[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Toronto Metropolitan University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":194},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,80,105,134,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100630971","the-role-of-solo-music-listening-in-reducing-loneliness-and-increasing-social-connectedness-in-older-adults-100630971",false,"NCT07494604","The Role of Solo Music Listening in Reducing Loneliness and Increasing Social Connectedness in Older Adults","Inclusion Criteria:\n\n* Over the age of 70\n* Access to internet\n\nExclusion Criteria:\n\n* Cognitive Impairment\n* Self-reported hearing loss","ALL","70 Years",{"count":18,"type":19},120,"ESTIMATED","INTERVENTIONAL",[22],"NA","Loneliness has become an increasingly prevalent concern among older adults. A number of adverse physical and mental health outcomes may result from loneliness in this age group including cognitive decline and depression. These outcomes may lead to a higher strain on healthcare systems. Finding accessible and cost-effective strategies for reducing loneliness and increasing feelings of social connectedness is important for the well-being of older adults. Solo music listening is commonly used to regulate emotions and to promote well-being. While some preliminary evidence suggests that these benefits may extend to loneliness, research has not been clear on the functions or qualities of music that are most effective for older adults. This research project will consist of two parts. In Part 1, an interview will be conducted with older adults to determine what functions of music are most often used and most beneficial when their goal is to reduce loneliness. Part 2 will consist of a between-subjects experiment with four conditions. The top three characteristics obtained from Part 1 will represent the three music conditions, and the fourth condition will be a pink-noise control. Prior to the experiment, participants will self-select three pieces from each of the three music conditions. After selecting their music, they will be randomly assigned to either a music or pink-noise condition. Participants in the three music conditions will listen to the three self-selected pieces that adhere to their assigned condition. Loneliness and social connection outcomes will be assessed before and after listening using a Visual Analogue Scale (VAS). Potential moderators will be assessed after listening, which include nostalgia, absorption in music, and music reward. The results of this project will clarify whether psychological benefits of decreased loneliness and increased social connectedness can be found through music listening to enhance well-being, and whether singing along provides additional benefits. These findings may also be useful in developing future music-based interventions for reducing loneliness.",[25,26,27],"Loneliness","Social Connectedness","Music Listening Intervention",[29,30,31,32,33,34],"music","loneliness","social conectedness","older adults","aging","music listening","NOT_YET_RECRUITING","2026-03-20",{"date":38,"type":39},"2026-03-27","ACTUAL",{"date":41,"type":19},"2026-03-15",{"date":43,"type":19},"2027-12-20",{"name":45,"class":46},"Toronto Metropolitan University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":15,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":20,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":47},"100610712","interaction-between-dairy-and-gut-hormone-response-on-cognitive-performance-in-children-100610712","NCT07231146","Interaction Between Dairy and Gut Hormone Response on Cognitive Performance in Children.","Interaction Between Milk and Yogurt and Gastrointestinal Hormone Response on Cognitive Performance in School-Aged Children","Inclusion Criteria:\n\n* 9 to 14 years of age;\n* Normal weight is defined as being between the 5th and 85th percentile for age and biological sex at birth according to the Centers for Disease Control growth reference charts\n\nExclusion Criteria:\n\n* Children with overweight\u002F obesity;\n* Children with food sensitivities or allergies to dairy, gluten or any foods used in the study;\n* Children with any diagnosed learning, emotional, or behavioural disabilities;\n* Children taking any medications that may influence cognitive performance.",true,"9 Years","14 Years",{"count":59,"type":19},48,[22],"The purpose of this study is to investigate the short-term effects of milk and yogurt of varying fat and protein content on cognitive performance in healthy children aged 9 - 14 years; and to provide insight into mechanisms by which dairy consumption may affect cognitive performance through gastrointestinal (GI) hormone responses. The investigators hypothesize that the consumption of dairy products, specifically their protein and fat components, will improve cognitive performance via its interaction with the gut-brain axis in children. Furthermore, the investigators hypothesize that all milk and yogurt products will enhance cognitive performance over 120- mins compared to snack skipping through its interaction with GI hormones, with a greater effect in higher fat containing milk and yogurt products.",[63,64],"Children","Healthy",[66,67,68,69,70],"Cognitive Performance","Dairy","Gastrointestinal Hormones","Emotions","Mood","RECRUITING","2025-12-02",{"date":74,"type":39},"2025-12-09",{"date":76,"type":39},"2025-11-15",{"date":78,"type":19},"2027-10",{"name":45,"class":46},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":55,"sex":15,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":20,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":104,"locationsCount":47},"100610697","interaction-between-white-potato-consumption-and-meal-timing-on-glycemic-response-and-appetite-in-adults-100610697","NCT07230951","Interaction Between White Potato Consumption and Meal Timing on Glycemic Response and Appetite in Adults","Interaction Between White Potato Consumption and Meal Timing on Glycemic Response, Subjective Appetite, and Energy Intake in Adults.","Inclusion Criteria:\n\n* 18 - 65 years\n* within the healthy body weight range \\[body mass index (BMI) between 18.5 - 24.9 kg\u002Fm2\\].\n\nExclusion Criteria:\n\n* have a previous diagnosis of diabetes and gastrointestinal, liver or kidney disease;\n* have had a major medical or surgical event within the past 6 months;\n* have had any significant weight fluctuation in the past 6-months;\n* are taking medication that may influence dependent measures;\n* are or have been on a diet within the past 6 months;\n* skip breakfast or are unable to consume test treatment food.","18 Years","65 Years",{"count":90,"type":19},30,[22],"The purpose of this study is to evaluate the interaction between white potato consumption and meal timing on glycemic response, subjective appetite, and energy intake in adults. The investigators hypothesize that white potatoes will modulate glycemic response, enhance satiety, and mitigate subsequent meal consumption and overall food intake when compared with meals containing low glycemic carbohydrates. Furthermore, they anticipate that the timing of white potato consumption will yield differential effects, with breakfast consumption exerting a more pronounced impact on satiety and subsequent food intake reduction compared to dinner consumption.",[64,94,95,96,97],"Adult","Appetite","Glycemic Response","Mealtiming","2025-11-13",{"date":100,"type":39},"2025-11-17",{"date":102,"type":39},"2025-10-30",{"date":78,"type":19},{"name":45,"class":46},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":15,"minAge":112,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":20,"phases":115,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},"100560722","benefits-of-choir-for-older-adults-with-unaddressed-hearing-loss-wp2-100560722","NCT06580847","Benefits of Choir for Older Adults With Unaddressed Hearing Loss (WP2)","Speech-in-noise, Psychosocial, and Heart Rate Variability Outcomes of Group Singing or Audiobook Club Interventions for Older Adults With Unaddressed Hearing Loss: a SingWell Project Multisite, Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Adults aged 60 years and older;\n2. Bilateral mild-to-moderate hearing loss (20-49 dB hearing level), measured using four-frequency pure-tone average across both ears (4FPTA) measured at 500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz;\n3. Unaddressed hearing loss (i.e., participants must not currently use a hearing aid, cochlear implant, or assistive listening device);\n4. No significant cognitive impairment, to be assessed with the Montreal Cognitive Assessment for people with hearing impairment (MoCA-H), with participants requiring a score ≥ 24;\n5. Not use a pacemaker or anti-arrhythmic agents\u002Fmedications;\n6. Not currently participating in regular active music learning (e.g., choir, formal music training) or audiobook clubs within the last year; and\n7. Sufficient language capacity to understand and complete the test materials. Note: all materials will be presented written and\u002For aurally in English at the sites located in Canada, United States of America, and Australia; Dutch at the Netherlands site; and German at the Germany site.","60 Years",{"count":114,"type":19},210,[22],"Unaddressed age-related hearing loss is highly prevalent among older adults, typified by negative consequences for speech-in-noise perception and psychosocial wellbeing. There is promising evidence that group singing may enhance speech-in-noise perception and psychosocial wellbeing. However, there is a lack of robust evidence, primarily due to the literature being based on small sample sizes, single site studies, and a lack of randomized controlled trials. Hence, to address these concerns, this SingWell Project study utilizes an appropriate sample size, multisite, randomized controlled trial approach, with a robust preplanned statistical analysis.\n\nThe objective of the study is to explore if group singing may improve speech-in-noise perception and psychosocial wellbeing for older adults with unaddressed hearing loss.\n\nThe investigators designed an international, multisite, randomized controlled trial to explore the benefits of group singing for adults aged 60 years and older with unaddressed hearing loss. After undergoing an eligibility screening process and completing an information and consent form, the investigators intend to recruit 210 participants that will be randomly assigned to either group singing or an audiobook club (control group) intervention for a training period of 12-weeks. The study has multiple timepoints for testing, that are broadly categorized as macro (i.e., pre- and post-measures across the 12-weeks), or micro timepoints (i.e., pre- and post-measures across a weekly training session). Macro measures include behavioural measures of speech and music perception, and psychosocial questionnaires. Micro measures include psychosocial questionnaires and heart-rate variability.\n\nThe investigators hypothesize that group singing may be effective at improving speech perception and psychosocial outcomes for older adults with unaddressed hearing loss-more so than participants in the control group.",[118,119,120],"Hearing Loss, Age-Related","Speech Intelligibility","Psychosocial Functioning",[122,123,124],"Hearing loss","speech in noise","psychosocial wellbeing","2025-09-13",{"date":127,"type":39},"2025-09-18",{"date":129,"type":39},"2025-04-15",{"date":131,"type":19},"2026-09",{"name":45,"class":46},7,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":142,"minAge":87,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":20,"phases":145,"briefSummary":146,"conditions":147,"keywords":150,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":168},"100551695","cognitive-processing-therapy-to-treat-ptsd-and-sexually-transmitted-infections-among-men-who-have-sex-with-men-100551695","NCT06463431","Cognitive Processing Therapy to Treat PTSD and Sexually Transmitted Infections Among Men Who Have Sex With Men","A Trial for An Integrated Cognitive Behavioural Therapy to Treat PTSD and Sexually Transmitted Infections Among Gay, Bisexual, and Other Men Who Have Sex With Men","CPT-T","Inclusion Criteria:\n\n* Live in Ontario or Quebec (able to travel to Toronto Metropolitan University or CLSC de Cote-des-Neiges, respectively)\n* Identify as a man\n* Are over 18 years of age\n* Have had anal sex without a condom with a person assigned male at birth in the past 3 months\n* Have experienced symptoms consistent with a diagnosis of PTSD\n* Are able to read, speak, and understand English\n\nExclusion Criteria:\n\n* if a 14-session protocol is deemed inappropriate for their treatment needs (e.g., psychotic or bipolar disorders not well-managed by medications)\n* if either our assessors or therapists identify that a participant's ability to respond to study measures is compromised by mental or physical disabilities or inability to speak and understand English","MALE",{"count":144,"type":19},56,[22],"Gay, bisexual, queer, and other men who have sex with men (GBM) continue to bear a disproportionate burden of the sexually transmitted and blood-borne infections (STBBI), largely attributable to efficient transmission during condomless anal sex (CAS; Baggaley et al., 2010). In 2022, GBM accounted for 38.1% of new HIV diagnoses in Canada (Public Health Agency of Canada, 2023). Incidence of syphilis, chlamydia and gonorrhea have risen among men who have sex with men (MSM), especially among HIV+ GBM living in Canadian urban centres, including Toronto and Quebec (Public Health Agency of Canada, 2022). Post-traumatic stress disorder prevalence is also higher among GBM than among heterosexual men (Roberts et al., 2010). Post-traumatic stress disorder (PTSD) is a risk factor for CAS and related STBBI among GBM (O'Cleirigh, 2019). Despite the strong association between PTSD and STBBI risk among GBM, no studies have examined the efficacy of PTSD treatment on STBBI risk among GBM. PTSD may also increase substance use in sexual situations, another risk factor for STBBIs among GBQM (Semple et al., 2011; Elkington et al., 2010). Substance use tends to follow PTSD because alcohol and other substances are often used to self-medicate trauma symptoms (as an avoidant coping strategy) in interpersonal situations (Tan et al., 2021). Alcohol and substance use in sexual situations are consistent risk factors for CAS among Canadian GBQM (Lambert et al., 2011), and are associated with higher HIV incidence. Due to consistent data linking substance use to STBBI risk, it has been suggested that incorporating alcohol and substance use treatment into sexual risk reduction counselling (Koblin et al., 2006; Parsons et al., 2005; Shoptaw \\& Frosch, 2000) may increase the efficacy of STBBI prevention efforts for GBQM. PTSD is highly treatable via cognitive-behavioural therapies, including by Cognitive Processing Therapy (CPT; Benight \\& Bandura, 2004; Monson \\& Shnaider, 2014; Watkins et al., 2018).\n\nThe present study will provide preliminary feasibility and acceptability data for a novel and innovative STI\u002FHIV prevention intervention for GBQM. This intervention builds upon empirically supported treatments for PTSD, including PTSD-related substance use, by adding risk reduction counselling to reduce sexually transmitted infections (STI) and HIV sexual risk behaviour. The present study will provide trial data for a novel and innovative STBBI prevention psychotherapy for GBM that could be administered by mental health providers across Canada. The intervention will consist of 14 90-minute sessions of an integrated cognitive-behavioural approach using CPT to treat PTSD and to reduce STBBI risks among GBQM. The primary outcome will be condomless anal sex with casual partners. The secondary outcomes will be PTSD prevalence, trauma symptoms, problematic substance use, sexual risk, and PTSD-related avoidance of negative thoughts and feelings.\n\nThis psychotherapy intervention will build upon empirically supported interventions to reduce HIV risk.",[148,149],"Stress Disorders, Post-Traumatic","Sexually Transmitted Infection (STI) Prevention",[151,152,153,154,155,156,157,158,159],"Cognitive Processing Therapy","men who have sex with men","gay bisexual queer men","gay men","post traumatic stress disorder","Cognitive Behavioral Therapy","sexually transmitted blood borne infections","sexual risk","prevention","2025-02-07",{"date":162,"type":39},"2025-02-11",{"date":164,"type":19},"2025-03-31",{"date":166,"type":19},"2026-08",{"name":45,"class":46},2,{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":55,"sex":15,"minAge":177,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":20,"phases":181,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":47},"100531523","self-care-training-for-family-caregivers-of-persons-with-neurodegeneration-100531523","NCT06200909","Self-Care Training for Family Caregivers of Persons With Neurodegeneration","Caring for the Family Caregiver: Testing the Effect of Two Wellness Programs That Support the Well-being of Family Caregivers of Persons With Neurodegenerative Disorders","MCP","Inclusion Criteria:\n\n* 50+ years of age\n* Currently a primary family caregiver\n* Fluent in English\n\nExclusion Criteria:\n\n* Existing mindfulness practice\n* Diagnosed\u002FPresenting with Post-traumatic Stress Disorder; Substance Disorder; Psychosis\n* Unable to attend 8 sessions\n* No access to a computer or high-speed internet\n* Not willing to be randomized","50 Years","100 Years",{"count":180,"type":19},232,[22],"The purpose of this study is to assess whether an 8-week mindfulness program enhances psychological well-being (e.g., stress, depressive symptoms), biological indicators of stress (e.g., inflammation), and cognitive function (e.g., attentional ability) in primary family caregivers of persons with dementia or a related neurodegenerative disease. A total of 232 primary family caregivers aged 50+ years of age will be recruited for this study and randomized to one of three groups: mindfulness meditation (MM), psychoeducation (PSY) or caregiver respite (CR). All participants will complete three testing sessions: baseline (pre-intervention \\[T1\\]), post 8-week follow-up (post-intervention, \\[T2\\]), and 12-month follow-up (T3).",[184,185],"Caregiver Burden","Caregiver Stress","2024-04-08",{"date":188,"type":39},"2024-04-10",{"date":190,"type":19},"2024-06",{"date":192,"type":19},"2028-09",{"name":45,"class":46},""]