 score less than 2, or greater than 14.","65 Years",{"count":270,"type":21},66,[24],"The importance and benefits of leading a physically active lifestyle have been long studied. Examples of the multiple advantages from physical activity are improved health of the heart and brain, having a more independent living and better quality of life. However, it is known that for many people, being active is challenging: physical activity is commonly viewed as a burden or inconvenience. In this study we will explore how some common everyday thoughts are hurdles to becoming physically active. We will discover ways to overcome this by using concepts from a field called \"behavioral economics\" that explains how we make decisions. The purpose of the program is to support participants in being more physically active. The study program is a newly developed way to overcome the intuitive preference for being sedentary. The experimental groups will learn simple ways to overcome expected hurdles in making decisions related to physical activity (the newly developed program), and the control groups will learn about the health benefits of physical activity and the health guidelines (the common practice today). We will compare the effectiveness of the newly developed intervention in promoting an active lifestyle, compared to the common practice today, of providing the knowledge and the recommended guidelines. The program in the study will be in small groups of 5-10 participants that will meet at The Royal for 60 minutes, twice a week, for 4 weeks.",[274,275,276],"Sedentary Older Adults","Sedentariness and Well-being","Sedentary; Aging",[278,279,280,281,282,283,284,285],"sedentary older adults","depressive symptoms","behavioural economics","A-B-C Program","physical activity","decision making","automatic thoughts","cognitive biases","2025-09-09",{"date":288,"type":41},"2025-09-16",{"date":290,"type":21},"2025-09",{"date":109,"type":21},{"name":47,"class":48},{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":11,"sex":16,"minAge":300,"maxAge":301,"enrollmentInfo":302,"targetDuration":4,"studyType":22,"phases":304,"briefSummary":305,"conditions":306,"keywords":307,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":315,"locationsCount":49},"100556732","comparing-the-efficacy-of-accelerated-vs-standard-fmri-guided-itbs-in-treating-adolescents-depression-100556732","NCT06528938","Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression","Randomized Pilot Trial Comparing the Feasibility and Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treatment-Resistant Depression in Adolescents","Inclusion Criteria:\n\n1. Voluntary and competent to consent.\n2. Ages 16-19 years old.\n3. Can speak and read English.\n4. Primary and\u002For predominant diagnosis of major depressive episode without psychotic features in the current episode, confirmed by The Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID).\n5. Depressive symptoms have not improved after ≥ 1 adequate dose of antidepressant in the current depressive episode.\n6. Moderate symptoms in the current depressive episode, indexed by a score of at least 40 on the Children's Depression Rating Scale Revised for depression (CDRS-R).\n7. Are able to adhere to the treatment schedule.\n8. Have stable psychotropic medications and\u002For psychotherapy regimen for at least four weeks before participating in the trial.\n\nExclusion Criteria:\n\n1. Diagnosis of bipolar I or II disorder, based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria.\n2. Current or past substance (\\\u003C 3 months) (excluding caffeine or nicotine) or alcohol abuse\u002Fdependence, as defined in the DSM-5 criteria. Based on DSM-5 criteria, mild cannabis or alcohol use would be allowed in the past 3 months, moderate to severe would be an exclusion.\n3. Current use of illegal substances or cannabis confirmed by urine screening test.\n4. Concomitant unstable major medical or neurological disease (e.g., uncontrolled diabetes or renal dysfunction).\n5. Organic cause of depressive symptoms (e.g. thyroid dysfunction), ruled out by the treating physician.\n6. Acute suicidality or life-threatening due to self-neglect.\n7. Are pregnant or breastfeeding, or plan to become pregnant during treatment (pregnancy will be assessed by a urine test).\n8. Have a specific contraindication to TMS and\u002For MRI (e.g., personal history of epilepsy or seizures, metal head implant, pacemaker).\n9. Unwilling to maintain the current antidepressant regimen.\n10. Taking more than 1 mg\u002Fday of lorazepam or equivalent.\n11. Any other condition that, in the opinion of the investigators, would impair the participant's ability to complete the study.","16 Years","19 Years",{"count":303,"type":21},10,[24],"Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS), a type of rTMS, is a very promising new treatment for major depression in adults and adolescents. However, very few studies have assessed the efficacy of accelerated, three times a day TBS in comparison with standard once a day TBS in adolescents. The study aims to explore further evidence in hopes to conduct a large-scale, randomized, multisite, placebo-controlled clinical trial evaluating the effects of a functional magnetic resonance imaging (fMRI)-guided accelerated rTMS protocol vs. standard once\u002Fdaily rTMS for treatment-resistant depression in adolescents.",[27,189],[308,309],"Accelerated rTMS","repetitive Transcranial Magnetic Stimulation","2025-09-02",{"date":286,"type":41},{"date":313,"type":41},"2024-08-01",{"date":43,"type":21},{"name":47,"class":48},{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":22,"phases":325,"briefSummary":326,"conditions":327,"keywords":329,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":347},"100575881","redirection--self-guided-icbt-to-reduce-the-risk-of-child-sexual-abuse-material-csam-use-100575881","NCT06778044","ReDirection \u002F Self-Guided ICBT to Reduce the Risk of Child Sexual Abuse Material (CSAM) Use","Evaluation of an Online Self-Help Program for CSAM","Inclusion Criteria:\n\n* 18 years of age or older\n* Able to read and understand English or Spanish\n* Have used or experienced urges to use CSAM within the last six months\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* Unable to read and understand English or Spanish\n* Have not used or experienced urges to use CSAM within the last six months",{"count":324,"type":21},300,[24],"The creation and distribution of child sexual abuse material (CSAM) is a large-scale global problem. CSAM is sometimes referred to as child pornography. It includes images, videos, live-streaming, and any other material that depicts sexual acts with a child or adolescent (i.e., a person under the age of 18). It also includes material that shows a child or adolescent in a sexually suggestive or explicit manner partially clothed, or nude, and can include material that does or does not illustrate sexual activity.\n\nCSAM use is a problem that continues to drastically increase in size despite the numerous political, police, and technological initiatives that have been put forth as solutions. Previous research also suggests that many active CSAM users desire help to stop their use, but have experienced difficulties finding support that is anonymous. Thus, there is a great need for anonymous intervention programs that assist active and at-risk CSAM users in developing skills to manage their thoughts, feelings, and behaviours related to CSAM.\n\nReDirection is a free, anonymous, online, self-guided, cognitive behavioural therapy (CBT)-based program for individuals concerned about their use or risk to use CSAM. The treatment program is based on many years of clinical experience working with patients who have committed sexual offences, and the results of several previous research projects.\n\nThis study will implement a scientifically rigorous design (a three-armed randomized waitlist-controlled trial) to evaluate two versions of this intervention (ReDirection 1.0 and ReDirection 2.0). The primary difference between the two versions of ReDirection is the length of the program and whether it includes the option for asynchronous messaging with a ReDirection specialist. The study design compares ReDirection 1.0 and ReDirection 2.0 with a waitlist control group. Participants in the waitlist control will wait six weeks before starting active treatment. While on the waitlist, participants will respond to questions about ongoing about sexual urges and behaviours.\n\nParticipants will be recruited directly from the ReDirection website, where they will be directed to a secure platform designed specifically for clinical trials of internet-mediated CBT. This platform is called Iterapi. Potential participants learn about the ReDirection program through advertisements on both the \"Clearnet\" and \"Darknet.\" All trial activities, including participant registration, random assignment, intervention, and evaluation will be conducted via Iterapi.\n\nTreatment includes five-to-six modules over five-to-six weeks and the content includes CBT-based psychoeducation and exercises that aim to help participants gain greater understanding of, and skills to manage risky sexual thoughts, feelings, and behaviours.",[328],"Pedophilia",[330,331,332,333,334,335,336,337,338],"Child Sexual Abuse Material","Paraphilic Disorders","Waitlist","Child sexual abuse","Cognitive behavioural therapy","Self-help intervention","Internet based intervention","Prevention","Pedophilic disorder","2025-01-23",{"date":341,"type":41},"2025-01-27",{"date":343,"type":41},"2025-01-15",{"date":345,"type":21},"2025-11",{"name":47,"class":48},2,{"id":349,"slug":350,"hasResults":11,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":355,"targetDuration":4,"studyType":22,"phases":357,"briefSummary":358,"conditions":359,"keywords":4,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":365,"leadSponsor":367,"locationsCount":49},"100373482","comparing-uni--and-bi-lateral-tbs-in-major-depression-100373482","NCT04142996","Comparing Uni- and Bi-lateral TBS in Major Depression","A Naturalistic Study Comparing Uni- and Bi-lateral Theta Burst Stimulation in Major Depression","Inclusion Criteria:\n\n1. voluntary and competent to consent to study,\n2. female or male aged 18 years old or older,\n3. can speak and read English and\u002For French\n4. primary and\u002For predominant diagnosis of major depressive episode without psychotic features in the current depressive episode (confirmed by a Mini-International Neuropsychiatric Interview),\n5. depressive symptoms have not improved after ≥ 1 adequate dose of antidepressant trial in the current depressive episode,\n6. moderate symptoms in the current depressive episode as indexed by a score of at least 15 at the 17-item Hamilton Rating Scale for Depression (HRSD-17),\n7. have been referred to rTMS treatment by their treating physician, and took a free and informed decision to follow this treatment,\n8. are able to adhere to treatment schedule,\n9. have received a stable psychiatric medication (including prescribed cannabis) or psychotherapy regimen for at least four weeks prior to entering the trial,\n10. have an education-adjusted score of ≥ 24 at the Mini-Mental State Evaluation (MMSE) if are aged ≥ 65.\n\nExclusion Criteria:\n\n1. current or past (\\\u003C 3 months) substance (excluding caffeine or nicotine) or alcohol abuse\u002Fdependence, as defined in the Diagnostic and Statistical Manual 5th Edition (DSM-5) criteria. Based on the DSM-5 criteria, mild cannabis or alcohol use would be permissible in the past 3 months, moderate to severe would be an exclusion\n2. current use of illegal substances or recreational cannabis\n3. have a concomitant major unstable medical or neurologic illness (e.g. uncontrolled diabetes or renal dysfunction),\n4. organic cause to the depressive symptoms (e.g. thyroid dysfunctions), determined by the referring physician\n5. acute suicidality or threat to life from self-neglect,\n6. are pregnant or breastfeeding, or thinking of becoming pregnant during course of treatment,\n7. have a specific contraindication for TMS (e.g., personal history of epilepsy or seizure, metallic head implant, pacemaker),\n8. unwilling to maintain current antidepressant regimen,\n9. are taking more than 1 mg of lorazepam or equivalent,\n10. any other condition that, in the opinion of the investigators, would adversely affect the participant's ability to complete the study,\n11. have failed a course of electroconvulsive therapy (ECT) within the current depressive episode due to the lower likelihood of response to rTMS.If they have had failed ECT in the past, this does not exclude them",{"count":356,"type":21},256,[24],"Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS) is a very promising new treatment for major depression that allows a 15-fold reduction in duration of daily sessions. However, no large scale naturalistic study has assessed the superiority of bilateral TBS in comparison with unilateral left TBS. In fact, no TBS study thus far has included both unipolar and bipolar depression, or other psychiatric comorbidities such as anxiety. Maintenance has yet to be studied with TBS, along with an effective maintenance protocol to prevent relapse. Our study aims to explore and address these gaps.",[360],"Major Depressive Episode","2023-11-28",{"date":363,"type":41},"2023-12-04",{"date":128,"type":41},{"date":366,"type":21},"2026-09",{"name":47,"class":48},""]