[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Second Affiliated Hospital of Kunming Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":189},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,39,62,86,111,131,149,170],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100594058","study-on-the-correlation-mechanism-and-application-of-genetic-susceptibility-hemoglobin-adaptation-changes-and-extubation-success-rate-in-stroke-patients-with-tracheotomy-at-different-altitudes-100594058",false,"NCT07014501","Study on the Correlation Mechanism and Application of Genetic Susceptibility, Hemoglobin Adaptation Changes, and Extubation Success Rate in Stroke Patients With Tracheotomy at Different Altitudes","Inclusion Criteria:\n\n1. Age between 18 and 75 years.\n2. Hospitalized patients in the rehabilitation department with acute non-traumatic ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage requiring tracheostomy.\n3. Hemodynamic stability: Systolic blood pressure maintained between 90-160 mmHg, diastolic blood pressure between 60-100 mmHg, respiratory rate between 12-30 breaths\u002Fmin, heart rate between 60-120 beats\u002Fmin, body temperature between 36.5°C-38.5°C, and arterial oxygen saturation (SaO₂) consistently \\>90% at admission and prior to tracheostomy.\n4. Glasgow Coma Scale (GCS) score of 5-15 at assessment.\n5. Tracheostomy performed within 24-72 hours after stroke onset.\n6. Peripheral blood hemoglobin concentration at admission within specified ranges (male: 120-180 g\u002FL; female: 110-160 g\u002FL).\n7. Signed informed consent provided by the patient or legal guardian.\n\nExclusion Criteria:\n\n1. History of severe cardiopulmonary dysfunction (e.g., chronic obstructive pulmonary disease, cor pulmonale, coronary artery disease, cardiomyopathy) with New York Heart Association (NYHA) functional class III or IV, or recent (within 6 months) acute myocardial infarction or unstable angina.\n2. Diagnosis of advanced malignancy (life expectancy \\\u003C6 months) with ongoing chemotherapy, radiotherapy, or palliative care.\n3. Severe hepatic or renal insufficiency (e.g., decompensated cirrhosis, chronic renal failure requiring long-term dialysis).\n4. Uncontrolled endocrine disorders (e.g., thyrotoxic crisis, myxedema coma, diabetic ketoacidosis, hyperosmolar hyperglycemic state).\n5. Coagulation disorders:\n\n   * Congenital or acquired coagulopathies (e.g., hemophilia, vitamin K deficiency, coagulation factor deficiency due to severe liver disease, antiphospholipid syndrome).\n   * Active anticoagulation therapy (e.g., warfarin with INR \\>3.0, heparin with APTT exceeding twice the upper limit of normal) unadjustable to a safe range within 72 hours.\n6. Major surgery within 3 months (e.g., cardiac, abdominal, or orthopedic surgery).\n7. Severe chest trauma (e.g., multiple rib fractures, pneumohemothorax) or abdominal trauma (e.g., liver\u002Fspleen rupture, intestinal perforation) within 1 month prior to stroke onset, with incomplete recovery.\n8. Active uncontrolled infection at admission (e.g., pneumonia, urinary tract infection, intracranial infection, sepsis) defined by:\n\n   * Temperature \\>38.5°C persisting \\>24 hours.\n   * Elevated white blood cell count, increased neutrophil percentage, and clinical signs of infection.\n   * Positive bacterial cultures (blood, sputum, urine).\n9. Recent (within 1 week) exposure to infectious diseases (e.g., travel to epidemic areas, contact with confirmed cases) with suspected latent or active infection.\n10. History of neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's disease) or motor neuron disorders (e.g., amyotrophic lateral sclerosis).\n11. Congenital neurological developmental abnormalities (e.g., hydrocephalus, cerebral palsy).\n12. Severe uncontrolled psychiatric disorders (e.g., schizophrenia, major depressive disorder, bipolar disorder) impairing daily function or treatment adherence.\n13. Cognitive impairment (e.g., dementia) with Mini-Mental State Examination (MMSE) score \\\u003C10.\n14. Pregnancy or lactation.\n15. Hypersensitivity or contraindications to study-related drugs or procedures (e.g., allergy to tracheostomy tube materials, antibiotic allergies without alternatives).\n16. Inability to complete follow-up or required tests (e.g., geographical barriers, unreliable contact information).\n17. Non-compliance of the patient or family members with the study protocol.\n18. Failure to obtain informed consent.\n19. Participation in other interventional clinical trials.","ALL","18 Years","75 Years",{"count":19,"type":20},717,"ESTIMATED","OBSERVATIONAL","Patients with brain injuries caused by various reasons often need tracheotomy to improve breathing, but this procedure can cause the air to lose its nasal regulation, increase the risk of lung infections, and reduce their quality of life. Tracheal extubation is crucial for patient recovery. Environmental factors in high-altitude areas have a significant impact on human cardiovascular function, including changes in blood oxygen caused by low oxygen environments and cardiovascular adaptability of long-term residents. There is limited research on the impact of high altitude on the success rate of tracheal extubation in brain injury. The research team conducted a retrospective study on 501 patients who underwent tracheotomy at the Second Affiliated Hospital of Kunming Medical University and found that high GCS scores and hemoglobin concentrations were beneficial for extubation. The increase in hemoglobin concentration among high-altitude residents may be an adaptive response to hypoxia, and the research team speculates that this may become a protective factor for successful extubation. However, some argue that altitude sickness and adaptive genetic changes may counteract each other. Simonson's team found that the decline of hemoglobin concentration in Tibetans was related to specific gene expression, indicating that the genetic adaptability of high altitude residents had a unique relationship with hemoglobin concentration. Therefore, the research team speculates that people living in highlands for a long time are more adaptable to hypoxic environments than those living in lowlands. Under severe stress (hypoxia), people living in highlands for a long time may have lower sensitivity to pulmonary blood flow redistribution or oxygen delivery compared to those living in lowlands. This study is a multicenter observational study, with sub centers listed as follows: Jiangchuan District People's Hospital, Huaning County People's Hospital, Baoshan Second People's Hospital, Huize County People's Hospital, Mengla County People's Hospital, Tonghai County People's Hospital, Jinghong City First People's Hospital, Xuanwei City First People's Hospital, Qiubei County People's Hospital, Fengqing County People's Hospital, Weixin County People's Hospital, Yulong County People's Hospital, Yanshan County People's Hospital, Xundian County People's Hospital, Shizong County People's Hospital, Luxi County People's Hospital, Yunnan Province Northeast Yunnan Central Hospital, Luoping County People's Hospital, Xinping County General Hospital, Suijiang County People's Hospital, Nanhua County Hospital, Guangnan County People's Hospital County People's Hospital, Jianshui County People's Hospital, Simao District People's Hospital of Pu'er City, Funing County People's Hospital, Xinping County Traditional Chinese Medicine Hospital Xundian County First People's Hospital and Jingdong County People's Hospital.",[24,25],"Stroke","Tracheotomy Patients","RECRUITING","2025-06-07",{"date":29,"type":30},"2025-06-11","ACTUAL",{"date":32,"type":30},"2025-01-01",{"date":34,"type":20},"2028-05-29",{"name":36,"class":37},"The Second Affiliated Hospital of Kunming Medical University","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":45,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":38},"100589497","dynamic-hot-spring-hydrotherapy-for-gait-disorders-and-balance-function-recovery-after-stroke-100589497","NCT06955182","Dynamic Hot Spring Hydrotherapy for Gait Disorders and Balance Function Recovery After Stroke","Inclusion Criteria:\n\n1. Patients with cerebral infarction or cerebral hemorrhage who meet the diagnostic criteria for stroke of the Chinese Medical Association; (2) Initial stroke\\\u003C6 months, or last stroke event\\>6 months; (3) Age\\>=18 years old,\\\u003C85 years old (increased risk of VCI over 85 years old); (4) NIHSS\\>4, NIHSS\\\u003C26 points; (5) MRS score\\>=2 points; (6) complete CT or MRI; (7) No serious neurological or mental illness; Unconscious disorders, able to cooperate with relevant treatments; No severe cognitive impairment (MMSE\\>=15 points); (8) Berg Balance Scale\\>40 points; (9) The patient or family member signs an informed consent form.\n\nExclusion Criteria:\n\n* (1) Concurrent major diseases, such as heart, lung, liver, kidney and other organ diseases or failure; (2) There are contraindications for hydrotherapy such as acute infectious diseases, open skin wounds, and severe epilepsy; (3) There are other clinical issues that may affect the assessment results, such as low vision, fractures, vestibular diseases, etc; (4) There are other neurological disorders, such as multiple sclerosis, Parkinson's disease, etc; (5) Serious mental and psychological problems exist; (6) Malignant tumor patients; (7) Early pregnancy or high-risk pregnancy; (8) Serious alcohol abusers; (9) Patients with active bleeding, such as gastrointestinal bleeding, nosebleeds, and excessive menstruation.","80 Years",{"count":47,"type":20},80,"INTERVENTIONAL",[50],"NA","Our research aims to analyze and compare the improvement of various indicators of gait disorders and balance function before and after dynamic hot spring hydrotherapy and conventional exercise intervention, and clarify the therapeutic effect of dynamic hot spring hydrotherapy on gait disorders and balance function in stroke patients.",[24],"NOT_YET_RECRUITING","2025-04-24",{"date":56,"type":30},"2025-05-02",{"date":58,"type":20},"2025-05",{"date":60,"type":20},"2026-03-30",{"name":36,"class":37},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":4,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":45,"enrollmentInfo":68,"targetDuration":4,"studyType":48,"phases":70,"briefSummary":72,"conditions":73,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":38},"100587357","phase-4-the-study-on-the-efficacy-of-tdcs-stimulation-of-the-cerebellum-combined-with-xingnaojing-injection-in-patients-with-consciousness-disorders-after-cranial-injury-100587357","NCT06927336","The Study on the Efficacy of tDCS Stimulation of the Cerebellum Combined With XingNaoJing Injection in Patients With Consciousness Disorders After Cranial Injury","Inclusion Criteria:\n\n1. aged 18-80 years;\n2. All patients met the diagnostic criteria of DoC;\n3. more than 1 month after the initial head injury;\n4. stable consciousness for at least 2 weeks before admission (no change in CRS-R total score);\n5. no skull defect or large area of skull repair;\n6. The legal representative authorized by the patient approved the experimental protocol and signed the informed consent form.\n\nExclusion Criteria:\n\n1. supratentorial abnormalities on computed tomography (CT) or magnetic resonance imaging (MRI) involving more than one third of the middle cerebral artery territory;\n2. a life expectancy of less than 3 months or a follow-up of less than 3 months;\n3. retention of intracranial metal objects, cranial debridement, or presence of cranial defects and any clinically significant or unstable medical diseases;\n4. EEG recording with significant muscle artifacts and inhibitory bursts;\n5. nonconvulsive status epilepticus; Periodic or burst rhythms evoked by stimulation;\n6. disturbance of consciousness due to surgical injury or tumor.",{"count":69,"type":20},200,[71],"PHASE4","The purpose of this study is to investigate the effect of tDCS stimulation of cerebellum combined with Xingnaojing on patients with disturbance of consciousness after craniocerebral injury, and to clarify the relationship between the following two points: (1) to clarify whether MMN, P300, fNIRS, BAEP, SEP can be used as objective indicators to distinguish VS from MCS. (2) To clarify the changes of consciousness level and brain function in DoC patients with craniocerebral injury treated with tDCS stimulation of cerebellum combined with Xingnaojing.",[74,75,76,77],"tDCS","Cerebellum","Brain Injury","Disturbance of Consciousness","2025-04-14",{"date":80,"type":30},"2025-04-15",{"date":82,"type":20},"2025-04-25",{"date":84,"type":20},"2026-12-30",{"name":36,"class":37},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":15,"minAge":16,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":48,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100586193","investigating-how-the-rect-impacts-brain-functional-states-through-the-acc-cerebellar-loop-100586193","NCT06912191","Investigating How the RECT Impacts Brain Functional States Through the ACC-cerebellar Loop","Inclusion Criteria:\n\n* Onset of stroke \\\u003C6 months ago, or \\>6 months since the last stroke event;\n* Age \\>=18 years and \\\u003C85 years (as the probability of Vascular Cognitive Impairment increases above 85);\n* Patients with damage in the middle cerebral artery territory;\n* NIHSS \\>4 and \\\u003C26;\n* mRS score \\>=2;\n* Completion of CT or MRI;\n* No neurological or psychiatric disorders; no impairment of consciousness; able to comply with relevant treatments; no severe cognitive dysfunction (MMSE \\>=15);\n* All participants are right-handed; Sign the informed consent form.\n\nExclusion Criteria:\n\n* History of epilepsy or psychiatric disorders (including depression, anxiety, or schizophrenia);\n* Severe comorbidities;\n* History of medication use: benzodiazepines, baclofen, antidepressants;\n* Non-compliance with the treatment plan;\n* Acute-phase cerebral hemorrhage, acute infectious diseases;\n* Severe suicidal tendencies in individuals with depression;\n* Individuals suffering from severe headaches, high blood pressure, malignant tumors, open wounds, vascular embolism, leukopenia, etc.;\n* Severe alcohol abuse;\n* History of cranial surgery, individuals with metal implants in the brain;\n* Individuals with an implanted cardiac pacemaker;\n* NIHSS \\>26, MMSE \\\u003C15;\n* Any disease likely to prevent the patient from surviving more than one month;\n* Pregnant individuals.",true,"85 Years",{"count":95,"type":20},100,[50],"Experiment1: Using a brain EEG-TMS combined system, researchers aim to investigate the impact of the rostral anterior cingulate cortexr (rACC)-engaging cognitive task (RECT) combined single-pulse TMS magnetic stimulation on theta neural oscillations in the medial frontal lobe. The study will be divided into 4 groups: the first group will receive left cerebellar single-pulse TMS stimulation combined with the RECT task, the second group will receive right cerebellar single-pulse TMS stimulation combined with the RECT task, the third group will receive midline cerebellar single-pulse TMS stimulation combined with the RECT task, and the fourth group will receive sham cerebellar single-pulse TMS stimulation combined with the RECT task. Divide the participants into groups of 15 people each, following a 1:1:1:1 ratio. Based on the above testing, the stimulus method that results in the most significant change in the midline of the frontal lobe will be identified.\n\nExperiment 2: Based on the research from Experiment 1, the most significant approach affecting theta neural oscillations in the medial frontal gyrus will be identified. This stimulation protocol will be combined with left dorsolateral prefrontal cortex iTBS stimulation in Experiment 2. The research aim of Experiment 2 is to investigate the most effective stimulation method for enhancing midline theta neural oscillations in the frontal lobe, in combination with left dorsolateral prefrontal cortex iTBS, for the treatment of post-stroke depression patients. This study will include 40 post-stroke depressed patients, and each participant must meet the inclusion criteria. The first group of participants, consisting of 20 individuals, will receive the optimal combination intervention. The second group of participants will only receive iTBS stimulation, without any additional intervention strategies used in Experiment 1. Patients will undergo Hamilton Depression Scale assessment and resting state and task state EEG collection at baseline, one week after intervention, and two weeks after intervention.The primary outcome will be the Hamilton Depression Scale, with EEG-related data being analyzed as a secondary outcome. Task-oriented EEG detection will include both facial expression recognition paradigm and oddball experiment paradigm. Reaction time, accuracy, and completion status will be recorded simultaneously in the experiment. The experiment will record patients' tolerance and any adverse events that occur.",[99],"Post-stroke Depression",[101,102],"EEG","ERP","2025-03-29",{"date":105,"type":30},"2025-04-04",{"date":107,"type":20},"2025-03-30",{"date":109,"type":20},"2027-05-30",{"name":36,"class":37},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":93,"enrollmentInfo":118,"targetDuration":4,"studyType":48,"phases":120,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100585248","the-research-team-aims-to-elucidate-the-impact-of-itbs-intermittent-theta-burst-stimulation-on-the-hpa-axis-and-post-stroke-negative-emotionsdepression-by-conducting-human-experiments-that-target-various-brain-regions-100585248","NCT06899893","The Research Team Aims to Elucidate the Impact of ITBS (intermittent Theta Burst Stimulation) on the HPA Axis and Post-stroke Negative Emotions\u002Fdepression by Conducting Human Experiments That Target Various Brain Regions.","Investigating the Impact of ITBS Stimulation on Various Brain Regions on the HPA Axis in Stroke Patients Using Resting-State EEG Data.","Inclusion Criteria:\n\n1. Initial stroke onset \\\u003C6 months, or the last stroke event occurred more than 6 months ago;\n2. Age ≥18 years, \\\u003C85 years (the likelihood of VCI increases beyond 85 years);\n3. Patients with lesions in the middle cerebral artery region;\n4. NIHSS \\>4, NIHSS \\\u003C26;\n5. mRS score ≥2;\n6. Completion of CT or MRI;\n7. No severe neurological or psychiatric disorders; no impairment of consciousness, able to cooperate with relevant treatments; no severe cognitive impairment (MMSE ≥15);\n8. All participants are right-handed;\n9. Signed informed consent form.\n\nExclusion Criteria:\n\n1. History of epilepsy or psychiatric disorders (including depression, anxiety, or schizophrenia);\n2. Severe comorbidities;\n3. History of medication use: benzodiazepines, baclofen, or antidepressants;\n4. Non-compliance with the protocol;\n5. Acute phase of cerebral hemorrhage or acute infectious diseases;\n6. Severe suicidal tendencies in patients with depression;\n7. Severe headache, hypertension, malignant tumors, open wounds, vascular embolism, leukopenia, or other serious conditions;\n8. Severe alcohol abuse;\n9. History of cranial surgery or presence of metal implants in the brain;\n10. Patients with cardiac pacemakers;\n11. NIHSS \\> 26 or MMSE \\\u003C 15;\n12. Any condition likely to result in the patient's survival for less than 1 month;\n13. Pregnancy.",{"count":119,"type":20},60,[50],"The project team will categorize stroke patients into three groups receiving iTBS stimulation targeting distinct brain regions: the cerebellum, the dorsolateral prefrontal cortex (DLPFC), and the primary motor cortex (M1), with 20 patients allocated to each group. Neurofunctional scores, anxiety and depression assessments, and transcranial magnetic stimulation evoked potentials (TEP) will be assessed pre- and post-treatment within each group. The relationship between anxiety and depression scores and brain network characteristics associated with emotions will be examined to investigate the impact of iTBS stimulation on post-stroke negative emotions. Furthermore, plasma and saliva samples will be collected from stroke patients in each group post iTBS intervention. ELISA will quantify ACTH levels in plasma and cortisol levels in both plasma and saliva, with the aim of exploring the effects of iTBS stimulation on the HPA axis across different brain regions.",[24,99],"2025-03-21",{"date":125,"type":30},"2025-03-28",{"date":127,"type":20},"2025-04-01",{"date":129,"type":20},"2027-07-30",{"name":36,"class":37},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":15,"minAge":16,"maxAge":93,"enrollmentInfo":136,"targetDuration":4,"studyType":48,"phases":138,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":4},"100582218","to-explore-the-neural-processing-mechanism-of-cerebellum-involved-in-facial-expression-recognition-based-on-transcranial-magnetic-stimulation-100582218","NCT06860451","To Explore the Neural Processing Mechanism of Cerebellum Involved in Facial Expression Recognition Based on Transcranial Magnetic Stimulation",{"count":137,"type":20},160,[50],"Experiment 1: Utilizing a transcranial magnetic stimulation-electroencephalography\u002Ffunctional near-infrared spectroscopy system, the investigators aim to determine whether transcranial magnetic stimulation of the cerebellum can alter neural oscillations and blood flow changes in the prefrontal cortex. The investigators will recruit 80 healthy volunteers and 80 stroke patients with middle cerebral artery infarction, each meeting the inclusion criteria. Twenty healthy volunteers and twenty patients will be randomly selected to receive a single-pulse transcranial magnetic stimulation (TMS) to the cerebellar vermis. The investigators will record cerebellar transcranial evoked potentials (TEP) in the EEG to assess cerebellar cortical excitability and inhibition and evaluate individuals using functional near-infrared spectroscopy to analyze changes in prefrontal blood flow and brain networks. The other 40 healthy volunteers and 40 patients will receive a single-pulse TMS to the right or left cerebellum, and similar assessments will be made. The remaining 20 healthy volunteers and 20 patients will receive a sham iTBS, with similar assessments.\n\nExperiment 2: Through a facial expression recognition task, this experiment aims to clarify the cerebellum's increased perception of negative emotions, thereby achieving a rebalance from \"controlled\" to \"automatic\" regulation of negative emotions, ultimately playing a role in \"automatic\" emotional adjustment. The 80 healthy volunteers from Experiment 1 will be equally divided into four groups based on stimulation site: the cerebellar vermis; the right cerebellum; the left cerebellum; the sham stimulation. Each group will perform the facial expression recognition task during the TMS stimulation. The investigators will collect functional near-infrared spectroscopy and task-based EEG data from the participants during stimulation while also recording their response times, accuracy rates, and completion conditions, including their tolerance of the experiment and any adverse events.",[99],"2025-03-03",{"date":143,"type":30},"2025-03-06",{"date":145,"type":20},"2025-03-25",{"date":147,"type":20},"2025-12-30",{"name":36,"class":37},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":45,"enrollmentInfo":156,"targetDuration":4,"studyType":48,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":38},"100562546","tapp-and-open-repair-for-recurrent-inguinal-hernia-100562546","NCT06604572","TAPP and Open Repair for Recurrent Inguinal Hernia","Clinical Study of Transabdominal Preperitoneal Approach Versus Open Tension-free Hernia Repair for the Treatment of Recurrent Inguinal Hernia","Inclusion Criteria:\n\n* age ≥ 18 years\n* the diagnosis of recurrent inguinal hernia made by ultrasound or computed tomography (CT) during the present visit\n* ability to tolerate general anesthesia and local anesthesia surgery\n* all patients and their families agreed to participate in this study and sign relevant informed consent.\n\nExclusion Criteria:\n\n* patch infection during the first surgery\n* multiple (≥ 2) relapses\n* inability to cooperate to complete follow-up after surgery",{"count":157,"type":20},70,[50],"The objective of this study was to explore the clinical efficacy of transabdominal preperitoneal approach (TAPP) and open tension-free hernia repair in the treatment of recurrent inguinal hernia. This study aims to provide a basis for selecting the optimal treatment methods for recurrent hernias.",[161],"Recurrent Inguinal Hernia","2024-09-18",{"date":164,"type":30},"2024-09-19",{"date":166,"type":30},"2022-05-01",{"date":168,"type":20},"2025-10-28",{"name":36,"class":37},{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":45,"enrollmentInfo":177,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":4},"100561892","clinical-study-of-intestinal-barrier-dysfunction-after-gastrointestinal-surgery-100561892","NCT06596070","Clinical Study of Intestinal Barrier Dysfunction After Gastrointestinal Surgery","Clinical Study of Intestinal Barrier Dysfunction in Patients After Gastrointestinal Surgery","Inclusion Criteria:\n\n* men or women aged 18-80 years\n* expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection)\n* no preoperative intestinal barrier dysfunction\n* patients voluntarily participated in this study and signed an informed consent form.\n\nExclusion Criteria:\n\n* Patients or their families refused to participate in this study\n* chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.)\n* history of antibiotic administration in the last 2 weeks\n* severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy\n* combined with severe hepatic, renal, and cardiac insufficiency patients.",{"count":178,"type":20},180,"The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?",[181],"Intestinal Barrier Dysfunction","2024-09-12",{"date":164,"type":30},{"date":185,"type":20},"2024-10",{"date":187,"type":20},"2025-04",{"name":36,"class":37},""]