[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"U.G.A. Nutraceuticals\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":57},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":5},"100632583","effect-of-compound-cardiol-forte-on-lipid-and-glycemic-parameters-in-low-cardiovascular-risk-individuals-100632583",false,"NCT07515573","Effect of Compound (Cardiol Forte) on Lipid And Glycemic Parameters in Low Cardiovascular Risk Individuals","A Randomized, Double-Blind, Placebo-Controlled, Two-Arm, Parallel-Group Clinical Trial With an Open-Label Extension to Evaluate the Effects of a Combination Dietary Supplement (Cardiol Forte) on Lipid and Glycemic Parameters in Subjects at Low Cardiovascular Risk With Suboptimal Cholesterol Levels","CLARISKI","Inclusion Criteria:\n\n* Male or female aged 18 to 79 years\n* Individuals in primary cardiovascular prevention\n* Estimated 10-year cardiovascular risk \\\u003C10%\n* Screening non-HDL-C between 140 and 220 mg\u002FdL, or screening LDL-C between 110 and 190 mg\u002FdL\n* Ability to communicate adequately, to be understood, and to comply with the study requirements\n* Willingness to participate in the study and provision of written, signed, and dated informed consent\n\nExclusion Criteria:\n\n* Triglycerides \\>400 mg\u002FdL at screening\n* Type 1 or type 2 diabetes mellitus\n* Body mass index \\>35 kg\u002Fm²\n* Current treatment with lipid-lowering drugs or use of dietary supplements active on lipid metabolism\n* Antihypertensive treatment not stabilized for at least 3 months\n* Known clinically significant alterations of thyroid, hepatic, and\u002For renal function\n* Women of childbearing potential not using adequate contraceptive methods\n* Pregnancy or breastfeeding\n* Any medical or surgical condition that, in the investigator's judgment, could make adherence to the protocol difficult or inconsistent, compromise participant safety, or interfere with study completion\n* Known intolerance or hypersensitivity to any component of the study products","ALL","18 Years","79 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will evaluate the effects of a combination dietary supplement, Cardiol Forte, on lipid and glycemic parameters in adults at low cardiovascular risk with suboptimal cholesterol levels. After a 14- to 28-day run-in period with standardized dietary and behavioral instructions, 50 participants will be randomized in a 1:1 ratio to receive either Cardiol Forte or matching placebo for 8 weeks under double-blind conditions. After completion of the double-blind phase, all participants will receive Cardiol Forte for an additional 8 weeks in an open-label extension. The primary objective is to compare the change in non-high-density lipoprotein cholesterol (non-HDL-C) from baseline to Week 8 between Cardiol Forte and placebo. Secondary objectives include evaluation of other lipid parameters, fasting plasma glucose, Omega-3 Index, selected inflammatory and liver-related markers, and endothelial reactivity.",[28],"Dyslipidemia",[30,28,31,32,33,34,35,36,37,38,39,40,41,42,43,44],"Cardiol Forte","non-HDL cholesterol","Glycemic profile","Cardiovascular prevention","Low cardiovascular risk","Eicosapentaenoic acid","EPA","Docosahexaenoic acid","DHA","Artichoke","Bergamot","Hydroxytyrosol","Coenzyme Q10","Folic acid","Vitamin E","NOT_YET_RECRUITING","2026-04-15",{"date":48,"type":49},"2026-04-20","ACTUAL",{"date":51,"type":22},"2026-05-04",{"date":53,"type":22},"2028-05-04",{"name":55,"class":56},"U.G.A. Nutraceuticals","INDUSTRY",""]