[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Theodoros Schizodimos\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100612085","contribution-of-transthoracic-and-transcranial-ultrasonography-to-the-titration-of-peep-in-patients-with-ards-and-abi-100612085",false,"NCT07248995","Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI","The Contribution of the Combination of Transthoracic and Transcranial Ultrasonography to the Titration of Positive End-expiratory Pressure in Patients With Acute Respiratory Distress Syndrome and Acute Brain Injury","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Severe acute brain injury (e.g., traumatic brain injury, subarachnoid hemorrhage, intracerebral hemorrhage, acute ischemic stroke)\n* Development of ARDS (according to Berlin criteria) within the first 10 days of ICU admission\n\nExclusion Criteria:\n\n* Severe chronic brain diseases\n* Brain tumor or central nervous system (CNS) infection\n* Severe chronic pulmonary or cardiovascular disease\n* Severe coagulopathy\n* Undergoing decompressive craniectomy\n* Lack of invasive neuromonitoring\n* Withdrawal of life-sustaining treatment\n* Poor acoustic window in ultrasound","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute respiratory distress syndrome and acute brain injury, aiming at an individualized, brain-protective ventilation strategy.",[26,27],"Acute Respiratory Distress Syndrome (ARDS)","Acute Brain Injury","RECRUITING","2025-12-26",{"date":31,"type":32},"2025-12-31","ACTUAL",{"date":34,"type":20},"2025-12-01",{"date":36,"type":20},"2027-07",{"name":38,"class":39},"Theodoros Schizodimos","OTHER",""]