[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Swedish School of Sport and Health Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":148},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,81,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100641741","stroke-rehabilitation-through-intensive-exercise-100641741",false,"NCT07650500","Stroke Rehabilitation Through Intensive Exercise","S-THRIVE","Inclusion Criteria:\n\n* Age between 18 and 70 years.\n* History of a first-ever stroke occurring at least 6 months before enrollment.\n* Independence in personal activities of daily living (e.g., dressing, undressing, and using the toilet).\n* Ability to take a few steps indoors without a walking aid and without supervision; use of an orthosis is permitted.\n\nExclusion Criteria:\n\n* Unstable cardiovascular disease or exercise-induced epilepsy.\n* Insufficient cognitive ability to participate in group-based training, including the capacity to understand, follow, and maintain verbal instructions during exercise tasks.\n* Blood pressure \\>140\u002F90 mmHg at the first visit.","ALL","18 Years","70 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether combining moderate to high intensity aerobic exercise with constraint-induced movement therapy (CI therapy) can improve walking ability in adults who have had a stroke. The study will also learn if telerehabilitation at home can support long-term recovery after intensive rehabilitation.\n\nThe main questions this study aims to answer are:\n\n* Does moderate to high intensity aerobic exercise before CI therapy improve walking ability, balance and lower extremity function in people with long-lasting gait difficulties after stroke?\n* Does CI therapy alone lead to similar or different improvements in walking ability, balance or lower extremity function?\n* Does telerehabilitation help participants maintain or further improve their function after the intensive rehabilitation period?\n\nResearchers will compare two groups. One group will receive 4 weeks of CI therapy, 5 days per week, plus 20 minutes of moderate-to-high-intensity aerobic exercise before the rehabilitation session on 3 of these days, and the other group will receive 4 weeks of CI therapy, 5 days per week, without preparatory aerobic exercise.\n\nAfter the completion of CI therapy, all participants will be offered an individualized 8-week telerehabilitation program to follow at home. They will use a mobile application to report physical activity and follow instructions for telerehabilitation.\n\nAll participants will complete two assessment visits (about 3 hours each), 1-2 weeks before and 1-2 weeks after CI therapy. They will also complete questionnaires electronically after the telerehabilitation program.\n\nDaily activity will be measured twice during the study: once during a week after the intensive rehabilitation and once during a week after the telerehabilitation program. A small movement sensor worn on the thigh will be used. The sensor is attached with a soft strap or an adhesive patch and is comfortable to wear all day. The sensor shows how much a person walks, stands, or sits in everyday life. It is light, does not disturb normal activities, and only collects movement information for the study. An instruction sheet will be included to make it easy to use.",[27,28,29,30,31,32],"Stroke","Rehabilitation","Rehabilitation Outcome","Aerobic Exercise","Telerehabilitation","Gait Impairment in Stroke Patients",[34,35,36],"Aerobic exercise, stroke rehabilitation, constraint-induced movement therapy","telerehabilitation","gait impairment","NOT_YET_RECRUITING","2026-06-11",{"date":40,"type":41},"2026-06-16","ACTUAL",{"date":43,"type":21},"2026-08-01",{"date":45,"type":21},"2029-06-30",{"name":47,"class":48},"The Swedish School of Sport and Health Sciences","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":69,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100628404","timing-of-broccoli-sprout-intake-to-improve-exercise-performance-100628404","NCT07461194","Timing of Broccoli Sprout Intake to Improve Exercise Performance","Effects of Acute and Subacute Intake of Broccoli Sprouts Intake on Exercise Performance and Recovery","Inclusion Criteria:\n\nHealthy, endurance-trained adults aged 18-64 years.\n\nRegular endurance training (e.g., cycling\u002Frunning) and ability to complete a standardized 2-hour high-intensity cycling session on an ergometer.\n\nApproved health declaration and screening assessment by study staff (including that ergometer testing can be performed safely).\n\nWilling and able to follow the study protocol (diet\u002Ffasting instructions, standardized training before visits, attendance at all four laboratory visits).\n\nNo known allergy\u002Fhypersensitivity to ingredients in the broccoli sprout drink or placebo drink.\n\nExclusion Criteria:\n\nDoes not meet inclusion criteria at screening (e.g., abnormal health declaration or medical findings making intense endurance exercise or muscle biopsy inappropriate).\n\nKnown allergy\u002Fhypersensitivity to ingredients in the intervention or placebo drink (broccoli\u002Fcruciferous vegetables or alfalfa) or other relevant food allergy.\n\nOngoing illness, fever, or infection at any test occasion, or other acute medical event judged to affect safety or data quality.\n\nOngoing treatment with medications\u002Fsupplements judged to affect primary outcomes or increase risk (e.g., anti-inflammatory medication close to test days per study instructions).\n\nPregnancy (if women are included) or breastfeeding.\n\nInability to comply with the study protocol (e.g., failure to standardize diet\u002Ffasting, deviating training\u002Falcohol intake despite instructions, or repeated missed visits).\n\nParticipant withdraws consent or investigator judges continued participation to pose risk.\n\n\\-",true,"50 Years",{"count":59,"type":21},30,[24],"This study examines how the timing of intake of a broccoli sprout-based drink (a natural source of isothiocyanates, ITCs) affects physiological responses, recovery, and performance after a standardized endurance cycling session. Healthy, endurance-trained adults (18-64 years) will complete four laboratory visits at the Swedish School of Sport and Health Sciences (GIH): one screening\u002Fphysiology test visit and three intervention visits in a randomized, double-blind, placebo-controlled cross-over design. On intervention visits, participants will ingest either an active broccoli sprout drink (50 g sprouts) or a placebo drink based on alfalfa sprouts (50 g sprouts) according to randomization. The drink will be consumed either approximately 16 hours before exercise (the evening before) or approximately 3 hours before exercise (the morning of the test), enabling comparison of timing in relation to a standardized \\~2-hour cycling protocol (individualized intensity) followed by a 10 km cycling time trial. Outcomes include measures of performance, heart rate, perceived exertion and recovery, blood glucose and lactate, and metabolic responses. Venous blood samples are collected at multiple time points before and after exercise and during the subsequent laboratory recovery period, and muscle biopsies are obtained at defined time points to assess muscle metabolism and recovery-related markers. Participants return \\~24 hours after exercise for follow-up sampling after an overnight fast, including a glucose tolerance test",[63,64,65,66,67,68],"Physical Performance","Glucose","Glycogen Metabolism","Lactate","Broccoli Sprout","Isothiocyanate",[70,66,71,72,68],"Broccoli Sprouts","Exercise","Glycogen","2026-03-04",{"date":75,"type":41},"2026-03-10",{"date":77,"type":21},"2026-03-31",{"date":79,"type":21},"2028-09-01",{"name":47,"class":48},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},"100624299","step-by-step-back---a-feasibility-study-of-a-physical-activity-intervention-for-adults-with-stress-related-exhaustion-100624299","NCT07407829","Step by Step Back - A Feasibility Study of a Physical Activity Intervention for Adults With Stress-related Exhaustion","Step by Step Back - A Feasibility Study of a CBT-Based Physical Activity Intervention for Stress-Related Exhaustion","Inclusion Criteria\n\n* Adult aged 20 to 64 years.\n* Experiencing stress-related exhaustion, assessed in regular clinical care (for example, symptoms consistent with exhaustion disorder or a closely related stress-related condition).\n* Symptoms are not in the acute phase (participant is able to engage in outpatient psychological treatment and gradual physical activity).\n* Elevated fatigue\u002Fexhaustion at screening, indicated by scores on screening questionnaires (Karolinska Exhaustion Disorder Scale and Multidimensional Fatigue Inventory).\n* Able to understand spoken and written Swedish.\n* Has access to a smartphone, tablet, or computer with an internet connection to complete study questionnaires and activity logging.\n* No medical condition that makes physical activity unsafe, based on clinical screening and participant self-report.\n\nExclusion Criteria\n\n* Currently receiving psychological treatment outside the recruiting clinic that is expected to interfere with participation in the program or study assessments.\n* Current or past diagnosis of a psychotic disorder.\n* Current or past diagnosis of bipolar disorder.\n* Severe mental health condition requiring another primary treatment approach at this time (for example, severe major depressive disorder, post-traumatic stress disorder, or an eating disorder).\n* Ongoing substance use disorder.\n* Medical condition or acute illness that makes physical activity inappropriate at this time (for example, recent blood clot, severe infection, or other serious condition).\n* Severe musculoskeletal condition that substantially limits ability to perform physical activity.\n* Started antidepressant medication within the past 4 weeks.\n\nAdditional notes (not eligibility criteria):\n\nParticipants may use psychotropic medication (for example, antidepressants, sleep medication, or anxiety medication) if the medication regimen is stable. Participants will be asked to report any medication changes during the study period. Mild to moderate comorbid anxiety or depression is allowed if stress-related exhaustion is the primary clinical problem.","20 Years","64 Years",{"count":91,"type":21},20,[24],"The goal of this clinical study is to learn whether a psychologist- or psychotherapist-guided physical activity program can be delivered and used as part of regular care for adults experiencing stress-related exhaustion. The program is designed to be integrated into regular psychological treatment as usual and supports participants in developing physical activity habits in a gradual, individualized, and sustainable way.\n\nThe main questions this study aims to answer are:\n\n* Can participants complete the program and attend the planned sessions?\n* Do participants and clinicians find the program acceptable, relevant, and useful?\n* Is the program safe, and do any negative experiences occur during the program?\n* What practical barriers and facilitators affect participation and delivery in routine care?\n* What descriptive patterns of change are seen in physical activity, symptoms, and everyday functioning from before to after the program?\n\nThe program is based on cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT). It includes strategies to help participants set meaningful goals, take step-by-step actions toward those goals, and respond more flexibly to uncomfortable thoughts, emotions, and body sensations that may arise in relation to physical activity.\n\nAbout 12 to 20 participants will take part. The program is designed to be integrated into about 5 to 6 individual sessions delivered over a flexible time period, depending on each participant's pace and circumstances.\n\nParticipants will:\n\n* Take part in the physical activity program as part of their regular psychological treatment\n* Complete online questionnaires before and after the program\n* Log their physical activity during the program\n* Provide feedback after the program (and some participants will also take part in an interview)\n\nThe results will be used to assess whether the program is feasible and acceptable for participants and clinicians and to inform further refinement and future evaluation.",[95,96],"Exhaustion Disorder","Stress-Related Disorders",[98,99,100,101,102,103,104,105,106,107],"Stress-related exhaustion","Exhaustion disorder","Fatigue","Burnout","Physical activity intervention","Exercise therapy","Feasibility study","Cognitive behavioral therapy (CBT)","Acceptance and Commitment Therapy (ACT)","Psychological flexibility","RECRUITING","2026-02-05",{"date":111,"type":41},"2026-02-12",{"date":113,"type":41},"2025-11-13",{"date":115,"type":21},"2026-10-01",{"name":47,"class":48},1,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":126,"minAge":57,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":117},"100550637","training-for-men-undergoing-androgen-deprivation-therapy-100550637","NCT06449664","Training for Men Undergoing Androgen Deprivation Therapy.","ADT-Train - A New Training Concept for Men With Prostate Cancer Receiving Androgen Deprivation Therapy.","ADT-train","Inclusion Criteria:\n\n1. signed informed consent\n2. histologically confirmed localised or locally advanced prostate cancer\n3. planned radiotherapy in combination with ADT for at least six months (unfavorable intermediate risk and high-risk prostate cancer) with curative intent and with no known metastasis.\n\nExclusion Criteria:\n\n1. very high risk localised prostate cancer planned for radiotherapy and ADT plus abiraterone and cortisone\n2. localized prostate cancer planned for radiotherapy without ADT\n3. on-going or previously treated with ADT or other hormonal treatments\n4. have any contraindications to physical testing\u002Fexercise as per the ACSM guidelines\n5. unable to comply with study procedures","MALE","80 Years",{"count":129,"type":21},60,[24],"The goal of this clinical trial is to evaluate the effects of a newly developed training concept on men with prostate cancer undergoing androgen deprivation therapy (ADT).\n\nThe main questions it aims to answer are:\n\n* How feasible and safe is the new training concept?\n* How efficient is the training concept to counteract side effects caused by ADT?\n\nResearchers will compare the new training concept with usual care to evaluate how efficient the training concept is to counteract the ADT-related side effects.\n\nParticipants in the intervention group will perform the new training concept twice weekly for 12 weeks. Participants in the control group will only receive usual care. All participants will visit the laboratory at baseline and after 6 and 12 weeks to measure the primary and secondary outcomes.",[133],"Prostate Cancer",[135,136,137,138,139],"Androgen deprivation therapy (ADT)","Flywheel training","High intensity training (HIT)","Resistance training","Aerobic training","2024-06-03",{"date":142,"type":41},"2024-06-10",{"date":144,"type":41},"2024-05-01",{"date":146,"type":21},"2028-12-20",{"name":47,"class":48},""]