[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tomas Bata Hospital, Czech Republic\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":141},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,88,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100628144","postoperative-pain-and-analgesic-use-after-total-knee-arthroplasty-100628144",false,"NCT07457814","Postoperative Pain and Analgesic Use After Total Knee Arthroplasty","Postoperative Pain and Analgesic Consumption in Patients Undergoing Total Knee Arthroplasty Under General Anesthesia With Peripheral Nerve Block Versus Spinal Anesthesia With Peripheral Nerve Block","Inclusion Criteria:\n\n* Age 18-100 years\n* Primary total knee arthroplasty (TKA)\n* ASA physical status I-III\n* Glasgow Coma Scale (GCS) score of 15\n* Ability to understand study procedures and provide informed consent\n* Ability to cooperate during pre-anesthetic evaluation\n* No severe sensory impairment (e.g., blindness, deafness)\n\nExclusion Criteria:\n\n* Revision or reoperation of TKA\n* ASA score IV or higher\n* Refusal to participate or inability to provide informed consent\n* GCS ≤ 14\n* Limited legal capacity\n* Active psychiatric disorder\n* Chronic use of strong opioid analgesics\n* Neurological disease affecting pain perception or cooperation\n* Cognitive impairment or language barrier preventing questionnaire completion\n* Use of anesthesia techniques other than GA + PNB or SA + PNB (e.g., epidural anesthesia, local infiltration without PNB)",true,"ALL","18 Years","100 Years",{"count":21,"type":22},50,"ESTIMATED","OBSERVATIONAL","This prospective observational study evaluates postoperative pain intensity and analgesic consumption in patients undergoing total knee arthroplasty (TKA) under different anesthesia techniques. Patients receive either general anesthesia with peripheral nerve block, spinal anesthesia with peripheral nerve block, spinal anesthesia alone, or general anesthesia with an epidural catheter. Pain scores (NRS), analgesic use, adverse effects, patient satisfaction, and the need for therapeutic interventions are assessed during the first 48 hours after surgery. The study aims to identify differences in postoperative pain control and factors associated with hypotension and other complications.",[26,27,28],"Postoperative Pain After Total Knee Arthroplasty","Postoperative Pain","Analgesic Consumption",[30,27,31,28,32,33,34,35,36],"Total Knee Arthroplasty","Anesthesia Techniques","Epidural Analgesia","Opioid Use","General Anesthesia","Spinal Anesthesia","Pain Management","NOT_YET_RECRUITING","2026-03-04",{"date":40,"type":41},"2026-03-09","ACTUAL",{"date":43,"type":22},"2026-03-01",{"date":45,"type":22},"2027-06-15",{"name":47,"class":48},"Tomas Bata Hospital, Czech Republic","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":16,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":61,"conditions":62,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},"100626159","orthopedic-procedures-and-postoperative-delirium-in-older-adults-in-the-czech-republic-100626159","NCT07432009","Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic","Orthopedic Procedures and Postoperative Delirium in the Czech Republic","ORTOPODCZ","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Elective total hip arthroplasty in general or regional anesthesia\n* ASA physical status I-III\n* Ability to understand and cooperate during testing; no severe sensory impairment (compensatory aids allowed)\n* Expected postoperative hospitalization in ICU, PACU, or standard ward\n\nExclusion Criteria:\n\n* Glasgow Coma Scale ≤ 14\n* Limited legal capacity\n* Active psychiatric disorder (e.g., psychotic disorder, bipolar disorder)\n* Active oncological disease\n* Chronic use of strong opioids\n* Premedication with anxiolytics or antipsychotics during preanesthetic evaluation\n* Acute reoperation within 3 months of primary surgery\n* Refusal to participate or withdrawal of consent","65 Years",{"count":60,"type":22},400,"This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total hip arthroplasty in the Czech Republic. Postoperative delirium is a frequent and serious neurocognitive complication in senior surgical patients and is associated with increased morbidity, mortality, prolonged hospitalization, and impaired functional and cognitive outcomes. Despite international recommendations, routine preoperative cognitive screening remains insufficiently implemented.\n\nThe study evaluates the predictive value of the ALBA test, a brief cognitive screening tool, performed during the pre-anesthetic assessment. Postoperative delirium will be assessed using the validated CAM-ICU instrument for up to 72 hours after surgery. Secondary objectives include assessing the relationship between POD and frailty, polypharmacy, comorbidities, type of anesthesia, intraoperative hemodynamics, blood loss, vasoactive support, and postoperative complications.\n\nApproximately 300-400 participants aged ≥65 years will be enrolled across seven centers. No additional procedures, biological sampling, or deviations from standard clinical care are required. Data will be collected in REDCap and analyzed according to a predefined statistical analysis plan. The study aims to provide robust evidence supporting the integration of cognitive screening into routine preoperative evaluation and to describe feasibility and implementation requirements for the ALBA test in clinical practice.",[63,64,65,66,67],"Frailty","Cognitive Impairment","Older Adults","Hip Arthroplasty","Postoperative Delirium",[69,70,71,72,73,74,75,76,77,78],"ALBA test","CAM-ICU","Cognitive Screening","Geriatric Patients","Perioperative Neurocognitive Disorders","Polypharmacy","Clinical Frailty Scale","Total Hip Replacement","Observational Study","Prospective Cohort","2026-02-24",{"date":81,"type":41},"2026-02-25",{"date":83,"type":22},"2026-04-01",{"date":85,"type":22},"2030-03-31",{"name":47,"class":48},7,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":49},"100594650","incidence-of-hypotension-in-the-post-anesthesia-care-unit-pacu-100594650","NCT07022210","Incidence of Hypotension in the Post-anesthesia Care Unit (PACU).","Inclusion Criteria:\n\n* patients over 18 years old\n* patients undergoing a procedure under general anesthesia\n* patients who have consented to data processing\n* postoperative stay in PACU\n\nExclusion Criteria:\n\n* patients younger than 18 years old.\n* patients transferred directly to the ICU\u002FAnesthesiology and Resuscitation Department after surgery without staying in the recovery room.\n* patients with incomplete medical documentation or missing blood pressure values in the recovery room.\n* patients with a pre-existing diagnosis of resistant hypotension or unstable hemodynamics before surgery\n* patients with a history of long-term use of anxiolytics, antipsychotics, or other psychotropic medications that may affect cognitive function, emotional state, or predictive outcomes\n* patient refusal to participate in the study (including cases where they initially consented), with an emphasis on respecting patient autonomy","105 Years",{"count":96,"type":22},100,"The perioperative period poses a heightened risk of complications for patients, including hypotension. While the issue of intraoperative hypotension is well-documented in medical literature, the occurrence and causes of hypotension in the post-anesthesia care unit often receive less attention. This phase of postoperative care, however, is vital for ensuring patient stability and preventing severe consequences. Failure to identify and manage a drop in blood pressure can lead to hypoperfusion of critical organs, increasing the risk of morbidity and mortality. The aim of this study is to examine the frequency of hypotension in the post-anesthesia care unit-defined as systolic blood pressure \\\u003C90 mmHg or a drop of more than 20% from baseline-and to identify factors contributing to its development.",[99,100],"Hypotension During Surgery","Surgery-Complications",[102,103,104,105],"hypotension","post-anesthesia care unit","surgery","adult","RECRUITING","2025-07-06",{"date":109,"type":41},"2025-07-10",{"date":111,"type":41},"2025-06-15",{"date":113,"type":22},"2026-05-01",{"name":47,"class":48},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":49},"100584998","urinary-infection-and-colonization-in-bone-procedures-100584998","NCT06896643","Urinary Infection and Colonization in Bone Procedures","Inclusion Criteria:\n\n* Age over 65 years, including\n* Elective or acute trauma\u002Forthopedic bone surgery\n* Urine examination as part of pre-anesthetic examination, urine + sediment, in case of suspicion - bacteriological examination\n* Signed informed consent for research as part of pre-anesthetic examination (I or II), respecting informed consent as an expression of the patient's \"free will\"\n\nExclusion Criteria:\n\n* Negative finding in urine: chemical examination + sediment preoperatively\n* Respondent under the influence of premedication, alcohol, or drugs\n* Sensory impairment (blindness)\n* Delirious preoperative state\n* Severe mental disorder\n* Sopor\n* coma\n* Septic state\n* Acute respiratory failure\n* Disagreement with participation in the study",{"count":122,"type":22},80,"For seniors aged 65 and over (inclusive) undergoing surgical procedures (bone surgery, traumatology, orthopedics) in an acute or elective setting, the relationship between preoperative urinary tract infection\u002Fcolonization (within 30 days before the procedure) and the occurrence of predefined postoperative complications (monitoring during the patients' hospitalization) will be observed",[125,126,127,63],"Urinary Tract Infection","Complications","Urinary Tract Infection (Diagnosis)",[129,130,131,132,133],"urinary","tract","infection","colonization","postoperative complications",{"date":135,"type":41},"2025-07-08",{"date":137,"type":41},"2025-06-01",{"date":139,"type":22},"2026-06-01",{"name":47,"class":48},""]