[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The University of Texas at Dallas\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":384},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,48,75,98,128,159,181,206,233,255,281,308,331,361],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100634031","treatment-of-cognitive-and-sensorimotor-deficits-in-parkinsons-disease-with-high-definition-transcranial-direct-current-stimulation-100634031",false,"NCT07534397","Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current Stimulation","Inclusion Criteria:\n\n* Diagnosed with PD having a verbal fluency deficit based on neuropsychological test (T-score \\\u003C 40 or a T-score \\\u003C-1.0 SD below the average T-score): Semantic Object Retrieval Test (SORT), COWAT (both letter and category fluency), Boston Naming Test (BNT), Rey Auditory Verbal Learning Test (RAVLT)\n* 50 - 90 years old\n* Capable of understanding and signing an informed consent (able to answer consent comprehension questions)\n* Fluent in speaking and reading English\n\nExclusion Criteria:\n\nA potentially study-confounding, tDCS-contraindicated, or EEG-contraindicated psychological, neuropsychiatric, neurological, or other medical issues:\n\n* Montreal Cognitve Assessment (MOCA) score \\\u003C23, unless an accompanying study partner\u002Fcaregiver is with them and we can obtain the written consent of both the participant and the participant's accompanying study partner\u002Fcaregiver (i.e., the participant's spouse, adult child, parent, or adult sibling);\n* history of seizures;\n* unexplained episodes of loss of consciousness (as these may be related to brain alterations or epilepsy);\n* suffering from severe or frequent headaches;\n* unstable or uncontrolled neuropsychiatric illness;\n* severe traumatic brain injury (based on the Ohio State TBI Identification; Method);\n* brain tumor; stroke; present drug abuse\u002Fmisuse;\n* brain tumor;\n* serious or life-threatening diseases, including congestive heart failure, chronic obstructive pulmonary disease, or active malignancy;\n* Huntington's disease;\n* stroke;\n* cranial implants or skull defects that affect tDCS administration;\n* implanted brain medical devices, including, deep brain stimulators (DBS);\n* implanted pacemakers;\n* any electrically, magnetically, or mechanically activated implants;\n* cardiac, neural, or medication implants;\n* vascular clips or other electrically sensitive support systems in the brain;\n* damaged skin at the sites of stimulation (the device should only be used on healthy, intact skin, as wounds may alter resistance to current);\n* skin conditions such as dermatitis, psoriasis, or eczema;\n* pregnant women;\n* diagnosis of just dysarthria;\n\nUse of medications that interact with or potentially interact with tDCS or EEG effects:\n\n* anti-convulsants;\n* carbamazepine;\n* sulpiride;\n* pergolide;\n* lorazepam;\n* rivastigmine;\n* dextromethorphan;\n* D-cycloserine;\n* flunarizine;\n* ropinirole;\n* citalopram;\n* stimulants;\n\nAdditionally, non-English speakers will be excluded because not all of the screening forms, questionnaires, and tests are available in languages other than English.","ALL","50 Years","90 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this research study is to examine the effects of transcranial Direct Current Stimulation (tDCS) on verbal retrieval and cognition and sensorimotor control and to determine if tDCS can be used as a way to improve retrieval, sensory, and motor abilities in individuals with Parkinson's disease (PD).",[26],"PARKINSON DISEASE (Disorder)",[28,29,30,31,32,33,34],"transcranial direct current stimulation (tDCS)","Parkinson's Disease","electroencephalography (EEG)","presupplementary motor area (preSMA)","verbal memory","speech sequencing","motor sequencing","NOT_YET_RECRUITING","2026-06-24",{"date":38,"type":39},"2026-06-26","ACTUAL",{"date":41,"type":20},"2026-08-01",{"date":43,"type":20},"2027-10-31",{"name":45,"class":46},"The University of Texas at Dallas","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":69,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100622759","clinical-and-neurobehavioral-changes-with-weight-loss-drug-discontinuation-and-reinitiation-100622759","NCT07387796","Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation","Clinical and Neurobehavioral Changes With GLP-1 (Glucagon-like Peptide-1) Discontinuation","CLIN-GLP1","Inclusion Criteria:\n\n* Aged 18-70 years.\n* Currently on tirzepatide.\n* Currently receiving care from University of Texas- Southwestern (UTSW) Weight Wellness Clinic.\n* Cognitively capable of understanding and signing informed consent.\n* Be proficient in English.\n\nExclusion Criteria:\n\n* History of major neurological or psychiatric disorders, including substance use disorders that might confound brain imaging results (e.g., stroke, epilepsy, multiple sclerosis, schizophrenia, major depression requiring hospitalization).\n* Diagnosis of Type 2 Diabetes.\n* Current diagnosis of an eating disorder.\n* Use of medications affecting weight other than tirzepatide.\n* Pregnancy or breastfeeding.\n* MR contraindications:\n* Heart pacemaker, heart valve replacement, or aortic clips\n* Metal fragments in the eyes, skin, or elsewhere in the body\n* Brain clips or pieces of metal used in aneurysm surgery or intercranial bypass\n* Venous umbrella\n* Pieces of metal in the body resulting from work as a sheet-metal worker or welder\n* Clips placed in an internal organ\n* Prosthetic devices, such as middle ear, eye, joint, or penile implants\n* Joint replacement\n* Hearing aid that cannot be removed\n* Neurostimulator\n* Insulin pump\n* Shunts or stents\n* Metal mesh or coil implants\n* Metal plate, pin, screws, or wires, or any other metal implants","18 Years","70 Years",{"count":59,"type":20},40,[23],"The goal of this clinical study with research procedures is to learn how stopping and restarting tirzepatide (a medication that helps regulate blood sugar and appetite) affects brain activity, behavior, and health in adults ages 18-70 who are currently taking tirzepatide. Specifically, the study aims to examine how a short pause in tirzepatide affects hunger, mood, sleep, and daily functioning; how stopping and restarting tirzepatide alters brain chemistry and brain responses to food-related images; and how these changes relate to health measures such as quality of life and emotional well-being. There is no comparison group; instead, researchers will assess changes within each participant across three time points: while taking tirzepatide, after stopping it for 3-4 weeks, and after restarting it for 6-8 weeks. Participants will attend three in-person visits lasting approximately 3-4 hours each, during which they will complete interviews, questionnaires, and cognitive tasks; provide a urine sample (pregnancy screening for females); undergo a brain scan using magnetic resonance imaging (MRI) and MR spectroscopy (MRS); and receive a kit to provide a small stool sample. Participants will also complete two brief check-in phone calls between visits and the online BrainHealth Index between sessions, which includes surveys and cognitive tasks. All changes to tirzepatide use will occur under the supervision of a study physician to support participant safety and comfort, and the total study duration is approximately 13 weeks.",[63,64,65,66],"Drug Discontinuation","Substance Use Disorders","Eating Behavior Changes","Tirzepatide",[66,63,64,65],"RECRUITING",{"date":38,"type":39},{"date":71,"type":20},"2026-06",{"date":73,"type":20},"2029-02",{"name":45,"class":46},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":15,"minAge":56,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":47},"100429210","the-brainhealth-project-100429210","NCT04869111","The BrainHealth Project","The BrainHealth Project, a Longitudinal Study in Generally Healthy Adults","Inclusion Criteria:\n\n* English-speaking\n* Access to an internet connect and device\n* Able to read information and hear sounds\n\nExclusion Criteria:\n\n* Diagnosed neurodegenerative disease\n* History of stroke, concussion, or brain injury that currently hinders you from functioning at your prior level\n* Diagnosed with Autism Spectrum Disorder and not functioning independently\n\nFor an overview of the study and LINK TO REGISTER please go to -- https:\u002F\u002Fbrainhealth.utdallas.edu\u002Fprograms\u002Fthe-brainhealth-project\u002F",true,"110 Years",{"count":85,"type":20},100000,[23],"The BrainHealth Project is a longitudinal study designed to identify factors associated with brain health and cognitive performance across the lifespan. Participants complete online assessments approximately twice per year to measure changes in cognitive, behavioral, and lifestyle-related domains.\n\nBetween assessments, participants have access to digital training modules, educational resources, and optional coaching sessions. A subset of participants may be invited to participate in additional components, including neuroimaging.\n\nFor an overview of the study and link TO REGISTER please go to -- https:\u002F\u002Fbrainhealth.utdallas.edu\u002Fprograms\u002Fthe-brainhealth-project\u002F",[89],"Healthy","2026-06-18",{"date":92,"type":39},"2026-06-23",{"date":94,"type":39},"2020-08-01",{"date":96,"type":20},"2038-08-01",{"name":45,"class":46},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":15,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":109,"briefSummary":110,"conditions":111,"keywords":113,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},"100572462","meeting-the-needs-of-young-hispanic-autistic-children-100572462","NCT06733584","Meeting the Needs of Young Hispanic Autistic Children","Meeting the Needs of Young Hispanic Autistic Children: Developing a Culturally and Linguistically Sensitive Intervention to Alleviate Core Social Challenges","Inclusion Criteria:\n\n* Children must be from a Hispanic family experiencing low income, defined as having an income-to-needs ratio of \\\u003C 320% of the federal poverty level, determined by their household size\n* Children must be between 18-42 months old at the start of the study\n* Children must have no other known neurological or genetic concerns or disorders determined by parent report\n* Children must receive a Calibrated Severity Score (CSS) of 4 or higher on the Autism Diagnostic Observational Schedule-2 (ADOS-2) administered by a qualified bilingual assessment associate\n* Families must have a primary home language of English and\u002For Spanish\n\nExclusion Criteria:\n\n* Children who are from a family that is not Hispanic and\u002For does not have an income-to-needs ratio of \\\u003C 320% of the federal poverty level, determined by their household size\n* Children younger than 18 months or older than 42 months at the start of the study\n* Children whose parents report they have any other known neurological or genetic concerns or disorders\n* Children who receive a Calibrated Severity Score (CSS) lower than 4 on the ADOS-2\n* Families who do not have English or Spanish as a primary home language","18 Months","42 Months",{"count":108,"type":20},200,[23],"Purpose of the Study: The goal of this clinical trial is to find out if a technique called the \"mutual gaze procedure\" used in a Culturally and Linguistically Responsive adaptation of Pathways Early Intervention (CLR-Pathways) is the key to improving social communication, language, and everyday skills in young (18-42 months) Hispanic autistic children experiencing low income.\n\nWhat Will Happen: Researchers will compare two versions of CLR-Pathways.\n\n* Version 1: Includes mutual gaze strategies.\n* Version 2: Does not include mutual gaze strategies.\n\nWhat to Expect: Participants will:\n\n* Attend 16 sessions (or 18 weeks if there are cancellations) of Pathways Intervention, each lasting 1.5 hours.\n* Come to the clinic for a developmental check-up three times: before starting Pathways, right after completing Pathways, and three months after finishing Pathways.",[112],"Autism",[114,115,116,117,118],"Autism Intervention","Cultural and Linguistic Responsivity","Social development","Social communication","Hispanic","2026-06-04",{"date":121,"type":39},"2026-06-05",{"date":123,"type":39},"2025-09-22",{"date":125,"type":20},"2028-01",{"name":45,"class":46},3,{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":15,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":21,"phases":138,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":127},"100536556","targeted-plasticity-therapy-for-ptsd-100536556","NCT06266364","Targeted Plasticity Therapy for PTSD","Targeted Plasticity Therapy for the Treatment of Post-Traumatic Stress Disorder","Inclusion Criteria:\n\n1. Diagnosis of chronic PTSD for at least 3 months based on DSM-5 criteria\n2. In the medical opinion of the Principal Investigator (PI), failed at least one adequate course of first-line PTSD treatment per American Psychological Association (APA) guidelines\n3. PCL-5 score greater than 33\n4. Age 22-79 years\n5. Appropriate surgical candidate for VNS device implantation\n6. Willing and able to comply with study protocol\n7. Able to provide informed consent.\n\nExclusion Criteria:\n\n1. Currently undergoing prolonged exposure therapy elsewhere\n2. Concurrent participation in another interventional clinical trial\n3. Prior injury to vagus nerve\n4. Prior or current treatment with vagus nerve stimulation\n5. Psychiatric disorders and\u002For cognitive impairments that would interfere with study participation, as assessed by medical evaluation\n6. Moderate-High Risk of Suicide according to Columbia - Suicide Severity Rating Scale (C-SSRS) Screen Version\n7. Persons with a current or past: (a) medical (psychiatric, non-psychiatric) condition, disease, disorder, injury, or disability or (b) non-medical situation or circumstance that, in the opinion of the principal investigator, study participation:\n\n   * may pose a significant or undue risk to the person,\n   * make it unlikely the person will complete all the study requirements per protocol, or\n   * may adversely impact the integrity of the data or the validity of the study results\n8. Persons with a neck circumference larger than 18.5 inches\n9. Females of childbearing potential who are either pregnant or planning to become pregnant and who are not using, or will not agree to use medically acceptable birth control methods\n10. Non-English speaking\n11. As determined by the principal investigator, is under current incarceration or legal detention","22 Years","79 Years",{"count":19,"type":20},[23],"Objectives of this study are to provide continued safety assessment for the ReStore system, and to gain further estimates of the effect size of Vagus Nerve Stimulation (VNS) therapy with Prolonged Exposure Therapy (PE) compared to PE with placebo (sham) stimulation in participants with posttraumatic stress disorder (PTSD)",[141],"PTSD, Post Traumatic Stress Disorder",[143,144,145,146,147,148,149,150,151],"PTSD, Post-Traumatic Stress Disorder","VNS, Vagus Nerve Stimulation","TPT, Targeted Plasticity Therapy","ReStore System","PE, Prolonged Exposure Therapy","Trauma and Stressor Related Disorders","Mental Disorders","Stress Disorders, Traumatic","Stress Disorders, Post-Traumatic",{"date":153,"type":39},"2026-06-08",{"date":155,"type":39},"2024-12-30",{"date":157,"type":20},"2028-06",{"name":45,"class":46},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":82,"sex":15,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":127},"100419528","neural-bases-of-vocal-sensorimotor-impairment-in-aphasia-100419528","NCT04742894","Neural Bases of Vocal Sensorimotor Impairment in Aphasia","Inclusion Criteria:\n\n* A total of 50 individuals with aphasia due to chronic left hemisphere stroke (\\> 6 months post-stroke) and 50 age- and gender-matched healthy control subjects will be recruited in this study. The general inclusion criteria for all subjects include: age range 21-75 years, right-handed, and native speaker of English. The aphasic subjects have previously undergone neuro-psychological speech\u002Flanguage testing and have been diagnosed with one type of aphasia (e.g., Broca's, Wernicke's, conduction or anomic). Subjects in the control group will meet the inclusion criteria with having normal voice, speech, language, and hearing function and no history of neurological and psychiatric disorder. We expect that a significant proportion of aphasic patients will show symptoms associated with Apraxia of Speech (AOS) or dysarthria; however, these patients will not be excluded unless their deficits will preclude them from performing the experimental tasks.\n\nExclusion Criteria:\n\n* Subjects with moderate to severe hearing, memory, and\u002For cognitive impairments will be excluded for both groups. In addition, subjects with history of peripheral laryngeal disorders (e.g., paresis or vocal fold paralysis) will be excluded. Subjects will undergo safety screening and will be excluded if there are any factors counter-indicative for EEG and\u002For MRI scanning.","21 Years","75 Years",{"count":168,"type":20},100,[23],"Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.",[172],"Aphasia","2026-05-26",{"date":175,"type":39},"2026-05-29",{"date":177,"type":39},"2021-07-11",{"date":179,"type":20},"2027-02-28",{"name":45,"class":46},{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":82,"sex":15,"minAge":56,"maxAge":187,"enrollmentInfo":188,"targetDuration":4,"studyType":21,"phases":190,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":47},"100580647","use-of-airpod-pros-as-assistive-technology-100580647","NCT06840015","Use of Airpod Pros as Assistive Technology","Inclusion Criteria:\n\n* Adults aged 18 to 60 years.\n* Fluent English speakers.\n* Mild-to-moderate hearing loss confirmed by a pure-tone hearing test (average hearing threshold screening 25 to 55 dB HL across octave frequencies from 250 to 8000 Hz).\n* Individuals with no prior hearing aid experience for a year.\n\nExclusion Criteria:\n\n* Normal hearing.\n* Hearing loss worse than moderate.\n* Neurological, psychiatric, or ophthalmological conditions that might alter the pupil response.\n* Non-fluent English speakers.\n* Individuals with prior hearing aid experience more than a year.","60 Years",{"count":189,"type":20},24,[23],"The goal of this study is to investigate the suitability and effectiveness of the AirPod Pro 2nd and 3rd generation (AP) as hearing assistive technology for individuals with mild-to-moderate hearing loss when listening in noisy environments. Researchers will compare four types of assistive technology: hearing aids (HAs), AP, dedicated wireless remote microphones, and Smartphone wireless remote microphone.\n\nThe main questions it aims to answer are:\n\n* Which assistive technology provides the greatest benefit for speech recognition in noisy environments?\n* How do these devices impact listening effort, as measured by reaction time in a dual-task activity and changes in pupil size?\n* What are participants' preferences for each device based on how easy it is to understand speech and their overall satisfaction? Participants will visit the lab for a single 3-hour session. They will listen to sentences using each device and repeat what they hear. During this task, their reaction times for the secondary task and changes in pupil size will be measured.",[193,194],"Hearing Loss, Adult-Onset","Hearing Aids",[196,194,197],"AirPod Pro (AP)","Hearing Loss","2026-05-07",{"date":200,"type":39},"2026-05-11",{"date":202,"type":39},"2025-07-01",{"date":204,"type":20},"2026-07",{"name":45,"class":46},{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":15,"minAge":135,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":21,"phases":215,"briefSummary":216,"conditions":217,"keywords":220,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":47},"100620170","using-non-invasive-brain-stimulation-to-explore-potential-treatments-to-reduce-speech-errors-in-adults-who-stutter-100620170","NCT07354139","Using Non-invasive Brain Stimulation to Explore Potential Treatments to Reduce Speech Errors in Adults Who Stutter","Examining Speech Production Errors in Stuttering Through High Definition - Transcranial Direct Current Stimulation","Inclusion Criteria:\n\n* Must be 22 years old or older\n* May be bi\u002Fmultilingual but must speak English as dominant language.\n* Must be diagnosed or suspected of developmental stuttering disorder. Participants will be administered the Stuttering Severity Instrument 4 and categorized as typical speakers or mild, moderate, or severe stutterers.\n* Must be able to attend the session at the physical location within the clinic\n\nExclusion Criteria:\n\n* Patients with preexisting speech\u002Flanguage disorders or previously diagnosed neurological disorders (including but not limited to apraxia of speech, cerebral palsy, dysarthria, tourettes, or any other neurological\u002Fmotor condition) that affect speech\u002Flanguage (except stuttering) are excluded to minimize the interference of atypical brain activity.\n* Participants who have acquired or neurogenic stuttering (stuttering resulting from a brain injury) are excluded, as this study focuses exclusively on the effects of developmental stuttering.\n* Participants with a history of seizures\n* Participants with unexplained episodes of loss of consciousness, since such condition could be related with brain alterations or epilepsy\n* Participants with unstable or non controlled neuropsychiatric illness\n* Participants having implanted brain medical devices\n* Participants with implanted pacemakers\n* Participants having any electrically,magnetically or mechanically activated implant\n* Participants having cardiac, neural or medication implants\n* Participants having vascular clips or any other electrically sensitive support system in the brain\n* Participants with serious brain injury\n* Participants showing damage of skin at sites of stimulation (the device can only be used in healthy skin without wounds, otherwise the resistance to current can be altered)\n* Participants suffering from skin problems, such as dermatitis, psoriasis or eczema\n* Participants suffering from severe or frequent headaches\n* Participants with any serious life-threatening disease such as congestive heart failure, pulmonary obstructive chronic disease, or active neoplasia\n* Pregnant women\n* Participants may not consume alcohol or controlled substances within 24 hours of the scheduled appointment\n\nParticipants will complete an additional screener upon enrollment to assess medical history and current drug\u002Fmedication use that may conflict with the study.",{"count":214,"type":20},50,[23],"The goal of this study is to find out whether a type of noninvasive brain stimulation can help reduce speech errors, such as repetitions, blocks, and prolongations, in people who stutter. This pilot study will help researchers design future treatments to see if targeting certain brain areas can improve speech fluency. The study will look at how people speak and behave during both speaking and non-speaking tasks before and after the brain stimulation.\n\nParticipants will complete an online survey about 24 hours before coming to the clinic. The clinic visit will last about 3 hours and will include three phases. All parts of the study will be audio-recorded.\n\n1. Pre-Testing: Participants will first complete a stuttering evaluation to determine whether they are typical speakers or have a mild, moderate, or severe stutter. Then, they will do several speaking and non-speaking tasks.\n2. Brain Stimulation: Participants will receive a session of targeted noninvasive brain stimulation (HD-tDCS).\n3. Post-Testing: After the brain stimulation, participants will repeat the same evaluation and tasks they completed during pre-testing.\n\nBrain stimulation description:\n\nHD-tDCS is a non-invasive technique that requires the placement of several sensors (metal electrodes) on a special cap and saline gel on your head. Very low levels of constant electrical current are delivered to specifically targeted areas of the brain via these electrodes. You may experience a slight feeling of dizziness when starting the stimulation. This occurs in a small number of subjects. This takes only a few seconds and does not affect balance after the stimulation has been completed. Several research centers have previously investigated the use of this device on healthy subjects and have found the device to be safe with no direct effect on the person's well-being. Following stimulation, participants will have the opportunity to rinse out residual gel from hair and scalp.",[218,219],"Stuttering","Fluency Disorder",[218,221,222,223,224],"HD-tDCS","neuromodulation","speech","fluency","2026-04-08",{"date":227,"type":39},"2026-04-14",{"date":229,"type":39},"2026-03-17",{"date":231,"type":20},"2026-09-30",{"name":45,"class":46},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":82,"sex":15,"minAge":56,"maxAge":83,"enrollmentInfo":239,"targetDuration":4,"studyType":21,"phases":241,"briefSummary":242,"conditions":243,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":254},"100571794","brain-health-on-college-campuses-100571794","NCT06724887","Brain Health on College Campuses","Inclusion Criteria:\n\n* Minimum age of 18\n* Either enrolled as a student and\u002For employed as staff\u002Ffaculty at UTD or Dallas College\n* Internet and device access\n* Must be able to hear and read over the computer\n* Fluent English speaker\n\nExclusion Criteria:\n\n* Currently or previously enrolled in The BrainHealth Project (NCT04869111)\n* Diagnosed neurodegenerative disease\n* History of stroke, concussion, or brain injury that currently hinders participant from functioning at their prior level\n* Diagnosed with autism spectrum disorder and not functioning independently",{"count":240,"type":20},1000,[23],"Center for BrainHealth is beginning a one-year pilot with local college campuses investigating the impact of (i) brain health assessment and training tools delivered through the online BrainHealth Platform and (ii) in-person educational brain health workshops delivered to college students and faculty\u002Fstaff, with the overarching goal to better understand how to promote brain-healthier campuses (i.e., reflecting generally positive function across cognitive, social, emotional, and lifestyle domains). This initial study is intended to be a one-year pilot, with findings informing feasibility and efficacy as well as future, more extended and expanded study informing translation to other colleges\u002Funiversities.",[244,245],"Health Behavior","Life Style, Healthy","2026-01-30",{"date":248,"type":39},"2026-02-03",{"date":250,"type":39},"2025-01-13",{"date":252,"type":20},"2027-12-31",{"name":45,"class":46},2,{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":82,"sex":15,"minAge":105,"maxAge":262,"enrollmentInfo":263,"targetDuration":4,"studyType":21,"phases":264,"briefSummary":265,"conditions":266,"keywords":269,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":47},"100566033","word-learning-from-parentese-in-autistic-children-100566033","NCT06649916","Word Learning From Parentese in Autistic Children","Autism Word Learning and Infant Directed-Speech","Inclusion Criteria:\n\n* children with or without a diagnosis of ASD between 18 and 59 months\n\nExclusion Criteria:\n\n* hears another language more than 10% of time based on parent report\n* has uncorrected visual impairment or hearing impairment\n* has developmental disorders or medical conditions other than ASD that affect language or cognition (excepting psychiatric conditions often comorbid with ASD such as ADHD)","59 Months",{"count":168,"type":20},[23],"The overall objective of this research is to determine whether parentese delivered in the video format (Aim 1) and in live interaction (Aim 2) facilitates novel word learning in autistic children and to investigate if there are factors that influence the effect of parentese on word learning (Aim 3).",[112,267,268],"Autism Spectrum Disorder","Neurodevelopmental Disorders",[270,271,272],"autism","word learning","language development","2025-10-21",{"date":275,"type":39},"2025-10-23",{"date":277,"type":39},"2024-10-04",{"date":279,"type":20},"2028-03-01",{"name":45,"class":46},{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":166,"enrollmentInfo":289,"targetDuration":4,"studyType":21,"phases":291,"briefSummary":292,"conditions":293,"keywords":295,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":307,"locationsCount":47},"100429206","treating-mild-traumatic-brain-injury-with-high-definition-transcranial-direct-current-stimulation-100429206","NCT04869059","Treating Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation","Treatment of Verbal Retrieval Deficits in Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation","HDtDCS-TBI","Inclusion Criteria: Participants are to be between the ages of 18-75, have previously served in the US armed services, and have had a traumatic brain injury that has led to a verbal retrieval deficit based on neuropsychological testing criteria. Traumatic brain injury must be in the mild to moderate range based on evaluation, including, the Ohio State TBI Identification Method (administered by our research group). You must be fluent in speaking and reading English.\n\nExclusion Criteria: Exclusion criteria include a history of a psychological or neurological disorder, including, dementia of any type, epilepsy or other seizure disorders, severe traumatic brain injury, post-traumatic stress disorder, brain tumor, present drug abuse, stroke, blood vessel abnormalities in the brain, Parkinson's disease, Huntington's disease, or multiple sclerosis. Additionally, exclusion criteria include inability to give informed consent; cranial implants or skull defects that affect tDCS administration; and use of medications that interact with or potentially interact with tDCS effects, including, anti-convulsants, amphetamines, L-dopa, carbamazepine, sulpiride, pergolide, lorazepam, rivastigmine, dextromethorphan, D-cycloserine, flunarizine, ropinirole, or citalopram.",{"count":290,"type":20},136,[23],"The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in military veteran participants with histories of traumatic brain injuries. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, both on assessments administered within the intervention period and at follow-up.",[294],"Traumatic Brain Injury",[296,297,298,299,300],"Traumatic brain injury","transcranial direct current stimulation","electroencephalography","cognition","veteran traumatic brain injury","2025-09-17",{"date":303,"type":39},"2025-09-23",{"date":305,"type":39},"2021-08-01",{"date":231,"type":20},{"name":45,"class":46},{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":82,"sex":15,"minAge":135,"maxAge":315,"enrollmentInfo":316,"targetDuration":4,"studyType":21,"phases":318,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":47},"100572298","exploring-neurophysiological-markers-of-brain-health-100572298","NCT06731452","Exploring Neurophysiological Markers of Brain Health","Exploring Markers of Brain Health With EEG and TMS: A Pilot Study","Inclusion Criteria:\n\n* Must be an active brain imaging participant in The BrainHealth Project (NCT04869111)\n* Minimum age of 22\n* Fluent in English\n* Able to read \\& hear information over a computer\n* Must pass an MRI safety screener to assess the presence of contraindicators for MRI compatibility (i.e., non-removable metal within\u002Fon the body, claustrophobia, pregnancy, non-correctable vision problems, head trauma, and CNS disease)or other standard requirements as determined by the Imaging Center.\n* Must pass a modified TMS Adult Safety Screen\n* Meet all criteria for study as determined by the study physician\n\nExclusion Criteria:\n\n* A diagnosis of a neurodegenerative disease\n* A history of stroke, concussion, or brain injury that currently hinders them from functioning at their prior level\n* A diagnosis of autism spectrum disorder that currently hinders them from functioning independently.\n* Metallic brain implants or fragments (like a shunt, pacemaker, clips, coils, bullet fragments, cochlear implants)\n* Magnetically activated implants or electronically implanted devices\n* Medication pumps\n* Personal or family history of epilepsy, seizure(s), seizure disorder.\n* History of, or risk factors for syncope (fainting)\n* Report significant cognitive challenges\n* Report untreated health issues (like substance abuse, hypertension, hypo- or hyper-thyroidism)\n* Have claustrophobia","100 Years",{"count":317,"type":20},63,[23],"The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been suggested as a promising brain imaging tool for identifying biomarkers of brain health.\n\nIn this pilot study, study investigators will explore the neurophysiological metrics of brain health with a non-invasive brain imaging technique, alongside behavioral and fMRI metrics collected through another study (NCT04869111).",[321,322],"Healthy Lifestyle","Health-Related Behavior","2025-09-09",{"date":325,"type":39},"2025-09-16",{"date":327,"type":39},"2025-09-03",{"date":329,"type":20},"2027-05-31",{"name":45,"class":46},{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":187,"enrollmentInfo":337,"targetDuration":4,"studyType":21,"phases":339,"briefSummary":340,"conditions":341,"keywords":343,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":127},"100357341","multi-site-confirmatory-efficacy-treatment-trial-of-combat-related-ptsd-100357341","NCT03932773","Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD","Inclusion Criteria:\n\n* Veterans of Post-9\u002F11 military conflicts\n* with diagnosis of PTSD based on CAPS-5 related to Post-9\u002F11 military combat\n\nExclusion Criteria:\n\n* current enrollment in an acute experimental treatment for PTSD or trauma-focused psychotherapy treatment\n* PTSD-inducing trauma exposure occurring within the last 3 months prior to pre-enrollment evaluation\n* history of epilepsy or seizure disorder, a history of major head trauma,\n* any neurologic condition likely to increase risk of seizures,\n* brain tumors,\n* moderate to severe substance use disorder in last 3 months or any substance use that puts the participant at increased risk or significant impairment\n* stroke, and blood vessel abnormalities in the brain,\n* dementia,\n* Parkinson's disease, Huntington's chorea, or multiple sclerosis\n* a high suicide risk\n* a lifetime history of psychotic disorder or bipolar disorder\n* inability to stop taking any medication that significantly lowers the seizure threshold\n* pregnant or nursing\n* metal fragments in the head, or any metal objects in or near the head that cannot be safely removed\n* We will screen for a history of traumatic brain injury and exclude potential participants from the study if they have a history of severe TBI or are at high risk for seizures.\n* history of seizures\n* non-English speakers because not all of the screening forms, questionnaires, and tests are available in any language except for English\n* cardiac pacemaker, implanted medication pumps of any sort that would increase the risk of rTMS\n* any current medical condition that could preclude being able to safely participate in TMS treatment,\n* use of prescription medication or illegal substances that lower the seizure threshold\n* previous rTMS",{"count":338,"type":20},330,[23],"The purpose of this study is to examine the benefits of combining repetitive Transcranial Magnetic Stimulation (rTMS) coupled with Cognitive Processing Therapy (CPT) in treating combat-related Posttraumatic Stress Disorder (PTSD) symptoms. The study will also examine change in depression, psychosocial functioning, and neurophysiological (i.e., electroencephalography and magnetic resonance images) measures.",[342],"Post Traumatic Stress Disorder",[344,345,346,347,348,349,350,351,352],"PTSD","post-traumatic stress disorder","military-related PTSD","CPT","cognitive processing therapy","rTMS","repetitive transcranial magnetic stimulation","combat","combat-related PTSD","2025-08-15",{"date":355,"type":39},"2025-08-22",{"date":357,"type":39},"2019-05-01",{"date":359,"type":20},"2026-07-31",{"name":45,"class":46},{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":21,"phases":370,"briefSummary":371,"conditions":372,"keywords":374,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":381,"leadSponsor":383,"locationsCount":47},"100512894","treatment-of-cognitive-deficits-in-multiple-sclerosis-with-high-definition-transcranial-direct-current-stimulation-100512894","NCT05958381","Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation","MS-HDtDCS","Inclusion Criteria:\n\nº Diagnosed with relapsing-remitting multiple sclerosis (RRMS)\n\nº Memory retrieval deficit based on neuropsychological testing done in our lab\n\nº Must be fluent in speaking and reading English.\n\nExclusion Criteria:\n\nº Relapse or acute MS exacerbation or a course of steroids in the two months preceding the testing\n\nº Participants using benzodiazepines must have been on a stable dose for at least two months\n\nº Potentially confounding psychological or neurological disorder, including:\n\n* dementia of any type\n* epilepsy or other seizure disorders\n* severe traumatic brain injury\n* brain tumor\n* present drug abuse\n* stroke\n* blood vessel abnormalities in the brain\n* Parkinson's disease\n* Huntington's disease\n\nº inability to give informed consent\n\nº cranial implants\n\nº skull defects that affect tDCS administration\n\nº use of medications that interact with or potentially interact with tDCS effects, including:\n\n* anti-convulsants\n* L-dopa\n* carbamazepine\n* sulpiride\n* pergolide\n* lorazepam\n* rivastigmine\n* dextromethorphan\n* D-cycloserine\n* flunarizine\n* ropinirole\n* stimulants (dextroamphetamine\u002Famphetamine\u002Fmodafinil\u002Farmodafinil) must be stopped during enrollment","65 Years",{"count":168,"type":20},[23],"The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in multiple sclerosis patients. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, both on assessments administered within the intervention period and at follow-up.",[373],"Multiple Sclerosis, Relapsing-Remitting",[28,375,30],"multiple sclerosis","2025-08-11",{"date":378,"type":39},"2025-08-14",{"date":380,"type":39},"2023-10-18",{"date":382,"type":20},"2027-06-30",{"name":45,"class":46},""]