[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tribhuvan University Teaching Hospital, Institute Of Medicine.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":106},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100636039","phase-4-optimal-intrathecal-morphine-dose-for-better-post-cesarean-section-analgesia-100636039",false,"NCT07560501","Optimal Intrathecal Morphine Dose for Better Post Cesarean Section Analgesia","Comparison of Postoperative Analgesia With Different Doses of Intrathecal Morphine With Hyperbaric Bupivacaine and Fentanyl in Cesarean Section Patients: A Randomized Controlled Trial","Analgesia","Inclusion Criteria:\n\n* Pregnant lady \\> 36 weeks of gestation presenting for cesarean section under spinal anesthesia\n* ASA II\u002F III\n* Maternal Height \\> 150 cm\n* BMI\\\u003C 40 Kg\u002Fm2\n* Elective Indication\n\nExclusion Criteria:\n\n* Patient unwilling to take part in the study\n* Patient with known allergy to the study medications\n* Contraindication to Spinal Anesthesia","FEMALE","18 Years","45 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Central neuraxial blocks (CNBs) remain the preferred anesthetic technique for cesarean section, with single shot spinal anesthesia (SSSA) being the standard practice at investigator's institute unless contraindicated. SSSA offers reliable intraoperative anesthesia and provides a few hours of postoperative analgesia. Enhanced recovery after cesarean section protocol has recommended the addition of intrathecal (IT) morphine to improve the postoperative quality of the recovery profile. Fentanyl improves the quality of intraoperative analgesia, while morphine significantly prolongs the postoperative pain relief, often lasting up to 24 hours.\n\nRoutine uterine exteriorization, practiced in all cases at investigator's institute, often results in peritoneal stretching pain during surgery. This visceral pain is managed with 10 mcg intrathecal fentanyl added to hyperbaric bupivacaine. For postoperative pain management, the intrathecal morphine is recommended by many guidelines and studies. Intrathecal morphine dose typically ranges from 50 to 300 mcg. The dose of morphine exceeding 150 mcg are usually associated with prolongation of analgesia with higher incidence of side effects like nausea, vomiting and pruritus. In selected cases, investigator had administered morphine 100-150 mcg and the clinical experience has shown reduced postoperative analgesic requirements and favorable recovery profile, with minimal adverse effects.\n\nDespite these promising experiences and extensive literature on IT morphine, their is still lack formal data on the efficacy and safety profile of IT morphine in cesarean section patient. This comparative study will help institute to find the optimum dose of IT morphine with better postoperative analgesia quality with low side effects profile. The finding could serve as a foundation to promote routine use of intrathecal morphine in cesarean section anesthesia at investigator's institute.",[28],"Post Cesarean Section Pain",[15,30,31,32],"Cesarean section","Intrathecal Morphine","Postoperative pain","NOT_YET_RECRUITING","2026-04-27",{"date":36,"type":37},"2026-05-01","ACTUAL",{"date":39,"type":22},"2026-04-01",{"date":41,"type":22},"2026-12-28",{"name":43,"class":44},"Tribhuvan University Teaching Hospital, Institute Of Medicine.","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":70,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},"100601981","phase-4-d-fab-pour-trial-dexmedetomidine-vs-fentanyl-as-adjuvants-to-bupivacaine-on-postoperative-urinary-retention-100601981","NCT07117565","D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary Retention","Comparison of Intrathecal Dexmedetomidine Versus Intrathecal Fentanyl as Adjuvants to Bupivacaine on Post-Operative Urinary Retention in Lower Limb Surgery","D-FAB-POUR","Inclusion Criteria:\n\n* Adults aged 18 to 60 years\n* Scheduled for elective lower limb surgery under spinal anesthesia\n* Classified as American Society of Anesthesiologists (ASA) physical status II or III\n* Minimum height of 150 cm (to ensure uniform drug volume)\n* Able to understand the study procedures and provide written informed consent (in English or Nepali)\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (e.g., coagulopathy, infection at injection site, hemodynamic instability)\n* Known allergy or hypersensitivity to bupivacaine, fentanyl, or dexmedetomidine\n* Chronic pain conditions or long-term opioid use\n* Neurological, Cardiac, Renal, or uncontrolled diabetic conditions\n* Current treatment for prostatic pathology or use of alpha-2 blockers\n* Presence of a Foley's catheter preoperatively\n* Estimated surgical duration: \\>2.5 hours\n* Inability or unwillingness to provide informed consent",true,"ALL","60 Years",{"count":57,"type":22},190,[25],"This study aims to compare two medications, dexmedetomidine and fentanyl, when used alongside a commonly used spinal anesthetic called bupivacaine in patients undergoing lower limb surgery. The main focus of the study is to see which combination causes fewer problems with urination after surgery - a condition known as postoperative urinary retention (POUR). POUR can lead to discomfort, delayed recovery, and a need for catheterization. Dexmedetomidine is a newer drug that may help reduce this problem compared to fentanyl, which is more commonly used but may increase the risk of urinary retention. This trial will help determine which medication combination provides better pain relief while reducing urinary side effects. The study is being conducted as a randomized, double-blind trial at a hospital in Nepal and will include 190 adult patients.\n\n\\-",[61,62,63,64,65,66,67,68,69],"Spinal Anesthesia","Postoperative Complications","Dexmedetomidine","Fentanyl","Anesthesia, Spinal","Bupivacaine","POUR","Orthopedic Surgery","Urinary Retention Postoperative",[71,72,73,63,64,74],"Postoperative urinary retention","Spinal anesthesia","Intrathecal adjuvants","Perioperative complications","2025-08-09",{"date":77,"type":37},"2025-08-12",{"date":79,"type":22},"2025-09-15",{"date":81,"type":22},"2026-11-25",{"name":43,"class":44},1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":4},"100600231","phase-4-comparison-of-intrathecal-bupivacaine-with-and-without-morphine-for-post-operative-analgesia-in-parturients-undergoing-elective-cesarean-section-a-randomized-controlled-trial-100600231","NCT07094802","Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Parturients undergoing elective caesarean section under Spinal anesthesia\n* ASA PS II, III\n* \\> 18 years\n\nExclusion Criteria:\n\n* Refusal to Participate\n* Contraindications to spinal anaesthesia and adjuvants INR ≥ 1.5 Plateletes \\\u003C 1,00,000\u002Fcumm Severe aortic stenosis, and\u002For severe mitral stenosis Infection at lumbar puncture site Known allergy to local anesthetics and opioids\n* Communication barrier\n* Height \\\u003C150 cm",{"count":91,"type":22},92,[25],"The goal of this clinical trial is to compare intrathecal bupivacaine with or without morphine for postoperative analgesia in patients undergoing elective cesarean section. The main questions it aims to answer are:\n\nIs intrathecal bupivacaine with morphine superior to intrathecal bupivacaine alone for postoperative analgesia for parturients undergoing cesarean section? What is the duration of analgesia in the two groups? Researchers will compare drug intrathecal bupivacaine with morphine to a iintrathecal bupivacaine alone to see if intrathecal morphine has benefits for psotoperative analgesia .\n\nParticipants will:\n\nGet intrathecal bupivacaine with Morphine or intrathecal bupivacaine alone during spinal anesthesia for cesarean section.\n\nThey will be followed up for NRS pain scores and side effects for 24 hours. Time to need of first rescue analgesic will be noted",[95,96,97],"Postoperative Pain","Cesarean Delivery","Analgesia, Obstetrical","2025-07-23",{"date":100,"type":37},"2025-07-30",{"date":102,"type":22},"2025-10-15",{"date":104,"type":22},"2026-08-15",{"name":43,"class":44},""]