[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tishreen University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":229},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,72,97,121,148,179,200],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100641702","clinical-evaluation-of-patient-specific-3d-printed-titanium-implants-for-facial-reconstruction-100641702",false,"NCT07654647","Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.","Evaluation of the Effectiveness of Patient-Specific 3D-Printed Titanium Facial Implants in the Reconstruction and Aesthetic Correction of Facial Defects: A Clinical Study","3DFACE","Inclusion Criteria:\n\n* Age 18 years or older.\n* Presence of facial bone defects resulting from cystic or tumoral osteolytic lesions.\n* Acquired or congenital facial deformities associated with bony defects or facial asymmetry.\n* Patients requiring patient-specific 3D-printed titanium implants for maxillofacial reconstruction.\n* Aesthetic indications requiring custom facial implant design, including microgenia (chin retrusion).\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Active pathological lesions at the time of enrollment.\n* Age below 18 years.\n* History of radiotherapy within 12 months prior to enrollment.\n* Chronic untreated vitamin D deficiency.\n* Uncontrolled diabetes mellitus.\n* Inability or unwillingness to comply with follow-up requirements.","ALL","18 Years","60 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This clinical study aims to evaluate the effectiveness of patient-specific 3D-printed titanium facial implants in the reconstruction and aesthetic correction of facial defects. The study will include patients presenting with congenital, traumatic, or post-surgical facial deformities requiring reconstructive intervention.\n\nEligible participants will undergo preoperative clinical assessment and radiological imaging to design customized implants using computer-aided design (CAD) and 3D printing technology. The implants will be fabricated from medical-grade titanium and surgically placed according to standardized maxillofacial reconstructive protocols.\n\nPostoperative follow-up will assess functional outcomes, implant stability, complication rates, and aesthetic improvement over a defined observation period. Outcome evaluation will include clinical examination and patient-reported satisfaction measures.\n\nThe objective of this study is to determine whether patient-specific 3D-printed titanium implants provide reliable functional restoration and improved aesthetic outcomes in facial reconstruction compared to conventional reconstructive techniques.",[28,29,30,31,32,33],"Hemifacial Microsomia","Mucormycosis","Oral Squamous Cell Carcinoma","Microgenia","Facial Asymmetry","Fibrous Dysplasia",[35],"3D-Printed Titanium Implant * Facial Reconstruction","RECRUITING","2026-06-11",{"date":39,"type":40},"2026-06-17","ACTUAL",{"date":42,"type":40},"2026-04-26",{"date":44,"type":22},"2026-11-01",{"name":46,"class":47},"Tishreen University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100636122","botulinum-toxin-type-a-for-frontal-hyperhidrosis-100636122","NCT07561580","Botulinum Toxin Type A for Frontal Hyperhidrosis","Evaluation of the Efficacy of Botulinum Toxin Type A in the Treatment of Frontal Hyperhidrosis","Inclusion Criteria:\n\n* Patients aged between 18 and 40 years.\n\nClinically and objectively confirmed primary focal frontal hyperhidrosis, defined by sweat production \\>50 mg\u002Fmin and a Hyperhidrosis Disease Severity Scale (HDSS) score ≥3 (moderate to severe).\n\nInadequate response to topical antiperspirant therapy.\n\nNo prior treatment with Botulinum toxin type A within the last 6 months.\n\nNo use of any other hyperhidrosis treatment within the last 3 months.\n\nExclusion Criteria:\n\n* Secondary hyperhidrosis due to systemic conditions such as hyperthyroidism, diabetes mellitus, or neurological disorders.\n\nNeuromuscular disorders including myasthenia gravis or Lambert-Eaton syndrome. Active dermatological conditions or anatomical abnormalities in the frontal region (e.g., infections, inflammation, scars).\n\nKnown hypersensitivity to Botulinum toxin or any of its components. Pregnancy or breastfeeding. Use of medications that may interfere with Botulinum toxin activity (e.g., aminoglycosides) within one month prior to treatment.","40 Years",{"count":21,"type":22},[25],"Frontal hyperhidrosis is a form of primary focal hyperhidrosis that significantly impairs patients' quality of life due to excessive visible sweating in the forehead region. Conventional treatment options often show limited efficacy or may be associated with undesirable side effects.\n\nThis study aims to evaluate the efficacy and safety of intradermal injections of Botulinum Toxin Type A in patients with primary frontal hyperhidrosis. Clinical outcomes will be assessed using Minor's iodine-starch test, the Hyperhidrosis Disease Severity Scale (HDSS), and patient satisfaction scores. Participants will be followed up one month after treatment to evaluate therapeutic response and potential adverse effects.",[61],"Primary Frontal Hyperhidrosis",[63],"Frontal hyperhidrosis, Primary focal hyperhidrosis, Botulinum toxin type A, Intradermal injection, HDSS, Minor's starch iodine test.","2026-04-24",{"date":66,"type":40},"2026-05-01",{"date":68,"type":40},"2025-11-20",{"date":70,"type":22},"2026-11-20",{"name":46,"class":47},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":48},"100600319","effectiveness-of-intraligament-vs-ianb-anesthesia-in-children-using-electronic-syringe-100600319","NCT07095946","Effectiveness of Intraligament vs IANB Anesthesia in Children Using Electronic Syringe","Comparing the Effectiveness of the Intraligament Anesthesia Technique With the Inferior Alveolar Nerve Block Technique Using the Electronic Syringe in Children: A Random Clinical Study","Inclusion Criteria:\n\n* Cooperative children based on Frankl Behavior Rating Scale (Positive or Definitely Positive)\n* No clinical signs or symptoms indicating irreversible pulpitis\n* No periodontal ligament inflammation of the tooth to be treated\n* Children aged between 5 and 9 years\n* Children without systemic health problems\n\nExclusion Criteria:\n\n* Children who are uncooperative based on Frankl Behavior Rating Scale (Negative or Definitely Negative)\n* Presence of spontaneous or nocturnal pain\n* Clinical signs and symptoms indicating irreversible pulpitis\n* Presence of periodontal ligament inflammation of the treated tooth\n* Child age older than 10 years or younger than 3 years\n* Children with systemic health problems",true,"6 Years","10 Years",{"count":21,"type":22},[25],"This randomized clinical study aims to evaluate the efficacy and pain response of two local anesthesia techniques in pediatric dental treatment using an electronic syringe: ligament anesthesia and inferior alveolar nerve block (IANB). The study applies both techniques to the same sample, where each child undergoes pulpectomy for two different teeth, each under the influence of a different anesthesia technique, during two separate visits.\n\nThis study comes in the context of technological advancements in dentistry, which led to the development of computerized syringes as an alternative to traditional syringes. These devices are characterized by precise control of the anesthetic flow rate, as well as containing musical and auditory systems aimed at distracting the child and reducing feelings of fear and anxiety associated with dental treatment. Additionally, computerized syringes provide audible indicators showing the amount of anesthetic injected and support multiple injection modes such as rapid injection, slow injection, and ligament injection, allowing for more efficient and comfortable anesthetic delivery.\n\nPain intensity will be assessed during three stages of the treatment procedure: during anesthesia administration, during placement of the rubber dam, and during opening of the pulp chambers. Post-procedure pain will also be evaluated using an age-appropriate validated pain scale, along with assessing the satisfaction level of both the children and their parents regarding the use of the electronic syringe as an alternative anesthesia tool. These combined measures aim to provide a comprehensive understanding of the child's experience during dental treatment and contribute to improving anesthesia practices in pediatric dentistry.",[86],"Effectiveness of Anesthesia Using Electronic Syringe in Children in the Context of Endotopy Treatment",[88],"Pediatric Dental Anesthesia Pulpitis Pain Management in Pediatric Dentistry Primary Teeth Endodontic Treatment","2026-04-01",{"date":91,"type":40},"2026-04-02",{"date":93,"type":40},"2025-05-28",{"date":95,"type":22},"2026-04-20",{"name":46,"class":47},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":17,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":106,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":48},"100619884","the-effectiveness-of-inhaled-salbutamol-in-the-management-of-transient-tachypnea-of-the-newbornttn-100619884","NCT07350421","The Effectiveness of Inhaled Salbutamol in the Management of Transient Tachypnea of the Newborn(TTN)","Inclusion Criteria:\n\nBirth at the study hospital at a gestational age greater than 35 weeks. Clinical signs of TTN (tachypnea, retractions, grunting, nasal flaring) within the first 6 hours after birth.\n\n\\-\n\nExclusion Criteria:\n\ngestational age is 35 weeks or less. Meconium aspiration syndrome Pulmonary hypertension Congenital pneumonia and sepsis Congenital cardiovascular malformations Congenital thoracic and pulmonary malformations (diaphragmatic hernia, pulmonary hypoplasia, etc.)\n\n\\-","1 Hour","6 Hours",{"count":48,"type":22},[25],"TTN is the most common respiratory disorder in the perinatal period, causing 40% of cases of respiratory distress after birth. Lung fluid absorption is initiated by beta-adrenergic agonists, such as endogenous steroids and Catecholamine, which increase during labor. Delayed absorption of fluid from the lungs is thought to be the primary mechanism of transient tachypnea of the newborn (TTN). The accumulation of fluid within the lungs impairs gas exchange, leading to increased respiratory effort. Tachypnea develops to compensate for this, and hypoxemia develops due to impaired alveolar ventilation . The main objective of the study:\n\nTo study the effectiveness of salbutamol in improving signs of respiratory distress according to the modified Downes score during the first 72 hours of life in infants with transient tachypnea of the newborn (TTN). Secondary objectives:\n\nDuration of tachypnea (time to resolution of respiratory distress) Reducing the duration of the need for oxygen support Reducing the length of hospital stay",[109],"TTN",[109,111],"newboen","NOT_YET_RECRUITING","2026-01-09",{"date":115,"type":40},"2026-01-20",{"date":117,"type":22},"2026-01-01",{"date":119,"type":22},"2028-03-01",{"name":46,"class":47},{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":79,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":129,"targetDuration":4,"studyType":23,"phases":131,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":48},"100613703","evaluation-the-efficacy-of-zinc-on-botulinum-toxin-a-injection-100613703","NCT07270042","Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection","Evaluation of the Efficacy of Zinc on the Duration and Effictiveness of Botulinum Toxin A Injection in the Context of Hyperactive Masseter Muscle (A Prospective Clinical Study)","BTX-A","Inclusion Criteria:\n\nParticipants will be adults aged 18-60 years presenting with clinically confirmed masseteric hypertrophy or hyperactivity, as approved by EMG.\n\nExclusion Criteria:\n\n* Pregnancy or lactation;\n* Patients have aminoglycosides or vit B12.\n* Prior BTX-A treatment to the masseter within the previous 12 months;\n* Neuromuscular disorders or hypersensitivity to BTX-A or zinc compounds;\n* Systemic illness affecting zinc metabolism (e.g., hepatic, renal, or metabolic disorders);\n* Active infection, inflammation, or cutaneous lesions at the injection site.",{"count":130,"type":22},20,[25],"This clinical trial seeks to investigate a promising new approach to enhance the effectiveness and duration of Botulinum Toxin A (BTX-A) for the treatment of hyperactive masseter muscles. By investigating the role of oral zinc supplementation, this study could provide a cost-effective, sustainable solution for patients suffering from both aesthetic concerns and functional limitations associated with MMH and bruxism. The findings of this study will expand the clinical applications of BTX-A, offering longer-lasting relief and reducing the need for frequent injections, which could revolutionize the management of MMH in clinical practice.",[134],"Hyperactive Masseter Muscle",[136,137,138,139],"Masseter Muscle","Botulinum Toxin","zinc","electromyographic (EMG)","2025-11-25",{"date":142,"type":40},"2025-12-08",{"date":144,"type":22},"2025-12-01",{"date":146,"type":22},"2026-12-01",{"name":46,"class":47},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":17,"minAge":156,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":161,"conditions":162,"keywords":167,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":48},"100607293","hall-technique-vs-conventional-crown-restoration-in-permanent-molars-split-mouth-trial-in-children-100607293","NCT07186673","Hall Technique vs Conventional Crown Restoration in Permanent Molars: Split-Mouth Trial in Children","The Effectiveness of Using the Hall Technique in Restoring First Permanent Molars","HTCC-SM","Inclusion Criteria (Clinical):\n\n* No signs or symptoms of irreversible pulpitis\n* Molars with carious lesions affecting two or more surfaces\n* Permanent first molars with developmental defects\n\nInclusion Criteria (Radiographic):\n\n* First molars with an intact dentin layer visible radiographically\n* No signs of internal or external resorption\n* No evidence of periradicular bone resorption\n\nExclusion Criteria:\n\n* Patients with known nickel allergy\n* Severely damaged molars not restorable with preformed crowns\n* First molars without opposing teeth\n* Pulp exposure during caries excavation","8 Years","15 Years",{"count":159,"type":22},10,[25],"The aim of this study is to compare the clinical and radiographic success of stainless steel crowns placed using the Hall Technique versus the conventional method in the restoration of permanent first molars in children, and to evaluate their effects on occlusal relationships, crown adaptation, and patient satisfaction.\n\nStudy Outcomes The primary outcome of this study was to evaluate the clinical and radiographic success of stainless steel crowns placed on permanent first molars using the Hall Technique in comparison to the conventional crown placement method. The secondary outcomes included assessment of the marginal fit and adaptation of preformed crowns using both techniques, analysis of changes in occlusal relationships-specifically the vertical dimension of occlusion and overbite-and evaluation of patient satisfaction. Patient satisfaction was measured using a five-point Likert scale at multiple time points: immediately post-treatment, and at one, three, and six months.",[163,164,165,166],"Permanent Molars","Dental Caries","Tooth Decay","Permanent First Molar Caries",[168,169,170,164],"Hall Technique","Stainless Steel Crowns","Permanent First Molars","2025-11-23",{"date":173,"type":40},"2025-11-28",{"date":175,"type":22},"2025-11",{"date":177,"type":22},"2026-05",{"name":46,"class":47},{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":48},"100605404","etch-bleach-seal-technique-in-managing-opacities-related-mih-using-icon-100605404","NCT07162077","Etch-bleach-seal Technique in Managing Opacities Related MIH Using Icon®","The Effectiveness of Sodium Hypochlorite Application in Managing Opacities of Molar-incisor Hypomineralization on Incisors Using Resin Infiltration","Inclusion Criteria:\n\n* Patients diagnosed with MIH-related opacities on the incisal and middle thirds of the buccal surface of their permanent incisors, ac- cording to EAPD diagnostic criteria of (MIH), only isolated lesions will be selected.\n\nExclusion Criteria:\n\n* Teeth with resin composite restorations, previously treated by exter- nal bleaching, micro-abrasion or re-mineralization(fluoride varnish or calcium-based products such asCPP-ACP) will be excluded.\n* Opacities present only on incisors without molar\n* WSLs caused by orthodomtic treatment\n* Teeth affected by dental fluorosis, Amelogenesis imperfecta and Tetracycline-pigmented teeth",{"count":187,"type":22},24,[25],"Objectives: to compare aesthetic effectiveness of resin infiltration with\u002Fwithout using sodium hypochlorite in managing opacities of MIH on incisors, and to compare parent's satisfaction with results of both application protocols.\n\nMethods: Twenty-four teeth with yellow\u002F brown opacities of MIH, will be diagnosed according to EAPD diagnostic criteria, will be randomly allocated to test or control group. In the test group, the investigators will be applied sodium hypochlorite 5.25% by using cotton wad before treatment, then after the first and second etching cycles (application of the Icon-Etch (ICON® -Etch; DMG, Hamburg, Germany) and Icon-dry (ICON® -Dry; DMG, Hamburg, Germany) according to the manufacturer's recommendations) as irrigation step and following the third -Etch etching cycle Icon-infiltrant (ICON® -Infiltrant; DMG, Hamburg, Germany) will be applied . In control group, the investigators will be applied the same protocol of test group but without using sodium hypochlorite. The masking efficacy will be analyzed using the Lab System to calculate the color difference (ΔE) between the opacity and the adjacent enamel in Adobe Photoshop 2024. The infiltration proportion of opacity will be measured using Image J software and the infiltrated area will be expressed as a percentage. The satisfaction of the parents with the results of both application protocols will be compared using Likert scale.",[191],"Molar Incisor Hypomineralisation","2025-09-07",{"date":194,"type":40},"2025-09-09",{"date":196,"type":40},"2025-08-25",{"date":198,"type":22},"2026-10",{"name":46,"class":47},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":79,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":213,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":4},"100600574","a-comparative-clinical-study-to-evaluate-crowns-designed-by-artificial-intelligence-versus-crowns-designed-traditional-design-software-100600574","NCT07099261","A Comparative Clinical Study to Evaluate Crowns Designed by Artificial Intelligence Versus Crowns Designed Traditional Design Software","A Comparative Clinical Study to Evaluate Crowns Designed by Artificial Intelligence Versus a Crowns Designed Traditional Design Software","AI","Inclusion Criteria:\n\n* Patients aged 18-60 years requiring a crown for a lower first molar\n* Good oral and gingival health\n* adjacent teeth in good condition\n* Natural opposing teeth\n* Willingness to participate and sign informed consent\n\nExclusion Criteria:\n\n* Abnormal occlusal habits such as bruxism\n* Active periodontal diseases\n* Allergy to crown materials (e.g., polymethyl methacrylate, PMMA)\n* Poor oral hygiene",{"count":159,"type":22},[25],"This clinical research aims to Evaluate Crowns Designed by Artificial Intelligence Versus Crowns Designed by Traditional Design Software\n\nThe research will be conducted on a sample of patients with an indication for crowning of the first lower molar. Ten dental crowns will be prepared.\n\nAfter obtaining written consent from patients who meet the inclusion and exclusion criteria, 10 dental crowns will be prepared. Measurements will be taken using silicone impressions and then converted into digital format.\n\nThe digital impression will be sent to the selected dental restoration design software used in the study. The same parameters will be adjusted in all software programs for each crown.\n\nAfter the design is completed, the designs will be sent to the milling unit. For each case, three crowns will be designed and milled from polymethyl methacrylate (PMMA).\n\nThe crown will be clinically examined and evaluated according to specific criteria. Marginal fit, proximal contact quality, and occlusion will be assessed.\n\nThe best crown will be milled from zirconia and delivered to the patient.",[212],"Dental Crown",[214,215,216,217,218,219,220],"Crowns","Crowns Designed by Artificial Intelligence","Artificial intelligence(AI)","CAD","CAD\\CAM","computer-aided design and computer-aided manufacturing","prosthesis","2025-07-25",{"date":223,"type":40},"2025-08-01",{"date":225,"type":22},"2025-10-01",{"date":227,"type":22},"2026-09-01",{"name":46,"class":47},""]