[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Uşak University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":345},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,47,71,103,129,151,172,192,216,240,268,292,320],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100640819","peloid-therapy-in-temporomandibular-joint-dysfunction-100640819",false,"NCT07576582","Peloid Therapy in Temporomandibular Joint Dysfunction","The Effect of Peloid Therapy on Pain and Functional Outcomes in Patients With Temporomandibular Joint Dysfunction","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Diagnosis of temporomandibular joint dysfunction based on DC\u002FTMD criteria\n* Presence of TMJ-related pain for at least 4 weeks\n* Baseline pain intensity ≥3 on a 0-10 visual analog scale\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* History of temporomandibular joint trauma, tumor, active infection, or acute inflammation\n* Previous temporomandibular joint surgery\n* Presence of systemic inflammatory rheumatologic disease\n* Pregnancy\n* Open wound, active dermatitis, or skin condition preventing peloid application at the treatment site\n* Injection therapy (e.g., botulinum toxin) or regular physical therapy for TMJ within the past 3 months\n* Any clinical or behavioral condition that may interfere with study compliance","ALL","18 Years","65 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, single-group clinical study will evaluate whether local peloid therapy improves pain and jaw function in adults with temporomandibular joint dysfunction. Participants will receive peloid therapy applied to the temporomandibular joint region and masticatory muscles for 20 minutes per session, 5 days per week, for 2 weeks. Pain and functional outcomes will be measured at baseline and at the end of treatment using validated clinical scales, including the Jaw Functional Limitation Scale-8, visual analog scale pain scores, Fonseca index, maximum mouth opening, and secondary otalgia assessment.",[27,28,29],"Temporomandibular Disorders (TMDs)","Pain","Otalgia",[31,32,33],"TMJ Disorders","pain","otalgia","RECRUITING","2026-06-29",{"date":37,"type":38},"2026-07-02","ACTUAL",{"date":40,"type":38},"2026-04-01",{"date":42,"type":21},"2027-02-01",{"name":44,"class":45},"Uşak University","OTHER",1,{"id":48,"slug":4,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100616725","NCT07309341","Effects of Isotretinoin on Smell","Effects of Isotretinoin on Nasal Mucociliary Clearance and Olfactory Function","Inclusion Criteria:\n\n* Diagnosed with acne and scheduled to start oral isotretinoin as part of routine dermatology care\n* Willing to participate and able to give informed consent\n* Not currently smoking\n* No history of allergic rhinitis, sinusitis, or active upper respiratory infection\n* No medical condition known to affect the sense of smell\n\nExclusion Criteria:\n\n* Younger than 18 years or older than 45 years\n* Current cigarette smoking\n* History of chronic sinonasal disease\n* Any condition that would prevent completing the smell test\n* Not willing to continue participation or withdrawal of consent at any time","45 Years",{"count":55,"type":21},54,[24],"Isotretinoin is a common medicine used to treat moderate to severe acne. It often causes dryness of the skin and the inside of the nose. Because a normal sense of smell depends on a healthy nasal lining, this dryness may affect how well a person can smell.\n\nThis study will examine whether isotretinoin treatment changes the sense of smell in adults with acne. Before starting isotretinoin, participants will complete a standardized smell test and two short questionnaires about nasal symptoms and quality of life: the Nasal Obstruction Symptom Evaluation (NOSE) scale and the 22-item Sino-Nasal Outcome Test (SNOT-22). After at least 4 weeks of treatment, the same smell test and questionnaires will be repeated.\n\nBy comparing results before and after treatment, the study will test the hypothesis that isotretinoin has a negative effect on olfactory function and may reduce patients' ability to smell.",[59],"Smell Dysfunction",[61,62,63],"olfaction","smell disfunction","isotretinoin",{"date":65,"type":38},"2026-06-30",{"date":67,"type":38},"2025-06-01",{"date":69,"type":21},"2026-08-01",{"name":44,"class":45},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":90,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":46},"100643936","cognitive-reserve-and-post-fatigue-recovery-in-older-adults-100643936","NCT07667985","Cognitive Reserve and Post-Fatigue Recovery in Older Adults","Determining the Post-Physical and Mental Fatigue Recovery Perspectives of Older Adults Based on Their Cognitive Reserves","Inclusion Criteria:\n\n* being 65 years of age or older,\n* not having any neurological, psychiatric, or systemic disease that would affect one's mental state, and not using any medication for these conditions.\n\nExclusion Criteria:\n\n* Being younger than 65 years old,\n* having an illness or taking medication that affects mental health, or being\n* unable to complete the questionnaires.",true,"90 Years",{"count":81,"type":21},400,"OBSERVATIONAL","As people grow older, it is common to experience a drop in physical stamina and memory functions. This can make recovering from daily physical and mental fatigue more difficult, which directly impacts an individual's independent daily life and overall quality of life.\n\n\"Cognitive reserve\" is a term that describes the brain's built-in resilience. Built over a lifetime through education, work, and social activities, a higher cognitive reserve acts like a buffer, helping the brain adapt to stress and aging. While research shows that a high cognitive reserve protects against conditions like dementia, we still do not fully understand how it helps older adults bounce back from normal, everyday physical and mental exhaustion.\n\nThe goal of this study is to investigate how cognitive reserve levels influence how individuals aged 65 and older perceive their recovery after experiencing physical and mental fatigue.\n\nWhat the Study Involves\n\nThe researchers will evaluate participants aged 65 and older to measure their baseline cognitive reserve levels. The study will look closely at how these levels affect the participants':\n\nAbility to cope with daily physical and mental fatigue. Need for rest and rest patterns. Time and ability to return to normal daily activities. Overall perception of their mental and physical recovery. Expected Outcome By understanding this relationship, the study aims to fill a gap in medical literature and help healthcare providers design better, more personalized rehabilitation and lifestyle support programs to improve the quality of life for older adults.",[85,86,87,88,89],"Cognitive Reserve","Aging","Mental Fatigue","Fatigue","Recovery of Function",[91,92,93,94],"aging","cognitive reserve","fatigue","Post-Fatigue Recovery","2026-06-19",{"date":97,"type":38},"2026-06-25",{"date":99,"type":38},"2026-06-20",{"date":101,"type":21},"2026-09-22",{"name":44,"class":45},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100620341","high-power-laser-therapy-for-notalgia-paresthetica-100620341","NCT07356362","High-power Laser Therapy for Notalgia Paresthetica.","The Effectiveness of High-power Laser Therapy in the Treatment of Notalgia Paresthetica: A Randomised Controlled Study.","Inclusion Criteria:\n\n* Adults aged 18-75 years\n* Clinical diagnosis of unilateral Notalgia Paresthetica for at least 3 months\n* Presence of characteristic symptoms (pruritus, paresthesia, and\u002For burning pain) in the typical T2-T6 dermatomal distribution\n* A minimum score of 4 on the Numeric Rating Scale (NRS) for pruritus intensity\n* Presence of hyperpigmentation in the affected area\n\nExclusion Criteria:\n\n* \\- Secondary causes of symptoms (e.g., spinal pathology, herpes zoster, renal failure)\n* Previous spinal surgery in the thoracic region\n* Coagulopathy or use of anticoagulant medication\n* Skin diseases or infections in the treatment area\n* Pregnancy or lactation\n* Cognitive impairment affecting ability to complete questionnaires\n* Previous treatment with botulinum toxin in the affected area within 6 months",{"count":20,"type":21},[24],"A non-invasive modality for the management of neuromusculoskeletal pain conditions that has emerged as a compelling option is high-power laser therapy (HPLT). The pathophysiology of notalgia paresthetica (NP) is treated uniquely by HPLT, which targets both the presumed muscular component of nerve entrapment and the resultant neuropathic symptoms. The main goal of this study, which is randomised, controlled and blinded by assessors, is to find out how well High-Power Laser Therapy (HPLT) works as an extra treatment to standard care in reducing itching, pain and improving quality of life for patients with long-term nerve pain.",[114],"Notalgia Paresthetica",[116,28,117,118,119],"Laser Therapy","Itching","Discopathy","Neuropathy","NOT_YET_RECRUITING","2026-01-21",{"date":123,"type":38},"2026-01-23",{"date":125,"type":21},"2026-01-27",{"date":127,"type":21},"2026-11-12",{"name":44,"class":45},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":136,"targetDuration":4,"studyType":22,"phases":138,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":148,"leadSponsor":150,"locationsCount":46},"100618187","the-efficacy-of-high-power-laser-therapy-in-meralgia-paresthetica-100618187","NCT07328360","The Efficacy of High-Power Laser Therapy in Meralgia Paresthetica","The Efficacy of High-Power Laser Therapy as an Adjunct to Conservative Management in Patients With Meralgia Paresthetica: A Randomized, Assessor-Blinded, Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-65 years.\n* Clinical diagnosis of MP (based on history: burning pain, tingling, numbness in the lateral thigh; tenderness over the inguinal ligament near the anterior superior iliac spine (ASIS); and a positive pelvic compression test or Tinel's sign over the lateral femoral cutaneous nerve (LFCN)).\n* Symptoms persistent for at least 3 months (chronic).\n* A baseline pain intensity of ≥4 on the Numeric Rating Scale (NRS).\n\nExclusion Criteria:\n\n* Secondary MP (e.g., due to pelvic surgery, trauma, or tumor mass effect confirmed by imaging).\n* Significant lumbar radiculopathy (L1-L2).\n* Coagulopathy, use of anticoagulants.\n* Pregnancy.\n* Skin disease or infection in the treatment area.\n* Presence of a cardiac pacemaker.\n* Severe cognitive impairment.",{"count":137,"type":21},50,[24],"The management of MP typically follows a conservative pathway, encompassing patient education, lifestyle modifications (e.g., avoidance of tight garments, weight loss), pharmacotherapy (such as neuropathic pain agents or corticosteroid injections), and physical therapy. However, evidence supporting the efficacy of these interventions is largely anecdotal or derived from low-quality studies, and a substantial proportion of patients experience persistent symptoms refractory to standard care.\n\nTherefore, the primary objective of this randomized, sham-controlled, assessor-blinded study is to investigate the efficacy of HPLT as an adjunct to standard conservative care on pain intensity, sensory symptoms, and functional capacity in patients with chronic Meralgia Paresthetica. The investigators hypothesize that patients receiving active HPLT will demonstrate significantly greater improvements in these outcomes compared to those receiving a sham laser procedure",[141],"Meralgia Paresthetica",[116,141,28,117,143],"discopathy","2026-01-12",{"date":146,"type":38},"2026-01-13",{"date":144,"type":38},{"date":149,"type":21},"2026-08-05",{"name":44,"class":45},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":169,"leadSponsor":171,"locationsCount":46},"100614198","inspiratory-muscle-training-after-stroke-100614198","NCT07276477","Inspiratory Muscle Training After Stroke","Effects of Inspiratory Muscle Training Via a Mobile Respiratory Trainer (AiroFit PRO™) on Pulmonary Function, Muscle Strength, and Quality of Life in Hemiplegic Individuals: A Randomized Controlled Study","Inclusion Criteria:\n\n* Clinical Diagnosis: A confirmed diagnosis of unilateral hemiplegia or hemiparesis (e.g., secondary to ischemic or hemorrhagic stroke), sustained at least 3 months prior to enrollment.\n* Age: Aged between 18 and 80 years.\n* Stable Medical Condition: Medically stable, as determined by the treating physician, with no changes in their primary rehabilitation regimen or medication for spasticity\u002Fneurological condition in the past 4 weeks.\n* Cognitive \\& Communication Ability: Sufficient cognitive function and language comprehension to understand and follow simple commands and provide informed consent, as assessed by a Mini-Mental State Examination (MMSE) score of ≥ 24 (or a similar validated tool).\n* Respiratory Status: Able to perform forced expiratory maneuvers for spirometry and tolerate the breathing training protocols.\n\nExclusion Criteria:\n\n* Pre-existing, significant respiratory diseases (e.g., severe COPD, asthma, pulmonary fibrosis, active lung cancer).\n* Unstable cardiovascular conditions (e.g., uncontrolled hypertension, unstable angina, recent myocardial infarction within the past 6 months, congestive heart failure NYHA Class III or IV).\n* Inability to achieve a proper seal with the breathing trainer mouthpiece due to facial muscle weakness or other anatomical reasons.\n* Inability to commit to the 6-week training and assessment schedule","80 Years",{"count":55,"type":21},[24],"Objective: To investigate and compare the efficacy of a 6-week, supervised respiratory training program using the AiroFit PRO™ mobile respiratory trainer against traditional Pursed-Lips Breathing exercises in individuals with hemiplegia.\n\nStudy Design: A single-blind, two-arm, randomized controlled trial.\n\nParticipants: Ambulatory adults with stable hemiplegia (≥3 months post-stroke), who are medically stable and able to follow commands.\n\nInterventions: Participants will be randomly assigned to one of two groups:\n\nExperimental Group: Will perform Inspiratory Muscle Training using the AiroFit PRO™ device for 15 minutes\u002Fday, 5 days\u002Fweek, for 6 weeks. The intensity will be progressively increased.\n\nActive Control Group: Will perform Pursed-Lips Breathing exercises for an identical duration and frequency.\n\nPrimary Outcomes: Changes in pulmonary function tests, including Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and Maximal Inspiratory Pressure (MIP).\n\nSignificance: This study will provide high-level evidence on the utility of smart, device-guided respiratory training as a novel component of neurorehabilitation, potentially offering a more effective strategy to improve respiratory health and overall recovery in hemiplegic patients compared to standard breathing exercises.",[163,164,165],"Stroke","Exercise","Pulmonary",{"date":167,"type":38},"2026-01-14",{"date":144,"type":38},{"date":170,"type":21},"2026-06-11",{"name":44,"class":45},{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":181,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":189,"leadSponsor":191,"locationsCount":46},"100614021","the-effect-of-graded-forced-expiration-on-intraocular-pressure-100614021","NCT07274176","The Effect of Graded Forced Expiration on Intraocular Pressure","The Effect of Graded Forced Expiration on Intraocular Pressure: A Study Using the Airofit Device","Inclusion Criteria:\n\n* Aged 18 years or older.\n* Willing and able to provide informed consent.\n* Have a best-corrected visual acuity of 6\u002F12 or better.\n* Able to understand and follow instructions for using the Airofit device.\n* Have an optic nerve cup\u002Fdisc ratio not exceeding 0.5, and have a c\u002Fd difference between both eyes not exceeding 0.2.\n* Did not have taken any anticholinergic medication, systemic beta-blockers, or corticosteroids within the last 3 months that could affect intraocular pressure levels.\n\nExclusion Criteria:\n\n* a history of intraocular surgery,\n* a history of uveitis,\n* a spherical refractive error exceeding 3D,\n* a history of regular topical treatment other than artificial tears",{"count":180,"type":21},60,[24],"The primary objective of this study is to utilize the Airofit device to systematically measure and characterize the changes in intraocular pressure across its six different levels of forced expiration. This investigation will provide crucial quantitative data on the IOP-respiratory effort relationship, enhancing our understanding of IOP dynamics during controlled respiratory stress and establishing a new, standardized paradigm for such research.",[184],"Intraocular Pressure","2025-12-15",{"date":187,"type":38},"2025-12-22",{"date":185,"type":38},{"date":190,"type":21},"2026-02-25",{"name":44,"class":45},{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":205,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":46},"100613251","laser-therapy-in-the-isotretinoin-induced-sacroiliitis-100613251","NCT07264153","Laser Therapy in the Isotretinoin-Induced Sacroiliitis","Efficacy of High-Intensity Laser Therapy (HILT) in the Management of Isotretinoin-Induced Sacroiliitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 35 years.\n* Receiving a stable dose of oral isotretinoin (e.g., 0.3-0.5 mg\u002Fkg\u002Fday) for at least one month.\n* Diagnosis of sacroiliitis based on: Clinical symptoms: Persistent (≥4 weeks) lower back\u002Fbuttock pain, morning stiffness \\>30 minutes, improvement with exercise. Positive physical findings: At least two positive sacroiliac joint provocation tests (e.g., FABER\u002FPatrick's test, Gaenslen's test, Compression\u002FDistraction test). Radiological confirmation (MRI): Active inflammation (bone marrow edema) on Short-Tau Inversion Recovery (STIR) sequences in one or both sacroiliac joints.\n* A baseline pain intensity of ≥4 on the Visual Analog Scale (VAS 0-10 cm).\n\nExclusion Criteria:\n\n* ankylosing spondylitis or other seronegative spondyloarthritis\n* the presence of pregnancy\n* the presence of any cancer\n* the presence of multiple sclerosis","35 Years",{"count":137,"type":21},[24],"The clinical significance of this adverse effect lies in its impact on quality of life and the potential for misdiagnosis. The symptomatology can be severe enough to limit daily activities and may be mistakenly attributed to a primary rheumatic disease, leading to unnecessary long-term immunosuppressive therapy if the temporal link to isotretinoin is not identified. Therefore, a high index of suspicion is crucial for dermatologists, rheumatologists, and primary care physicians alike.\n\nAim: To compare the effectiveness of High-Intensity Laser Therapy (HILT) in reducing pain intensity, in patients diagnosed with Isotretinoin-Induced Sacroiliitis.",[204],"Sacroilitis",[116,206,207,28],"Isotretinoin","Sacroiliitis","2025-12-04",{"date":210,"type":38},"2025-12-12",{"date":212,"type":38},"2025-11-24",{"date":214,"type":21},"2026-05-11",{"name":44,"class":45},{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":199,"enrollmentInfo":223,"targetDuration":4,"studyType":22,"phases":225,"briefSummary":226,"conditions":227,"keywords":229,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":46},"100608071","exercise-therapy-for-isotretinoin-users-100608071","NCT07196787","Exercise Therapy for Isotretinoin Users","Prophylactic Exercise Therapy for Musculoskeletal Side Effects in Isotretinoin Users: A Controlled Study","Inclusion Criteria:\n\n* The participant is between the ages of 18-35,\n* Not having a regular exercise habit,\n* Starting Isotretinoin treatment for the first time.\n\nExclusion Criteria:\n\n* Presence of any diagnosed rheumatologic disease,\n* The presence of any diagnosed neurological disease,\n* Having any diagnosed psychiatric illness,\n* Having a physical disability that prevents them from exercising for any reason.",{"count":224,"type":21},160,[24],"Isotretinoin (13-cis retinoic acid) is a retinoic acid that is a derivative of vitamin A. Isotretinoin has been used effectively alone in acne treatment for 35 years. However, it has many side effects. Among the musculoskeletal side effects of this treatment, acute sacroileitis is a common condition. In this clinical picture, recovery may last for a few months after discontinuation of isotretinoin treatment. However, it may become permanent in some cases. According to our current knowledge, there is no study in the literature that prescribes exercise therapy for this patient group. This study, planned to investigate the effects of stretching and sacroiliac mobilization exercises on musculoskeletal pain and quality of life, which are among the side effects of isotretinoin treatment.",[206,228],"Isotretinoin Adverse Reaction",[230,32,231,232],"exercise","prophylaxis","side effects",{"date":234,"type":38},"2025-12-02",{"date":236,"type":38},"2025-09-30",{"date":238,"type":21},"2026-03-26",{"name":44,"class":45},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":78,"sex":247,"minAge":17,"maxAge":199,"enrollmentInfo":248,"targetDuration":4,"studyType":22,"phases":250,"briefSummary":251,"conditions":252,"keywords":255,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":46},"100606551","the-effects-of-breathing-exercises-and-music-intervention-during-labor-on-pain-perception-birth-expectations-and-birth-satisfaction-in-primiparous-women-100606551","NCT07177027","The Effects of Breathing Exercises and Music Intervention During Labor on Pain Perception, Birth Expectations, and Birth Satisfaction in Primiparous Women","The Effects of Breathing Exercises and Music Intervention During Labor on Pain Perception, Birth Expectations, and Birth Satisfaction in Primiparous Women: A Randomized Controlled Trial","Inclusion Criteria:Participants were included in the study if they met the following criteria:\n\nVoluntary participation in the study and provision of written informed consent, Being a primiparous pregnant woman, Aged between 18 and 35 years, Gestational age between 38 and 42 weeks, Ability to read and write, No hearing impairment that would prevent listening to music, Planning to deliver vaginally, No respiratory disorders (e.g., asthma, COPD) that would interfere with breathing exercises, No obstetric complications that could affect labor progression (e.g., precipitous labor, prolonged labor), Attendance in antenatal childbirth education classes, including learning breathing exercises and listening to the music pieces planned for the intervention.\n\nNot receiving any labor-inducing medications\n\n\\-\n\nExclusion Criteria: Participants were excluded if they met any of the following:\n\nWithdrawal of consent or unwillingness to continue cooperation at any stage of the study, Refusal to continue with breathing exercises or music intervention during any phase of labor, Undergoing cesarean section due to medical indications despite initial plan for vaginal delivery, Gestational age outside of 38-42 weeks, Development of labor-related complications such as precipitous or prolonged labor during the study.","FEMALE",{"count":249,"type":21},90,[24],"This randomized controlled trial aimed to evaluate the effects of music listening and breathing exercises during labor on pain perception, birth expectations, and birth satisfaction among primiparous women. This randomized controlled trial was conducted in the delivery unit of a hospital located in the Inner Aegean Region of Turkey. The study included 90 primiparous pregnant women admitted for vaginal delivery. Participants without visual, auditory, or neurological impairments were included and randomly assigned into three groups: music intervention group, breathing exercise group, and control group (n=30 in each group).\n\nParticipants were randomly assigned to one of three groups (Music Intervention, Breathing Exercise, Control) using a computer-generated randomization sequence. Allocation concealment was ensured by using sealed, opaque envelopes prepared by a researcher who was not involved in participant recruitment or assessment.\n\nIn the music intervention group, participants were introduced to 12 music tracks at 36 weeks of gestation during childbirth preparation classes. Short samples of these tracks were played during the class, and the full tracks were then shared with participants via WhatsApp to encourage regular listening at home.\n\nDuring the prenatal period, participants received regular WhatsApp reminders every few days to listen to the music.\n\nDuring labor, participants were encouraged to listen to music whenever they wished. Additionally, at 4 cm, 6 cm, and 8 cm cervical dilation, all participants in this group listened to their preferred tracks from the playlist for 20 minutes. Pain intensity was measured using the Visual Analog Scale (VAS) before and after each music session.\n\nIn the breathing exercise group, Lamaze breathing techniques were taught during prenatal classes and practiced throughout the labor process. They were encouraged to practice these exercises throughout labor. At 4, 6, and 8 cm cervical dilation, guided breathing exercises were conducted, and pain was assessed using the Visual Analog Scale (VAS) before and after each exercise.\n\nIn the control group, participants received routine maternity care. VAS pain assessments were conducted at the same cervical dilation points (4, 6, and 8 cm), without any additional interventions.\n\nFor all participants, the durations of the first, second, and third stages of labor were recorded and compared across groups. In the postpartum period, the Birth Expectation Scale and Birth Satisfaction Scale were administered.\n\nStudy data included sociodemographic information, VAS pain scores, and scores from the birth expectation and satisfaction scales.",[253,254],"Music Intervention","Breathing Exercises",[256,257,258,259],"Music intervention","Breathing exercises","Birth","Pregnancy","2025-09-09",{"date":262,"type":38},"2025-09-16",{"date":264,"type":38},"2024-12-03",{"date":266,"type":21},"2025-09-22",{"name":44,"class":45},{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":274,"targetDuration":4,"studyType":22,"phases":276,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":46},"100597363","the-effect-of-emotional-freedom-technique-on-psychological-health-and-well-being-in-people-with-type-2-diabetes-100597363","NCT07057518","The Effect of Emotional Freedom Technique on Psychological Health and Well-being in People With Type 2 Diabetes.","Inclusion Criteria:\n\n* being over 18 years of age,\n* having type 2 diabetes,\n* no psychiatric diagnosis\n* agreeing to participate in the study.\n\nExclusion Criteria:\n\n* be under 18 years of age,\n* have type 1 diabetes or gestational diabetes,\n* attend any course on coping with diabetes distress and anxiety,\n* have advanced mental health problems.",{"count":275,"type":21},80,[24],"Type 2 diabetes is a major meatbolic condition. People living with Type 2 diabetes come across a wide range of health issues, including psychological health. Specifically, diabetes distress are in high levels among them. Diabetes distress is associated with psychological states such as anxiety, lower levels of self-care, and higher hemoglobin A1c (HbA1c) levels. The Emotional Freedom Technique consists of cognitive and somatic components and is used to heal an individual's negative emotions and manage associated emotional and physical disorders. The basic principle of this technique is to regulate the flow of energy by stimulating the meridian system and to relax the individual while focusing on the emotional reactions that lead to disability. Although the prevalence of psychological problems associated with T2DM and diabetes is increasing, there are not enough studies showing the effect of Emotional Freedom Technique on the psychological well-being of T2DM individuals.",[279],"Type 2 Diabetes",[281,282,283],"Type 2 diabetes","Emotional Freedom Technique","RCTs","2025-07-07",{"date":286,"type":38},"2025-07-10",{"date":288,"type":38},"2025-05-06",{"date":290,"type":21},"2025-07",{"name":44,"class":45},{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":296,"acronym":297,"eligibilityCriteria":298,"healthyVolunteers":78,"sex":16,"minAge":299,"maxAge":158,"enrollmentInfo":300,"targetDuration":4,"studyType":22,"phases":301,"briefSummary":302,"conditions":303,"keywords":306,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":46},"100592569","evaluation-of-aqueous-humor-del-1-and-il-17-levels-in-diabetic-cataract-patients-100592569","NCT06995131","Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients","DEL-1 and IL-1","Inclusion Criteria:\n\n* Cataract diagnosed and surgery planned\n* Patients without any other ocular pathology other than cataract.\n* Type 2 DM for at least 5 years in the diabetic group\n\nExclusion Criteria:\n\n* Patients with previous intraocular surgery\n* Those with inflammatory eye diseases (e.g. uveitis)\n* Those with autoimmune diseases or systemic inflammatory diseases\n* Those receiving local or systemic steroid therapy\n* Those with severe systemic disease (e.g. advanced renal failure, malignancy)","50 Years",{"count":180,"type":21},[24],"By comparing DEL-1 and IL-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in the eye.",[304,305],"Diabetic Group (n=30)","Non-diabetic Group",[307,308,309,310,311],"Diabetes Mellitus","cataract","aqueous humor","Del 1","IL17","2025-06-03",{"date":314,"type":38},"2025-06-05",{"date":316,"type":38},"2025-05-01",{"date":318,"type":21},"2025-08-15",{"name":44,"class":45},{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":11,"sex":247,"minAge":327,"maxAge":328,"enrollmentInfo":329,"targetDuration":4,"studyType":22,"phases":330,"briefSummary":331,"conditions":332,"keywords":334,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":342,"leadSponsor":344,"locationsCount":46},"100588785","effect-of-swimming-exercise-on-diastolic-dysfunction-100588785","NCT06945913","Effect of Swimming Exercise on Diastolic Dysfunction","The Effect Of Variable Intensity Swimming Exercise On Cardiovascular Parameters And Echocardiography In Women With Diastolic Dysfunction","Inclusion Criteria\n\nParticipants who met the following criteria were included in the study:\n\n* No echocardiographic abnormalities detected except for stage 1 diastolic dysfunction based on examinations conducted in the cardiology outpatient clinic,\n* Female gender,\n* Aged between 40 and 60 years as of the study initiation date,\n* No history of substance use, including smoking and alcohol,\n* Willingness to participate by completing the informed consent form.\n\nExclusion Criteria\n\nParticipants who met at least one of the following conditions were excluded from the study:\n\n* Refusal to sign the informed consent form,\n* Failure to participate in at least one of the study measurements,\n* Inability to meet the necessary criteria for training and measurements,\n* Presence of illness or injury during training or measurements,\n* Voluntary withdrawal from the study.","40 Years","60 Years",{"count":180,"type":21},[24],"The aim of the study was to determine the rehabilitative effects of 12-week variable intensity swimming exercises on the cardiovascular system in women with diastolic dysfunction. Studies on how variable intensity swimming exercises contribute to the course of the disease in sedentary women with cardiovascular problems are limited. Previous studies generally consisted of studies on the effects of exercise applications on the cardiovascular system in different branches and their effects were determined.",[333],"Diastolic Dysfunction",[333,164,335,336,337],"High Intensity Interval Training","Moderate Intensity Continuous Training","Women Health","2025-04-22",{"date":340,"type":38},"2025-04-27",{"date":316,"type":21},{"date":343,"type":21},"2025-07-15",{"name":44,"class":45},""]