[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tianjin Eye Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":184},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,41,64,91,116,134,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100637867","nomogram-for-astigmatism-correction-of-klex-100637867",false,"NCT07605221","Nomogram for Astigmatism Correction of KLEx","Nomogram Optimization for Astigmatism Precision Correction of Corneal Refractive Correction","Inclusion Criteria:\n\n* age ≥18 years; preoperative sphere -0.50 D to -10.00 D; preoperative cylinder -1.50 D to -5.00 D; stable refraction (±0.50 D) for 1 year; normal corneal topography; central corneal thickness \\>500 μm or predicted residual stromal bed \\>280 μm; intraocular pressure \\\u003C21 mmHg\n\nExclusion Criteria:\n\n* ocular or systematic disease","ALL","18 Years","45 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if nomogram could promote treatment outcomes in astigmatism correction. The main question it aims to answer is:\n\ndoes the nomogram could promote treatment outcomes in astigmatism correction? If there is a comparison group: Researchers will compare non-nomogram adopted to see if the outcome acceptable.\n\nParticipants will ask to complete 3-month follow-up of manifest refraction and visual acuity test.",[27],"Astigmatism","RECRUITING","2026-05-18",{"date":31,"type":32},"2026-05-22","ACTUAL",{"date":34,"type":32},"2025-02-18",{"date":36,"type":21},"2027-12-31",{"name":38,"class":39},"Tianjin Eye Hospital","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":4},"100632794","factors-influencing-subjective-visual-quality-in-human-eyes-100632794","NCT07518316","Factors Influencing Subjective Visual Quality in Human Eyes","Factors Influencing Subjective Visual Quality in Normal Human Eyes and Before and After Refractive Surgery","Inclusion Criteria:\n\n* Myopic or myopic astigmatism patients aged 18 to 45 years.\n* Transparent ocular media, absence of ocular diseases such as corneal leucoma, cataract, etc.\n* Round pupils with normal light reflex, absence of dyscoria, corectopia, significant persistent pupillary membrane, or absence of the pupil.\n* Absence of severe psychological or psychiatric disorders, ability to cooperate with examinations and questionnaire completion.\n* Subject agrees to participate in this clinical study and cooperate with examinations and related procedures.\n\nExclusion Criteria:\n\n* Opacities of the ocular media, such as corneal leucoma, cataract, etc.\n* Pupil deformation, displacement, significant persistent pupillary membrane, or absence of the pupil.\n* Severe psychological or psychiatric disorders.\n* Concurrent diagnosis of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis, etc.).\n* History of ocular surgery or trauma.\n* Nystagmus or inability to cooperate.",{"count":49,"type":21},300,[24],"To assess subjective visual symptoms using the QoV questionnaire, measure pupil size using the Atongmu Pupillometer, measure wavefront aberrations using the OPD-Scan III Aberrometer, and measure\u002Fcalculate the effective optical zone using the Pentacam system. The relationships between pupil size, higher-order aberrations (HOAs), effective optical zone after refractive surgery, and subjective visual symptoms will be explored.",[53,54],"Corneal Wavefront Aberration","Refractive Errors","NOT_YET_RECRUITING","2026-04-04",{"date":58,"type":32},"2026-04-08",{"date":60,"type":21},"2026-03-18",{"date":62,"type":21},"2026-09-01",{"name":38,"class":39},{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":16,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":40},"100611722","comparison-of-compressed-continuous-suture-and-conventional-suture-in-pterygium-surgery-100611722","NCT07244276","Comparison of Compressed Continuous Suture and Conventional Suture in Pterygium Surgery","Comparison of Compression Continuous Suture Versus Conventional Suture for Autologous Conjunctival Implant Fixation in Primary Pterygium Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Diagnosis of primary pterygium according to diagnostic criteria;\n2. The pterygium head invades the cornea by 2-5mm;\n3. The patient agrees to the surgical treatment and signs the surgical consent form.\n\nExclusion Criteria:\n\n1. History of previous eye surgery;\n2. Have active ocular inflammatory lesions;\n3. recurrent and pseudopterygium;\n4. The patient refuses surgery or is unable to have regular follow-ups",true,"30 Years","70 Years",{"count":75,"type":21},40,[24],"To compare the advantages and disadvantages of continuous suture with suture and conventional Suture in primary pterygium surgery for autologous conjunctival graft fixation",[79],"Primary Pterygium",[79,81,82],"Compression Continuous Suture","Conventional Suture","2025-11-21",{"date":85,"type":32},"2025-11-24",{"date":87,"type":32},"2024-04-02",{"date":89,"type":21},"2026-07-02",{"name":38,"class":39},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":71,"sex":16,"minAge":98,"maxAge":72,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":40},"100574563","clinical-treatment-of-transcranial-direct-current-stimulation-in-older-adolescents-with-amblyopia-100574563","NCT06760910","Clinical Treatment of Transcranial Direct Current Stimulation in Older Adolescents With Amblyopia","Efficacy of Transcranial Direct Current Stimulation in the Amblyopia Treatment of Older Adolescents: A Cohort Study","Inclusion Criteria:\n\n* Children and their legal guardians have obtained consent in writing.\n* Participants aged 10-30, of any gender.\n* Participants must meet the diagnostic criteria for amblyopia: unilateral amblyopia with a difference of two lines or more in visual acuity between the eyes, or bilateral amblyopia with best-corrected visual acuity worse than 20\u002F30 (or worse than 0.2 logMAR). The visual acuity charts to be used are LEA SYMBOLS® (Good-Lite Co., Elgin, IL) or HOTV visual acuity chart.\n\nExclusion Criteria:\n\n* Participants who may have eye diseases affecting vision or refractive errors (such as cataracts, crystalline lens damage, glaucoma, macular degeneration, corneal disorders, retinitis pigmentosa, retinal detachment, severe vitreous opacities, etc\n* History of eye trauma or intraocular surgery\n* Inability to cooperate with examinations\n* Presence of concomitant systemic diseases (such as epilepsy)\n* Participation in any other experimental treatment within the past 3 months\n* Other situations deemed unsuitable by the investigator.","10 Years",{"count":75,"type":21},[24],"As a neurodevelopmental visual disorder, amblyopia, especially monocular form-deprivation amblyopia, can lead to severe visual developmental impairments. Due to reduced neural plasticity in the visual cortex after the critical period of visual development, older children and adults with amblyopia show poor responses to conventional treatments, lacking effective therapeutic options. Recent basic and clinical research has shown that transcranial direct current stimulation can effectively treat adult amblyopia by altering cortical excitability, enhancing synaptic plasticity, and affecting the excitatory\u002Finhibitory balance in the cortex to reboot adult visual cortex plasticity. This proposed study aims to conduct a large-scale prospective randomized controlled trial to objectively assess the efficacy and safety of transcranial direct current stimulation in treating amblyopia in older adolescents and adults. By comparing changes in best-corrected visual acuity, visual evoked potentials(VEPs), contrast sensitivity, and functional connectivity between the visual cortex and other cortical areas using fMRI, the study seeks to provide robust clinical evidence, clarify the treatment effects of transcranial direct current stimulation in adult amblyopia, elucidate potential mechanisms of enhancing adult visual cortex plasticity with transcranial direct current stimulation, and potentially offer a safe and effective treatment modality for adult amblyopia.",[103],"Amblyopia",[103,105,106,107],"transcranial direct current stimulation(tDCs)","adolescent","treatment","2025-01-06",{"date":110,"type":32},"2025-01-07",{"date":112,"type":32},"2021-01-30",{"date":114,"type":21},"2026-12-30",{"name":38,"class":39},{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":71,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":40},"100569423","application-of-phototherapeutic-keratectomy-mode-to-mark-the-axis-of-astigmatism-100569423","NCT06694051","Application of Phototherapeutic Keratectomy Mode to Mark the Axis of Astigmatism","Inclusion Criteria:\n\n* at least 18 years old\n\nExclusion Criteria:\n\n* ocular disease",{"count":20,"type":21},[24],"Corneal refractive surgery is an effective way to correct refractive error. Modern corneal refractive surgery for the correction of myopia or hyperopia can achieve or close to the expected goal, but to eliminate astigmatism is always one of the major problems of corneal refractive surgery. The key point in the correction of astigmatism is that as a vector parameter, astigmatism has both magnitude and direction. The angle error may be caused by the rotation of the patient's head position and the involuntary rotation of eyes. Phototherapeutic keratectomy can precisely cut the corneal tissue, and is often used in clinic to remove corneal scars or repair corneal surface morphology. In this study, the excimer laser therapeutic keratectomy mode was used to achieve accurate marking of the axis of astigmatism by setting the treatment laser parameters. With the help of the static cyclotorsion of the eye, the precise treatment of astigmatism could realize.",[27],"2024-11-15",{"date":128,"type":32},"2024-11-19",{"date":130,"type":32},"2024-10-01",{"date":132,"type":21},"2025-12-31",{"name":38,"class":39},{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":143,"phases":4,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":40},"100532316","artificial-intelligence-for-screening-of-multiple-corneal-diseases-100532316","NCT06211218","Artificial Intelligence for Screening of Multiple Corneal Diseases","Application of Deep Learning for Screening Multiple Corneal Diseases","Inclusion Criteria:\n\n1. The quality of slit-lamp images should clinical acceptable.\n2. More than 90% of the slit-lamp image area including three main regions (sclera, pupil, and lens) are easy to read and discriminate.\n\nExclusion Criteria:\n\n1）Insufficient information for diagnosis.",{"count":142,"type":21},3000,"OBSERVATIONAL","This study developed a deep learning algorithm based on anterior segment images and prospectively validated its ability to identify corneal diseases.The effectiveness and accuracy of this algorithm was evaluated by sensitivity, specificity, positive predictive value, negative predictive value, and area under curve.",[146,147,148],"Deep Learning","Corneal Disease","Screening","2024-10-31",{"date":151,"type":32},"2024-11-04",{"date":153,"type":32},"2020-12-06",{"date":155,"type":21},"2024-12-06",{"name":38,"class":39},{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":71,"sex":16,"minAge":164,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":172,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":40},"100547264","to-evaluate-the-efficacy-and-safety-of-an-defocus-lens-in-slowing-the-progression-of-myopia-100547264","NCT06405711","To Evaluate the Efficacy and Safety of an Defocus Lens in Slowing the Progression of Myopia","To Evaluate the Efficacy and Safety of an Defocus Lens in Slowing the Progression of Myopia：a Prospective Study","Inclusion Criteria:\n\n* The subjects had spherical RE of -1.00 to -6.00 D, astigmatism ≤ 1.50 D, anisometropia ≤ 1.50 D\n* the best corrected visual acuity in the left and right eyes subjective optometry is greater than or equal to 1.0\n\nExclusion Criteria:\n\n* Candidate subjects were excluded from the study if they had strabismus, ocular limitations, or systemic abnormalities affecting vision and ocular motility","8 Years","13 Years",{"count":167,"type":21},138,[24],"To confirm the efficacy of DIMS lenses in controlling myopia progression, we planned a prospective, single-centre, randomised, double-blind, controlled, non-inferiority clinical study.",[171],"Myopia, Progressive",[173,174,175],"myopia","axial length","defocus","2024-05-05",{"date":178,"type":32},"2024-05-08",{"date":180,"type":21},"2024-05",{"date":182,"type":21},"2026-12",{"name":38,"class":39},""]