[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The University of Texas Health Science Center, Houston\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":585},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,181,0,25,[9,47,68,92,115,139,164,188,213,234,259,282,309,332,357,374,393,407,421,444,469,492,513,538,559],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100053959","phase-2-lipid-infusions-to-optimize-nutrition-trial-100053959",false,"NCT06915441","Lipid Infusions to Optimize Nutrition Trial","Lipid Infusions to Optimize Nutrition (LION) and Minimize Bronchopulmonary Dysplasia and Neurodevelopmental Impairment in Extremely Preterm Infants: A Randomized Comparative Effectiveness Trial","LION","Inclusion Criteria:\n\n* inborn \\\u003C28 weeks gestational age (GA) or ≤1000g birth weight (BW)\n* survives until 12 hours after birth.\n\nExclusion Criteria:\n\n* Infants who are unable to be enrolled by 96 hours postnatal age\n* Major anomaly\n* Overt non-bacterial infection\n* Infants likely to expire soon defined as limiting or withdrawal of intensive care recommended or requested by the parents.","ALL","12 Hours","28 Weeks",{"count":22,"type":23},230,"ESTIMATED","INTERVENTIONAL",[26],"PHASE2","The purpose of this study is to identify survival free of bronchopulmonary dysplasia (BPD), fatty acid profiles, and early biochemical measures for oxidative stress comparing mixed oil lipid emulsion (MOLE) vs soybean oil-based lipid emulsion (SOLE) and to establish whether MOLE or SOLE is more effective in minimizing pulmonary outcomes, neonatal morbidities, long-term morbidity and mortality, and improving discharge growth and Bayley Scales of Infant Development Fourth Edition (BSID-IV) neurodevelopmental assessment at two years",[29,30],"Bronchopulmonary Dysplasia","Neurodevelopmental Impairment",[32,33],"soybean oil-based lipid emulsion (SOLE)","mixed oil lipid emulsion (MOLE)","RECRUITING","2026-07-09",{"date":37,"type":38},"2026-07-13","ACTUAL",{"date":40,"type":38},"2026-04-01",{"date":42,"type":23},"2030-12-31",{"name":44,"class":45},"The University of Texas Health Science Center, Houston","OTHER",1,{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":46},"100053996","accelerating-healthcare-engagement-in-healthy-food-interventions---food-rx-in-high-risk-pregnant-mothers-with-about-fresh-and-community-health-choice-100053996","NCT06275568","Accelerating Healthcare Engagement in Healthy Food Interventions - Food Rx in High Risk Pregnant Mothers With About Fresh and Community Health Choice","Inclusion Criteria:\n\n* Less than or equal to 20 weeks medically confirmed viable pregnancy\n* high-risk pregnant mothers receiving care at Community Health Choice managed care organizations in Houston, Texas (High risk may include overweight\u002Fobese pre-pregnancy or at first trimester (self-report or measured BMI\\>30.0), and\u002For prior history of diabetes or gestational diabetes, and\u002For prior history of hypertension or pregnancy-induced hypertension)\n\nExclusion Criteria:\n\n* Does not Speak English or Spanish","FEMALE","18 Years",{"count":56,"type":23},620,[58],"NA","The purpose of the study is to assess if the Fresh Connect food prescription (Fresh Connect Food Rx) program that provides consistent access to healthy fresh produce through purchases at the grocery store plus nutrition education impacts gestational weight gain, other pregnancy and birth outcomes, and food and nutrition security in low-income, ethnically diverse, at-risk women residing in Houston, Texas. Enrollment of participants will begin in pregnancy at the time of the first prenatal visit (as long as the first visit occurs before the end of the first trimester); each participant will be followed until 60 days post-partum (up to 11 months follow-up per participant).",[61],"Nutrition in High-Risk Pregnancy",{"date":37,"type":38},{"date":64,"type":38},"2025-07-03",{"date":66,"type":23},"2027-12-01",{"name":44,"class":45},{"id":69,"slug":70,"hasResults":12,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":24,"phases":77,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":46},"100053844","virtual-lifestyle-medicine-group-visits-for-high-blood-pressure-100053844","NCT07698509","Virtual Lifestyle Medicine Group Visits for High Blood Pressure","A Scalable, Lifestyle Medicine Intervention for Hypertension Using Virtual Group Shared Medical Appointments","Inclusion Criteria:\n\n* Current diagnosis of hypertension (ICD codes I10.0-I14.0 billed within the last 5 years Essential HTN, Essential HTN, Primary HTN)\n* Currently receives care at a UTPhysicians; Last seen by a PCP at Victory location within the last 1 year.\n* Able to participate in a virtual format\n* Willingness to participate and engage in home blood pressure monitoring\n\nExclusion Criteria:\n\n* Unstable cardiovascular disease (recent Myocardial Infarction (MI), unstable angina, decompensated HF)\n* Advanced Chronic kidney disease (CKD) (eGFR \\\u003C 30) without nephrology co-management\n* Active cancer treatment\n* Severe cognitive impairment (unable to engage)\n* Uncontrolled psychiatric illness (e.g., active psychosis)\n* Resistant hypertension (requiring\\> 3 medications at maximum doses)\n* Unable to participate in English class format\n* Unstable internet or lack of smartphone",{"count":76,"type":23},18,[58],"The purpose of this study is to learn whether virtual Lifestyle medicine shared medical appointments (LMSMAs) can help people better manage their blood pressure and improve their overall health.",[80],"Hypertension",[82,83],"high blood pressure","Lifestyle medicine shared medical appointments (LMSMAs)","NOT_YET_RECRUITING","2026-07-06",{"date":37,"type":38},{"date":88,"type":23},"2026-08-03",{"date":90,"type":23},"2027-02-07",{"name":44,"class":45},{"id":93,"slug":94,"hasResults":12,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":24,"phases":101,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":46},"100645106","disseminating-effective-sexual-health-programs-in-schools-using-ichampss-100645106","NCT07679620","Disseminating Effective Sexual Health Programs in Schools Using iCHAMPSS","Inclusion Criteria:\n\n* Licensed educator or administrator who holds one of the following positions: 1) district or school administrator (e.g., health coordinators, instructional specialists, and curriculum coordinators), 2) health and physical education teachers, and 3) social and health service staff (e.g., nurses and counselors) in a Texas school district participating in the iCHAMPSS 2.0 study\n\nExclusion Criteria:\n\n* not holding a job in a Texas school district as a school stakeholder, OR holding a job in a Texas school district as a school stakeholder but not in a school district participating in the iCHAMPSS 2.0 study",true,{"count":100,"type":23},75,[58],"The purpose of this study is to assess the efficacy of iCHAMPSS 2.0 in impacting Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) implementation outcomes, with implementation of a sexual health evidence-based program (EBP) assess iCHAMPSS 2.0's efficacy in impacting determinants of sexual health EBP implementation and to conduct a process evaluation to monitor iCHAMPSS 2.0 implementation, reach, dosage, and barriers and facilitators to implementing iCHAMPSS 2.0 during the study.",[104],"Sexual Health Education",[106],"iCHAMPSS","2026-06-29",{"date":109,"type":38},"2026-07-01",{"date":111,"type":38},"2026-04-02",{"date":113,"type":23},"2028-04-01",{"name":44,"class":45},{"id":116,"slug":117,"hasResults":12,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":12,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":24,"phases":124,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":46},"100586045","leveraging-adult-protective-service-interaction-to-offer-evidence-based-treatment-for-depression-in-elder-neglectself-neglect-100586045","NCT06910267","Leveraging Adult Protective Service Interaction to Offer Evidence-Based Treatment for Depression in Elder Neglect\u002FSelf Neglect","Inclusion Criteria:\n\n* APS Case in APS Region VI- Must have open case\n* PHQ 9 score- Must have score of nine (9) or more\n\nExclusion Criteria:\n\n* Previous mental health diagnosis of bipolar disorder, psychotic disorders, and moderate to severe dementia\n* Assessment of Consent Proxy- Those who need assessment of consent proxy\n* Suicidal Intent (as indexed by PhQ-9 question 9)- Those scoring 2 or 3\n* Current Alcohol and Drug Dependency- As evidenced by Cut down, Annoyed, Guilty, and Eye-opener (CAGE) score of 3 or more","65 Years",{"count":123,"type":23},50,[58],"The purpose of this study is to test the feasibility and acceptability of an evidence-based treatment for depression delivered over an ipad, computer, or smartphone can help Adult Protective Services (APS) clients with their activities of daily living to evaluate whether reductions on measures of depression and apathy (a) mediate reduced Elder Neglect\u002FSelf Neglect (EN\u002FSN) behaviors; and (b) whether secondary posited mediating mechanisms are also active in impacting depression and apathy",[127],"Depression in Old Age",[129,130],"Elder neglect","Self neglect","2026-06-26",{"date":133,"type":38},"2026-06-30",{"date":135,"type":38},"2026-05-15",{"date":137,"type":23},"2027-01-24",{"name":44,"class":45},{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":98,"sex":18,"minAge":54,"maxAge":121,"enrollmentInfo":146,"targetDuration":4,"studyType":24,"phases":148,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":46},"100630663","contingency-management-plus-deep-transcranial-magnetic-stimulation-for-the-treatment-of-cocaine-use-disorder-100630663","NCT07490600","Contingency Management Plus Deep Transcranial Magnetic Stimulation for the Treatment of Cocaine Use Disorder","Contingency Management Plus Deep Transcranial Magnetic Stimulation for the Treatment","Inclusion Criteria:\n\n* Able to provide informed consent before any study-related activity, willing to comply with all study procedures, and be available for the duration of the study.\n* Meet Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) diagnostic criteria for moderate-to-severe CUD and report recent cocaine use (verified by at least one positive urine drug screen (UDS) for the cocaine metabolite benzoylecgonine (BE), during intake).\n* Agree (if the participant is female and of child-bearing potential) to use effective contraceptive methods, unless the participant's male partner(s) is surgically sterile (underwent vasectomy).\n\nAcceptable contraceptives include:\n\n1. oral contraceptives\n2. contraceptive sponge\n3. patch\n4. double barrier (diaphragm\u002Fspermicidal or condom\u002Fspermicidal)\n5. intrauterine contraceptive system\n6. etonogestrel implant\n7. medroxyprogesterone acetate contraceptive injection\n8. complete abstinence from sexual intercourse\n9. hormonal vaginal ring\n\nContraceptive measures sold for emergency use after unprotected sex are not acceptable methods for routine use.\n\n* Women of child-bearing potential must provide negative urine pregnancy test prior to randomization.\n* Be able to provide the names and contact information of at least 2 persons who can consistently locate their whereabouts\n\nExclusion Criteria:\n\n* Current DSM-5 diagnosis for substance use disorder (of at least moderate severity) other than cocaine, cannabis, or nicotine or a substance Use Disorder (SUD) requiring medical detoxification (e.g., alcohol, opioid, benzodiazepine)\n* Presence of any medical, neurological, psychiatric, or physical condition, disease, or illness (including psychosis and bipolar disorder) that, in the opinion of the PIs and the Certified Registered Nurse Anesthetist (CNRA)Medical Director could: (a) compromise interfere, limit, or reduce the subject's ability to complete the study; or (b) adversely impact the safety of the subject or the integrity of the data.\n* Has current or recent (within 3 months of potential enrollment) suicidal ideation, suicidal behavior, homicidal ideation or a homicidal plan sufficient to raise subject safety concerns based on the following assessments:\n\n  1. Structured Clinical Interview for DSM-5 (SCID-5)\n  2. Columbia-Suicide Severity Rating Scale - Answers YES to Questions 3, 4, 5, or 6\n  3. Assault \\& Homicidal Danger Assessment Tool - Key to Danger \\> 1\n* Any contraindications to MRI scans (metal in the body; claustrophobia). -Medical implants contraindicating TMS (i.e., aneurysm clips or coils, stents, implanted stimulators, implanted vagus nerve or deep brain stimulators, implanted electrical devices such as pacemakers or medication pumps, electrodes for monitoring brain activity, cochlear implants for hearing, any magnetic implants, bullet fragments, any other metal device or object implanted in your body closer than 30 cm from the coil).\n* History of brain surgery.\n* History of an intracranial lesion or any medical or neurological diagnosis\u002Fcondition associated with increased intracranial pressure (i.e., Idiopathic Intracranial Hypertension\u002FPseudotumor Cerebri) OR any of the following symptoms within 30 days of enrollment: headaches \\> 15 days\u002Fmonth, loss of vision or decreased vision\n* Moderate-to-severe heart disease.\n* History of stroke.\n* Taking any antidepressant or antipsychotic medication at a dose above the maximum recommended dose or at a dose deemed to be potentially unsafe according to the study physician; has taken any of the following medications, which are known to increase the risk of seizures, within 1 week of study enrollment; or does not agree to abstain from taking the following medications during study participation:\n\n  1. clozapine\n  2. chlorpromazine\n  3. bupropion\n  4. clomipramine hydrochloride\n  5. amoxapine\n  6. maprotiline hydrochloride\n  7. diphenhydramine\n  8. stimulants other than cocaine including the following:\n  9. Dextroamphetamine and amphetamine ii. Dextroamphetamine iii. Lisdexamfetamine dimesylate iv. Methamphetamine\n\n  v. Methylphenidate i. tramadol j. isoniazid.\n* Personal history of epilepsy or seizure disorder and\u002For family history including a first degree relative\n* Serious head injury with loss of consciousness\n* Having conditions of probation or parole requiring reports of drug use to officers of the court or impending incarceration\n* For adolescent aged participants (18-21 only): any risk factor for neurocardiogenic syncope (history of syncope\u002F presyncope related to noxious stimuli, anxiety, micturition, or posture).\n* Pregnant or nursing for female participants\n* Inability to read, write, or speak English.",{"count":147,"type":23},100,[58],"The purpose of this study is to evaluate the effects of Contingency Management (CM)+transcranial magnetic stimulation (TMS) on treatment outcomes in individuals who are initial non-responders and to evaluate the effects of CM+TMS on putative mechanisms of change",[151],"Cocaine Use Disorder (CUD)",[153,154,155],"Cocaine treatment","Cocaine","Crack","2026-06-22",{"date":158,"type":38},"2026-06-25",{"date":160,"type":38},"2026-04-21",{"date":162,"type":23},"2029-09-01",{"name":44,"class":45},{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":24,"phases":174,"briefSummary":175,"conditions":176,"keywords":178,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":46},"100609783","bispectral-monitoring-on-mechanically-ventilated-patients-100609783","NCT07219069","Bispectral Monitoring on Mechanically Ventilated Patients","Bispectral Monitoring on Mechanically Ventilated Patients, a Randomized Clinical Trial. (BIMV Trial)","BIMV","Inclusion Criteria:\n\n* Admission to the medical ICU\n* Intubated on mechanical ventilation\n* On sedation medication infusion\n\nExclusion Criteria:\n\n* Patients with a history of chronic opioid use\n* Patients with end-stage liver disease at ICU admission (i.e., International normalized ratio \\>1.5 and not taking warfarin and\u002For a total serum bilirubin 1.5 times above normal limits)\n* Pregnant patients\n* Current prisoner\n* Refractory shock: Mean arterial blood pressure below 65 millimeters of mercury(65mmHg) despite maximum doses of 3 pressors. Norepinephrine 70mcg\u002Fmin; vasopressin 0.03 units\u002Fmin; epinephrine 35mcg\u002Fmin; dopamine 20mcg\u002Fkg\u002Fmin and phenylephrine 350mcg\u002Fmin\n* Inability to complete the required time for follow-up\n* Surgical admission diagnosis\n* Patients with skin conditions precluding BIS monitor sensor adherence\n* Patients on neuromuscular blockade infusion or benzodiazepine infusion",{"count":173,"type":23},30,[58],"The purpose of this study is to determine the difference in the duration of mechanical ventilation, to evaluate the difference in ICU length of stay and to determine the difference in the overall dose of sedation medications between the between participants who were monitored using Bispectral index monitoring (BIS) monitors and those who were not.",[177],"Sedation",[179,180],"sedation","Bispectral Monitoring","2026-06-20",{"date":158,"type":38},{"date":184,"type":38},"2025-11-01",{"date":186,"type":23},"2026-11-01",{"name":44,"class":45},{"id":189,"slug":190,"hasResults":12,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":195,"enrollmentInfo":196,"targetDuration":4,"studyType":24,"phases":198,"briefSummary":199,"conditions":200,"keywords":202,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":46},"100642398","breestim-in-managing-neuropathic-pain-after-spinal-cord-injury-sci-100642398","NCT07659743","BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)","A Randomized, Double-blind, Sham-controlled, Parallel-group Trial Designed to Evaluate the Efficacy of BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)","Inclusion Criteria:\n\n* has a history of SCI \\> 1 year\n* has a DN4 (Douleur Neuropathique en 4 Questions) score of 4 or greater\n* has neuropathic pain \\>3 months\n* is stable on oral pain medications at least one month\n* Able to tolerate BreEStim treatment for 1 minute\n\nExclusion Criteria:\n\n* is on a mechanical ventilator\n* is currently having active urinary tract infection (UTI)\n* does not have any residual sensation in the arms\n* has other pain (musculoskeletal, visceral etc.), but not neuropathic, e.g., shoulder pain from wheelchair use\n* has a pacemaker to avoid possible side effect of electrical stimulation\n* is not able to follow commands, or to give consent\n* has asthma or other pulmonary disease\n* has a history of cardiac pathology, implanted pacemakers, or current use of rhythm altering medication like beta-blockers\n* has baclofen pump or deep brain implants\n* has respiratory tract\u002Fsinus infection and rhinorrhea\n* has low motor neuron injury that no responses will be triggered by electrical stimulation\n* has severe mental disorders (e.g., depression, substance abuse) and is receiving active treatment and frequent monitoring\n* is not medically stable","80 Years",{"count":197,"type":23},66,[58],"The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and sham BreEStim and Transcutaneous Electrical Nerve Stimulation (TENS) in management of neuropathic pain in patients after spinal cord injury (SCI).",[201],"Pain Management",[203,204],"neuropathic pain","BreEStim","2026-06-18",{"date":207,"type":38},"2026-06-23",{"date":209,"type":23},"2026-10-01",{"date":211,"type":23},"2029-09-30",{"name":44,"class":45},{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":98,"sex":18,"minAge":219,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":24,"phases":222,"briefSummary":223,"conditions":224,"keywords":226,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":228,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":46},"100615922","non-invasive-deep-brain-neuromodulation-for-smoking-cessation-100615922","NCT07298902","Non-Invasive Deep Brain Neuromodulation for Smoking Cessation","Inclusion Criteria:\n\n1. Must be a smoker for 5 or more years and within 20 to 60 years of age\n2. Must not meet exclusion criteria for MRI scanning (e.g., non-fixed magnetizable objects)\n3. Must not have ongoing unstable medical, neurological or psychiatric illness as determined by a combination of history, medical record, and\u002For examination.\n4. Must be a current smoker with average of 5 cigarettes or more a day for the last month or longer.\n5. Report 3 or more trials of smoking cessation attempts using nicotine replacement, e-cig, TMS, varenicline or other smoking cessation drugs, psychotherapy or other means.\n\nExclusion Criteria:\n\n1. Failed TMS screening questionnaire.\n2. Significant alcohol or other drug use (substance dependence within the recent months) or positive urine toxicology screen for substance not prescribed other than nicotine or marijuana dependence.\n3. Cannot refrain from using alcohol and\u002For marijuana 24 hours or more prior to experiments.\n4. Taking \\> 400 mg clozapine\u002Fday and not on anti-seizure medication(s) with sufficient dose.\n5. Woman who is pregnant (child-bearing potential but not on contraceptive and missing menstrual period; or by self-report; or by positive pregnancy test) or has had unprotected sexual intercourse without birth control in the last 4 weeks.\n6. In ongoing smoking cessation treatment, clinical trial, or nicotine replacements (except for the current study)","20 Years","60 Years",{"count":147,"type":23},[58],"This study will develop novel low intensity focused ultrasound (LIFU) therapy to help people to quit cigarette smoking. Smoking is associated with cancers of the lung. Available smoking cessation methods help many to quit. However, for the many who continue to smoke despite the strong desire to quit and after exhausting existing therapeutic approaches, new treatment methods are needed. Without more effective treatment, many will continue to smoke, and our progress on cancer prevention through smoking cessation may decelerate as these associated cancer risks will remain. Brain imaging research has identified specific areas of the brain linked to severe nicotine addiction, but up to now there are no effective ways to directly target most of these deeper brain regions. LIFU is a new and safe method to modulate brain functions that can either inhibit overactive activity or restore normal activity levels. The purpose of this study is to provide a novel ultrasound-based neuromodulation strategy for smoking cessation in people who have difficulty to quit smoking despite numerous serious attempts in their lives. LIFU works by sending acoustic pressure modulating neural activity in the human brain.",[225],"Nicotine Addiction",[227],"low intensity focused ultrasound",{"date":207,"type":38},{"date":230,"type":38},"2026-04-13",{"date":232,"type":23},"2030-11-30",{"name":44,"class":45},{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":98,"sex":18,"minAge":241,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":244,"phases":4,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":46},"100122228","neurosciences-research-repository-100122228","NCT00857922","Neurosciences Research Repository","NRR","Inclusion Criteria:\n\n1. Neurosurgical patient (primary or consulting); patients\\\u003C18 includes residual tissue only, no blood samples.\n2. Family members of specific vascular, trauma, brain tumor and functional disorder cohorts (will be identified in future addendums to this repository)\n\nExclusion Criteria:\n\n1\\. Inability to obtain informed consent","0 Years",{"count":243,"type":23},15000,"OBSERVATIONAL","In order to expand neuroscience research and move laboratory advances to patients, there is a need to integrate reliable clinical data with biologic information from patient tissue specimens. The Neuroscience Research Repository (NRR) seeks to meet this need. The NRR is a prospective database and sample bank created to collect information and samples for current and future neuroscience research. The objective of this NRR is to develop a data and sample repository for study of neurological conditions. A repository utilizing standardized electronic health data and samples collected in a uniform manner serves to foster the ability to perform research on current and future projects. Samples and data for clinical, genomic and proteomic analysis will be provided to optimize their value for neuroscience research.\n\nThe NRR will enroll patients and collect clinically recorded longitudinal data for as long as they are followed by the Neurosurgery service and up to an additional 5 years after being released from care. Patients will be enrolled on admission to the service and samples will be taken at three time points: Time One, within 24 hours of event (preferably first blood draw); Time Two, within 48 hours of event; and Time Three, time of any residual tissue availability. Family members of select groups of patients will also be approached for enrollment.\n\nSamples and data will be labeled with a study code to maintain confidentiality. Samples and data will be maintained in secure, limited access environments with back-up\u002Fredundancy procedures in place. Sample inventory will be maintained with a bar-coding system. A duty to warn clause will be included in the consent as will the determination of willingness to be re-contacted for future research. Time of sample acquisition to time of sample processing will be documented for quality control purposes. Freezers will be monitored for temperature stability. Recipient investigators will be requested to provide feedback on sample quality. Samples will be distributed to neuroscience investigators after approval from the Neurosurgery Scientific Review Committee - Dissemination Review Committee and the Committee for the Protection of Human Subjects (CPHS).",[247],"Neurological Conditions",[249,250],"Neurological","Neurosurgical","2026-06-12",{"date":253,"type":38},"2026-06-16",{"date":255,"type":38},"2009-03",{"date":257,"type":23},"2030-08",{"name":44,"class":45},{"id":260,"slug":261,"hasResults":12,"nctId":262,"briefTitle":263,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":195,"enrollmentInfo":266,"targetDuration":4,"studyType":24,"phases":268,"briefSummary":269,"conditions":270,"keywords":272,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":46},"100642027","reduce-inefficiencies-in-management-of-spasticity-100642027","NCT07639632","Reduce Inefficiencies in Management of Spasticity","ReIMage","Inclusion Criteria:\n\n* Currently admitted for an acute hemorrhagic or ischemic stroke; recurrent stroke allowed if no spasticity at baseline\n* NIHSS score of \\> 0 on items 5 or 6 (required of at least 1 limb)\n* Willingness to participate in the study for 24 months\n* Able to sign consent form or availability of a legally authorized representative to sign\n* Able to read\u002Fwrite in English\n* Identified MD for follow up post hospitalization\n\nExclusion Criteria:\n\n* Botulinum toxin use for any indication within the past 12 weeks\n* Acute life threatening illness\n* Prior limb injury or neurological diagnosis that limited movement in the now affected limb(s)\n* Any terminal illness that would limit participation in study follow ups\n* Known spasticity or other movement disorders that impact tone",{"count":267,"type":23},80,[58],"The purpose of this study is to evaluate the effectiveness of a spasticity screener and to determine if the spasticity screener results are useful to healthcare providers and impact clinical decision making",[271],"Stroke",[273,274],"acute ischemic stroke","intracerebral hemorrhage","2026-06-10",{"date":251,"type":38},{"date":278,"type":23},"2026-06-15",{"date":280,"type":23},"2029-11-30",{"name":44,"class":45},{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":12,"sex":18,"minAge":290,"maxAge":291,"enrollmentInfo":292,"targetDuration":4,"studyType":24,"phases":294,"briefSummary":295,"conditions":296,"keywords":299,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":305,"completionDateStruct":306,"leadSponsor":308,"locationsCount":46},"100643450","feasibility-usability-and-acceptability-of-virtual-reality-based-cognitive-and-physical-rehabilitation-in-individuals-with-mild-cognitive-impairment-100643450","NCT07638748","Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment","Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment (VR-MCI)","(VR-MCI)","Inclusion Criteria:\n\n* Clinical diagnosis of MCI (MoCA 18-26) or self-reported subjective cognitive decline (SCD)\n* Capacity to provide informed consent\n* Able to provide own transportation to sessions\n* Speaks and understands English\n* Ambulatory\n\nExclusion Criteria:\n\n* Uncontrolled seizures or epilepsy\n* Severe psychiatric illness or active suicidality\n* Inability to follow instructions or tolerate VR (severe motion sickness)\n* Cognitive impairment as a result of a known cause (e.g., dementia, stroke, Traumatic Brain Injury (TBI), medications, etc.)\n* Any condition that the research team determines would interfere with safe participation","55 Years","90 Years",{"count":293,"type":23},10,[58],"The purpose of this study is to demonstrate feasibility, usability, and acceptability of VR-based cognitive and physical rehabilitation, evaluate adherence, tolerability, and fidelity to the VR intervention and explore preliminary effectiveness of VR-based rehabilitation on cognitive, physical, and functional outcomes",[297,298],"Mild Cognitive Impairment","Subjective Cognitive Decline (SCD)",[300,301,302],"Virtual Reality","Cognitive Rehabilitation","Physical Rehabilitation","2026-06-09",{"date":275,"type":38},{"date":251,"type":23},{"date":307,"type":23},"2026-11-30",{"name":44,"class":45},{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":24,"phases":318,"briefSummary":319,"conditions":320,"keywords":322,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":326,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":46},"100641738","mentalizing-imagery-therapy-for-caregivers-to-address-risk-of-elder-mistreatment-100641738","NCT07648238","Mentalizing Imagery Therapy for Caregivers to Address Risk of Elder Mistreatment","Mentalizing Imagery Therapy for Caregivers to Address Risk of Elder Mistreatment (MIT-CARE)","(MIT-CARE)","Inclusion Criteria:\n\n* Primary family ADRD caregivers\n* Recruited nationally.\n* Caring for someone aged 60 or older\n* Provide at least 8 hours of care weekly\n* Report at least mild depressive symptoms (PHQ-9 ≥5)\n* Use a smartphone at least five days per week.\n\nExclusion Criteria:\n\n* Active psychosis or mania\n* A suicide attempt in the last 6 months or current suicidal intent\n* Self-reported memory or cognitive complaints\n* Unstable medical conditions or planned major surgery\n* Moderate to severe substance use disorders.",{"count":123,"type":23},[58],"The purpose of this study is to establish the clinical efficacy of Mentalizing Imagery Therapy (MIT) for Alzheimer's Disease and Related Disorders (ADRD) family caregivers in terms of mentalizing and elder mistreatment (EM) risk factors of stress, depression, and suicidality and to identify the mechanistic impacts of MIT on ADRD family caregivers' mental health,including stress, depression, and suicidality.",[321],"Mental Health",[323,324,325],"Mentalizing Imagery Therapy","Mindfulness Exercises","dementia family caregiver",{"date":278,"type":38},{"date":328,"type":23},"2026-08-01",{"date":330,"type":23},"2028-06-30",{"name":44,"class":45},{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":339,"enrollmentInfo":340,"targetDuration":4,"studyType":24,"phases":342,"briefSummary":343,"conditions":344,"keywords":346,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":46},"100518325","tacs-for-neuropathic-pain-management-after-sci-100518325","NCT06029075","tACS for Neuropathic Pain Management After SCI","tACS Brain Neuromodulation for Sensory and Motor Recovery After Neurological Impairments","Inclusion\u002Fexclusion criteria for SCI subjects\n\nInclusion criteria: A patient who\n\n1. has neuropathic pain after traumatic spinal cord injury or amputation or brain injury;\n2. has chronic pain, \\>3 months;\n3. is between 18 to 75 years of age;\n4. is stable on oral pain medications at least two weeks. Patients are allowed to continue their pain medications, i.e., no change in pain medications.\n\nNOTE: we plan to begin the study with the spinal cord injury (SCI) subject population as a cohort first, then expand to other subject populations\n\nExclusion criteria: Patients will be excluded if they\n\n1. are currently adjusting oral pain medications for their neuropathic pain;\n2. have pain, but not neuropathic, e.g., from inflammation at the incision wound of the residual limb or neuroma;\n3. have a pacemaker metal implants or supplemental oxygen;\n4. have amputation in their arm(s);\n5. fail to have a motor contraction in the arm muscles with TMS;\n6. are not able to follow commands, or to give consent;\n7. have asthma or other pulmonary disease;\n8. are not medically stable;\n9. have preexisting psychiatric disorders;\n10. alcohol or drug abuse.","75 Years",{"count":341,"type":23},14,[58],"The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for neuropathic pain management in people after spinal cord injury.",[345],"Neuropathic Pain Management",[347,348],"tACS","Neuropathic Pain","2026-06-01",{"date":351,"type":38},"2026-06-03",{"date":353,"type":38},"2025-09-01",{"date":355,"type":23},"2028-03-31",{"name":44,"class":45},{"id":358,"slug":359,"hasResults":12,"nctId":360,"briefTitle":361,"officialTitle":337,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":339,"enrollmentInfo":363,"targetDuration":4,"studyType":24,"phases":364,"briefSummary":365,"conditions":366,"keywords":368,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":370,"startDateStruct":371,"completionDateStruct":372,"leadSponsor":373,"locationsCount":46},"100518324","tacs-for-sensory-motor-recovery-after-stroke-100518324","NCT06029062","tACS for Sensory Motor Recovery After Stroke","Inclusion\u002Fexclusion criteria for stroke subjects\n\nInclusion criteria:\n\n1. Age between 18\\~75 years old\n2. ≥ 6 months post stroke, medically stable;\n3. Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke);\n4. Visible finger flexor activation\u002Fmovement\n5. The ability to give consent\n\nExclusion criteria:\n\n1. Patients with visual deficit\u002Fneglect; hearing or cognitive impairment;\n2. Patients that are currently adjusting tone alternating medications (e.g., baclofen), or\n3. Patients received botulinum toxin injection to the arm\u002Ffingers \\\u003C4 months, or phenol injections \\\u003C2 years;\n4. Patients with pacemaker, metal implants or supplemental oxygen;\n5. Patients who have musculoskeletal disorders, including pain in the affected side\n6. Women who are pregnant.",{"count":341,"type":23},[58],"The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for motor recovery in stroke survivors.",[367],"Motor Recovery",[347,369],"Motor recovery",{"date":351,"type":38},{"date":353,"type":38},{"date":355,"type":23},{"name":44,"class":45},{"id":375,"slug":376,"hasResults":12,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":339,"enrollmentInfo":381,"targetDuration":4,"studyType":24,"phases":383,"briefSummary":384,"conditions":385,"keywords":386,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":388,"startDateStruct":389,"completionDateStruct":390,"leadSponsor":392,"locationsCount":46},"100420116","breestim-for-post-stroke-motor-recovery-100420116","NCT04750551","BreEStim for Post-Stroke Motor Recovery","BreEStim for Motor Recovery in Chronic Stroke With Moderate Impairment (Pilot).","Inclusion criteria:\n\n* has post stroke ≥ 6 months , medically stable;\n* Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke);\n* MAS score ≥ 1, i.e., detectable finger flexor hypertonia;\n\nExclusion criteria include:\n\n* Patients with visual deficit\u002Fneglect; hearing or cognitive impairment;\n* Patients with history of pulmonary disease (Asthma, chronic obstruction pulmonary disease, COPD);\n* Patients that are currently adjusting tone alternating medications (e.g., baclofen), or\n* Patients received botulinum toxin injection to the arm\u002Ffingers \\\u003C4 months, or phenol injections \\\u003C 2 years;\n* Patients with a pacemaker;\n* Women who are pregnant.",{"count":382,"type":23},4,[58],"The overall goal is to investigate the effectiveness of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) on finger flexor spasticity reduction and hand function improvement in chronic stroke with moderate impairment.",[367],[387,367,204],"Finger flexor spasticity",{"date":351,"type":38},{"date":184,"type":38},{"date":391,"type":23},"2027-12-31",{"name":44,"class":45},{"id":394,"slug":395,"hasResults":12,"nctId":396,"briefTitle":397,"officialTitle":378,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":339,"enrollmentInfo":398,"targetDuration":4,"studyType":24,"phases":399,"briefSummary":400,"conditions":401,"keywords":402,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":403,"startDateStruct":404,"completionDateStruct":405,"leadSponsor":406,"locationsCount":46},"100420252","breestim-for-motor-recovery-in-chronic-stroke-with-moderate-impairment-after-a-long-term-use-pilot-100420252","NCT04752319","BreEStim for Motor Recovery in Chronic Stroke With Moderate Impairment After a Long-term Use (Pilot).",{"count":382,"type":23},[58],"The overall goal is to investigate the effectiveness of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) on finger flexor spasticity reduction and hand function improvement in chronic stroke with moderate impairment after a long-term use.",[367],[387,367,204],{"date":351,"type":38},{"date":353,"type":38},{"date":355,"type":23},{"name":44,"class":45},{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":378,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":339,"enrollmentInfo":412,"targetDuration":4,"studyType":24,"phases":413,"briefSummary":414,"conditions":415,"keywords":416,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":417,"startDateStruct":418,"completionDateStruct":419,"leadSponsor":420,"locationsCount":46},"100420117","breestim-for-motor-recovery-in-chronic-stroke-with-severe-impairment-pilot-100420117","NCT04750564","BreEStim for Motor Recovery in Chronic Stroke With Severe Impairment (Pilot)",{"count":382,"type":23},[58],"The overall goal is to investigate the effectiveness of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) on finger flexor spasticity reduction and hand function improvement in chronic stroke with severe impairment.",[367],[387,367,204],{"date":351,"type":38},{"date":353,"type":38},{"date":391,"type":23},{"name":44,"class":45},{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":98,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":427,"targetDuration":4,"studyType":24,"phases":429,"briefSummary":430,"conditions":431,"keywords":432,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":437,"lastUpdatePostDateStruct":438,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":46},"100535843","improving-adult-protective-services-client-outcomes-a-stepped-care-social-and-mental-health-engagement-program-100535843","NCT06257095","Improving Adult Protective Services Client Outcomes: A Stepped-Care Social and Mental Health Engagement Program","Inclusion Criteria:\n\nOlder Adults\n\n* an APS validated EM\u002FSN case\n* able to provide informed consent\n* able to speaks English or Spanish\n* able to hear sufficiently using the telephone\n* transitioning out of APS intervention (i.e. in the case closure phase of the APS service).\n\nStudent\n\n* college or university student\n* enrolled in a health-related program\n* commit to making 8-weekly consecutive calls\n* complete the required 1-hour training and assessment.\n\nExclusion Criteria:\n\nOlder Adults\n\n* Individuals needing a proxy to consent\n* suspected or confirmed decision-making capacity impairments or uncontrolled psychiatric illnesses such as schizophrenia, paranoia, delusion, or delirium\n\nStudent\n\n-only engaging in the program to fulfill some educational requirement",{"count":428,"type":23},400,[58],"The purpose of this study is to ascertain the feasibility and effectiveness of an 8-week social engagement program aimed at reducing depression and increasing social engagement among seniors who are transitioning out of Adult Protective Services (APS) for either elder abuse or self-neglect.",[127],[433,434,435,436],"social engagement","Adult Protective Services (APS)","elder abuse","self neglect","2026-05-29",{"date":351,"type":38},{"date":440,"type":38},"2023-08-09",{"date":442,"type":23},"2026-10-31",{"name":44,"class":45},{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":450,"eligibilityCriteria":451,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":4,"enrollmentInfo":452,"targetDuration":4,"studyType":24,"phases":454,"briefSummary":455,"conditions":456,"keywords":458,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":465,"completionDateStruct":466,"leadSponsor":468,"locationsCount":46},"100533980","continuous-versus-intermittent-ward-monitoring-100533980","NCT06232876","Continuous Versus Intermittent Ward Monitoring","Continuous Versus Intermittent Ward Monitoring on Vital Sign Abnormalities, Clinical Interventions, and Serious Complications: the CONSTANT Trial","CONSTANT","Inclusion Criteria:\n\n1. Are admitted to one of the wards equipped with the Masimo Radius PPG and Rad-97 monitors;\n2. Are ≥18 years old;\n3. Are designated American Society of Anesthesiologists physical status 1-4;\n4. Had major noncardiac surgery lasting at least 1.5 hours;\n5. Are expected to remain hospitalized at least two postoperative nights;\n6. Had general anesthesia with or without neuraxial anesthesia.\n\nExclusion Criteria:\n\n1. Have language, vision, or hearing impairments that may compromise continuous monitoring;\n2. Are designated Do Not Resuscitate, hospice, or receiving end of life care;\n3. Have previously participated in the study.",{"count":453,"type":23},492,[58],"The investigators will randomize adults having major non-cardiac inpatient surgery to blinded versus unblinded continuous postoperative vital sign monitoring (saturation, ventilation, and heart rate). The investigators will use a wearable, untethered, and battery-powered sensor (Masimo Radius PPG, Masimo, Irvine, CA) that wirelessly connects to a Masimo monitor and continuously records saturation, ventilation, and pulse rate.\n\nThe primary outcome will be areas-exceeding-thresholds for desaturation (\\\u003C85%), bradypnea (\\\u003C7 breaths\u002Fmin), tachypnea (\\>30 breaths\u002Fmin), tachycardia (heart rate \\>130 beats\u002Fmin), and bradycardia (heart rate \\\u003C45 beats\u002Fmin). These exposure thresholds represent a balance between events that are clinically meaningful and excessive alarms that will discourage clinician participation. The investigators expect about 1 alert per patient per day with these thresholds, with most being considered informative or actionable by nurses. In unblinded patients, clinician alerts will be activated at these thresholds.",[457],"Surgery",[459,460,457,461],"monitoring","Vital signs","Postoperative","2026-05-24",{"date":464,"type":38},"2026-05-28",{"date":349,"type":23},{"date":467,"type":23},"2029-03-01",{"name":44,"class":45},{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":473,"acronym":474,"eligibilityCriteria":475,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":4,"enrollmentInfo":476,"targetDuration":4,"studyType":24,"phases":477,"briefSummary":478,"conditions":479,"keywords":481,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":485,"lastUpdatePostDateStruct":486,"startDateStruct":488,"completionDateStruct":489,"leadSponsor":491,"locationsCount":46},"100638764","delivery-of-a-culturally-tailored-exercise-training-intervention-for-hispanics-with-multiple-sclerosis-100638764","NCT07606742","Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis","VAMOS-MS","Inclusion Criteria:\n\n* diagnosis of MS\n* relapse-free in the past 30 days\n* self-identify as Hispanic\u002FLatino\n* Patient Determined Disease Steps Scale (PDDS) score between 3.0 (gait disability) and 6.0 (bilateral support) indicates walking disability.\n* MSWS-12 score between 25 and 75, indicating walking disability\n* Willingness to complete the questionnaires and undergo randomization\n* English or Spanish as a primary language\n\nExclusion Criteria:\n\n* significant exercise-related risk factors or contraindications, assessed individually using the Physical Activity Readiness Questionnaire (PAR-Q; requires clearance from physician).",{"count":197,"type":23},[58],"The purpose of this study is to establish differences in the primary outcome of walking dysfunction using the 12-Item Multiple Sclerosis Walking Scale (MSWS-12) and to establish differences in the secondary outcome of HRQoL using the 29-Item Multiple Sclerosis Walking Scale (MSWS-29) between the exercise training intervention condition and the waitlist control condition following the 16-week intervention period.",[480],"Multiple Sclerosis",[482,483,484],"Exercise training","mobility disability","implementation","2026-05-18",{"date":487,"type":38},"2026-05-26",{"date":109,"type":23},{"date":490,"type":23},"2028-10-31",{"name":44,"class":45},{"id":493,"slug":494,"hasResults":12,"nctId":495,"briefTitle":496,"officialTitle":496,"acronym":497,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":4,"enrollmentInfo":499,"targetDuration":4,"studyType":24,"phases":500,"briefSummary":501,"conditions":502,"keywords":503,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":507,"startDateStruct":509,"completionDateStruct":510,"leadSponsor":512,"locationsCount":46},"100638122","virtually-assisted-home-rehabilitation-after-stroke-for-underserved-texas-communities-100638122","NCT07597226","Virtually Assisted Home Rehabilitation After Stroke for Underserved Texas Communities","VAST TX","Inclusion Criteria:\n\n* Hospital admission with primary ICD-10 discharge diagnosis of Acute Ischemic Stroke (AIS) or Intracerebral Hemorrhage (ICH)\n\n  o those being referred from the community settings must be within 60 days of post-acute discharge.\n* Post-stroke functional deficits warranting PASUC rehabilitation\n* Clinically stable and appropriate for discharge per acute care facility\n* Completion of a rehabilitation evaluation within the acute setting\n* Planned discharge to home (with or without Home Health (HH)\u002FOutpatient Rehabilitation (OPR), Inpatient Rehabilitation Facility (IRF), or Skilled Nursing Facility (SNF)\n* Ability to speak and read English or Spanish\n* Ability to provide informed consent (patient or LAR)\n\n  o If LAR is consenting, patient must be able to follow simple commands\n* Access to a video-capable device and internet\n\nExclusion Criteria:\n\n* Clinically unstable medical condition\n* Poorly controlled severe mental illness\n* Planned discharge to a long-term care facility (LTACH)\n* Inability to complete follow-up (psychiatric hospitalization, hospice, incarceration, homelessness)\n* Discharge against medical advice\n* Significant language impairment (NIHSS Commands \\>1 or Best Language \\>2)- Cognitive impairment (Six-Item, PROMIS) -Severe depression (PHQ-8 \\>20 or psychiatric hospitalization previous 30 days)- Pre-stroke mRS \\>3\n* Other neurological or musculoskeletal conditions substantially limiting participation o Patients excluded for one of these criteria may be reassessed at 60-days to see if improvement has occurred.",{"count":267,"type":23},[58],"The purpose of this study is to evaluate the clinical effectiveness of Virtually Assisted Home Rehabilitation After Acute STroke (VAST) + post-acute stroke usual care (PASUC) compared to PASUC alone and examine how social determinants of health (SDOH) influence access to and utilization of PASUC rehabilitation.",[271],[504,505],"Tele-Rehabilitation","stroke survivors","2026-05-12",{"date":508,"type":38},"2026-05-19",{"date":278,"type":23},{"date":511,"type":23},"2027-01-31",{"name":44,"class":45},{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":517,"acronym":518,"eligibilityCriteria":519,"healthyVolunteers":98,"sex":53,"minAge":4,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":244,"phases":4,"briefSummary":521,"conditions":522,"keywords":525,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":537},"100622748","feasibility-and-clinical-utility-of-paired-non-invasive-hemodynamic-and-tissue-oximetry-monitoring-to-detect-limb-ischemia-in-lithotomy-positioned-surgeries-100622748","NCT07387653","Feasibility and Clinical Utility of Paired Non-Invasive Hemodynamic and Tissue Oximetry Monitoring to Detect Limb Ischemia in Lithotomy-Positioned Surgeries","LIMB","Inclusion Criteria:\n\n1. Adult patients\n2. Undergoing minimally invasive pelvic surgery (such as hysterectomy, myomectomy, or endometriosis surgery)\n3. Surgery performed in lithotomy position\n4. Expected surgical duration \\> 2 hours as determined by the primary surgeon\n\nExclusion Criteria:\n\n1. Pregnant patients\n2. Procedures expected to last \\\u003C 2 hours\n3. Open surgical approaches\n4. Minor procedures\n5. Known allergy or sensitivity to adhesives used for monitoring sensors\n6. Vulnerable populations (incarcerated, elderly or pregnant)",{"count":173,"type":23},"The LIMB Study is a prospective, observational pilot study evaluating the feasibility of combined non-invasive hemodynamic and lower-limb tissue oximetry monitoring during prolonged minimally invasive pelvic surgeries performed in lithotomy position. Thirty patients will undergo continuous intraoperative monitoring, with the primary outcome being the frequency and duration of tissue oxygen desaturation events and secondary outcomes examining correlations with postoperative limb pain, sensation, and motor function. The study is non-interventional, poses minimal risk, and aims to generate preliminary data to inform future strategies for early detection and prevention of limb ischemia and well-leg compartment syndrome",[523,524],"Neuropathy;Peripheral","Limb Ischemia",[526,527,528,529],"trendelemberg","nerve injury","position nerve injury","prolonged surgery",{"date":531,"type":38},"2026-05-14",{"date":533,"type":38},"2026-01-29",{"date":535,"type":23},"2026-12",{"name":44,"class":45},2,{"id":539,"slug":540,"hasResults":12,"nctId":541,"briefTitle":542,"officialTitle":542,"acronym":543,"eligibilityCriteria":544,"healthyVolunteers":98,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":545,"targetDuration":4,"studyType":24,"phases":547,"briefSummary":548,"conditions":549,"keywords":551,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":554,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":558,"locationsCount":46},"100606937","impact-of-uterine-and-ovarian-vessel-occlusion-on-blood-loss-in-high-burden-minimally-invasive-myomectomy-100606937","NCT07182045","Impact of Uterine and Ovarian Vessel Occlusion on Blood Loss in High Burden Minimally Invasive Myomectomy.","Myo-Bleed","Inclusion Criteria:\n\n* Patient undergoing minimally invasive myomectomy with either a single intramural or Submucosal fibroid =\u002F\\>5cm or\n* Patients undergoing minimally invasive Myomectomy with =\u002F\\> 5 fibroids\n\nExclusion Criteria:\n\n* Pregnancy,\n* Age \\\u003C18yo,\n* Patients undergoing concomitant surgery such as endometriosis surgery,\n* Suspected malignancy",{"count":546,"type":23},120,[58],"This study hypothesizes that temporary bilateral uterine and utero-ovarian artery occlusion with laparoscopic clamps at time of minimally invasive myomectomy will lead to a decreased blood loss at time of myomectomy compared to minimally invasive myomectomy without temporary occlusion.",[550,457],"Myoma",[552,553],"myoma","blood loss",{"date":531,"type":38},{"date":556,"type":38},"2025-09-18",{"date":211,"type":23},{"name":44,"class":45},{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":4,"eligibilityCriteria":565,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":4,"enrollmentInfo":566,"targetDuration":4,"studyType":24,"phases":568,"briefSummary":569,"conditions":570,"keywords":573,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":581,"completionDateStruct":582,"leadSponsor":584,"locationsCount":46},"100637016","evaluation-of-hypersensitivity-reactions-to-silk-fibroin-versus-2-octyl-cyanoacrylate-mesh-in-shoulder-surgery-100637016","NCT07573202","Evaluation of Hypersensitivity Reactions to Silk Fibroin Versus 2-octyl Cyanoacrylate Mesh in Shoulder Surgery","Silk Fibroin Versus 2-octyl Cyanoacrylate Mesh a Randomized Controlled Trial to Evaluate Hypersensitivity Reactions in Shoulder Surgery","Inclusion Criteria:\n\n* open shoulder procedure with Dr. James Gregory or Dr. Robert Fullick.\n\nExclusion Criteria:\n\n* Prior documented medical adhesive contact allergy.\n* Negative pressure wound dressings.\n* Any procedure involving a wound problem at the planned surgical site.",{"count":567,"type":23},350,[58],"The purpose of this study is to document the incidence of allergic contact dermatitis (ACD) to silk fibroin and 2-octyl cyanoacrylate mesh dressings after open shoulder surgery, to identify differences in clinic utilization for complications related to silk fibroin and 2-octyl cyanoacrylate mesh dressings and to collect patient reported outcome measures (PROMs) related to patient comfort and satisfaction for silk fibroin and 2-octyl cyanoacrylate mesh dressings.",[571,572],"Hypersensitivity Reactions","Allergic Contact Dermatitis",[574,575,576,577,578],"silk fibroin (SYLKE)","2-octyl cyanoacrylate mesh (Dermabond PRINEO)","open shoulder surgery","hypersensitivity","contact dermatitis","2026-05-11",{"date":531,"type":38},{"date":133,"type":23},{"date":583,"type":23},"2028-07-30",{"name":44,"class":45},""]