[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"UPECLIN HC FM Botucatu Unesp\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":94},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100541157","phase-1-cell-therapy-for-lower-limb-ulcers-in-patients-with-critical-limb-ischemia-100541157",false,"NCT06326203","Cell Therapy for Lower Limb Ulcers in Patients With Critical Limb Ischemia","Randomized, Prospective, Controlled, Single-center, Open-label Phase II Clinical Trial Aimed at Evaluating the Safety and Efficacy of Autologous Mesenchymal Stem Cell Therapy for Lower Limb Ulcers in Patients With Critical Limb Ischemia","Inclusion Criteria:\n\n* Absence of distal pulses in the leg (anterior tibial and posterior tibial) and presence or absence of popliteal pulse.\n* Peripheral Arterial Disease (PAD).\n* Having foot or leg ulcer(s) (distal third) with a minimum area of 1cm2 and a maximum of 3 ulcers totaling up to 20cm2 in the lower limb.\n* Having previously received conventional dressing treatment for ulcer indicating no improvement over a minimum period of 3 weeks (antibiotic therapy - if necessary - local care such as mechanical, surgical or chemical debridements - if necessary, dressings).\n* PAD with IC classified as Fontaine IV and Rutherford 5.\n* Having Ankle Brachial Index (ABI) \\\u003C0.9 in infragenicular arteries (anterior tibial, posterior tibial, and fibular) or ABI\\>1.3 in one or more infragenicular arteries when suffering from chronic DMT2 (disease duration \\> 5 years) not subjected to revascularization treatment or subjected to partial revascularization treatment or treatment failure (stenosis or occlusion) in the last 12 months.\n* Inability to revascularize the affected limb (do not have visible infragenicular arteries for surgical approach) and or incomplete revascularization of this limb (undergone endovascular and or surgical treatment that was not able to restore infragenicular pulses) and defined by the doctor that the best available treatment from the surgical vascular point of view has already been performed and was not successful in promoting ulcer healing.\n* Drug treatment for PAD and for comorbidities.\n* Availability to attend medical appointments.\n\nExclusion criteria:\n\n* Being pregnant or in the puerperium.\n* Having a healed ulcer during the screening period.\n* Having signs of systemic infection or active infection in the arterial ulcer or infection of surgical prostheses (bypass, pins, screws). They may be eligible again if they have been successfully treated with antibiotics and the infectious focus has been removed.\n* Having an ulcer with devitalized tissue (necrosis). They may be eligible again if they have undergone successful surgical debridement or minor amputations (amputation of toes or limited to the forefoot).\n* Having neoplasia and\u002For being in chemotherapy or radiotherapy treatment or in remission for less than 6 months.\n* Being on colchicine or immunomodulators.\n* Having infectious diseases such as Human Immunodeficiency Virus (HIV), Hepatitis B and C viruses, Human T-cell Lymphotropic Virus (HTLV); due to the risk of contagion during the manipulation of biological material in the laboratory.\n* Having undergone amputation at the level of the leg or thigh in the limb intended to be studied.\n* Having COVID-19, diagnosed less than 4 weeks ago.","ALL","18 Years","90 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","Peripheral arterial disease (PAD) can progress to critical limb ischemia (CLI) of the affected lower limb, characterized by pain at rest, ulcerations or gangrene, with a high risk of amputation. In this phase, the best treatment is arterial limb revascularization, but this is not always possible or even effective for promoting pain relief, healing of ulcers or preventing amputations, in addition to the high socioeconomic cost caused by the disease. Recent advances in cell therapy represent a promising supporting alternative for the treatment of PAD in cases where conventional alternatives have run out. Objective: To evaluate the safety and efficacy of cell therapy with expanded autologous mesenchymal stem cells in the treatment of patients with PAD with CLI and chronic arterial ulcers. Methods: An open randomized clinical study will be performed with 2 groups of 20 patients with CLI: in group 1, a fragment of abdominal fat tissue (10g) will be collected to obtain mesenchymal stem cells, which will be expanded and applied using subcutaneous perilesional injection in the affected lower limb, in addition to the application in the form of a personalized curative biological on the wounds. Group 2 will receive conventional treatment with a Hydrogel dressing with essential fatty acids. Periodic clinical evaluations, complementary exams and photographic record will be carried out. The main outcome of effectiveness will be partial or total wound healing. Safety outcomes will be monitored for infections, gangrene, amputations and deaths. Participants will be monitored for 120 days. Major amputation cases will not be included. An independent external evaluator and blind to the groups will evaluate the results. It is an innovative procedure with high impact and financial return for SUS, in view of the high prevalence of the disease and the high socioeconomic impact of the disease when it progresses to limb amputation.",[28,29],"Peripheral Arterial Disease","Leg Ulcer","NOT_YET_RECRUITING","2026-05-04",{"date":33,"type":34},"2026-05-06","ACTUAL",{"date":36,"type":21},"2026-06-01",{"date":38,"type":21},"2028-03-31",{"name":40,"class":41},"UPECLIN HC FM Botucatu Unesp","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},"100532563","shear-wave-elastography-for-carotid-atherosclerotic-plaques-100532563","NCT06214429","Shear Wave Elastography for Carotid Atherosclerotic Plaques","Evaluation of Atherosclerotic Carotid Plaque Stiffness by Shear Wave Elastography, Greyscale Median, Magnetic Resonance Imaging and Histopathological Analysis: Diagnostic Test Study","Inclusion Criteria:\n\n* Patients with atherosclerotic carotid plaques that develop stenosis superior to 50%.\n\nExclusion Criteria:\n\n* Previous cervical surgery;\n* Previous cervical radiotherapy;\n* Stenosis caused by vascular inflammatory diseases;\n* Pregnant women;\n* High carotid bifurcation (inaccessible by vascular ultrasound linear probe);\n* Posterior acoustic shadowing that impair morphological evaluation of the plaque.",{"count":50,"type":21},43,"OBSERVATIONAL","The goal of this prospective diagnostic accuracy cohort study is to compare the accuracy of carotid atherosclerotic plaques stiffness assessed by shear wave elastography (SWE) with greyscale median values (GSM), magnetic resonance imaging (MRI) and histopathological findings in patients with carotid atherosclerotic plaques causing stenosis above 50%, symptomatic or not.\n\nThe main question it aims to answer is: is the plaque stiffness correlatable with GSM values, MRI findings or histopathological findings? Participants will be subjected to a vascular ultrasound study in which the SWE and GSM will be assessed. The second imaging modality for stenosis confirmation will be MRI and patients with confirmed symptomatic stenosis above 50% or assymptomatic stenosis above 70% will be considered for surgery intervention (endarterectomy or angioplasty). Patients that undergo endarterectomy will have the carotid plaques subjected to a histopathological study. The study will not arbitrate about the treatment decision.",[54],"Carotid Atherosclerosis","RECRUITING","2025-04-02",{"date":58,"type":34},"2025-04-06",{"date":60,"type":34},"2023-03-01",{"date":62,"type":21},"2025-12-31",{"name":40,"class":41},1,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":74,"studyType":51,"phases":4,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":64},"100567825","inspire-respiratory-health-program-in-botucatu-so-paulo-brazil-100567825","NCT06673225","INSPIRE Respiratory Health Program in Botucatu, São Paulo, Brazil","Evaluation of the Implementation of the INSPIRE Respiratory Health Program: Integration of Early Diagnosis and Emergency Response for Respiratory Diseases in the City of Botucatu, São Paulo, Brazil","Inclusion Criteria:\n\n* Age equal to or greater than 18 years old;\n* Respiratory symptoms\n* History of active or passive smoking\n* Signing of informed consent form\n\nExclusion Criteria:\n\n* Difficulty understanding the issues addressed\n* Inability to contact by phone\n* Non-signing or withdrawal of informed consent",{"count":73,"type":21},2000,"5 Years","The goal of this observational study is to evaluate the implementation of the INSPIRE program and to plan actions for the preparation, coordination, monitoring, diagnosis, and treatment of respiratory diseases in the municipality of Botucatu. Methods: Individuals with respiratory symptoms from the municipality of Botucatu, aged 18 or older, will be invited to participate in the study, and socioeconomic data, as well as information on sex, gender, race, nutritional risk, frailty, tobacco exposure, and its derivatives, will be collected. For those with exposure, screening and treatment for respiratory diseases will be offered through assessment of pulmonary function, body composition, respiratory and peripheral muscle strength. Additionally, individuals over 40 years old with tobacco exposure equal to or greater than 30 pack-years will be offered low-dose chest CT screening for lung cancer. Expected results: To identify and assess vulnerable groups that face difficulties in accessing respiratory healthcare, as well as implement specific strategies for the treatment of respiratory diseases and tobacco control for these groups. To ensure equitable access to respiratory health for the entire population at risk due to smoking. Moreover, through proactive and reactive risk reduction actions implemented by the program, to intervene in distinct groups and other regions.",[77,78,79],"Community Health Services","Respiratory Disease","Tobacco Smoking",[81,82,83,84,85],"Primary care","Health promotion","Pulmonary function tests","Nicotine addiction","Smoking cessation","2024-10-31",{"date":88,"type":34},"2024-11-04",{"date":90,"type":34},"2024-04-16",{"date":92,"type":21},"2029-12-01",{"name":40,"class":41},""]